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公开(公告)号：US06350466B1
公开(公告)日：2002-02-26
申请号：US09650276
申请日：2000-08-29
申请人： King Chuen Li , Mark David Bednarski , Richard Wood Storrs , Henry Y. Li , Francois Daniel Tropper , Curtis Kang Hoon Song , Dorothy Anna Sipkins , Jeremy Kenji Kuniyoshi
发明人： King Chuen Li , Mark David Bednarski , Richard Wood Storrs , Henry Y. Li , Francois Daniel Tropper , Curtis Kang Hoon Song , Dorothy Anna Sipkins , Jeremy Kenji Kuniyoshi
IPC分类号： A61K9127
CPC分类号： G01N33/586 , A61K49/1812 , A61K49/22 , A61K51/1237 , Y10S424/812 , Y10S436/829 , Y10S977/775 , Y10S977/795 , Y10S977/808 , Y10S977/897 , Y10S977/907 , Y10S977/918 , Y10S977/927 , Y10S977/928 , Y10S977/93
摘要： Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.
摘要翻译： 聚合的脂质体颗粒与靶向剂连接并且还可与造影增强剂连接和/或连接或包封处理剂。 靶向成像增强聚合的脂质体颗粒与保持图像增强剂的生物靶标与特定位点相互作用，通过磁共振，放射性，x射线或光学成像在疾病期间细胞和组织中分子的表达提供体外和体内研究，以及 病理。 靶向聚合的脂质体可以连接或包封处理剂，例如蛋白质，药物或激素，用于定向递送到特定生物位点用于治疗。
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公开(公告)号：US6090408A
公开(公告)日：2000-07-18
申请号：US122807
申请日：1998-07-27
申请人： King Chuen Li , Mark David Bednarski , Richard Wood Storrs , Henry Y. Li , Francois Daniel Tropper , Curtis Kang Hoon Song , Dorothy Anna Sipkins , Jeremy Kenji Kuniyoshi
发明人： King Chuen Li , Mark David Bednarski , Richard Wood Storrs , Henry Y. Li , Francois Daniel Tropper , Curtis Kang Hoon Song , Dorothy Anna Sipkins , Jeremy Kenji Kuniyoshi
CPC分类号： G01N33/586 , A61K49/1812 , A61K49/22 , A61K51/1237 , Y10S424/812 , Y10S436/829 , Y10S977/775 , Y10S977/795 , Y10S977/808 , Y10S977/897 , Y10S977/907 , Y10S977/918 , Y10S977/927 , Y10S977/928 , Y10S977/93
摘要： Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.
摘要翻译： 聚合的脂质体颗粒与靶向剂连接并且还可与造影增强剂连接和/或连接或包封处理剂。 靶向成像增强聚合的脂质体颗粒与保持图像增强剂的生物靶标与特定位点相互作用，通过磁共振，放射性，x射线或光学成像在疾病期间细胞和组织中分子的表达提供体外和体内研究，以及 病理。 靶向聚合的脂质体可以连接或包封处理剂，例如蛋白质，药物或激素，用于定向递送到特定生物位点用于治疗。
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公开(公告)号：US06569451B1
公开(公告)日：2003-05-27
申请号：US10083422
申请日：2002-02-26
申请人： King Chuen Li , Mark David Bednarski , Richard Wood Storrs , Henry Y. Li , Francois Daniel Tropper , Curtis Kang Hoon Song , Dorothy Anna Sipkins , Jeremy Kenji Kuniyoshi
发明人： King Chuen Li , Mark David Bednarski , Richard Wood Storrs , Henry Y. Li , Francois Daniel Tropper , Curtis Kang Hoon Song , Dorothy Anna Sipkins , Jeremy Kenji Kuniyoshi
IPC分类号： A61K9127
CPC分类号： G01N33/586 , A61K49/1812 , A61K49/22 , A61K51/1237 , Y10S424/812 , Y10S436/829 , Y10S977/775 , Y10S977/795 , Y10S977/808 , Y10S977/897 , Y10S977/907 , Y10S977/918 , Y10S977/927 , Y10S977/928 , Y10S977/93
摘要： Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.
