公开(公告)号：US20120214812A1

公开(公告)日：2012-08-23

申请号：US13414385

申请日：2012-03-07

Applicant: VALENTINA MOLTENI ,  XIAOLIN LI ,  JULIET NABAKKA ,  DAVID ARCHER ELLIS ,  BETH ANACLERIO ,  ENRIQUE SAEZ ,  JOHN WITAK

Inventor： VALENTINA MOLTENI ,  XIAOLIN LI ,  JULIET NABAKKA ,  DAVID ARCHER ELLIS ,  BETH ANACLERIO ,  ENRIQUE SAEZ ,  JOHN WITAK

IPC: A61K31/433 ,  C07D417/12 ,  C07D417/04 ,  A61K31/4439 ,  C07D417/10 ,  A61K31/506 ,  C07D417/14 ,  A61K31/444 ,  A61K31/5377 ,  A61P9/00 ,  A61P3/10 ,  A61P25/00 ,  A61P29/00 ,  C07D417/06 ,  A61K31/513 ,  C07D285/12

CPC classification number: C07D285/12 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K45/06 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of liver X receptors (LXRs).

Abstract translation: 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与肝脏X受体（LXR）活性相关的疾病或病症的方法。

公开(公告)号：US08158634B2

公开(公告)日：2012-04-17

申请号：US11718016

申请日：2005-10-26

Applicant: Hong Liu ,  Xiaohui He ,  Ha-Soon Choi ,  Kunyong Yang ,  David Woodmansee ,  Zhicheng Wang ,  David Archer Ellis ,  Baogen Wu ,  Yun He ,  Truc Ngoc Nguyen

Inventor： Hong Liu ,  Xiaohui He ,  Ha-Soon Choi ,  Kunyong Yang ,  David Woodmansee ,  Zhicheng Wang ,  David Archer Ellis ,  Baogen Wu ,  Yun He ,  Truc Ngoc Nguyen

IPC: C07D487/04 ,  A61K31/519 ,  A61P3/04 ,  C07D471/04 ,  C07D473/30 ,  A61K31/5025 ,  A61K31/5365

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D473/30 ,  C07D498/04

Abstract: The invention provides compounds having Formula Ia, or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and Y are as defined in the specification; as well as pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).

Abstract translation: 本发明提供具有式Ia化合物或其药学上可接受的盐，其中R1，R2，R3，R4和Y如说明书中所定义; 以及包含这些化合物的药物组合物和使用这些化合物治疗或预防与大麻素受体1（CB1）的活性相关的疾病或病症的方法。

公开(公告)号：US20080255136A1

公开(公告)日：2008-10-16

申请号：US12107637

申请日：2008-04-22

Applicant: Baogen Wu ,  Yun He ,  Truc Nguyen ,  Kelli L. Kuhen ,  David Archer Ellis ,  Tao Jiang ,  Xiaohui He ,  Kunyong Yang ,  Badry Bursulaya

Inventor： Baogen Wu ,  Yun He ,  Truc Nguyen ,  Kelli L. Kuhen ,  David Archer Ellis ,  Tao Jiang ,  Xiaohui He ,  Kunyong Yang ,  Badry Bursulaya

IPC: A61K31/501 ,  A61K31/53 ,  C07D403/12 ,  A61K31/4015 ,  C07D207/26 ,  C07D417/12 ,  A61K31/427

CPC classification number: C07D207/26 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.

Abstract translation: 本发明涉及使用吡咯烷酮和与吡咯烷酮有关的化合物来抑制病毒，例如HIV。 本发明还涉及用于鉴定和使用试剂的方法，包括抑制细胞中HIV的小分子化学组合物; 以及与艾滋病毒感染和相关疾病状态如艾滋病相关的预防和治疗方法。

公开(公告)号：US20080185808A1

公开(公告)日：2008-08-07

申请号：US12025364

申请日：2008-02-04

Applicant: David Archer ,  David M. Oberholtzer ,  Michael Pritchett

Inventor： David Archer ,  David M. Oberholtzer ,  Michael Pritchett

IPC: B62D25/18

CPC classification number: B62D25/188 ,  B62D25/186

Abstract: A mudflap assembly comprising a bracket for connection to a vehicle and a swiveling support is claimed. A mudflap hanger arm rotatably couples with the bracket via a hinged pin joint. A ramping sleeve is coupled to the pin between the hanger arm and bracket on one end, and a spring installed on the other end provides compressive force against the hanger arm when it travels up the ramping sleeve in response to a horizontal force.

