公开(公告)号：US07378496B2

公开(公告)日：2008-05-27

申请号：US10722189

申请日：2003-11-24

申请人： K. George Chandy ,  J. Jay Gargus ,  George Gutman ,  Emmanuelle Fantino ,  Katarin Kalman

发明人： K. George Chandy ,  J. Jay Gargus ,  George Gutman ,  Emmanuelle Fantino ,  Katarin Kalman

IPC分类号： C07K14/705

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

摘要： The present invention is based on the discovery and cloning of the human small conductance calcium activated potassium channel type 3 (hKCa3/KCNN3) gene, which is expressed in neuronal cells, skeletal muscle, heart, and lymphocytes. Alterations in the hKCa3/KCNN3 gene or its protein product may enhance susceptibility to schizophrenia and/or bipolar disorder. hKCa3/KCNN3 may be involved in neuropsychiatric, neurological, neuromuscular, and immunological disorders. Substantially purified hKCa3/KCNN3 polypeptides and polynucleotides are provided. Antibodies which bind to hKCa3/KCNN3 polypeptides are also disclosed. A method for identifying a compound which affects hKCa3/KCNN3 polynucleotide or polypeptide is provided. A method for diagnosis and determining the prognosis and treatment regimen of a subject having or at risk of having a hKCa3/KCNN3-associated disorder is also provided. A method of treating a subject having or at risk of having an hKCa3/KCNN3-associated disorder by administering a therapeutically effective amount of a polynucleotide encoding SEQ ID NO:2 is also provided. A formulation for administration of hKCa3/KCNN3 to a patient of a therapeutically effective amount of hKCa3/KCNN3 polypeptide is provided. Kits useful for detecting the presence of hKCa3/KCNN3 polypeptide or polynucleotide in a sample from a subject having a hKCa3/KCNN3-associated disorder are provided. Transgenic nonhuman animals having a transgene encoding hKCa3/KCNN3 are also described.

摘要翻译： 本发明是基于在神经细胞，骨骼肌，心脏和淋巴细胞中表达的人小电导钙激活钾通道3型（hKCa3 / KCNN3）基因的发现和克隆。 hKCa3 / KCNN3基因或其蛋白质产物的改变可能增加对精神分裂症和/或双相情感障碍的易感性。 hKCa3 / KCNN3可能参与神经精神，神经，神经肌肉和免疫疾病。 提供了大量纯化的hKCa3 / KCNN3多肽和多核苷酸。 还公开了与hKCa3 / KCNN3多肽结合的抗体。 提供了鉴定影响hKCa3 / KCNN3多核苷酸或多肽的化合物的方法。 还提供了用于诊断和确定具有hKCa3 / KCNN3相关病症或具有hKCa3 / KCNN3相关病症风险的受试者的预后和治疗方案的方法。 还提供了通过施用治疗有效量的编码SEQ ID NO：2的多核苷酸治疗患有或具有hKCa3 / KCNN3相关病症风险的受试者的方法。 提供了将hKCa3 / KCNN3给予治疗有效量的hKCa3 / KCNN3多肽的患者的制剂。 提供了可用于检测来自具有hKCa3 / KCNN3相关病症的受试者的样品中hKCa3 / KCNN3多肽或多核苷酸的存在的试剂盒。 还描述了具有编码hKCa3 / KCNN3的转基因的转基因非人动物。

公开(公告)号：US20060133575A1

公开(公告)日：2006-06-22

申请号：US11190424

申请日：2005-07-27

申请人： George Gutman ,  Emil Strumban

发明人： George Gutman ,  Emil Strumban

IPC分类号： H05G2/00 ,  G21G4/00 ,  H01J35/00 ,  A61N5/10

CPC分类号： H01J35/32 ,  A61B6/08 ,  A61B6/542 ,  A61N5/1001 ,  A61N5/1027 ,  G21K1/06

摘要： The invention is directed to an x-ray device and method for radiation treatment comprising an x-ray source 1, a collimator 4 incorporating conditional optics, such as a capillary lens 3 for directing and focusing the x-ray radiation, and implantable needles. One or more capillary semilenses 16, 17 are positioned along the optical axis of the x-ray beam allow to form a movable focus by changing the distance between the semilenses. The input end of the collimator 4 is optically and mechanically conjugated with the x-ray source 1. The output end of the collimator is optically and mechanically conjugated with an originating end of the needle 5. At its output end is a transparent window 6 on which can repose a layer 13 that substantially absorbs and re-emits radiation which passes through the window 6.

