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    BREATH CONDENSATE SAMPLER AND DETECTOR AND BREATH/BREATH CONDENSATE SAMPLER AND DETECTOR
    2.
    发明申请
    BREATH CONDENSATE SAMPLER AND DETECTOR AND BREATH/BREATH CONDENSATE SAMPLER AND DETECTOR 有权
    呼吸冷凝器和探测器和呼吸器/呼吸器冷凝器和检测器

    公开(公告)号：US20100268106A1

    公开(公告)日：2010-10-21

    申请号：US12761290

    申请日：2010-04-15

    申请人： Bradley N. Johnson ,  Kanchan Joshi ,  Ying-Lan Chang ,  Ray Radtkey

    发明人： Bradley N. Johnson ,  Kanchan Joshi ,  Ying-Lan Chang ,  Ray Radtkey

    IPC分类号： A61B5/097

    CPC分类号： A61B5/097 ,  A61B5/0803 ,  A61B5/082 ,  A61B5/14539 ,  B82Y30/00 ,  G01N33/497 ,  G01N2001/2282

    摘要： The present invention provides a direct sampler and detector for analytes found in exhaled breath condensate. Analytes in the breath condensate are detected instantaneously as they condense prior to reaching the sensor surface or condense directly on the sensor surface. Because the analysis or assay is performed immediately after patient exhalation, analyte stability is significantly improved providing accurate, reliable, consistent, and clinically applicable results. In certain embodiments, combined breath condensate/breath samplers and detectors are provided, enabling multiplexed analysis of condensed and vapor-phase analytes provided in a single sampling session. Breath is collected and directed to one or more subsystems. Within each subsystem, the breath portion is either condensed or prevented from condensing. The technique also allows real-time continuous monitoring, thus allowing immediate feedback to both medical professionals and additional hardware such as ventilators, anesthesia machines, drug infusion systems and cardiac pacemakers.

    摘要翻译： 本发明提供了一种用于呼出凝结水中分析物的直接取样器和检测器。 呼吸冷凝液中的分析物在到达传感器表面之前凝结，或者直接凝结在传感器表面上瞬间被检测到。 因为在患者呼气后立即进行分析或测定，所以分析物的稳定性得到显着改善，可提供准确，可靠，一致和临床适用的结果。 在某些实施方案中，提供组合的呼吸冷凝物/呼吸取样器和检测器，使得能够对在单个采样会话中提供的冷凝和气相分析物进行复用分析。 呼吸被收集并引导到一个或多个子系统。 在每个子系统内，呼吸部分被冷凝或防止冷凝。 该技术还允许实时连续监测，从而允许立即反馈医疗专业人员和附加硬件，如呼吸机，麻醉机，药物输注系统和心脏起搏器。

    HIGH EFFICIENCY, LOW LOSS NO TO NO2 CATALYTIC CONVERTER
    4.
    发明申请
    HIGH EFFICIENCY, LOW LOSS NO TO NO2 CATALYTIC CONVERTER 审中-公开
    NO2催化转化器的高效率，低损耗

    公开(公告)号：US20090056419A1

    公开(公告)日：2009-03-05

    申请号：US12193353

    申请日：2008-08-18

    申请人： Ying-Lan CHANG ,  Bradley N. JOHNSON ,  Craig BRYANT ,  William MICKELSON

    发明人： Ying-Lan CHANG ,  Bradley N. JOHNSON ,  Craig BRYANT ,  William MICKELSON

    IPC分类号： G01N33/00 ,  B01J19/00 ,  B01J8/06

    CPC分类号： G01N1/28 ,  G01N33/0013

    摘要： Provided herein are catalytic converters that have improved characteristics. According to various embodiments, the converters include high surface area catalyst supports conformally coated with nanoparticulate thin films of a catalyst (e.g., Pt, Pd and Rh). The films are continuous, preventing absorption of species within the converter on the catalyst support. The converters provide higher oxidation efficiency than conventional catalytic converters, in certain embodiments approaching the stoichiometric ratio for the reaction. The converters also provide minimal loss of chemical species within the converter. Also provided are novel methods of fabricating catalytic converters that involve atomic layer deposition of Pt or other catalyst on the support, as well as methods and devices for sensing NO in samples that involve catalytic conversion of NO to NO2.

