专利检索 ap:"Biswajit Samanta" 第 1 页

1.

发明授权
Piperidinyl monocarboxylic acids as S1P1 receptor agonists 有权
标题翻译：哌啶基单羧酸作为S1P1受体激动剂

公开(公告)号：US09266867B2

公开(公告)日：2016-02-23

申请号：US14111438

申请日：2012-04-10

申请人： Marc Capet , Isabelle Berrebi-Bertrand , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte , Rajamannar Thennati , Ranjan Kumar Pal , Biswajit Samanta , Muthukumaran Natarajan Pillai , Japan Nitinkumar Desai , Dijixa Chandubhai Rana , Kaushik Dhanjubhai Prajapati , Sandeep Pankajbhai Pathak , Bhavesh M. Panchal , Jayraj D. Aradhye

发明人： Marc Capet , Isabelle Berrebi-Bertrand , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte , Rajamannar Thennati , Ranjan Kumar Pal , Biswajit Samanta , Muthukumaran Natarajan Pillai , Japan Nitinkumar Desai , Dijixa Chandubhai Rana , Kaushik Dhanjubhai Prajapati , Sandeep Pankajbhai Pathak , Bhavesh M. Panchal , Jayraj D. Aradhye

IPC分类号： C07D413/10 , C07D271/06 , A61K31/454 , A61K45/06

CPC分类号： C07D413/10 , A61K31/454 , A61K45/06 , C07D271/06

摘要： The present invention relates to novel compounds acting as agonists at S1P (sphingosine-1-phosphate) receptors, compositions containing these compounds, use of these compounds in medicine and their process of preparation.

摘要翻译： 本发明涉及作为S1P（鞘氨醇-1-磷酸）受体的激动剂的新化合物，含有这些化合物的组合物，这些化合物在医药中的应用及其制备方法。

2.

发明申请
NOVEL PIPERIDINYL MONOCARBOXYLIC ACIDS AS S1P1 RECEPTOR AGONISTS 有权
标题翻译：新型PIPERIDINYL单羧酸作为S1P1受体激动剂

公开(公告)号：US20140099316A1

公开(公告)日：2014-04-10

申请号：US14111438

申请日：2012-04-10

申请人： Marc Capet , Isabelle Berrebi-Bertrand , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte , Rajamannar Thennati , Ranjan Kumar Pal , Biswajit Samanta , Muthukumaran Natarajan Pillai , Japan Nitinkumar Desai , Dijixa Chandubhai Rana , Kaushik Dhanjubhai Prajapati , Sandeep Pankajbhai Pathak , Bhavesh M. Panchal , Jayraj D. Aradhye

发明人： Marc Capet , Isabelle Berrebi-Bertrand , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte , Rajamannar Thennati , Ranjan Kumar Pal , Biswajit Samanta , Muthukumaran Natarajan Pillai , Japan Nitinkumar Desai , Dijixa Chandubhai Rana , Kaushik Dhanjubhai Prajapati , Sandeep Pankajbhai Pathak , Bhavesh M. Panchal , Jayraj D. Aradhye

IPC分类号： C07D413/10 , A61K31/454 , A61K45/06 , C07D271/06

CPC分类号： C07D413/10 , A61K31/454 , A61K45/06 , C07D271/06

摘要： The present invention relates to novel compounds acting as agonists at S1P (sphingosine-1-phosphate) receptors, compositions containing these compounds, use of these compounds in medicine and their process of preparation.

摘要翻译： 本发明涉及作为S1P（鞘氨醇-1-磷酸）受体的激动剂的新化合物，含有这些化合物的组合物，这些化合物在医药中的应用及其制备方法。

3.

发明申请
NOVEL DICARBOXYLIC ACID DERIVATIVES AS S1P1 RECEPTOR AGONISTS 有权
标题翻译：新型二羧酸衍生物作为S1P1受体激动剂

公开(公告)号：US20100249187A1

公开(公告)日：2010-09-30

申请号：US12664718

申请日：2008-06-16

申请人： Marc Capet , Nicolas Levoin , Isabelle Berrebi-Bertrand , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte , Jayraj Dilipbhal Aradhye , Muthukumaran Natarajan Pillai , Bhavesh Mohanbhai Panchal , Jignesh Kantilal Jivani , Biswajit Samanta , Ranjan Kumar Pal , Rajamannar Thennati

发明人： Marc Capet , Nicolas Levoin , Isabelle Berrebi-Bertrand , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte , Jayraj Dilipbhal Aradhye , Muthukumaran Natarajan Pillai , Bhavesh Mohanbhai Panchal , Jignesh Kantilal Jivani , Biswajit Samanta , Ranjan Kumar Pal , Rajamannar Thennati

IPC分类号： A61K31/4545 , C07D401/14 , C07D213/02 , A61K31/454 , A61P37/06

CPC分类号： C07D413/10 , C07D271/06 , C07D413/14

摘要： The present invention relates to new compounds of formula (I) possessing agonistic activity at sphingosine-1-phosphate (S1P) receptors, their process of preparation and their use as immunosuppressive agents. The invention is also directed to pharmaceutical compositions containing these compounds and use of these compounds for treatment/prevention of immune mediated diseases and conditions or inflammatory diseases and conditions.

摘要翻译： 本发明涉及在鞘氨醇-1-磷酸（S1P）受体，其制备方法及其作为免疫抑制剂的用途中具有激动作用的式（I）化合物。本发明还涉及含有这些化合物的药物组合物和这些化合物用于治疗/预防免疫介导的疾病和病症或炎性疾病和病症的药物组合物。

4.

