公开(公告)号：US07131956B1

公开(公告)日：2006-11-07

申请号：US09787624

申请日：2000-07-28

申请人： Paolo Pirazzoli ,  Antonio Bosetto ,  Francesco Paolini

发明人： Paolo Pirazzoli ,  Antonio Bosetto ,  Francesco Paolini

IPC分类号： A61M37/00 ,  C02F1/44 ,  C02F1/00 ,  B01D35/14 ,  A31M1/36

CPC分类号： A61M1/16 ,  A61M1/1601 ,  A61M1/1647 ,  A61M1/3403 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/361 ,  A61M1/3639 ,  A61M2205/18 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/50 ,  A61M2205/702 ,  A61M2205/707 ,  A61M2205/7563 ,  A61M2230/207

摘要： A dialysis machine comprises: means for calculating (60) a filtration factor (FF) as a function of the ultrafiltration rate (UFR) and of a plasma flow rate (Qp); first comparison means (65) for comparing the filtration factor (FF) with a limit value of admissibility; and signaling means (70) for generating a signal (A) indicating the result of the comparison.

摘要翻译： 一种透析机包括：用于根据超滤速率（UFR）和等离子体流速（Q >P）计算（60）过滤因子（FF）的装置; 用于将过滤因子（FF）与可接受性的极限值进行比较的第一比较装置（65） 以及用于产生指示比较结果的信号（A）的信令装置（70）。

公开(公告)号：US20060191850A1

公开(公告)日：2006-08-31

申请号：US11402024

申请日：2006-04-12

申请人： Antonio Bosetto ,  Francesco Paolini

发明人： Antonio Bosetto ,  Francesco Paolini

IPC分类号： B01D61/26

CPC分类号： A61M1/1656 ,  A61M1/1666 ,  A61M1/167 ,  B01F3/088 ,  Y10S210/929

摘要： A method for preparing a medical liquid from a liquid, such as water, and two concentrated solutions comprises the following steps: circulating the liquid in a conduit (15), at a flowrate Q0; injecting into the conduit (15), at a flowrate Q1, a first concentrated solution containing a first ionic substance A and a second ionic substance B, the ionic substances A and B having, respectively, in the first concentrated solution, a concentration [Asol] and a first concentration [B1sol]; injecting into the conduit (15), at a flowrate Q2, a second concentrated solution containing the first ionic substance A and the second ionic substance B, the first ionic substance A having, in the second concentrated solution, the same concentration [Asol] as in the first concentrated solution, and the second ionic substance B having, in the second concentrated solution, a second concentration [B2sol] different than the first concentration [B1sol] in the first concentrated solution; regulating the injection flowrate Q1 and the injection flowrate Q2 of the first and second concentrated solutions in such a way that at any given time the diluted solution resulting from the mixing of the liquid and the concentrated solutions has a desired concentration [Ades] of first substance A and a desired concentration [Bdes] of second substance B.

摘要翻译： 从液体如水和两种浓缩溶液制备医用液体的方法包括以下步骤：以流量Q 0在管道（15）中循环液体; 以流量Q 1，含有第一离子物质A和第二离子物质B的第一浓缩溶液将第一浓缩溶液中的离子物质A和B分别注入管道（15）中， Asol]和第一浓度[B1sol]; 以流量Q 2，含有第一离子物质A和第二离子物质B的第二浓缩溶液注入到管道（15）中，第一离子物质A在第二浓缩溶液中具有相同的浓度[Asol] 与第一浓缩溶液一样，第二离子物质B在第二浓缩溶液中具有与第一浓缩溶液中的第一浓度[B1sol]不同的第二浓度[B2sol] 调节第一和第二浓缩溶液的注入流量Q 1和注入流速Q 2，使得在任何给定时间，由液体和浓缩溶液的混合产生的稀释溶液具有所需的浓度[Ades] 第一物质A和第二物质B的所需浓度[Bdes]

公开(公告)号：US07074191B2

公开(公告)日：2006-07-11

申请号：US10479796

申请日：2002-05-16

申请人： Antonio Bosetto ,  Annalisa Delnevo

发明人： Antonio Bosetto ,  Annalisa Delnevo

IPC分类号： A61B5/021 ,  G01L9/00 ,  G01L7/00 ,  A61M1/14 ,  B01D61/28

CPC分类号： A61M1/3639 ,  A61B5/02154

摘要： A method for the non-intrusive measurement of blood pressure in a circuit of a dialysis machine, using a device provided with a sleeve forming a portion of the blood circuit and having at least one part which moves according to the pressure difference between the inside and the outside of the sleeve, and with an emitter and a receiver of electromagnetic waves. The method comprising the emission of a beam of electromagnetic waves and the receiving of a beam of electromagnetic waves reflected from the moving part, in order to measure the displacement of the moving part in such a way as to establish a relationship between the position of the moving part and the pressure of the blood circulating in the sleeve.