    摘要翻译： 本文提供具有改进特征的催化转化器。 根据各种实施方案，转化器包括保形涂覆有催化剂（例如Pt，Pd和Rh）的纳米颗粒薄膜的高表面积催化剂载体。 膜是连续的，防止转化器内的物质在催化剂载体上的吸收。 转换器提供比常规催化转化器更高的氧化效率，在某些实施方案中接近反应的化学计量比。 转换器还可以在转换器内提供化学物质的最小损失。 还提供了制造催化转化器的新方法，其涉及Pt或其它催化剂在载体上的原子层沉积，以及用于检测涉及NO转化为NO2的样品中的NO的方法和装置。

    Breath condensate sampler and detector and breath/breath condensate sampler and detector
    5.
    发明授权
    Breath condensate sampler and detector and breath/breath condensate sampler and detector 有权
    呼吸冷凝取样器和检测器和呼吸/呼吸冷凝液取样器和检测器

    公开(公告)号：US09357946B2

    公开(公告)日：2016-06-07

    申请号：US12761290

    申请日：2010-04-15

    申请人： Bradley N. Johnson ,  Kanchan Joshi ,  Ying-Lan Chang ,  Ray Radtkey

    发明人： Bradley N. Johnson ,  Kanchan Joshi ,  Ying-Lan Chang ,  Ray Radtkey

    IPC分类号： A61B5/08 ,  A61B5/097 ,  A61B5/145 ,  B82Y30/00 ,  G01N33/497 ,  G01N1/22

    CPC分类号： A61B5/097 ,  A61B5/0803 ,  A61B5/082 ,  A61B5/14539 ,  B82Y30/00 ,  G01N33/497 ,  G01N2001/2282

    摘要： The present invention provides a direct sampler and detector for analytes found in exhaled breath condensate. Analytes in the breath condensate are detected instantaneously as they condense prior to reaching the sensor surface or condense directly on the sensor surface. Because the analysis or assay is performed immediately after patient exhalation, analyte stability is significantly improved providing accurate, reliable, consistent, and clinically applicable results. In certain embodiments, combined breath condensate/breath samplers and detectors are provided, enabling multiplexed analysis of condensed and vapor-phase analytes provided in a single sampling session. Breath is collected and directed to one or more subsystems. Within each subsystem, the breath portion is either condensed or prevented from condensing. The technique also allows real-time continuous monitoring, thus allowing immediate feedback to both medical professionals and additional hardware such as ventilators, anesthesia machines, drug infusion systems and cardiac pacemakers.

    摘要翻译： 本发明提供了一种用于呼出凝结水中分析物的直接取样器和检测器。 呼吸冷凝液中的分析物在到达传感器表面之前凝结，或者直接凝结在传感器表面上瞬间被检测到。 因为在患者呼气后立即进行分析或测定，所以分析物的稳定性得到显着改善，可提供准确，可靠，一致和临床适用的结果。 在某些实施方案中，提供组合的呼吸冷凝物/呼吸取样器和检测器，使得能够对在单个采样会话中提供的冷凝和气相分析物进行复用分析。 呼吸被收集并引导到一个或多个子系统。 在每个子系统内，呼吸部分被冷凝或防止冷凝。 该技术还允许实时连续监测，从而允许立即反馈医疗专业人员和附加硬件，如呼吸机，麻醉机，药物输注系统和心脏起搏器。

    Magnetic carbon nanotube based biodetection
    6.
    发明授权
    Magnetic carbon nanotube based biodetection 有权
    基于磁性碳纳米管的生物检测

