Method and a device for preparing a medical liquid
    2.
    发明申请
    Method and a device for preparing a medical liquid 审中-公开
    方法和用于制备医用液体的装置

    公开(公告)号:US20060191850A1

    公开(公告)日:2006-08-31

    申请号:US11402024

    申请日:2006-04-12

    IPC分类号: B01D61/26

    摘要: A method for preparing a medical liquid from a liquid, such as water, and two concentrated solutions comprises the following steps: circulating the liquid in a conduit (15), at a flowrate Q0; injecting into the conduit (15), at a flowrate Q1, a first concentrated solution containing a first ionic substance A and a second ionic substance B, the ionic substances A and B having, respectively, in the first concentrated solution, a concentration [Asol] and a first concentration [B1sol]; injecting into the conduit (15), at a flowrate Q2, a second concentrated solution containing the first ionic substance A and the second ionic substance B, the first ionic substance A having, in the second concentrated solution, the same concentration [Asol] as in the first concentrated solution, and the second ionic substance B having, in the second concentrated solution, a second concentration [B2sol] different than the first concentration [B1sol] in the first concentrated solution; regulating the injection flowrate Q1 and the injection flowrate Q2 of the first and second concentrated solutions in such a way that at any given time the diluted solution resulting from the mixing of the liquid and the concentrated solutions has a desired concentration [Ades] of first substance A and a desired concentration [Bdes] of second substance B.

    摘要翻译: 从液体如水和两种浓缩溶液制备医用液体的方法包括以下步骤:以流量Q 0在管道(15)中循环液体; 以流量Q 1,含有第一离子物质A和第二离子物质B的第一浓缩溶液将第一浓缩溶液中的离子物质A和B分别注入管道(15)中, Asol]和第一浓度[B1sol]; 以流量Q 2,含有第一离子物质A和第二离子物质B的第二浓缩溶液注入到管道(15)中,第一离子物质A在第二浓缩溶液中具有相同的浓度[Asol] 与第一浓缩溶液一样,第二离子物质B在第二浓缩溶液中具有与第一浓缩溶液中的第一浓度[B1sol]不同的第二浓度[B2sol] 调节第一和第二浓缩溶液的注入流量Q 1和注入流速Q 2,使得在任何给定时间,由液体和浓缩溶液的混合产生的稀释溶液具有所需的浓度[Ades] 第一物质A和第二物质B的所需浓度[Bdes]

    Device and a method for determining blood recirculation in a vascular access
    3.
    发明授权
    Device and a method for determining blood recirculation in a vascular access 失效
    用于测定血管通路中的血液再循环的装置和方法

    公开(公告)号:US07001353B2

    公开(公告)日:2006-02-21

    申请号:US09913857

    申请日:2000-12-18

    摘要: A method is described for determining recirculation of blood in a vascular access of a patient undergoing dialysis treatment using a dialysis machine with an arterial line for withdrawing blood from the patient's body, a dialysis filter, and a venous line for returning blood to the patient's body. The method induces a disturbance in the blood flowing in the venous line. The disturbance is of a magnitude capable of bringing the system into a transient state and determining blood recirculation in the vascular access during the transient state as a function of the magnitude of the disturbance induced in the arterial line. In particular, the disturbance relates to the variation of the hemoglobin concentration in the blood flowing in the venous line. The variation is caused by controlling a change in the ultrafiltration flow in the dialysis filter.

