公开(公告)号：US20070118197A1

公开(公告)日：2007-05-24

申请号：US11457004

申请日：2006-07-12

Applicant: Gerald Loeb

Inventor： Gerald Loeb

IPC: A61N1/05

CPC classification number: A61N1/0534 ,  A61N1/0539

Abstract: Devices and systems for recording and/or stimulating electrical signals in order to identify a target site within a patient's brain for further electrical stimulation and chemical treatments of the brain. The deep brain stimulation devices and methods include implantable devices having various microelectrode configurations and drug delivery mechanisms. The devices can be used to treat a variety of neurological conditions.

Abstract translation: 用于记录和/或刺激电信号的装置和系统，以便识别患者脑内的目标部位，以进一步进行电刺激和大脑的化学治疗。 深脑刺激装置和方法包括具有各种微电极配置和药物递送机制的可植入装置。 该装置可用于治疗各种神经病症。

公开(公告)号：US20060004424A1

公开(公告)日：2006-01-05

申请号：US11146761

申请日：2005-06-06

Applicant: Gerald Loeb ,  Jack Wills

Inventor： Gerald Loeb ,  Jack Wills

IPC: A61N1/18

CPC classification number: A61N1/08 ,  A61N1/3605 ,  A61N1/37205 ,  A61N1/378

Abstract: Disclosed are biomedical stimulators and systems that deliver stimulus power efficiently to electrodes and tissues, provide reliable control of stimulus efficacy over a wide dynamic range of available power and voltage, avoid damaging net direct current flow through tissue, minimize the amount of data that must be transmitted to specify a particular stimulus strength, and extend the range of received field strengths for which stimulators can function safely and reliably. These biomedical stimulators and systems provide reliable stimulation of known intensity by measuring charging currents and discharging predetermined quantities of charge.

Abstract translation: 公开了生物医学刺激器和系统，可以有效地向电极和组织提供刺激功率，在可用功率和电压的宽动态范围内提供可靠的刺激功效控制，避免损害通过组织的净直流电流，从而最大限度地减少必须 传输以指定特定的刺激强度，并且扩展刺激器可以安全可靠地起作用的接收场强的范围。 这些生物医学刺激器和系统通过测量充电电流和放电预定量的电荷来提供已知强度的可靠刺激。

公开(公告)号：US20070129772A1

公开(公告)日：2007-06-07

申请号：US11469357

申请日：2006-08-31

Applicant: Gerald Loeb

Inventor： Gerald Loeb

IPC: A61N1/00

CPC classification number: A61N1/36036 ,  H04R25/606

Abstract: Systems and methods for fitting cochlear implants. The cochlear implant fitting systems and methods can be used to generate various stimulus patterns for fitting patients with speech processors for cochlear implants. The fitting systems and methods provide means to identify rapidly which of several speech processing strategies could function effectively in cochlear implant patients.

Abstract translation: 耳蜗植入物的系统和方法。 耳蜗植入物适配系统和方法可用于产生各种刺激模式，用于使具有用于耳蜗植入物的语音处理器的患者拟合。 拟合系统和方法提供了快速识别哪些语音处理策略在人工耳蜗患者中有效发挥作用的手段。

公开(公告)号：US20070016265A1

公开(公告)日：2007-01-18

申请号：US11350482

申请日：2006-02-09

Applicant: Rahman Davoodi ,  Gerald Loeb ,  Junkwan Lee

Inventor： Rahman Davoodi ,  Gerald Loeb ,  Junkwan Lee

IPC: A61N1/18

CPC classification number: G06F3/011 ,  A61F2/68 ,  A61F2/72 ,  A61F2/76 ,  A61N1/08 ,  A61N1/36003 ,  G09B19/003 ,  G16H50/50

Abstract: Disclosed are methods and systems for a virtual reality simulation and display of limb movement that facilitate the development and fitting of prosthetic control of a paralyzed or artificial limb. The user generates command signals that are then processed by the control system. The output of the control system drives a physics-based simulation of the limb that simulates the limb to be controlled. The computed movements of the model limb are displayed to the user as a 3D animation from the perspective of the user so as to give the impression that the user is watching the actual movements of his/her own limb. The user learns to adjust his/her command signals to perform tasks successfully with the virtual limb. Alternatively or additionally, the errors produced by the virtual limb and/or the responses of the user during the training process can provide information for adapting the properties of the control system itself.