摘要翻译： 本发明涉及一种用于放射线治疗的X射线装置和方法，其包括x射线源1，包括条件光学元件的准直仪4，例如用于引导和聚焦x射线辐射的毛细管透镜3以及可植入的针。 一个或多个毛细管半纤维16,17沿X射线束的光轴定位允许通过改变半固体之间的距离来形成可移动聚焦。 准直器4的输入端与X射线源1光学和机械共轭。准直器的输出端与针5的起始端光学和机械共轭。其输出端为透明窗6， 其可以放置基本上吸收和再发射穿过窗口6的辐射的层13。

公开(公告)号：US06653100B1

公开(公告)日：2003-11-25

申请号：US09565590

申请日：2000-05-04

申请人： K. George Chandy ,  J. Jay Gargus ,  George Gutman ,  Emmanuelle Fantino ,  Katarin Kalman

发明人： K. George Chandy ,  J. Jay Gargus ,  George Gutman ,  Emmanuelle Fantino ,  Katarin Kalman

IPC分类号： C12N1512

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

摘要： The present invention is based on the discovery and cloning of the human small conductance calcium activated potassium channel type 3 (hKCa3/KCNN3) gene, which is expressed in neuronal cells, skeletal muscle, heart, and lymphocytes. Alterations in the hKCa3/KCNN3 gene or its protein product may enhance susceptibility to schizophrenia and/or bipolar disorder. hKCa3/KCNN3 may be involved in neuropsychiatric, neurological, neuromuscular, and immunological disorders. Substantially purified hKCa3/KCNN3 polypeptides and polynucleotides are provided. Antibodies which bind to hKCa3/KCNN3 polypeptides are also disclosed. A method for identifying a compound which affects hKCa3/KCNN3 polynucleotide or polypeptide is provided. A method for diagnosis and determining the prognosis and treatment regimen of a subject having or at risk of having a hKCa3/KCNN3-associated disorder is also provided. A method of treating a subject having or at risk of having an hKCa3/KCNN3-associated disorder by administering a therapeutically effective amount of a polynucleotide encoding SEQ ID NO:2 is also provided. A formulation for administration of hKCa3/KCNN3 to a patient of a therapeutically effective amount of hKCa3/KCNN3 polypeptide is provided. Kits useful for detecting the presence of hKCa3/KCNN3 polypeptide or polynucleotide in a sample from a subject having a hKCa3/KCNN3-associated disorder are provided. Transgenic nonhuman animals having a transgene encoding hKCa3/KCNN3 are also described.

摘要翻译： 本发明是基于在神经细胞，骨骼肌，心脏和淋巴细胞中表达的人小电导钙激活钾通道3型（hKCa3 / KCNN3）基因的发现和克隆。 hKCa3 / KCNN3基因或其蛋白质产物的改变可能增加对精神分裂症和/或双相情感障碍的易感性。 hKCa3 / KCNN3可能参与神经精神，神经，神经肌肉和免疫疾病。 提供了大量纯化的hKCa3 / KCNN3多肽和多核苷酸。 还公开了与hKCa3 / KCNN3多肽结合的抗体。 提供了鉴定影响hKCa3 / KCNN3多核苷酸或多肽的化合物的方法。 还提供了用于诊断和确定具有hKCa3 / KCNN3相关病症或具有hKCa3 / KCNN3相关病症风险的受试者的预后和治疗方案的方法。 还提供了通过施用治疗有效量的编码SEQ ID NO：2的多核苷酸治疗患有或具有hKCa3 / KCNN3相关病症风险的受试者的方法。 提供了将hKCa3 / KCNN3给予治疗有效量的hKCa3 / KCNN3多肽的患者的制剂。 提供了可用于检测来自具有hKCa3 / KCNN3相关病症的受试者的样品中hKCa3 / KCNN3多肽或多核苷酸的存在的试剂盒。 还描述了具有编码hKCa3 / KCNN3的转基因的转基因非人动物。

