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公开(公告)号：US07358066B2
公开(公告)日：2008-04-15
申请号：US10484690
申请日：2002-07-22
申请人： Gilbert Thill , Philippe Jais , Pascale Grel , Sandrine Mace
发明人： Gilbert Thill , Philippe Jais , Pascale Grel , Sandrine Mace
摘要： The present invention provides polypeptide and polynucleotide sequences for novel splice variants of the sodium and chloride-dependent glycine transporter type 1 (GlyT1). These polypeptides and polynucleotides are useful in the treatment and diagnosis of disorders such as neurological and psychiatric disorders including schizophrenia. The invention also provides antibodies directed specifically against these novel polypeptides, and kits comprising the herein-described polynucleotides, polypeptides, and/or antibodies.
摘要翻译： 本发明提供了用于钠和氯化物依赖的甘氨酸转运蛋白1型（GlyT1）的新剪接变体的多肽和多核苷酸序列。 这些多肽和多核苷酸可用于治疗和诊断疾病如神经和精神疾病，包括精神分裂症。 本发明还提供了针对这些新型多肽的抗体，以及包含本文描述的多核苷酸，多肽和/或抗体的试剂盒。
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公开(公告)号：US20080201789A1
公开(公告)日：2008-08-21
申请号：US12050255
申请日：2008-03-18
申请人： Gilbert Thill , Philippe Jais , Pascale Grel , Sandrine Mace
发明人： Gilbert Thill , Philippe Jais , Pascale Grel , Sandrine Mace
摘要： The present invention provides polypeptide and polynucleotide sequences for novel splice variants of the sodium and chloride-dependent glycine transporter type 1 (GlyT1). These polypeptides and polynucleotides are useful in the treatment and diagnosis of disorders such as neurological and psychiatric disorders including schizophrenia. The invention also provides antibodies directed specifically against these novel polypeptides, and kits comprising the herein-described polynucleotides, polypeptides, and/or antibodies.
摘要翻译： 本发明提供了用于钠和氯化物依赖的甘氨酸转运蛋白1型（GlyT1）的新剪接变体的多肽和多核苷酸序列。 这些多肽和多核苷酸可用于治疗和诊断疾病如神经和精神疾病，包括精神分裂症。 本发明还提供了针对这些新型多肽的抗体，以及包含本文描述的多核苷酸，多肽和/或抗体的试剂盒。
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3.发明授权公开(公告)号：US06632610B2
公开(公告)日：2003-10-14
申请号：US09882608
申请日：2001-06-15
申请人： Gilbert Thill
发明人： Gilbert Thill
IPC分类号： C12Q168
CPC分类号： C12Q1/6809 , C12Q1/6816 , C12Q2539/101 , C12Q2522/101
摘要： The present invention is directed to methods of isolation of related polynucleotides harboring nucleic acid difference within a polynucleotide sample. The method will be useful in detecting and identifying alternative splicing events and corresponding splicing isoforms and to detect genomic DNA differences between genomes. The method according to the present invention is based on the use of a single-stranded trap. The single-stranded trap preferably involves the use of single-strand binding protein.
摘要翻译： 本发明涉及分离在多核苷酸样品中含有核酸差异的相关多核苷酸的方法。 该方法可用于检测和鉴定选择性剪接事件和相应的剪接同种型，并检测基因组之间的基因组DNA差异。 根据本发明的方法是基于单链陷阱的使用。 单链陷阱优选涉及单链结合蛋白的使用
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