Abstract translation: 公开了用于虚拟现实模拟和显示肢体运动的方法和系统，其有助于瘫痪或假肢的假肢控制的开发和拟合。 用户产生然后由控制系统处理的命令信号。 控制系统的输出驱动肢体的基于物理的仿真来模拟要控制的肢体。 从用户的角度，将计算出的模型肢体的运动作为3D动画显示给用户，以给出用户正在观看他/她自己的肢体的实际运动的印象。 用户学习调整他/她的命令信号，使用虚拟肢体成功地执行任务。 或者或另外，虚拟肢体产生的错误和/或用户在训练过程中的响应可以提供用于调整控制系统本身的属性的信息。

公开(公告)号：US20050267326A1

公开(公告)日：2005-12-01

申请号：US11088460

申请日：2005-03-24

Applicant: Gerald Loeb ,  Kuo-Chih (Vincent) Liao ,  Thieo Hogen-Esch

Inventor： Gerald Loeb ,  Kuo-Chih (Vincent) Liao ,  Thieo Hogen-Esch

IPC: A61B1/00 ,  A61B5/00 ,  A61K49/00 ,  C12M1/34

CPC classification number: A61B5/1459 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/14532 ,  A61B5/14546 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0067 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/7703 ,  G01N2021/6432 ,  G01N2021/772

Abstract: A biosensing device for detecting biological analytes, and methods of use and manufacture, are disclosed. The device includes a biosensing element that can remain implanted for extended periods of time. The biosensing element is connected to an optical fiber terminating outside of the body. The optical fiber is also connected to an information analyzer. The information analyzer directs light through the optical fiber into the biosensing element. The light excites fluorophores, created by a chemical reaction between analytes and biosensing material within the biosensing element. Emitted fluorescent light is redirected through the optical fiber to the information analyzer. Detectors detect the deflected fluorescent emissions and, according to their determined wavelength, report the presence or quantity of specific analytes to the patient on an external display.

Abstract translation: 公开了用于检测生物分析物的生物传感装置及其使用和制造方法。 该装置包括可以长时间保持植入的生物传感元件。 生物传感元件连接到终端外部的光纤。 光纤也连接到信息分析仪。 信息分析仪将光线通过光纤引导到生物传感元件中。 光激发由生物感应元件内的分析物和生物传感材料之间的化学反应产生的荧光团。 发射的荧光灯通过光纤重定向到信息分析仪。 检测器检测偏转的荧光发射，并根据其确定的波长，在外部显示器上向患者报告特定分析物的存在或数量。

公开(公告)号：US20070270722A1

公开(公告)日：2007-11-22

申请号：US11679109

申请日：2007-02-26

Applicant: Gerald Loeb ,  Wei Tan

Inventor： Gerald Loeb ,  Wei Tan

IPC: A61B5/103

CPC classification number: A61B5/1116 ,  A61B5/06 ,  A61B5/1114 ,  A61B5/1121 ,  A61B5/6861 ,  A61B5/725 ,  A61B2560/0219 ,  A61B2562/0223 ,  A61B2562/162 ,  A61N1/36003

Abstract: A signal transmitting and receiving system to track the position and orientation of limb segments in order to provide feedback information for the control of the limb movement. The user will generally be seated in a wheelchair that provides a structure upon which orthogonal and/or non-orthogonally oriented coils can be mounted and energized selectively so as to create variously oriented magnetic fields. Multiple wireless sensors injected into the limb detect the local field strength and send information telemetrically to a central controller. The controller extracts information about the position and orientation of each limb segment by combining signals from various sensors according to calibration information and optimal filtering methods for extracting information from multiple nonlinear sensors in mechanically constrained systems.

Abstract translation: 一种信号发送和接收系统，用于跟踪肢段的位置和方向，以便提供用于控制肢体运动的反馈信息。 使用者通常将坐在轮椅上，该轮椅提供一种可以选择性地安装和激励正交和/或非正交取向线圈的结构，以便产生各种取向的磁场。 注射到肢体中的多个无线传感器检测局部场强并以遥测方式将信息发送到中央控制器。 控制器通过组合来自各种传感器的信号根据校准信息和用于在机械约束系统中从多个非线性传感器提取信息的最佳滤波方法来提取关于每个肢段的位置和方向的信息。

公开(公告)号：US20070265582A1

公开(公告)日：2007-11-15

申请号：US11680363

申请日：2007-02-28

Applicant: Hilton Kaplan ,  Gerald Loeb

Inventor： Hilton Kaplan ,  Gerald Loeb

IPC: A61M25/14

CPC classification number: A61M37/0069 ,  A61B17/3468 ,  A61B2090/034 ,  A61B2090/035 ,  A61B2090/3987 ,  A61N1/37205

Abstract: Devices and methods for positioning an implant at a target location in the body. The methods include testing an implant while within an injection device at a target location to determine whether the implant is functioning effectively. The methods also include testing from or delivery of materials to the target location during implantation, and loading the injection device for use. The device may be configured to permit the longitudinal and/or axial position of the implant to be maintained relative to an injection device during implantation. The device may also be configured to permit testing of the implant. Implants configured for use in the injection devices may also be included.

