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    PRODUCTION OF KETOALDEHYDE
    3.
    发明专利
    PRODUCTION OF KETOALDEHYDE 失效

    公开(公告)号：JPH1045660A

    公开(公告)日：1998-02-17

    申请号：JP22451696

    申请日：1996-08-07

    申请人： TOYOTAMA PERFUMERY

    发明人： FUKAWA HIDEMICHI ,  CHIBA MITSUO ,  MURAKAMI RURIKO

    IPC分类号： C07D307/33 ,  C07C45/57 ,  C07C49/185 ,  C07C49/258 ,  C07C49/355 ,  C07C49/583 ,  C07C49/86 ,  C07D309/32

    摘要： PROBLEM TO BE SOLVED: To provide a method for producing a ketoaldehyde, enabling to obtain the ketoaldehyde useful as an intermediate in the fields of medicines, perfumes, etc., in a high yield by simple operations by reducing a specific unsaturated lactone with a metal hydride reducing agent. SOLUTION: (A) A compound of formula I [R2 is (substituted) (un)saturated hydrocarbon group, a (substituted) alicyclic hydrocarbon group, a (substituted) aromatic hydrocarbon group; R1 is H, R2 ; (n) is 1-3] is reduced with (C) a metal hydride reducing agent such as diisobutylaluminum hydride or sodium dimethoxyethoxyaluminum hydride in (B) an organic solvent such as toluene, tetrahydrofuran or n-hexane e.g. in an inert atmosphere at a temperature of -20 to -78 deg.C to obtain the objective compound of formula II.

    Method for producing capsanthin and intermediate
    7.
    发明专利
    Method for producing capsanthin and intermediate 审中-公开
    生产芹菜素和中间体的方法

    公开(公告)号：JP2003073386A

    公开(公告)日：2003-03-12

    申请号：JP2001266883

    申请日：2001-09-04

    申请人： Sumitomo Chem Co Ltd ,  住友化学工業株式会社

    发明人： ITOU MASAYOSHI ,  YAMANO YUMIKO

    IPC分类号： C07C45/68 ,  C07B53/00 ,  C07B61/00 ,  C07C49/355 ,  C07C67/343 ,  C07C69/732 ,  C07F7/18 ,  C07F7/22

    摘要： PROBLEM TO BE SOLVED: To provide a method for the production of capsanthin. SOLUTION: An epoxyaldehyde derivative easily synthesizable from (4R,6R)-4- hydroxy-2,2,6-trimethylcyclohexanone widely used as an optically active raw material for carotenoid synthesis is subjected to site- and stereo-specific ring- opening and rearrangement reaction to obtain cyclopentyl ketone expressed by formula (7). The cyclopentyl ketone is reacted with a Wittig salt in the presence of a base and the obtained acetal is hydrolyzed to obtain apocarotenal. Capsanthin is produced by reacting the apocarotenal with a Wittig salt in the presence of a base. The invention further relates to an intermediate of the above reaction.

    摘要翻译： 要解决的问题：提供一种生产辣椒红的方法。 解决方案：广泛用作类胡萝卜素合成的光学活性原料的（4R，6R）-4-羟基-2,2,6-三甲基环己酮容易合成的环氧甲醛衍生物进行位点和立体特异性开环和重排 反应得到式（7）表示的环戊酮。 将环戊基酮与维t嗪盐在碱的存在下反应，并将所得缩醛水解，得到糊状的。 辣椒红素通过在碱的存在下使山梨酸角质酯与维蒂克盐进行反应来制备。 本发明还涉及上述反应的中间体。