    摘要翻译: 描述了一种用于确定使用透析机进行透析治疗的患者的血管通路中的血液再循环的方法,所述透析机具有用于从患者身体抽出血液的血管,透析过滤器和用于将血液返回到患者体内的静脉管线 。 该方法引起在静脉血管中流动的血液中的干扰。 扰动是能够使系统进入瞬态并且在过渡状态期间确定血管通路中的血液再循环作为动脉线路中引起的干扰的幅度的函数的大小。 特别地,扰动涉及在静脉线中流动的血液中的血红蛋白浓度的变化。 该变化是通过控制透析过滤器中的超滤流量的变化引起的。

    Method and device for preparing a medical fluid
    4.
    发明授权
    Method and device for preparing a medical fluid 有权
    用于制备医用流体的方法和装置

    公开(公告)号:US06793827B1

    公开(公告)日:2004-09-21

    申请号:US09869712

    申请日:2001-10-09

    IPC分类号: B01D6124

    摘要: A method for extracorporeal treatment of blood includes preparing a treatment liquid from a liquid and two concentrated solutions by circulating the liquid in a preparation conduit at a flowrate Q0; injecting a first concentrated solution containing at least a first ionic substance A and a second ionic substance B into the preparation conduit at a flowrate Q1; and injecting a second concentrated solution containing at least the first ionic substance A into the preparation conduit at a flowrate Q2. The ionic substance B may have a first concentration in the first concentrated solution and a second concentration, different from the first concentration, in the second concentrated solution. The method may also include regulating the injection flowrates Q1 and Q2 in such a way that at any given time the diluted solution resulting from the mixing of the liquid and the concentrated solutions has a desired concentration of the first ionic substance A and a desired concentration of the second ionic substance B. The method may further include supplying the treatment liquid to an inlet of a membrane exchanger; removing a spent liquid from an outlet of the membrane exchanger; measuring the concentration of the second ionic substance in the treatment liquid; and measuring the concentration of the second ionic substance in the spent liquid. The injection flowrates Q1 and Q2 may be regulated on the basis of the concentrations of the second ionic substance measured in the treatment liquid and in the spent liquid.

    摘要翻译: 一种体外血液处理方法包括通过以液体流量Q0将制剂导管中的液体循环从液体制备处理液和两种浓缩溶液; 以流量Q1将至少含有第一离子物质A和第二离子物质B的第一浓缩溶液注入制备管道; 并以流量Q2将至少含有第一离子物质A的第二浓缩溶液注入制备管道。 离子物质B可以在第一浓缩溶液中具有第一浓度,在第二浓缩溶液中可以具有与第一浓度不同的第二浓度。 该方法还可以包括调节注入流量Q1和Q2,使得在任何给定时间,由液体和浓缩溶液的混合产生的稀释溶液具有所需浓度的第一离子物质A和所需浓度的 第二离子物质B.该方法还可以包括将处理液供给到膜交换器的入口; 从所述膜交换器的出口去除废液体; 测量处理液中第二离子物质的浓度; 并测量废液体中第二离子物质的浓度。 喷射流量Q1和Q2可以基于在处理液体中和在废液中测量的第二离子物质的浓度来调节。

    Method and a device for preparing a medical liquid
    5.
    发明授权
    Method and a device for preparing a medical liquid 有权
    方法和用于制备医用液体的装置

    公开(公告)号:US07067061B2

    公开(公告)日:2006-06-27

    申请号:US10844422

    申请日:2004-05-13

    摘要: A method for preparing a medical liquid from a liquid, such as water, and two concentrated solutions comprises the following steps: circulating the liquid in a conduit (15), at a flowrate Q0; injecting into the conduit (15), at a flowrate Q1, a first concentrated solution containing a first ionic substance A and a second ionic substance B, the ionic substances A and B having, respectively, in the first concentrated solution, a concentration [Asol] and a first concentration [B1sol]; injecting into the conduit (15), at a flowrate Q2, a second concentrated solution containing the first ionic substance A and the second ionic substance B, the first ionic substance A having, in the second concentrated solution, the same concentration [Asol] as in the first concentrated solution, and the second ionic substance B having, in the second concentrated solution, a second concentration [B2sol] different than the first concentration [B1sol] in the first concentrated solution; regulating the injection flowrate Q1 and the injection flowrate Q2 of the first and second concentrated solutions in such a way that at any given time the diluted solution resulting from the mixing of the liquid and the concentrated solutions has a desired concentration [Ades] of first substance A and a desired concentration [Bdes] of second substance B.

