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公开(公告)号：US20150150514A1
公开(公告)日：2015-06-04
申请号：US13204460
申请日：2011-08-05
IPC分类号： A61B5/00 , A61B5/0205
CPC分类号： A61B5/0205 , A61B5/0022 , A61B5/021 , A61B5/024 , A61B5/0245 , A61B5/0402 , A61B5/08 , A61B5/0816 , A61B5/14551 , A61B5/7228 , A61B5/7257 , A61B5/7275 , A61B5/7278 , A61B5/7282 , A61B5/742 , A61B5/746 , G06F19/3418 , G16H50/20
摘要： Disclosed are systems and methods to provide a patient care recommendation. The systems and methods receive patient information and a plurality of patient physiological signals that are related to a patient. The systems and methods are then operable to produce at least one derived patient signal from at least one of the plurality of patient physiological signals. The systems and methods use the patient information, at least one of the plurality of patient physiological signals, and the at least one derived patient signal to provide at least one patient care recommendation.
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公开(公告)号：US08383036B2
公开(公告)日：2013-02-26
申请号：US12973681
申请日：2010-12-20
IPC分类号： A61L2/00
CPC分类号： C12Q1/6825 , C12Q1/6837 , C12Q2565/607
摘要： The present invention concerns methods, compositions and apparatus for neutralizing bioagents, wherein bioagents comprise biowarfare agents, biohazardous agents, biological agents and/or infectious agents. The methods comprise exposing the bioagent to an organic semiconductor and exposing the bioagent and organic semiconductor to a source of energy. Although any source of energy is contemplated, in some embodiments the energy comprises visible light, ultraviolet, infrared, radiofrequency, microwave, laser radiation, pulsed corona discharge or electron beam radiation. Exemplary organic semiconductors include DAT and DALM. In certain embodiments, the organic semiconductor may be attached to one or more binding moieties, such as an antibody, antibody fragment, or nucleic acid ligand. Preferably, the binding moiety has a binding affinity for one or more bioagents to be neutralized. Other embodiments concern an apparatus comprising an organic semiconductor and an energy source. In preferred embodiments, the methods, compositions and apparatus are used for neutralizing anthrax spores.
摘要翻译： 本发明涉及用于中和生物标签的方法，组合物和装置，其中生物制剂包括生物武器，生物危害剂，生物制剂和/或感染剂。 所述方法包括将生物制剂暴露于有机半导体并将生物制剂和有机半导体暴露于能量源。 尽管预期了任何能量源，但在一些实施例中，能量包括可见光，紫外线，红外线，射频，微波，激光辐射，脉冲电晕放电或电子束辐射。 示例性有机半导体包括DAT和DALM。 在某些实施方案中，有机半导体可以连接到一个或多个结合部分，例如抗体，抗体片段或核酸配体。 优选地，结合部分对一种或多种待中和的生物剂具有结合亲和力。 其他实施例涉及包括有机半导体和能量源的装置。 在优选的实施方案中，所述方法，组合物和装置用于中和炭疽芽孢。
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3.发明授权公开(公告)号：US07892484B2
公开(公告)日：2011-02-22
申请号：US10291336
申请日：2002-11-08
IPC分类号： A61L2/00
CPC分类号： C12Q1/6825 , C12Q1/6837 , C12Q2565/607
摘要： The present invention concerns methods, compositions and apparatus for neutralizing bioagents, wherein bioagents comprise biowarfare agents, biohazardous agents, biological agents and/or infectious agents. The methods comprise exposing the bioagent to an organic semiconductor and exposing the bioagent and organic semiconductor to a source of energy. Although any source of energy is contemplated, in some embodiments the energy comprises visible light, ultraviolet, infrared, radiofrequency, microwave, laser radiation, pulsed corona discharge or electron beam radiation. Exemplary organic semiconductors include DAT and DALM. In certain embodiments, the organic semiconductor may be attached to one or more binding moieties, such as an antibody, antibody fragment, or nucleic acid ligand. Preferably, the binding moiety has a binding affinity for one or more bioagents to be neutralized. Other embodiments concern an apparatus comprising an organic semiconductor and an energy source. In preferred embodiments, the methods, compositions and apparatus are used for neutralizing anthrax spores.
