이작용성 신코나-알칼로이드 기재 촉매를 사용하는 비대칭마이클 및 알돌 부가반응
    5.
    发明公开
    이작용성 신코나-알칼로이드 기재 촉매를 사용하는 비대칭마이클 및 알돌 부가반응 无效
    不对称的MICHAEL和ALDOL添加剂使用双官能碱性碱性碱性催化剂

    公开(公告)号:KR1020070024667A

    公开(公告)日:2007-03-02

    申请号:KR1020067027625

    申请日:2005-05-27

    Inventor: 뎅,리 리,홍밍

    Abstract: One aspect of the present invention relates to quinine-based and quinidine-based catalysts. Another aspect of the invention relates to a method of preparing a derivatized quinine-based or quinidine-based catalyst comprising 1) reacting quinine or quinidine with 5 base and a compound that has a suitable leaving group, and 2) converting the ring methoxy group to a hydroxy group. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral electron-deficient alkene or azo compound or prochiral aldehyde or prochiral ketone, comprising the step of: reacting a prochiral electron-deficient alkene or azo compound or prochiral aldehyde or prochiral 10 ketone with a nucleophile in the presence of a catalyst; thereby producing a chiral, non racemic compound; wherein said catalyst is a derivatized quinine or quinidine. Another aspect of the present invention relates to a method of kinetic resolution, comprising the step of reacting racemic chiral alkene with a nucleophile in the presence of a derivatized quinine or quinidine. ® KIPO & WIPO 2007

    Abstract translation: 本发明的一个方面涉及基于奎宁和奎尼丁的催化剂。 本发明的另一方面涉及一种制备衍生的基于奎宁或奎尼丁的催化剂的方法,其包括:1)将奎宁或奎尼丁与5碱和具有合适离去基团的化合物反应,和2)将环甲氧基转化为 羟基。 本发明的另一方面涉及从前手电子缺乏烯烃或偶氮化合物或前手性醛或前手性酮制备手性非外消旋化合物的方法,其包括以下步骤:使前手电子缺乏烯烃或偶氮 化合物或前手性醛或前手性10酮与亲核试剂在催化剂存在下反应; 从而产生手性非外消旋化合物; 其中所述催化剂是衍生的奎宁或奎尼丁。 本发明的另一方面涉及一种动力学拆分方法,其包括在衍生的奎宁或奎尼丁存在下使外消旋手性烯与亲核试剂反应的步骤。 ®KIPO&WIPO 2007

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