Abstract translation: 要求具有用于连接到车辆的支架和旋转支架的挡泥板组件。 一个挡泥板衣架臂通过一个铰链销接头可旋转地与支架相连。 倾斜套筒在一端连接到衣架臂和支架之间的销上，并且安装在另一端上的弹簧当其响应于水平力而在斜坡套筒上行时提供抵靠衣架臂的压缩力。

公开(公告)号：US07330704B2

公开(公告)日：2008-02-12

申请号：US10476088

申请日：2002-04-25

Applicant: Nicholas David Archer

Inventor： Nicholas David Archer

IPC: H04B1/04

CPC classification number: H03F1/3241

Abstract: A method and circuitry for pre-conditioning an electrical signal. The method comprises limiting the strength of the signal to not exceed a limit signal strength corresponding to the onset of substantial non-linear response of an amplifier to which the limited signal is to be supplied for amplification.

Abstract translation: 一种用于预处理电信号的方法和电路。 该方法包括将信号的强度限制为不超过对应于放大器的基本非线性响应的开始的限制信号强度，限制信号将被提供给放大器。

公开(公告)号：US06955288B2

公开(公告)日：2005-10-18

申请号：US10659893

申请日：2003-09-11

Applicant: John James Barnes ,  Joseph Gerard Biondo ,  Peter Gideon Gelblum ,  Richard Delbert Lanam ,  Charles Joseph Noelke ,  David Archer Wells

Inventor： John James Barnes ,  Joseph Gerard Biondo ,  Peter Gideon Gelblum ,  Richard Delbert Lanam ,  Charles Joseph Noelke ,  David Archer Wells

IPC: B32B15/01 ,  C23C26/00 ,  B21D39/04

CPC classification number: C23C26/00 ,  B32B15/01 ,  B32B15/018 ,  Y10T428/12889 ,  Y10T428/12944

Abstract: A layered article having a curved surface made of a supporting metal metallurgically bonded to a supported metal.

Abstract translation: 具有由金属冶金结合到支撑金属的支撑金属制成的曲面的层叠体。

公开(公告)号：US20050227357A1

公开(公告)日：2005-10-13

申请号：US10947168

申请日：2004-09-23

Applicant: Ralph Bohlmann ,  Nigel Belshaw ,  David Archer ,  Marcos Alcocer ,  Neville Fish ,  Jerome Pierrard ,  Carole Guitton

Inventor： Ralph Bohlmann ,  Nigel Belshaw ,  David Archer ,  Marcos Alcocer ,  Neville Fish ,  Jerome Pierrard ,  Carole Guitton

IPC: C12N1/16 ,  C12N9/24 ,  C12N9/64 ,  C12N15/74 ,  C12N15/80

CPC classification number: C12N9/248 ,  C07K2319/036 ,  C12N9/2402 ,  C12N9/2437 ,  C12N9/2442 ,  C12N9/6413 ,  C12N15/80

Abstract: The present invention relates to a recombinant P. funiculosum strain for the production of homologous and heterologous proteins, and a transformation method for obtaining such recombinant P. funiculosum. Expression cassettes designed with genetic regulatory elements functional in P. funiculosum such as promoters, terminators and signal peptide encoding sequences are also encompassed by the present invention.