公开(公告)号：US5384817A

公开(公告)日：1995-01-24

申请号：US89832

申请日：1993-07-12

申请人： David J. Crowther ,  George Gutman

发明人： David J. Crowther ,  George Gutman

IPC分类号： G21K1/06

CPC分类号： B82Y10/00 ,  G21K1/062 ,  G21K2201/061 ,  G21K2201/067

摘要： X-ray dispersive elements comprise a stacked array of layer pairs of boron nitride and either nickel, tungsten, chromium, vanadium, iron, manganese, cobalt and combinations thereof. The boron nitride is preferably deposited through a planar magnetron sputtering process.

摘要翻译： X射线分散元件包括氮化硼和镍，钨，铬，钒，铁，锰，钴及其组合的层对的堆叠阵列。 氮化硼优选通过平面磁控溅射工艺沉积。

公开(公告)号：US07120224B2

公开(公告)日：2006-10-10

申请号：US11258261

申请日：2005-10-25

申请人： George Gutman

发明人： George Gutman

IPC分类号： A61B6/04

CPC分类号： A61B5/6848 ,  A61B6/08 ,  A61B6/4429 ,  A61B6/502 ,  A61B2562/17

摘要： An x-ray imaging apparatus for mammography. The apparatus places the focal spot of the x-ray source as close as possible to a compression paddle or into a desired region of tissue. The apparatus comprises an x-ray source, a collimator with conditioning optics which focus and direct x-ray radiation to a metal pseudo-target in the collimator or a needle placed along the x-ray beam, paddles for breast compression and a detector. The pseudo-target re-emits monochromatic x-ray radiation with an energy, intensity, and space distribution that are adjustable in accordance with a desired imaging procedure.

摘要翻译： 一种用于乳房X线摄影的X射线成像装置。 该装置将x射线源的焦斑尽可能靠近压缩桨或组织的期望区域。 该装置包括x射线源，具有调节光学器件的准直器，其将x射线辐射聚焦并引导到准直仪中的金属伪靶或沿x射线束放置的针，用于乳房压缩的桨和检测器。 伪目标重新发射具有根据期望的成像过程可调节的能量，强度和空间分布的单色x射线辐射。

公开(公告)号：US20060093084A1

公开(公告)日：2006-05-04

申请号：US11258261

申请日：2005-10-25

申请人： George Gutman

发明人： George Gutman

IPC分类号： A61B6/04

CPC分类号： A61B5/6848 ,  A61B6/08 ,  A61B6/4429 ,  A61B6/502 ,  A61B2562/17

摘要： An x-ray imaging apparatus for mammography. The apparatus places the focal spot of the x-ray source as close as possible to a compression paddle or into a desired region of tissue. The apparatus comprises an x-ray source, a collimator with conditioning optics which focus and direct x-ray radiation to a metal pseudo-target in the collimator or a needle placed along the x-ray beam, paddles for breast compression and a detector. The pseudo-target re-emits monochromatic x-ray radiation with an energy, intensity, and space distribution that are adjustable in accordance with a desired imaging procedure.

公开(公告)号：US20050082698A1

公开(公告)日：2005-04-21

申请号：US10600041

申请日：2003-06-20

申请人： George Gutman ,  Michael Hennessey ,  Barry Clark ,  David Strand

发明人： George Gutman ,  Michael Hennessey ,  Barry Clark ,  David Strand

IPC分类号： B29C35/08 ,  B29C43/02 ,  B29C59/02 ,  B29C59/04 ,  B29D17/00 ,  B29D11/00

CPC分类号： B29D17/007 ,  B29C43/00 ,  B29C43/021 ,  B29C59/026 ,  B29C59/04 ,  B29C2035/0811 ,  B29C2043/025 ,  B29C2059/023 ,  B29K2105/256 ,  B29L2017/00 ,  B29L2017/005