摘要翻译： 一种透析机电路的非侵入式血压测定方法，其特征在于，使用设置有形成所述血液回路的一部分的套筒的装置，并且具有至少一部分，所述至少一部分根据所述血液回路的内部和 袖子的外侧，以及电磁波的发射器和接收器。 该方法包括发射电磁波束和从运动部件反射的电磁波束的接收，以便以这样的方式测量移动部件的位移，以便确定 运动部分和血液在袖子中循环的压力。

公开(公告)号：US07001353B2

公开(公告)日：2006-02-21

申请号：US09913857

申请日：2000-12-18

申请人： Antonio Bosetto ,  Francesco Paolini

发明人： Antonio Bosetto ,  Francesco Paolini

IPC分类号： A61M37/00 ,  A61M1/14 ,  B01D11/00 ,  C02F1/00

CPC分类号： A61M1/16 ,  A61M1/3609 ,  A61M1/3658 ,  A61M2230/65

摘要： A method is described for determining recirculation of blood in a vascular access of a patient undergoing dialysis treatment using a dialysis machine with an arterial line for withdrawing blood from the patient's body, a dialysis filter, and a venous line for returning blood to the patient's body. The method induces a disturbance in the blood flowing in the venous line. The disturbance is of a magnitude capable of bringing the system into a transient state and determining blood recirculation in the vascular access during the transient state as a function of the magnitude of the disturbance induced in the arterial line. In particular, the disturbance relates to the variation of the hemoglobin concentration in the blood flowing in the venous line. The variation is caused by controlling a change in the ultrafiltration flow in the dialysis filter.

摘要翻译： 描述了一种用于确定使用透析机进行透析治疗的患者的血管通路中的血液再循环的方法，所述透析机具有用于从患者身体抽出血液的血管，透析过滤器和用于将血液返回到患者体内的静脉管线 。 该方法引起在静脉血管中流动的血液中的干扰。 扰动是能够使系统进入瞬态并且在过渡状态期间确定血管通路中的血液再循环作为动脉线路中引起的干扰的幅度的函数的大小。 特别地，扰动涉及在静脉线中流动的血液中的血红蛋白浓度的变化。 该变化是通过控制透析过滤器中的超滤流量的变化引起的。

公开(公告)号：US06793827B1

公开(公告)日：2004-09-21

申请号：US09869712

申请日：2001-10-09

申请人： Antonio Bosetto ,  Francesco Paolini

发明人： Antonio Bosetto ,  Francesco Paolini

IPC分类号： B01D6124

CPC分类号： A61M1/1656 ,  A61M1/1666 ,  A61M1/167 ,  B01F3/088 ,  Y10S210/929

摘要： A method for extracorporeal treatment of blood includes preparing a treatment liquid from a liquid and two concentrated solutions by circulating the liquid in a preparation conduit at a flowrate Q0; injecting a first concentrated solution containing at least a first ionic substance A and a second ionic substance B into the preparation conduit at a flowrate Q1; and injecting a second concentrated solution containing at least the first ionic substance A into the preparation conduit at a flowrate Q2. The ionic substance B may have a first concentration in the first concentrated solution and a second concentration, different from the first concentration, in the second concentrated solution. The method may also include regulating the injection flowrates Q1 and Q2 in such a way that at any given time the diluted solution resulting from the mixing of the liquid and the concentrated solutions has a desired concentration of the first ionic substance A and a desired concentration of the second ionic substance B. The method may further include supplying the treatment liquid to an inlet of a membrane exchanger; removing a spent liquid from an outlet of the membrane exchanger; measuring the concentration of the second ionic substance in the treatment liquid; and measuring the concentration of the second ionic substance in the spent liquid. The injection flowrates Q1 and Q2 may be regulated on the basis of the concentrations of the second ionic substance measured in the treatment liquid and in the spent liquid.

