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公开(公告)号：US08524900B2
公开(公告)日：2013-09-03
申请号：US13309488
申请日：2011-12-01
Applicant: Brian K. Albrecht , David Bauer , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie K. Springer , Markian Stec , Ning Xi , Kevin Yang
Inventor： Brian K. Albrecht , David Bauer , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie K. Springer , Markian Stec , Ning Xi , Kevin Yang
IPC: C07D487/04 , C07D403/12 , C07D403/14 , C07D401/12 , C07D401/14 , C07D413/14 , A61K31/5025 , A61K31/4353 , A61K31/4523 , A61P35/00
CPC classification number: A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号：US07153865B2
公开(公告)日：2006-12-26
申请号：US10488025
申请日：2002-08-23
Applicant: Derin D'Amico
Inventor： Derin D'Amico
IPC: A61K31/47 , C07D215/38
CPC classification number: A61K31/5377 , A61K31/4706 , C07D215/44
Abstract: Compounds useful for the treatment of pain in accord with the following structural diagram, wherein A, R1, b, R3, d, R4, R5, R6 and R7 are any of a number of groups as defined in the specification, and pharmaceutical compositions and methods of treatment utilizing such compounds.
Abstract translation: 用于治疗疼痛的化合物符合以下结构图，其中A，R 1，b，R 3，d，R 4， >，R 5，R 6和R 7是本说明书中定义的多个基团中的任何一个，以及药物组合物和方法 利用这些化合物进行治疗。
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公开(公告)号：US20060100213A1
公开(公告)日：2006-05-11
申请号：US11247046
申请日：2005-10-11
Applicant: Toshihiro Aya , Guolin Cai , Jian Chen , Derin D'Amico , Thomas Nguyen , Wenyuan Qian
Inventor： Toshihiro Aya , Guolin Cai , Jian Chen , Derin D'Amico , Thomas Nguyen , Wenyuan Qian
IPC: A61K31/497 , C07D405/14
CPC classification number: C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D471/04
Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号：US20080020978A1
公开(公告)日：2008-01-24
申请号：US11584177
申请日：2006-10-19
Applicant: Colin Gegg , Eileen Johnson , Leslie Miranda , Kenneth Walker , Jerry Holder , Marie Wright , Derin D'Amico
Inventor： Colin Gegg , Eileen Johnson , Leslie Miranda , Kenneth Walker , Jerry Holder , Marie Wright , Derin D'Amico
CPC classification number: A61K38/225 , C07K14/57527
Abstract: Disclosed is a composition of matter that involves a CGRP peptide antagonist. A pharmaceutical composition is disclosed that comprises the composition of matter and a pharmaceutically acceptable carrier, which can be configured for administration to a patient. Also disclosed is a method of producing the composition of matter. Methods of treating, preventing or mitigating migraine, are also disclosed.
Abstract translation: 公开了涉及CGRP肽拮抗剂的物质组合物。 公开了包含物质组合物和药学上可接受的载体的药物组合物，其可被配置用于给予患者。 还公开了一种生产物质组合物的方法。 还公开了治疗，预防或减轻偏头痛的方法。
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公开(公告)号：US20060199812A1
公开(公告)日：2006-09-07
申请号：US11338371
申请日：2006-01-23
Applicant: Derin D'Amico , Benny Askew
Inventor： Derin D'Amico , Benny Askew
IPC: A61K31/542 , C07D498/14 , C07D498/04
CPC classification number: C07K1/1077 , A61K38/043 , A61K47/60 , C07D513/04
Abstract: The present invention relates to a novel chemical process that provides novel vehicle derivatives that are exceptional 1,2- or 1,3-aminothiol specific reagents for conjugation to unprotected targeted compounds (e.g., polypeptides, peptides, or organic compounds) having or modified to have a 1,2- or 1,3 aminothiol group. The invention further relates to the methods of using novel water-soluble polymer derivatives and conjugates thereof.