摘要： The present invention provides a method and apparatus for the continuous manufacturing of optical memory or optical memory substrates, and/or optical disks, which includes supplying a web of material to a substrate forming apparatus, embossing a microform image onto a polymeric film, such as an information track structure for an optical device, onto one or both sides of the web with a flat stamper and punching a hole through the web during the embossing. During the embossing, the polymeric material is heated to above the glass transition temperature (Tg). A flat stamper limits the potential for warp in the web, particularly when the web is stabilized in the stamp zone. The disclosed invention is particularly useful in the production of optical disk substrates, such as polycarbonate, having a thickness of 0.6 mm or less.

摘要翻译： 本发明提供了用于连续制造光学存储器或光学存储器基板和/或光盘的方法和装置，其包括将材料幅材供应到基板成形装置，将微型图像压印到聚合物膜上，例如 用于光学装置的信息轨道结构，在平坦的压模的幅材的一侧或两侧上，并且在压印期间穿过网穿孔。 在压花过程中，将聚合物材料加热至高于玻璃化转变温度（Tg）。 平坦的压模限制了网中翘曲的可能性，特别是当幅材在印模区域中稳定时。 所公开的发明在厚度为0.6mm以下的光盘基板（例如聚碳酸酯）的制造中特别有用。

公开(公告)号：US5799056A

公开(公告)日：1998-08-25

申请号：US755294

申请日：1996-11-22

申请人： George Gutman

发明人： George Gutman

IPC分类号： G21K1/06

CPC分类号： B82Y10/00 ,  G21K1/062 ,  G21K2201/061 ,  G21K2201/064 ,  G21K2201/067 ,  G21K2201/068

摘要： This invention relates to novel methods of producing flat and curved optical elements with laterally and depth graded multilayer thin films, in particular multilayers of extremely high precision, for use with soft and hard x-rays and neutrons and the optical elements achieved by these methods. In order to improve the performance of an optical element, errors in d spacing and curvature are isolated and subsequently compensated.

摘要翻译： 本发明涉及生产具有横向和深度梯度多层薄膜的平面和弯曲光学元件的新方法，特别是具有极高精度的多层，用于软和硬x射线和中子以及通过这些方法实现的光学元件。 为了提高光学元件的性能，分离出d间隔和曲率的误差并随后进行补偿。

公开(公告)号：US06580940B2

公开(公告)日：2003-06-17

申请号：US09776559

申请日：2001-02-02

申请人： George Gutman

发明人： George Gutman

IPC分类号： A61N510

CPC分类号： A61N5/1001 ,  A61N2005/1091 ,  H01J2235/164

摘要： An x-ray system for treatment cancer by delivering x-ray radiation directly to a desired region of tissue comprising an x-ray source with directed narrow space distribution of x-rays (linear accelerator), conditioning optics which direct and monochromotize x-ray radiation, an implantable needle with means for shaping beam installed across the x-ray beam, and expanding pipe-guide connecting conditioning optics with implantable needle whereby the energy, intensity, and space distribution of the delivered to the tumor x-ray radiation may be adjusted in accordance with the predefined treatment requirements.

公开(公告)号：US06041099A

公开(公告)日：2000-03-21

申请号：US26385

申请日：1998-02-19

申请人： George Gutman ,  Licai Jiang ,  Boris Verman

发明人： George Gutman ,  Licai Jiang ,  Boris Verman

IPC分类号： G02B17/00 ,  G21K1/06

CPC分类号： B82Y10/00 ,  G21K1/06 ,  G21K1/062 ,  G21K2201/064

摘要： An x-ray reflecting system comprising a Kirkpatrick-Baez side-by-side optic in a single corner configuration having multi-layer Bragg x-ray reflective surfaces.

摘要翻译： 包括具有多层布拉格x射线反射表面的单角配置的Kirkpatrick-Baez并排光学器件的x射线反射系统。