摘要翻译： 一种体外血液处理方法包括通过以液体流量Q0将制剂导管中的液体循环从液体制备处理液和两种浓缩溶液; 以流量Q1将至少含有第一离子物质A和第二离子物质B的第一浓缩溶液注入制备管道; 并以流量Q2将至少含有第一离子物质A的第二浓缩溶液注入制备管道。 离子物质B可以在第一浓缩溶液中具有第一浓度，在第二浓缩溶液中可以具有与第一浓度不同的第二浓度。 该方法还可以包括调节注入流量Q1和Q2，使得在任何给定时间，由液体和浓缩溶液的混合产生的稀释溶液具有所需浓度的第一离子物质A和所需浓度的 第二离子物质B.该方法还可以包括将处理液供给到膜交换器的入口; 从所述膜交换器的出口去除废液体; 测量处理液中第二离子物质的浓度; 并测量废液体中第二离子物质的浓度。 喷射流量Q1和Q2可以基于在处理液体中和在废液中测量的第二离子物质的浓度来调节。

公开(公告)号：US5618441A

公开(公告)日：1997-04-08

申请号：US483456

申请日：1995-06-07

申请人： Jim Rosa ,  Steve Love ,  Preben A. Peterson ,  Antonio Bosetto

发明人： Jim Rosa ,  Steve Love ,  Preben A. Peterson ,  Antonio Bosetto

IPC分类号： A61M1/16 ,  B01D61/32

CPC分类号： A61M1/16 ,  B01D61/32 ,  Y10S706/924

摘要： A dialysis machine uses a single microcontroller to perform both safety system functions and control system functions. A single segmented memory records the safety system code and data separately and in isolation from the control system code and data. Access to the safety system software is limited to the operating system and safety system contexts. A protected mode of operation of an embedded processor allows recovery of a state vector upon failures of the operating system, the safety system and the control system. The operating system allows recovery of a state vector upon failure of the safety system and the operating system. A watchdog timer circuit places the dialysis machine in a safe patient state if a total failure of the microcontroller occurs. This functionality assures that the machine is placed in safe patient state under failure conditions and that the safety system software is isolated from the control system software to avoid having to re-validate the safety system when control system software changes are made.

摘要翻译： 透析机使用单个微控制器执行安全系统功能和控制系统功能。 单个分段存储器分别记录安全系统代码和数据，并与控制系统代码和数据隔离。 访问安全系统软件仅限于操作系统和安全系统环境。 嵌入式处理器的保护操作模式允许在操作系统，安全系统和控制系统故障时恢复状态向量。 操作系统允许在安全系统和操作系统故障时恢复状态向量。 看门狗定时器电路如果发生单片机的全部故障，将透析机置于安全的患者状态。 该功能确保机器在故障条件下处于安全的患者状态，并且安全系统软件与控制系统软件隔离，以避免在进行控制系统软件更改时重新验证安全系统。

公开(公告)号：US07067061B2

公开(公告)日：2006-06-27

申请号：US10844422

申请日：2004-05-13

申请人： Antonio Bosetto ,  Francesco Paolini

发明人： Antonio Bosetto ,  Francesco Paolini

IPC分类号： B01D61/26 ,  B01D35/00 ,  A61M37/00 ,  B01D61/28 ,  B01D61/32

CPC分类号： A61M1/1656 ,  A61M1/1666 ,  A61M1/167 ,  B01F3/088 ,  Y10S210/929

摘要： A method for preparing a medical liquid from a liquid, such as water, and two concentrated solutions comprises the following steps: circulating the liquid in a conduit (15), at a flowrate Q0; injecting into the conduit (15), at a flowrate Q1, a first concentrated solution containing a first ionic substance A and a second ionic substance B, the ionic substances A and B having, respectively, in the first concentrated solution, a concentration [Asol] and a first concentration [B1sol]; injecting into the conduit (15), at a flowrate Q2, a second concentrated solution containing the first ionic substance A and the second ionic substance B, the first ionic substance A having, in the second concentrated solution, the same concentration [Asol] as in the first concentrated solution, and the second ionic substance B having, in the second concentrated solution, a second concentration [B2sol] different than the first concentration [B1sol] in the first concentrated solution; regulating the injection flowrate Q1 and the injection flowrate Q2 of the first and second concentrated solutions in such a way that at any given time the diluted solution resulting from the mixing of the liquid and the concentrated solutions has a desired concentration [Ades] of first substance A and a desired concentration [Bdes] of second substance B.

