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    Planar Waveguide Detection Chips and Chambers for Performing Multiple PCR Assays
    1.
    发明申请
    Planar Waveguide Detection Chips and Chambers for Performing Multiple PCR Assays 审中-公开
    用于执行多个PCR测定的平面波导检测芯片和室

    公开(公告)号：US20090075273A1

    公开(公告)日：2009-03-19

    申请号：US12092280

    申请日：2006-11-09

    申请人： Ingmar Dorn ,  John J. Quinn ,  Brian D. Warner

    发明人： Ingmar Dorn ,  John J. Quinn ,  Brian D. Warner

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： G01N21/6428 ,  G01N21/648 ,  G01N21/7703

    摘要： Provided are planar waveguide (“PWG”) detection chips that are used to perform multiplex PCR and kinetic PCR assays with a single fluorescent dye. The PWG detection chips are housed in PWG detection chambers that house at least one PWG chip. The PWG detection chambers may be in a single chamber or a dual chamber configuration. Also provided are methods for analyzing amplification products using the PWG detection chambers of the present invention.

    摘要翻译： 提供了用于使用单个荧光染料进行多重PCR和动力学PCR测定的平面波导（“PWG”）检测芯片。 PWG检测芯片安装在容纳至少一个PWG芯片的PWG检测室中。 PWG检测室可以在单室或双室配置中。 还提供了使用本发明的PWG检测室分析扩增产物的方法。

    Method for determining an active agent dose
    2.
    发明申请
    Method for determining an active agent dose 审中-公开
    确定活性剂剂量的方法

    公开(公告)号：US20050074803A1

    公开(公告)日：2005-04-07

    申请号：US10947982

    申请日：2004-09-23

    申请人： Walter Schmitt ,  Stefan Willmann ,  Edgar Diessel ,  Ingmar Dorn ,  Jens Burmeister

    发明人： Walter Schmitt ,  Stefan Willmann ,  Edgar Diessel ,  Ingmar Dorn ,  Jens Burmeister

    IPC分类号： G06F19/18 ,  G06Q50/24 ,  C12Q1/68 ,  G06F17/60 ,  G06F19/00 ,  G01N33/48 ,  G01N33/50

    CPC分类号： G06Q50/24 ,  G16B20/00

    摘要： Method for determining the dose of at least one active agent based on a genetic analysis. The method comprises analyzing specific genes for their nucleotide sequence or their expression levels of gene-specific proteins and/or RNA molecules. The gene-specific data is assigned one or more relevant physiological functions of the human or animal body, in particular those which have an influence on the metabolism, absorption, excretion or distribution of the active agent in the body. The gene-specific data and the assigned physiological functions are then integrated into a physiology-based pharmacokinetic model (PBPK model). The PBPK model integrates pharmacokinetic data relating to one or more active agents. The PBPK model may also receive and evaluate patient-specific data directly inputted and combined with data from a knowledge database comprising known values of pharmacokinetic parameters. The PBPK's integration of these data provide a calculation of the individual dose of the active agent.

    摘要翻译： 基于遗传分析确定至少一种活性剂的剂量的方法。 该方法包括分析其核苷酸序列的特定基因或其基因特异性蛋白质和/或RNA分子的表达水平。 基因特异性数据被分配人或动物体的一个或多个相关的生理功能，特别是那些对体内活性剂的代谢，吸收，排泄或分布有影响的那些。 然后将基因特异性数据和分配的生理功能整合到基于生理学的药代动力学模型（PBPK模型）中。 PBPK模型整合了与一种或多种活性剂有关的药代动力学数据。 PBPK模型还可以接收和评估直接输入的患者特异性数据，并与包括已知的药代动力学参数值的知识数据库的数据组合。 PBPK对这些数据的整合提供了活性剂个体剂量的计算。

    SINGLE-USE MICROFLUIDIC TEST CARTRIDGE FOR THE BIOASSAY OF ANALYTES
    7.
    发明申请
    SINGLE-USE MICROFLUIDIC TEST CARTRIDGE FOR THE BIOASSAY OF ANALYTES 审中-公开
    一次性使用微生物测试仪器进行生物分析

    公开(公告)号：US20120040470A1

    公开(公告)日：2012-02-16

    申请号：US13263356

    申请日：2010-03-27

    申请人： Ingmar Dorn ,  Andreas Schade

    发明人： Ingmar Dorn ,  Andreas Schade

    IPC分类号： G01N21/75

    CPC分类号： B01L3/502 ,  B01L2200/16 ,  B01L2300/0816

    摘要： A disposable test cassette for qualitative and/or quantitative analysis of analytes, having a structured body having introduced cavities connected to one another by channels, at least one inlet for introducing a sample fluid containing the analyte, at least one reagent chamber in which one or more reagents are stored and at least one detection chamber in which a signal for detection or quantitative analysis of the analyte is detected, wherein a floor or ceiling of the detection chamber is a signal transducer or a window for detection of a signal, fluid cannot be drawn by capillary forces into the reagent chamber or to the opening, and at least the reagents in the reagent chamber are stored in dry form. Also disclosed is an apparatus for bioassaying analytes including the test cassette, and also a method for operating this apparatus.

    摘要翻译： 一种用于对分析物进行定性和/或定量分析的一次性测试盒，其具有通过通道彼此连接的引入空腔的结构体，至少一个用于引入含有分析物的样品流体的入口，至少一个试剂室，其中一个或 存储更多的试剂和至少一个检测室，其中检测到用于分析物的检测或定量分析的信号，其中检测室的底板或天花板是用于检测信号的信号转换器或窗口，流体不能 通过毛细管拉入试剂室或开口，并且至少试剂室中的试剂以干燥形式储存。 还公开了用于生物分析包括测试盒的分析物的装置，以及用于操作该装置的方法。