Abstract translation: 用于将植入物定位在体内目标位置的装置和方法。 所述方法包括在目标位置的注射装置内测试植入物以确定植入物是否有效地起作用。 所述方法还包括在植入期间从材料到目标位置的测试或输送，以及装载注射装置以供使用。 该装置可以被配置为允许在植入期间相对于注射装置保持植入物的纵向和/或轴向位置。 该装置还可以被配置为允许对植入物进行测试。 还可以包括配置用于注射装置中的植入物。

公开(公告)号：US5697076A

公开(公告)日：1997-12-09

申请号：US432605

申请日：1995-05-01

Applicant: Philip R. Troyk ,  William Heetderks ,  Martin Schwan ,  Gerald Loeb

Inventor： Philip R. Troyk ,  William Heetderks ,  Martin Schwan ,  Gerald Loeb

IPC: H01Q7/06 ,  H01Q23/00 ,  H04L27/04 ,  H01Q11/12 ,  H04B1/04

CPC classification number: H01Q23/00 ,  H01Q7/06 ,  H04L27/04

Abstract: A method for on-off modulation of a transmitter coil current of a high-Q resonant circuit transmitter comprising the steps of sensing a zero-crossing of the transmitter coil current and substantially instantaneously interrupting the transmitter coil current, and a high-Q resonant circuit transmitter for carrying out said method.

Abstract translation: 一种用于开关调制高Q谐振电路发射器的发射器线圈电流的方法，包括以下步骤：感测发射器线圈电流的过零并且基本上瞬时中断发射器线圈电流;以及高Q谐振电路 发射机用于执行所述方法。

公开(公告)号：US20070048226A1

公开(公告)日：2007-03-01

申请号：US11350695

申请日：2006-02-08

Applicant: Gerald Loeb ,  Laura Marcu ,  Sanmao Kang ,  Kuo-Chih Liao

Inventor： Gerald Loeb ,  Laura Marcu ,  Sanmao Kang ,  Kuo-Chih Liao

IPC: A61K49/00 ,  C12Q1/00

CPC classification number: G01N21/6428 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/4848 ,  A61K49/0021 ,  A61K49/0056 ,  G01N1/30 ,  G01N21/645 ,  G01N2021/6484 ,  G01N2510/00

Abstract: A probe device for detecting chemotherapy effectiveness, and methods of use are disclosed. The device includes a fiber optic probe element that can be injected into a tumor. The probe element is connected to an external controlling/measurement element, which injects a reagent through the probe and into the tumor. The reagent reacts with biological markers indicative of chemotherapy effectiveness.

Abstract translation: 公开了一种用于检测化疗效果的探针装置及其使用方法。 该装置包括可注入肿瘤的光纤探针元件。 探针元件连接到外部控制/测量元件，其通过探针注入试剂并进入肿瘤。 试剂与指示化疗有效性的生物标志物反应。

公开(公告)号：US20070010726A1

公开(公告)日：2007-01-11

申请号：US11351158

申请日：2006-02-08

Applicant: Gerald Loeb ,  Thomas George ,  Cesar Blanco ,  Laura Marcu

Inventor： Gerald Loeb ,  Thomas George ,  Cesar Blanco ,  Laura Marcu

IPC: A61B5/00

CPC classification number: A61B5/14542 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/415 ,  A61B5/418 ,  G01N21/7703 ,  G01N2021/7786

Abstract: A biosensing device for detecting biological analytes, and methods of use and manufacture, are disclosed. The device includes a biosensing element that can remain implanted for extended periods of time. The biosensing element is connected to an optical fiber terminating outside of the body. The optical fiber is also connected to an information analyzer. The information analyzer receives light from the reaction of fluorescent molecules in the biosensing element. The biosensing device can be used to detect and analyze the effectiveness of chemotherapy agents and molecules associated with various diseases.

Abstract translation: 公开了用于检测生物分析物的生物传感装置及其使用和制造方法。 该装置包括可以长时间保持植入的生物传感元件。 生物传感元件连接到终端外部的光纤。 光纤也连接到信息分析仪。 信息分析器从生物传感元件中的荧光分子的反应接收光。 生物传感装置可用于检测和分析与各种疾病相关的化疗药物和分子的有效性。