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公开(公告)号：US6132764A
公开(公告)日：2000-10-17
申请号：US629056
申请日：1996-04-08
申请人： King Chuen Li , Mark David Bednarski , Richard Wood Storrs , Henry Y. Li , Francois Daniel Tropper , Curtis Kang Hoon Song , Dorothy Anna Sipkins , Jeremy Kenji Kuniyoshi
发明人： King Chuen Li , Mark David Bednarski , Richard Wood Storrs , Henry Y. Li , Francois Daniel Tropper , Curtis Kang Hoon Song , Dorothy Anna Sipkins , Jeremy Kenji Kuniyoshi
CPC分类号： G01N33/586 , A61K49/1812 , A61K49/22 , A61K51/1237 , Y10S424/812 , Y10S436/829 , Y10S977/775 , Y10S977/795 , Y10S977/808 , Y10S977/897 , Y10S977/907 , Y10S977/918 , Y10S977/927 , Y10S977/928 , Y10S977/93
摘要： Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.
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公开(公告)号：US07514098B2
公开(公告)日：2009-04-07
申请号：US10159241
申请日：2002-05-30
CPC分类号： B82Y5/00 , A61K47/6911 , A61K48/00
摘要： The in vivo delivery of nucleic acids is targeted by delivery of the nucleic acid in a complex with cross-linked nanoparticles; where the nanoparticles comprise cross-linked neutral amphipathic molecules, cationic amphipathic molecules and targeting amphipathic molecules. Optionally the cationic and targeting amphipathic molecules are also cross-linked. A targeting moiety present on the targeting amphipathic molecule provides for selective delivery of the complex to a predetermined target site, e.g. blood vessels, endothelial cells, tumor cells, liver cells, and the like.
摘要翻译： 核酸的体内递送通过将核酸递送到具有交联纳米颗粒的复合物中来靶向; 其中纳米颗粒包含交联的中性两亲分子，阳离子两亲分子和靶向两亲分子。 任选地，阳离子和靶向两亲分子也是交联的。 存在于靶向两亲性分子上的靶向部分提供复合物到预定靶位点的选择性递送，例如。 血管，内皮细胞，肿瘤细胞，肝细胞等。
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6.发明申请THERMALLY-ACTIVATABLE LIPOSOME COMPOSITIONS AND METHODS FOR IMAGING, DIAGNOSIS AND THERAPY 审中-公开热激活脂肪组合物和成像，诊断和治疗方法公开(公告)号：US20110190623A1
公开(公告)日：2011-08-04
申请号：US13057671
申请日：2009-08-05
申请人： King Chuen Li , Zheng Li , Guoting Qin
发明人： King Chuen Li , Zheng Li , Guoting Qin
IPC分类号： A61B8/00 , A61K9/127 , C12N5/00 , C12N5/071 , A61K49/00 , A61K51/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P25/00 , A61P31/00 , A61B5/055 , A61B6/03 , A61M37/00
CPC分类号： A61K9/127 , A61K9/1273
摘要： Disclosed are thermally-activatable liposomal compositions and methods for their use in the formulation and administration of therapeutic, prophylactic, and diagnostic agents. The disclosed liposome structures are capable of carrying a variety of biologically active reagents, and permitting their controlled release in vivo by exploiting properties of their thermoregulatable lability.