    摘要翻译: 从液体如水和两种浓缩溶液制备医用液体的方法包括以下步骤:以流量Q 0在管道(15)中循环液体; 以流量Q 1,含有第一离子物质A和第二离子物质B的第一浓缩溶液将第一浓缩溶液中的离子物质A和B分别注入管道(15)中, Asol]和第一浓度[B 1 sol]; 以流量Q 2,含有第一离子物质A和第二离子物质B的第二浓缩溶液注入到管道(15)中,第一离子物质A在第二浓缩溶液中具有相同的浓度[Asol] 与第一浓缩溶液一样,第二离子物质B在第二浓缩溶液中具有与第一浓缩溶液中的第一浓度[B 1 sol]不同的第二浓度[B 2 sol] 调节第一和第二浓缩溶液的注入流量Q 1和注入流速Q 2,使得在任何给定时间,由液体和浓缩溶液的混合产生的稀释溶液具有所需的浓度[Ades] 第一物质A和第二物质B的所需浓度[Bdes]

    Method for determining a parameter indicative of the progress of an extracorporeal blood treatment
    6.
    发明授权
    Method for determining a parameter indicative of the progress of an extracorporeal blood treatment 有权
    用于确定指示体外血液治疗进展的参数的方法

    公开(公告)号:US06691040B2

    公开(公告)日:2004-02-10

    申请号:US09726484

    申请日:2000-12-01

    IPC分类号: G01N3348

    摘要: A method for continuously determining a parameter (D, Cbin, K, Kt/V) indicative of an extracorporeal blood treatment includes flowing patient's blood and a treatment liquid flow on opposite sides of a semipermeable membrane. The treatment liquid has a characteristic (Cd) associated with the effectiveness of the treatment flow through the exchanger. A succession of variations are caused in the characteristic (Cd) upstream of the exchanger, and a plurality of values (Cdin1 . . . Cdinj . . . Cdinp) of the characteristic (Cd) upstream of the exchanger are continuously stored in memory. Similarly, plurality of values (Cdout1 . . . Cdoutj . . . Cdoutp) adopted by the characteristic (Cd) downstream of the exchanger are continuously stored in memory. From the stored values, the effectiveness of the treatment is calculated using a mathematical model.

    摘要翻译: 用于连续地确定表示体外血液处理的参数(D,Cbin,K,Kt / V)的方法包括在半透膜的相对侧流动患者的血液和处理液体流。 处理液具有与通过交换器的处理流的有效性相关的特征(Cd)。 在交换器上游的特征(Cd)中引起了一系列变化,并且交换机上游特征(Cd)的多个值(Cdin1。Cdinj。Cdinp)连续存储在存储器中。 类似地,由交换机下游特性(Cd)采用的多个值(Cdout1。Cdoutj。Cdoutp)连续存储在存储器中。 从存储的值中,使用数学模型计算治疗的有效性。

    Automatic dialysis method and apparatus
    7.
    发明授权
    Automatic dialysis method and apparatus 失效
    自动透析法及装置

    公开(公告)号:US5938938A

    公开(公告)日:1999-08-17

    申请号:US836758

    申请日:1997-05-21

    IPC分类号: A61M1/16 G05B13/04 B01D61/32

    CPC分类号: A61M1/16 A61M2230/30

    摘要: A method for automatic dialysis using a dialysis unit which, in service, is connected to a patient undergoing a dialysis treatment, including the phases of acquiring allowed values of input parameters and desired values of patient parameters, acquiring actual values of the patient parameters, the patient parameters including the relative variation in blood volume (BV) and the weight loss (WL), acquiring actual values of machine parameters including the weight loss rate (WLR) and the conductivity of the (CD) dialysis fluid, and controlling the operation of the dialysis unit using controlled values of the machine parameters to make the patient parameters take on the desired values.