Abstract translation: 本发明涉及一种新颖的化学方法，其提供新的载体衍生物，其是用于与未保护的靶向化合物（例如，多肽，肽或有机化合物）缀合的特殊的1,2-或1,3-氨基硫醇特异性试剂，其具有或修饰为 具有1,2-或1,3-氨基硫醇基团。 本发明还涉及使用新的水溶性聚合物衍生物及其共轭物的方法。
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Patent Agency Ranking
公开(公告)号：US20050215470A1
公开(公告)日：2005-09-29
申请号：US10972236
申请日：2004-10-21
Applicant: Gordon Ng , Yue-Sheng Li , Colin Gegg , Benny Askew , Thomas Storz , Yuelie Lu , Derin D'Amico
Inventor： Gordon Ng , Yue-Sheng Li , Colin Gegg , Benny Askew , Thomas Storz , Yuelie Lu , Derin D'Amico
Abstract: The present invention relates to certain biologically active peptides and conjugated peptides which can be used as therapeutics or prophylactics against diseases or conditions linked to B1 as the causative agent. In a preferred embodiment of the invention biologically active PEG-conjugated peptides are provided. In one aspect of the present invention, pharmacologically active PEG-conjugated peptides of the present invention are useful to treat inflammation or pain.
Abstract translation: 本发明涉及某些生物活性肽和缀合肽，其可以用作治疗剂或预防药物，其与作为致病剂的B1连接的疾病或病症。 在本发明的优选实施方案中，提供生物活性PEG-缀合的肽。 在本发明的一个方面，本发明的药理学活性的PEG-缀合的肽可用于治疗炎症或疼痛。
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公开(公告)号：US20050014749A1
公开(公告)日：2005-01-20
申请号：US10874086
申请日：2004-06-21
Applicant: Jian Chen , Ben Askew , Kaustav Biswas , Jennifer Chau , Derin D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Yuan , Nianhe Han , Rana Nomak , Kevin Yang
Inventor： Jian Chen , Ben Askew , Kaustav Biswas , Jennifer Chau , Derin D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Yuan , Nianhe Han , Rana Nomak , Kevin Yang
IPC: A61K31/495 , C07D241/00 , C07D241/08 , C07D243/08 , C07D245/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D279/12 , A61K31/537 , A61K31/54
CPC classification number: C07D241/08 , C07D243/08 , C07D245/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14
Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Abstract translation: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物，类似物，前药和药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US20120148531A1
公开(公告)日：2012-06-14
申请号：US13309488
申请日：2011-12-01
Applicant: Brian K. ALBRECHT , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
Inventor： Brian K. ALBRECHT , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
IPC: A61K31/5025 , A61K31/5377 , A61K38/21 , A61P35/00 , A61P35/04 , C07D487/04 , A61K31/538
CPC classification number: A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Abstract translation: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US07612060B2
公开(公告)日：2009-11-03
申请号：US11247046
申请日：2005-10-11
Applicant: Toshihiro Aya , Guolin Cai , Jian J. Chen , Derin D'Amico , Thomas Nguyen , Wenyuan Qian
Inventor： Toshihiro Aya , Guolin Cai , Jian J. Chen , Derin D'Amico , Thomas Nguyen , Wenyuan Qian
IPC: C07D403/00 , C07D401/00 , C07D413/00 , A01N43/46 , A61K31/535 , A61K31/497
CPC classification number: C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D471/04
Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Abstract translation: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US20120107275A1
公开(公告)日：2012-05-03
申请号：US13323692
申请日：2011-12-12
Applicant: Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
Inventor： Brian K. Albrecht , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
IPC: A61K31/5025 , A61K31/5377 , C07D498/04 , A61K31/538 , A61K38/21 , A61P31/00 , A61P3/00 , A61P5/00 , A61P37/00 , C07D487/04 , A61P35/00
CPC classification number: C07D471/04 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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