Abstract translation: 本发明涉及用于产生同源和异源蛋白质的重组真菌菌株，以及用于获得这种重组真菌的转化方法。 设计具有在真菌例如启动子，终止子和信号肽编码序列中功能的遗传调控元件的表达盒也包括在本发明中。

公开(公告)号：US5317720A

公开(公告)日：1994-05-31

申请号：US34581

申请日：1993-03-22

Applicant: Rebecca L. Stamm ,  John Edmondson ,  David Archer ,  Samyojita Nadkarni ,  Raymond Strouble

Inventor： Rebecca L. Stamm ,  John Edmondson ,  David Archer ,  Samyojita Nadkarni ,  Raymond Strouble

IPC: G06F9/32 ,  F02B75/02 ,  G06F9/38 ,  G06F12/08 ,  G06F13/00

CPC classification number: G06F12/0804 ,  G06F12/0811 ,  G06F12/0831 ,  G06F9/3836 ,  G06F9/3838 ,  G06F9/3855 ,  G06F9/3857 ,  F02B2075/025

Abstract: A pipelined CPU executing instructions of variable length, and referencing memory using various data widths. A writeback cache is used (instead of writethrough) in a hierarchical cache arrangement, and writeback is allowed to proceed even though other accesses are suppressed due to queues being full. Separate queues are provided for the return data from memory and cache invalidates, yet the order or bus transactions is maintained by a pointer arrangement. The bus protocol used by the CPU to communicate with the system bus is of the pended type, with transactions on the bus identified by an ID field specifying the originator, and arbitration for bus grant goes one simultaneously with address/data transactions on the bus.

Abstract translation: 执行可变长度指令的流水线CPU，并使用各种数据宽度引用存储器。 在分层高速缓存布置中使用回写高速缓存（而不是写通），并且即使由于队列已满而抑制其他访问，也允许回写。 提供单独的队列用于来自存储器的返回数据，并且高速缓存无效，但是顺序或总线事务由指针排列来维护。 CPU与系统总线通信使用的总线协议是挂起类型，由总线标识的总线标识的总线上的事务，总线授权的仲裁与总线上的地址/数据事务同时进行。

公开(公告)号：US4570809A

公开(公告)日：1986-02-18

申请号：US659822

申请日：1984-10-05

Applicant: David Archer

Inventor： David Archer

IPC: B65D50/04 ,  B65D55/08 ,  B65D55/02

CPC classification number: B65D50/041 ,  B65D55/089

Abstract: A closure cap for a container comprises an inner cap which can be screwed onto the neck of a bottle, and an outer cap which covers and surrounds the inner cap. The outer cap has a tamper evident rim part of which extends into an annular groove in the inner cap. Portions on the top of the inner cap can be brought into engagement with portions provided under the top of the outer cap following downward movement of the outer cap. This downward movement of the outer cap enables rotation of the outer cap to effect removal of the cap, but such downward movement is only possible after the tamper evident rim has been removed.

Abstract translation: 用于容器的封闭盖包括可以拧在瓶颈上的内盖和覆盖并围绕内盖的外盖。 外盖具有防篡改的边缘部分，其延伸到内盖中的环形槽中。 内盖的顶部上的部分可以在外盖的向下移动之后与设置在外盖的顶部下方的部分接合。 外盖的这种向下运动能够旋转外盖以实现盖的移除，但是这种向下运动仅在去除显窃启边缘之后才可能。

公开(公告)号：US4090778A

公开(公告)日：1978-05-23

申请号：US776596

申请日：1977-03-11

Applicant: Michael James Phillips ,  John David Archer

Inventor： Michael James Phillips ,  John David Archer

IPC: G02B6/38 ,  H02G15/08 ,  G02B5/14

CPC classification number: G02B6/3835 ,  G02B6/3873

Abstract: An optical fiber connector assembly employs a tubular alignment portion in which two watch jewels, one fitted to each fiber end, are aligned. The jewels are mounted on the ends of ferrules and have diameters greater than that of the ferrules so that alignment of the fibers is made off the jewels rather than the ferrules.

Abstract translation: 光纤连接器组件采用管状对准部分，其中安装在每个光纤端部的两个手表珠宝对准。 珠宝安装在套圈的端部上，其直径大于套圈的直径，使得纤维的排列从珠宝而不是套圈上取下。