摘要翻译： 本发明涉及用于中和生物标签的方法，组合物和装置，其中生物制剂包括生物武器，生物危害剂，生物制剂和/或感染剂。 所述方法包括将生物制剂暴露于有机半导体并将生物制剂和有机半导体暴露于能量源。 尽管预期了任何能量源，但在一些实施例中，能量包括可见光，紫外线，红外线，射频，微波，激光辐射，脉冲电晕放电或电子束辐射。 示例性有机半导体包括DAT和DALM。 在某些实施方案中，有机半导体可以连接到一个或多个结合部分，例如抗体，抗体片段或核酸配体。 优选地，结合部分对一种或多种待中和的生物剂具有结合亲和力。 其他实施例涉及包括有机半导体和能量源的装置。 在优选的实施方案中，所述方法，组合物和装置用于中和炭疽芽孢。
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4.发明授权公开(公告)号：US09273345B2
公开(公告)日：2016-03-01
申请号：US11965039
申请日：2007-12-27
IPC分类号： C12N15/115 , C12Q1/68
CPC分类号： C12Q1/6811 , C12N15/115 , Y10T436/143333 , C12Q2525/205 , C12Q2565/101
摘要： Embodiments herein relate to compositions and methods for making and using aptamers, for example, DNA aptamers (DCEs) and/or RNA aptamers. In some embodiments, methods relate to making and amplifying target DCEs. In certain embodiments, methods for making capture elements or aptamers concern using a reporter moiety and signal reducing moiety prior to amplifying a target-specific capture element. In some embodiments, methods disclosed herein may be used to rapidly generate large quantities of aptamers such as DCEs directed to a particular target agent. Some embodiments relate to systems for performing automated generation of aptamers.
摘要翻译： 本文的实施方案涉及用于制备和使用适体的组合物和方法，例如DNA适体（DCE）和/或RNA适体。 在一些实施方案中，方法涉及制备和扩增目标DCE。 在某些实施方案中，用于制备捕获元件或适体的方法在放大靶特异性捕获元件之前关注使用报道部分和信号降低部分。 在一些实施方案中，本文公开的方法可用于快速产生大量适配体，例如针对特定目标试剂的DCE。 一些实施例涉及用于执行适配体的自动生成的系统。
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公开(公告)号：US20150157213A1
公开(公告)日：2015-06-11
申请号：US13204502
申请日：2011-08-05
IPC分类号： A61B5/0205 , A61B5/1455 , A61B5/0402 , A61B5/08 , A61B5/00
CPC分类号： A61B5/0205 , A61B5/0022 , A61B5/021 , A61B5/024 , A61B5/0245 , A61B5/0402 , A61B5/08 , A61B5/0816 , A61B5/14551 , A61B5/7228 , A61B5/7257 , A61B5/7275 , A61B5/7278 , A61B5/7282 , A61B5/742 , A61B5/746 , G06F19/3418 , G16H50/20
摘要： Disclosed are systems and methods to provide a patient care recommendation. The systems and methods receive patient information and a plurality of patient physiological signals that are related to a patient. The systems and methods are then operable to produce at least one derived patient signal from at least one of the plurality of patient physiological signals. The systems and methods use the patient information, at least one of the plurality of patient physiological signals, and the at least one derived patient signal to provide at least one patient care recommendation.