    公开(公告)号：US08993346B2

    公开(公告)日：2015-03-31

    申请号：US13389247

    申请日：2010-08-06

    申请人： Ray Radtkey ,  Kanchan Joshi ,  Bradley N. Johnson ,  Ying-Lan Chang

    发明人： Ray Radtkey ,  Kanchan Joshi ,  Bradley N. Johnson ,  Ying-Lan Chang

    IPC分类号： G01N33/563 ,  G01N33/553 ,  G01N33/543 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B31/02 ,  G01N27/22

    CPC分类号： G01N33/5438 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/16 ,  C01B32/162 ,  C01B32/174 ,  G01N27/226

    摘要： Provided herein is a new hybrid material system, mCNT, including magnetic carbon nanotubes for biological and medical sensing applications. In certain embodiments, the systems include magnetic material on the interior of carbon nanotubes (CNTs). The amount of magnetic particles inside CNTs may be such that mCNT can respond to small, low cost, portable magnet. The exterior CNT surface is kept intact for biomolecular attachments or other functionalizations. Performance enhancement with this novel material includes improved sensitivity, reduced response time, and reduced sample volume. According to various embodiments, the mCNTs are substrates for the adherence of molecules participating in these assays or as active sensing elements. Also provided are methods of fabricating two-dimensional mCNT and CNT networks on printed electrodes.

    摘要翻译： 本文提供了一种新的混合材料系统，mCNT，包括用于生物和医学感测应用的磁性碳纳米管。 在某些实施例中，系统包括在碳纳米管（CNT）内部的磁性材料。 碳纳米管内的磁性颗粒的量可以使得mCNT可以响应于小型，低成本的便携式磁体。 外部CNT表面保持完整，用于生物分子附着或其他功能化。 这种新型材料的性能增强包括改进的灵敏度，减少的响应时间和减少的样品体积。 根据各种实施方案，mCNT是用于粘附参与这些测定的分子或作为主动感测元件的底物。 还提供了在印刷电极上制造二维mCNT和CNT网络的方法。

    MAGNETIC CARBON NANOTUBE BASED BIODETECTION
    7.
    发明申请
    MAGNETIC CARBON NANOTUBE BASED BIODETECTION 有权
    基于磁性碳纳米管的生物保护

    公开(公告)号：US20120178187A1

    公开(公告)日：2012-07-12

    申请号：US13389247

    申请日：2010-08-06

    申请人： Ray Radtkey ,  Kanchan Joshi ,  Bradley N. Johnson ,  Ying-Lan Chang

    发明人： Ray Radtkey ,  Kanchan Joshi ,  Bradley N. Johnson ,  Ying-Lan Chang

    IPC分类号： G01N33/551 ,  B82Y5/00

    CPC分类号： G01N33/5438 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/16 ,  C01B32/162 ,  C01B32/174 ,  G01N27/226

    摘要： Provided herein is a new hybrid material system, mCNT, including magnetic carbon nanotubes for biological and medical sensing applications. In certain embodiments, the systems include magnetic material on the interior of carbon nanotubes (CNTs). The amount of magnetic particles inside CNTs may be such that mCNT can respond to small, low cost, portable magnet. The exterior CNT surface is kept intact for biomolecular attachments or other functionalizations. Performance enhancement with this novel material includes improved sensitivity, reduced response time, and reduced sample volume. According to various embodiments, the mCNTs are substrates for the adherence of molecules participating in these assays or as active sensing elements. Also provided are methods of fabricating two-dimensional mCNT and CNT networks on printed electrodes.

    摘要翻译： 本文提供了一种新的混合材料系统，mCNT，包括用于生物和医学感测应用的磁性碳纳米管。 在某些实施例中，系统包括在碳纳米管（CNT）内部的磁性材料。 碳纳米管内的磁性颗粒的量可以使得mCNT可以响应于小型，低成本的便携式磁体。 外部CNT表面保持完整，用于生物分子附着或其他功能化。 这种新型材料的性能增强包括改进的灵敏度，减少的响应时间和减少的样品体积。 根据各种实施方案，mCNT是用于粘附参与这些测定的分子或作为主动感测元件的底物。 还提供了在印刷电极上制造二维mCNT和CNT网络的方法。