发明申请
NOVEL DERIVATIVES OF ACYL CYANOPYRROLIDINES 审中-公开
标题翻译： ACYL CYANOPRROLIDINES的新型衍生物

公开(公告)号：US20120040897A1

公开(公告)日：2012-02-16

申请号：US12812436

申请日：2009-01-09

申请人： Nakul Pramod Akolkar , Jay Prakashchandra Adhyapak , Javraj Dilipbhai Aradhye , Anil Savajihai Kumbhani , Bhavesh Mohanbhai Panchal , Jignesh Kantilal Jivani , Biswajit Samanta , Ranjan Kumar Pal , Rajamannar Thennati

发明人： Nakul Pramod Akolkar , Jay Prakashchandra Adhyapak , Javraj Dilipbhai Aradhye , Anil Savajihai Kumbhani , Bhavesh Mohanbhai Panchal , Jignesh Kantilal Jivani , Biswajit Samanta , Ranjan Kumar Pal , Rajamannar Thennati

IPC分类号： A61K38/28 , C07H15/04 , C07D405/14 , C07H1/00 , A61K31/706 , A61K31/454 , A61P3/10 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61P9/10 , A61P9/00 , A61P1/00 , A61P29/00 , A61P1/18 , A61P25/28 , A61P27/02 , A61P25/00 , A61P43/00 , A61P15/00 , A61P17/00 , A61P17/06 , A61P37/06 , A61P25/24 , A61P25/18 , A61P13/12 , A61P25/22 , A61P25/20 , A61P25/08 , A61P31/18 , A61P37/08 , A61P19/02 , A61P9/12 , A61P9/04 , A61P35/00 , A61K38/26 , A61K38/17 , A61K38/22 , C07H9/04

CPC分类号： C07D493/04 , A61K31/7052 , A61K31/706 , A61K45/06 , C07D493/14 , C07H13/00 , C07H13/08 , C07H19/04 , A61K2300/00

摘要： A compound of formula (I) or a tautomeric form, regioisomer, stereoisomer, solvate, N-oxide or pharmaceutically acceptable salts thereof; wherein ‘a’—is selected from the group consisting of substituted or unsubstituted heterocycloalkyl ring and substituted or unsubstituted carbohydrate moiety y is a member selected from —O—, —CO—, —S02-, aminoalkyl or formula (II) wherein, Rw is hydrogen, substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl; x is a member selected from -0-, —S—, —SO—, —S02-, CONR10, NR10CO and —NRd—, or x and y together represent a chemical bond; Z is selected from —CH—, —N—. t is an integer selected from O to 4; with the provisos that when ‘a’ is substituted or unsubstituted heterocycloalkyl ring then ‘t’ is not O and when y=—CO—, x is not NRd.

摘要翻译： 式（I）化合物或互变异构体，区域异构体，立体异构体，溶剂合物，N-氧化物或其药学上可接受的盐; 其中'a'选自取代或未取代的杂环烷基环和取代或未取代的碳水化合物部分y是选自-O-，-CO-，-SO 2 - ，氨基烷基或式（II）的成员，其中，Rw 是氢，取代或未取代的烷基，烯基，炔基，环烷基，芳基，杂芳基; x是选自-O - ， - S-，-SO-，-SO 2 - ，CONR 10，NR 10 CO和-NR d - 的成员，或x和y一起代表化学键; Z选自-CH-，-N-。 t是选自O至4的整数; 条件是当'a'为取代或未取代的杂环烷基环时，则't'不为O，当y = -CO-时，x不为NRd。

5.

发明授权
Dicarboxylic acid derivatives as S1P1 receptor agonists 有权
标题翻译：二羧酸衍生物作为S1P1受体激动剂

公开(公告)号：US08809539B2

公开(公告)日：2014-08-19

申请号：US12664718

申请日：2008-06-16

申请人： Marc Capet , Nicolas Levoin , Isabelle Berrebi-Bertrand , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte , Jayraj Dilipbhai Aradhye , Muthukumaran Natarajan Pillai , Bhavesh Mohanbhai Panchal , Jignesh Kantilal Jivani , Biswajit Samanta , Ranjan Kumar Pal , Rajamannar Thennati

发明人： Marc Capet , Nicolas Levoin , Isabelle Berrebi-Bertrand , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte , Jayraj Dilipbhai Aradhye , Muthukumaran Natarajan Pillai , Bhavesh Mohanbhai Panchal , Jignesh Kantilal Jivani , Biswajit Samanta , Ranjan Kumar Pal , Rajamannar Thennati

IPC分类号： C07D211/18 , A61K31/445 , C07D413/10

CPC分类号： C07D413/10 , C07D271/06 , C07D413/14

摘要： The present invention relates to new compounds of formula (I) possessing agonistic activity at sphingosine-1-phosphate (S1P) receptors, their process of preparation and their use as immunosuppressive agents. The invention is also directed to pharmaceutical compositions containing these compounds and use of these compounds for treatment/prevention of immune mediated diseases and conditions or inflammatory diseases and conditions.

摘要翻译： 本发明涉及在鞘氨醇-1-磷酸（S1P）受体，其制备方法及其作为免疫抑制剂的用途中具有激动作用的式（I）化合物。本发明还涉及含有这些化合物的药物组合物和这些化合物用于治疗/预防免疫介导的疾病和病症或炎性疾病和病症的药物组合物。