摘要翻译： 公开了可热活化的脂质体组合物及其用于制剂和给药治疗剂，预防剂和诊断剂的方法。 所公开的脂质体结构能够携带各种生物活性试剂，并且通过利用它们的可热定性不稳定性质允许其在体内的受控释放。
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7.发明申请公开(公告)号：US20090048201A1
公开(公告)日：2009-02-19
申请号：US12195261
申请日：2008-08-20
IPC分类号： A61K31/715 , A61K31/7088 , A61P43/00
CPC分类号： B82Y5/00 , A61K47/6911 , A61K48/00
摘要： The in vivo delivery of nucleic acids is targeted by delivery of the nucleic acid in a complex with cross-linked nanoparticles; where the nanoparticles comprise cross-linked neutral amphipathic molecules, cationic amphipathic molecules and targeting amphipathic molecules. Optionally the cationic and targeting amphipathic molecules are also cross-linked. A targeting moiety present on the targeting amphipathic molecule provides for selective delivery of the complex to a predetermined target site, e.g. blood vessels, endothelial cells, tumor cells, liver cells, and the like.
摘要翻译： 核酸的体内递送通过将核酸递送到具有交联纳米颗粒的复合物中来靶向; 其中纳米颗粒包含交联的中性两亲分子，阳离子两亲分子和靶向两亲分子。 任选地，阳离子和靶向两亲分子也是交联的。 存在于靶向两亲性分子上的靶向部分提供复合物到预定靶位点的选择性递送，例如。 血管，内皮细胞，肿瘤细胞，肝细胞等。
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8.发明授权公开(公告)号：US08163305B2
公开(公告)日：2012-04-24
申请号：US12195261
申请日：2008-08-20
CPC分类号： B82Y5/00 , A61K47/6911 , A61K48/00
摘要： The in vivo delivery of nucleic acids is targeted by delivery of the nucleic acid in a complex with cross-linked nanoparticles; where the nanoparticles comprise cross-linked neutral amphipathic molecules, cationic amphipathic molecules and targeting amphipathic molecules. Optionally the cationic and targeting amphipathic molecules are also cross-linked. A targeting moiety present on the targeting amphipathic molecule provides for selective delivery of the complex to a predetermined target site, e.g. blood vessels, endothelial cells, tumor cells, liver cells, and the like.
摘要翻译： 核酸的体内递送通过将核酸递送到具有交联纳米颗粒的复合物中来靶向; 其中纳米颗粒包含交联的中性两亲分子，阳离子两亲分子和靶向两亲分子。 任选地，阳离子和靶向两亲分子也是交联的。 存在于靶向两亲性分子上的靶向部分提供复合物到预定靶位点的选择性递送，例如。 血管，内皮细胞，肿瘤细胞，肝细胞等。
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公开(公告)号：US20110270151A1
公开(公告)日：2011-11-03
申请号：US13062666
申请日：2009-09-08
申请人： King Chuen Li
发明人： King Chuen Li
IPC分类号： A61M5/00 , C07H15/252 , A61K9/127 , A61K31/496 , A61K31/704 , A61K51/04 , A61K51/12 , C07D311/82 , A61K49/00 , A61K9/14 , C07K2/00 , C07K16/00 , C12N9/96 , C07H21/04 , C07H21/02 , C07J41/00 , A61P35/00 , A61P37/02 , A61P25/00 , A61P29/00 , A61P31/00 , A61P3/10 , A61P3/06 , C07D403/06
CPC分类号： A61K49/0043 , A61K47/64 , A61K49/0032 , A61K49/0054 , A61K51/065
摘要： Disclosed are compositions and methods for targeted drug delivery using image-guided energy deposition to help localize active compounds to particular sites within the body of an animal. Also provided are compounds and formulations thereof for use in the targeted administration of therapeutically, prophylactically, and/or diagnostically effective amounts of such agents to a population of cells or tissues of a mammal in need thereof.
摘要翻译： 公开了使用图像引导能量沉积的靶向药物递送的组合物和方法，以帮助将活性化合物定位在动物身体内的特定部位。 还提供了用于向有需要的哺乳动物的细胞或组织群体靶向施用治疗，预防和/或诊断有效量的此类药剂的化合物及其制剂。
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