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公开(公告)号：US20150150517A1
公开(公告)日：2015-06-04
申请号：US13204490
申请日：2011-08-05
IPC分类号： A61B5/00 , A61B5/0205
CPC分类号： A61B5/0205 , A61B5/0022 , A61B5/021 , A61B5/024 , A61B5/0245 , A61B5/0402 , A61B5/08 , A61B5/0816 , A61B5/14551 , A61B5/7228 , A61B5/7257 , A61B5/7275 , A61B5/7278 , A61B5/7282 , A61B5/742 , A61B5/746 , G06F19/00 , G06F19/3418 , G16H50/20
摘要： Disclosed are systems and methods to provide a patient care recommendation. The systems and methods receive patient information and a plurality of patient physiological signals that are related to a patient. The systems and methods are then operable to produce at least one derived patient signal from at least one of the plurality of patient physiological signals. The systems and methods use the patient information, at least one of the plurality of patient physiological signals, and the at least one derived patient signal to provide at least one patient care recommendation.
摘要翻译： 公开了提供患者护理推荐的系统和方法。 系统和方法接收与患者相关的患者信息和多个患者生理信号。 然后系统和方法可操作以从多个患者生理信号中的至少一个产生至少一个导出的患者信号。 系统和方法使用患者信息，多个患者生理信号中的至少一个和至少一个导出的患者信号来提供至少一个患者护理推荐。
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7.发明申请METHODS AND COMPOSITIONS FOR PROCESSES OF RAPID SELECTION AND PRODUCTION OF NUCLEIC ACID APTAMERS 有权快速选择和生产核酸APTAMERS的方法和组合物公开(公告)号：US20090004644A1
公开(公告)日：2009-01-01
申请号：US11965039
申请日：2007-12-27
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6811 , C12N15/115 , Y10T436/143333 , C12Q2525/205 , C12Q2565/101
摘要： Embodiments herein relate to compositions and methods for making and using aptamers, for example, DNA aptamers (DCEs) and/or RNA aptamers. In some embodiments, methods relate to making and amplifying target DCEs. In certain embodiments, methods for making capture elements or aptamers concern using a reporter moiety and signal reducing moiety prior to amplifying a target-specific capture element. In some embodiments, methods disclosed herein may be used to rapidly generate large quantities of aptamers such as DCEs directed to a particular target agent. Some embodiments relate to systems for performing automated generation of aptamers.
摘要翻译： 本文的实施方案涉及用于制备和使用适体的组合物和方法，例如DNA适体（DCE）和/或RNA适体。 在一些实施方案中，方法涉及制备和扩增目标DCE。 在某些实施方案中，用于制备捕获元件或适体的方法在放大靶特异性捕获元件之前关注使用报道部分和信号降低部分。 在一些实施方案中，本文公开的方法可用于快速产生大量适配体，例如针对特定目标试剂的DCE。 一些实施例涉及用于执行适配体的自动生成的系统。
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公开(公告)号：US20040078229A1
公开(公告)日：2004-04-22
申请号：US10448665
申请日：2003-05-30
发明人： Larry Gay , Daniel Shelton , Joel Sprowls
IPC分类号： G06F017/60
摘要： The present invention provides a medical record management system and method capable of providing patients and CDOs with secure access to medical information. In one embodiment, medical records are created, maintained and stored in one or more databases. In one embodiment, the database(s) are located apart from participating CDOs such that electronic data may pass between them through one or more computer networks. The present invention further provides a Health Employer Data and Information Set (HEDIS) rules engine capable of cataloging, retrieving and storing recommended treatments and/or procedures for individual patients. The present invention is capable of accessing this information in order to remind the physician, nurse, administrator and/or patient of recommended treatments and/or procedures.
摘要翻译： 本发明提供一种能够向患者和CDO提供对医疗信息的安全访问的医疗记录管理系统和方法。 在一个实施例中，创建，维护并存储在一个或多个数据库中的医疗记录。 在一个实施例中，数据库与参与的CDO分开，使得电子数据可以通过一个或多个计算机网络在它们之间通过。 本发明还提供了一种健康雇主数据和信息集（HEDIS）规则引擎，能够对各个患者进行编目，检索和存储推荐的治疗和/或程序。 本发明能够访问该信息，以便提醒医师，护士，管理者和/或患者推荐的治疗和/或程序。
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