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公开(公告)号：US12125145B2
公开(公告)日：2024-10-22
申请号：US17426602
申请日：2020-02-03
发明人： Robert K. Gantzer
CPC分类号： G06T19/006 , G06T13/20 , G06V20/20 , G09B5/02 , G09B19/24 , G06K7/1413 , G06K7/1417
摘要： Systems and methods for providing instructing mixed reality overlays for configuring automation protocols in laboratory processes using computing systems include receiving an image from an image feed of an environment. Component markers in the image of the environment are detected and matched with an associated environment component, an environment component action or both. The environment component or environment component action, or both are selected and an animation of an instruction is rendered. An overlay of the animation is caused to display in an augmented reality device associated with a user to appear in a location in the environment of the environment component or environment component action, or both.
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公开(公告)号：US20240335542A1
公开(公告)日：2024-10-10
申请号：US18746787
申请日：2024-06-18
CPC分类号： A61K47/20 , A61K9/5123 , A61K47/28 , A61K47/544 , B82Y5/00 , B82Y40/00
摘要： The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.
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公开(公告)号：US20240327802A1
公开(公告)日：2024-10-03
申请号：US18428690
申请日：2024-01-31
发明人： ChieYu Lin , Fei Ran , Apurva Govande
CPC分类号： C12N7/00 , A61K48/0041 , C07K14/005 , C12N9/22 , C12N15/11 , C12N15/86 , C12N2310/20 , C12N2760/20021 , C12N2760/20022 , C12N2760/20043
摘要： Provided herein are chimeric pseudotyped recombinant RABV particles, wherein the chimeric envelope protein comprises, from N-terminus to C-terminus, a non-RABV envelope protein ectodomain, a non-RABV envelope protein transmembrane domain, and a RABV C-terminal domain. Also provided are methods for their use in delivering a transgene into a target cell.
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公开(公告)号：US20240325533A1
公开(公告)日：2024-10-03
申请号：US18737787
申请日：2024-06-07
发明人： RYAN MURRAY , Michail Sitkovsky , Stephen Hatfield
IPC分类号： A61K39/00 , A61P35/00 , C07K14/725 , C07K16/28 , C12N9/22 , C12N9/78 , C12N15/11 , C12N15/90
CPC分类号： A61K39/4634 , A61K39/4611 , A61K39/4643 , A61P35/00 , C07K14/7051 , C07K16/2863 , C12N9/22 , C12N9/78 , C12N15/11 , C12N15/907 , C12Y305/04004 , A61K2239/26 , C12N2310/20
摘要： The present invention features modified immune cells (e.g., T- or NK-cells) having increased resistance to hypoxia-adenosinergic immunosuppression. Methods for producing and using the same are also provided.
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公开(公告)号：US20240287453A1
公开(公告)日：2024-08-29
申请号：US18441740
申请日：2024-02-14
CPC分类号： C12N5/0634 , A61K35/17 , C12N15/111 , C12N15/85 , C12N2510/00
摘要： The present disclosure features allogeneic modified immune cells (e.g., T- or NK-cells) having increased persistence, increased resistance to immune rejection, or decreased risk of eliciting a host-versus-graft reaction, or a combination thereof. Methods for producing and using the same are also provided.
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公开(公告)号：US12059477B2
公开(公告)日：2024-08-13
申请号：US17579115
申请日：2022-01-19
IPC分类号： A61K47/69 , A61K31/7105 , A61K31/711 , A61K47/24 , A61K47/26 , A61P1/16 , C07C219/06 , C07D295/13
CPC分类号： A61K47/6929 , A61K31/7105 , A61K31/711 , A61K47/24 , A61K47/26 , A61P1/16 , C07C219/06 , C07D295/13
摘要： The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.
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公开(公告)号：US20240132868A1
公开(公告)日：2024-04-25
申请号：US18519954
申请日：2023-11-27
发明人： David BRYSON , Jack SULLIVAN
CPC分类号： C12N9/78 , C12N9/22 , C12N15/11 , C12N15/907 , C12Y305/04004 , C12N2310/20
摘要： The invention features polynucleotides that encode bases editors having a heterologous intron for self-inactivation, compositions comprising such polynucleotides, and methods of inactivating a base editor encoded by such polynucleotides.
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公开(公告)号：US20230348359A1
公开(公告)日：2023-11-02
申请号：US18220874
申请日：2023-07-12
发明人： Mina Fawzy Shehata , Gregory Lawrence Hamilton , Neeraj Narendra Patwardhan , Cory Dane Sago , Milloni Balwantkumar Chhabra
IPC分类号： A61K9/51 , C07J41/00 , C07C219/06 , A61K48/00
CPC分类号： C07C219/06 , A61K9/5123 , A61K48/0033 , C07J41/0088 , C07C2601/14 , C07C2603/74
摘要： The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.
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公开(公告)号：US20230331656A1
公开(公告)日：2023-10-19
申请号：US18211822
申请日：2023-06-20
发明人： Gregory Lawrence Hamilton , Neeraj Narendra Patwardhan , Cory Dane Sago , Mina Fawzy Shehata , Milloni Balwantkumar Chhabra
IPC分类号： C07C229/12 , A61K39/385 , A61K9/51 , C07C217/40 , C07C219/04
CPC分类号： C07C229/12 , A61K39/385 , A61K9/5123 , C07C217/40 , C07C219/04 , C07C2603/74
摘要： The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.
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公开(公告)号：US20230279373A1
公开(公告)日：2023-09-07
申请号：US17641356
申请日：2020-09-09
发明人： Bernd ZETSCHE , Luis BARRERA
CPC分类号： C12N9/22 , C12N9/78 , C12N15/86 , C12N15/11 , C12N2310/20 , C12N2750/14141 , C12Y305/04005 , C12Y305/04004
摘要： The present invention provides novel systems, methods and compositions for making and using a recombinantly engineered novel Cas9 optimized for human cells, for nucleic acid targeting and manipulation. The present invention is based on the discovery of a novel Cas9 species from Lachnospira bacterium that was codon-optimized and recombinantly produced for use in human ceils. In some embodiments, the novel Cas9 can be used in a base editor. In some embodiments, the novel engineered Cas9 is used to treat human diseases.
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