摘要翻译： 从液体如水和两种浓缩溶液制备医用液体的方法包括以下步骤：以流量Q 0在管道（15）中循环液体; 以流量Q 1，含有第一离子物质A和第二离子物质B的第一浓缩溶液将第一浓缩溶液中的离子物质A和B分别注入管道（15）中， Asol]和第一浓度[B 1 sol]; 以流量Q 2，含有第一离子物质A和第二离子物质B的第二浓缩溶液注入到管道（15）中，第一离子物质A在第二浓缩溶液中具有相同的浓度[Asol] 与第一浓缩溶液一样，第二离子物质B在第二浓缩溶液中具有与第一浓缩溶液中的第一浓度[B 1 sol]不同的第二浓度[B 2 sol] 调节第一和第二浓缩溶液的注入流量Q 1和注入流速Q 2，使得在任何给定时间，由液体和浓缩溶液的混合产生的稀释溶液具有所需的浓度[Ades] 第一物质A和第二物质B的所需浓度[Bdes]

公开(公告)号：US06691040B2

公开(公告)日：2004-02-10

申请号：US09726484

申请日：2000-12-01

申请人： Antonio Bosetto ,  Francesco Paolini

发明人： Antonio Bosetto ,  Francesco Paolini

IPC分类号： G01N3348

CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1613 ,  A61M1/1617 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/52

摘要： A method for continuously determining a parameter (D, Cbin, K, Kt/V) indicative of an extracorporeal blood treatment includes flowing patient's blood and a treatment liquid flow on opposite sides of a semipermeable membrane. The treatment liquid has a characteristic (Cd) associated with the effectiveness of the treatment flow through the exchanger. A succession of variations are caused in the characteristic (Cd) upstream of the exchanger, and a plurality of values (Cdin1 . . . Cdinj . . . Cdinp) of the characteristic (Cd) upstream of the exchanger are continuously stored in memory. Similarly, plurality of values (Cdout1 . . . Cdoutj . . . Cdoutp) adopted by the characteristic (Cd) downstream of the exchanger are continuously stored in memory. From the stored values, the effectiveness of the treatment is calculated using a mathematical model.

摘要翻译： 用于连续地确定表示体外血液处理的参数（D，Cbin，K，Kt / V）的方法包括在半透膜的相对侧流动患者的血液和处理液体流。 处理液具有与通过交换器的处理流的有效性相关的特征（Cd）。 在交换器上游的特征（Cd）中引起了一系列变化，并且交换机上游特征（Cd）的多个值（Cdin1。Cdinj。Cdinp）连续存储在存储器中。 类似地，由交换机下游特性（Cd）采用的多个值（Cdout1。Cdoutj。Cdoutp）连续存储在存储器中。 从存储的值中，使用数学模型计算治疗的有效性。

公开(公告)号：US5938938A

公开(公告)日：1999-08-17

申请号：US836758

申请日：1997-05-21

申请人： Antonio Bosetto ,  Francesco Paolini

发明人： Antonio Bosetto ,  Francesco Paolini

IPC分类号： A61M1/16 ,  G05B13/04 ,  B01D61/32

CPC分类号： A61M1/16 ,  A61M2230/30

摘要： A method for automatic dialysis using a dialysis unit which, in service, is connected to a patient undergoing a dialysis treatment, including the phases of acquiring allowed values of input parameters and desired values of patient parameters, acquiring actual values of the patient parameters, the patient parameters including the relative variation in blood volume (BV) and the weight loss (WL), acquiring actual values of machine parameters including the weight loss rate (WLR) and the conductivity of the (CD) dialysis fluid, and controlling the operation of the dialysis unit using controlled values of the machine parameters to make the patient parameters take on the desired values.

摘要翻译： PCT No.PCT / IB96 / 00644 Sec。 371日期1997年5月21日 102（e）日期1997年5月21日PCT提交1996年7月3日PCT公布。 第WO97 / 02057号公报 日期1997年1月23日一种使用透析单元进行自动透析的方法，所述透析单元在使用中连接到进行透析治疗的患者，包括获取输入参数的允许值和患者参数的期望值的阶段，获取实际值 患者参数，包括血容量（BV）和体重减轻量（WL）的相对变化的患者参数，获取包括（CD）透析液的体重减轻率（WLR）和电导率的机器参数的实际值， 以及使用所述机器参数的受控值来控制所述透析单元的操作，以使所述患者参数达到期望值。