    摘要翻译: PCT No.PCT / IB96 / 00644 Sec。 371日期1997年5月21日 102(e)日期1997年5月21日PCT提交1996年7月3日PCT公布。 第WO97 / 02057号公报 日期1997年1月23日一种使用透析单元进行自动透析的方法,所述透析单元在使用中连接到进行透析治疗的患者,包括获取输入参数的允许值和患者参数的期望值的阶段,获取实际值 患者参数,包括血容量(BV)和体重减轻量(WL)的相对变化的患者参数,获取包括(CD)透析液的体重减轻率(WLR)和电导率的机器参数的实际值, 以及使用所述机器参数的受控值来控制所述透析单元的操作,以使所述患者参数达到期望值。

    Fluid Bag, Use of One or More Fluid Bags, and a System Including One or More Fluid Bags
    9.
    发明申请
    Fluid Bag, Use of One or More Fluid Bags, and a System Including One or More Fluid Bags 审中-公开
    流体袋,一个或多个流体袋的使用以及包括一个或多个流体袋的系统

    公开(公告)号:US20070265594A1

    公开(公告)日:2007-11-15

    申请号:US10588963

    申请日:2005-02-10

    IPC分类号: A61J1/10

    摘要: The invention concerns a fluid bag that contains either dialysis fluid for hemodialysis or a replacement fluid for replacing ultra-filtrate that is withdrawn from a patient or a fluid that is a rest product from a process of hemodialysis or the like. The fluid bag has a first main sheet and a second main sheet located opposite to the first main sheet. The fluid bag is sized to contain at least a certain quantity (q) of fluid, measured in ml, when it is completely filled with fluid. The fluid bag is configured so that the distance between the first and second sheets never exceeds a certain value (v), measured in mm, wherein: q≧2000, and v≦2q/100. The invention also concerns a fluid bag assembly including one or more such fluid bags as well as a system including one or more such fluid bags.

    摘要翻译: 本发明涉及一种流体袋,其包含用于血液透析的透析液或用于替换从患者抽出的超滤液的替代液体或者是来自血液透析过程等的静止产物的流体。 流体袋具有与第一主片相对的第一主片和第二主片。 当流体袋完全充满流体时,流体袋的尺寸至少包含一定量的(q)流体,以ml计。 流体袋被配置成使得第一和第二片之间的距离不会超过以mm测量的特定值(v),其中:q> = 2000,v <= 2q / 100。 本发明还涉及包括一个或多个这种流体袋的流体袋组件以及包括一个或多个这种流体袋的系统。

    Control equipment and method for an extracorporeal blood circuit
    10.
    发明申请
    Control equipment and method for an extracorporeal blood circuit 审中-公开
    用于体外血液回路的控制设备和方法

    公开(公告)号:US20050020958A1

    公开(公告)日:2005-01-27

    申请号:US10500324

    申请日:2002-12-20

    摘要: Control equipment for an extracorporeal blood circuit (2), in which the extracorporeal circuit (2) has an access branch (8) and a return branch (10) connected to a blood treatment element (4; 4, 11a; 4, 11v; 25; 25, 11a; 25, 11v), is provided with a sensor for measuring a first temperature (TP) of the blood leaving a patient (P) along the access branch (8), with a heat exchanger formed by a portion (19) of the return branch (10) and by a device for regulating the temperature (T) of the blood coupled to the portion (19) of the return branch (10), and with a control unit (15) for operating the regulating device (18) as a function of the first temperature (TP) and of a reference temperature (Tset).

    摘要翻译: 用于体外血液回路(2)的控制设备,其中体外回路(2)具有接入分支(8)和与血液处理元件(4; 4,11a; 4,11v; 25; 25,11a; 25,11v)设置有用于测量沿着所述进入支路(8)离开患者(P)的血液的第一温度(TP)的传感器,其中热交换器由一部分( (10)的部分(19)和用于调节与返回分支(10)的部分(19)相连的血液的温度(T)的装置,以及用于操作调节的控制单元(15) 装置(18)作为第一温度(TP)和参考温度(Tset)的函数。