-
公开(公告)号：US06350466B1
公开(公告)日：2002-02-26
申请号：US09650276
申请日：2000-08-29
申请人： King Chuen Li , Mark David Bednarski , Richard Wood Storrs , Henry Y. Li , Francois Daniel Tropper , Curtis Kang Hoon Song , Dorothy Anna Sipkins , Jeremy Kenji Kuniyoshi
发明人： King Chuen Li , Mark David Bednarski , Richard Wood Storrs , Henry Y. Li , Francois Daniel Tropper , Curtis Kang Hoon Song , Dorothy Anna Sipkins , Jeremy Kenji Kuniyoshi
IPC分类号： A61K9127
CPC分类号： G01N33/586 , A61K49/1812 , A61K49/22 , A61K51/1237 , Y10S424/812 , Y10S436/829 , Y10S977/775 , Y10S977/795 , Y10S977/808 , Y10S977/897 , Y10S977/907 , Y10S977/918 , Y10S977/927 , Y10S977/928 , Y10S977/93
摘要： Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.
摘要翻译： 聚合的脂质体颗粒与靶向剂连接并且还可与造影增强剂连接和/或连接或包封处理剂。 靶向成像增强聚合的脂质体颗粒与保持图像增强剂的生物靶标与特定位点相互作用，通过磁共振，放射性，x射线或光学成像在疾病期间细胞和组织中分子的表达提供体外和体内研究，以及 病理。 靶向聚合的脂质体可以连接或包封处理剂，例如蛋白质，药物或激素，用于定向递送到特定生物位点用于治疗。
-
公开(公告)号：US5512294A
公开(公告)日：1996-04-30
申请号：US286555
申请日：1994-08-05
申请人： King C. Li , Mark D. Bednarski , Richard W. Storrs , Henry Y. Li , Francois D. Trooper , Curtis K. H. Song , Dorothy A. Sipkins , Jeremy K. Kuniyoshi
发明人： King C. Li , Mark D. Bednarski , Richard W. Storrs , Henry Y. Li , Francois D. Trooper , Curtis K. H. Song , Dorothy A. Sipkins , Jeremy K. Kuniyoshi
CPC分类号： A61K49/1812 , A61K49/22 , A61K51/1237 , Y10S436/829 , Y10S977/797 , Y10S977/898 , Y10S977/927 , Y10S977/928
摘要： Polymerized liposome particles based upon lipids having a polymerizable functional group and a metal chelator to attach an imaging enhancement agent and lipids having an active targeting group to provide targeted polymerized liposome contrast agents. The polymerized imaging enhancement liposome particles interact with receptor targets holding the image enhancement agent to specific sites providing in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology.
摘要翻译： 基于具有可聚合官能团的脂质和附着成像增强剂的金属螯合剂和具有活性靶向基团的脂质以提供靶向聚合的脂质体造影剂的聚合脂质体颗粒。 聚合成像增强脂质体颗粒与保持图像增强剂的受体靶物相互作用，通过磁共振，放射性，X射线或光学成像在疾病和病理学中在细胞和组织中表达分子，提供体内研究。
-
公开(公告)号：US06569451B1
公开(公告)日：2003-05-27
申请号：US10083422
申请日：2002-02-26
申请人： King Chuen Li , Mark David Bednarski , Richard Wood Storrs , Henry Y. Li , Francois Daniel Tropper , Curtis Kang Hoon Song , Dorothy Anna Sipkins , Jeremy Kenji Kuniyoshi
发明人： King Chuen Li , Mark David Bednarski , Richard Wood Storrs , Henry Y. Li , Francois Daniel Tropper , Curtis Kang Hoon Song , Dorothy Anna Sipkins , Jeremy Kenji Kuniyoshi
IPC分类号： A61K9127
CPC分类号： G01N33/586 , A61K49/1812 , A61K49/22 , A61K51/1237 , Y10S424/812 , Y10S436/829 , Y10S977/775 , Y10S977/795 , Y10S977/808 , Y10S977/897 , Y10S977/907 , Y10S977/918 , Y10S977/927 , Y10S977/928 , Y10S977/93
摘要： Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.
-
公开(公告)号：US6132764A
公开(公告)日：2000-10-17
申请号：US629056
申请日：1996-04-08
申请人： King Chuen Li , Mark David Bednarski , Richard Wood Storrs , Henry Y. Li , Francois Daniel Tropper , Curtis Kang Hoon Song , Dorothy Anna Sipkins , Jeremy Kenji Kuniyoshi
发明人： King Chuen Li , Mark David Bednarski , Richard Wood Storrs , Henry Y. Li , Francois Daniel Tropper , Curtis Kang Hoon Song , Dorothy Anna Sipkins , Jeremy Kenji Kuniyoshi
CPC分类号： G01N33/586 , A61K49/1812 , A61K49/22 , A61K51/1237 , Y10S424/812 , Y10S436/829 , Y10S977/775 , Y10S977/795 , Y10S977/808 , Y10S977/897 , Y10S977/907 , Y10S977/918 , Y10S977/927 , Y10S977/928 , Y10S977/93
摘要： Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.
-
公开(公告)号：US6090408A
公开(公告)日：2000-07-18
申请号：US122807
申请日：1998-07-27
申请人： King Chuen Li , Mark David Bednarski , Richard Wood Storrs , Henry Y. Li , Francois Daniel Tropper , Curtis Kang Hoon Song , Dorothy Anna Sipkins , Jeremy Kenji Kuniyoshi
发明人： King Chuen Li , Mark David Bednarski , Richard Wood Storrs , Henry Y. Li , Francois Daniel Tropper , Curtis Kang Hoon Song , Dorothy Anna Sipkins , Jeremy Kenji Kuniyoshi
CPC分类号： G01N33/586 , A61K49/1812 , A61K49/22 , A61K51/1237 , Y10S424/812 , Y10S436/829 , Y10S977/775 , Y10S977/795 , Y10S977/808 , Y10S977/897 , Y10S977/907 , Y10S977/918 , Y10S977/927 , Y10S977/928 , Y10S977/93
摘要： Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.
摘要翻译： 聚合的脂质体颗粒与靶向剂连接并且还可与造影增强剂连接和/或连接或包封处理剂。 靶向成像增强聚合的脂质体颗粒与保持图像增强剂的生物靶标与特定位点相互作用，通过磁共振，放射性，x射线或光学成像在疾病期间细胞和组织中分子的表达提供体外和体内研究，以及 病理。 靶向聚合的脂质体可以连接或包封处理剂，例如蛋白质，药物或激素，用于定向递送到特定生物位点用于治疗。
-
-
-
-
搜索结果
5 条记录 (耗时 0.017 秒)
