公开(公告)号：US08747396B2

公开(公告)日：2014-06-10

申请号：US12581145

申请日：2009-10-18

申请人： Thach Duong ,  Jay J. Eum

发明人： Thach Duong ,  Jay J. Eum

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/00274 ,  A61B2017/0046 ,  A61B2018/00547 ,  A61B2018/0262 ,  A61B2090/3925

摘要： A cryosurgical probe assembly that includes a gas delivery assembly, including a stem and a fluid conduit subassembly bonded to the stem. The fluid conduit subassembly delivers and returns cooling fluid used for cryogenic cooling. The fluid conduit subassembly, comprises a shaft for providing a heat exchange surface for cryogenic ablation; a housing securely connected to said shaft; and, an insulation element slideably engaged with an inner surface of the shaft and slideably engaged with the stem. The cryosurgical probe assembly includes an adjustable sliding apparatus that includes a slider assembly securely attached to said insulation tube for slideably guiding the insulation tube along said shaft; and, a button assembly operatively connected to the slider assembly for allowing a user to actuate the slider assembly to provide a desired adjustment of the insulation tube relative to the shaft. A handle assembly is positioned about the housing.

摘要翻译： 一种冷冻手术探针组件，其包括气体输送组件，其包括杆和结合到所述杆的流体导管子组件。 流体导管子组件输送并返回用于低温冷却的冷却流体。 流体导管子组件包括用于提供用于低温消融的热交换表面的轴; 牢固地连接到所述轴的壳体; 以及绝缘元件，其与所述轴的内表面可滑动地接合并且可滑动地与所述杆接合。 冷冻手术探针组件包括一个可调节的滑动装置，其包括牢固地附接到所述绝缘管的滑动器组件，用于沿着所述轴可滑动地引导绝缘管; 以及可操作地连接到滑块组件的按钮组件，用于允许使用者致动滑块组件以提供相对于轴的绝缘管的期望调节。 手柄组件围绕壳体定位。

公开(公告)号：US08187260B1

公开(公告)日：2012-05-29

申请号：US11618492

申请日：2006-12-29

申请人： Shenghao Bao ,  Jay J. Eum

发明人： Shenghao Bao ,  Jay J. Eum

IPC分类号： A61B18/18 ,  A61B8/00

CPC分类号： A61B18/0218 ,  A61B5/0008 ,  A61B5/01 ,  A61B8/0841 ,  A61B8/085 ,  A61B8/0858 ,  A61B8/4254 ,  A61B8/4263 ,  A61B8/4416 ,  A61B8/5223 ,  A61B8/5238 ,  A61B8/5253 ,  A61B8/546 ,  A61B18/02 ,  A61B34/10 ,  A61B2017/00274 ,  A61B2018/00011 ,  A61B2018/00511 ,  A61B2018/00529 ,  A61B2018/00547 ,  A61B2018/00744 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00982 ,  A61B2034/104 ,  A61B2090/378

摘要： A cryosurgical system for assisting an operator in placing and operating cryosurgical probes in the prostate of a human patient. The cryosurgical system includes a computer system being programmed with software capable of performing the following steps: a) capturing a plurality of transverse views of the prostate; b) capturing a sagittal view of the prostate; c) outlining the capsule of the prostate, the urethra and the rectal wall of the patient with the assistance of the operator, utilizing the captured plurality of transverse views and the captured sagittal view; d) constructing a 3-dimensional model of the prostate, the urethra and the rectal wall utilizing the outlines of step c), above; and, e) utilizing the 3-dimensional model of the prostate, the urethra and the rectal wall to determine i) the number of cryosurgical probes to be utilized; ii) probe settings; and, iii) probe placement positions. The resultant ice thus produced by the cryosurgical probes is optimized for a specific patient.

摘要翻译： 一种用于帮助操作者将冷冻手术探针置于和操作人类前列腺的冷冻手术系统。 所述冷冻手术系统包括用软件编程的计算机系统，所述软件能够执行以下步骤：a）捕获前列腺的多个横向视图; b）捕获前列腺的矢状视图; c）在操作者的帮助下，使用所捕获的多个横向视图和所述被捕获的矢状视图概述前列腺的胶囊，患者的尿道和直肠壁; d）利用上述步骤c）的轮廓构建前列腺，尿道和直肠壁的3维模型; 和e）利用前列腺，尿道和直肠壁的三维模型来确定i）要使用的冷冻手术探针的数量; ii）探针设置; 和iii）探测放置位置。 由冷冻手术探针产生的所得到的冰针对特定患者进行了优化。

公开(公告)号：US20100180607A1

公开(公告)日：2010-07-22

申请号：US12690866

申请日：2010-01-20

申请人： THACH DUONG ,  JAY J. EUM

发明人： THACH DUONG ,  JAY J. EUM

IPC分类号： F04B15/08 ,  F17C13/00 ,  F04B53/10 ,  F04B9/123 ,  F04B23/06

CPC分类号： F04B37/08 ,  F04B15/08 ,  F04B53/1012

摘要： The cryogenic fluid generator includes at least one pump assembly having an actuator mounted to a container assembly. A pump assembly housing includes a longitudinal positioning opening and a pressurization cavity at a distal end terminating with a pump assembly outlet. An internal check valve assembly includes a shaft positioned within an opening of the pump assembly housing that extends into the pressurization cavity. The shaft is attached to the actuator and includes a longitudinal guidance slot; a fluid passageway; and, an internal sealing surface. A positioning bar assembly is positioned within the guidance slot. A connecting rod is securely connected at a first end to the positioning bar assembly, the connecting rod being positioned within the fluid passageway and terminating with a flow inhibiting element. A seal is positioned between the pump assembly housing and the check valve to provide a closure for the pressurization cavity.

摘要翻译： 低温流体发生器包括至少一个具有安装到容器组件的致动器的泵组件。 泵组件壳体包括纵向定位开口和在终端具有泵组件出口的远端处的加压腔。 内部止回阀组件包括位于泵组件壳体的开口内延伸进入加压腔的轴。 轴连接到致动器并且包括纵向引导槽; 流体通道; 和内密封面。 定位杆组件定位在引导槽内。 连杆在第一端处牢固地连接到定位杆组件，连杆位于流体通道内并且终止于流动抑制元件。 密封件定位在泵组件壳体和止回阀之间，以为加压腔提供封闭件。

公开(公告)号：US20100100088A1

公开(公告)日：2010-04-22

申请号：US12581145

申请日：2009-10-18

申请人： THACH DUONG ,  JAY J. EUM

发明人： THACH DUONG ,  JAY J. EUM

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/00274 ,  A61B2017/0046 ,  A61B2018/00547 ,  A61B2018/0262 ,  A61B2090/3925

摘要： A cryosurgical probe assembly that includes a gas delivery assembly, including a stem and a fluid conduit subassembly bonded to the stem. The fluid conduit subassembly delivers and returns cooling fluid used for cryogenic cooling. The fluid conduit subassembly, comprises a shaft for providing a heat exchange surface for cryogenic ablation; a housing securely connected to said shaft; and, an insulation element slideably engaged with an inner surface of the shaft and slideably engaged with the stem. The cryosurgical probe assembly includes an adjustable sliding apparatus that includes a slider assembly securely attached to said insulation tube for slideably guiding the insulation tube along said shaft; and, a button assembly operatively connected to the slider assembly for allowing a user to actuate the slider assembly to provide a desired adjustment of the insulation tube relative to the shaft. A handle assembly is positioned about the housing.

摘要翻译： 一种冷冻手术探针组件，其包括气体输送组件，其包括杆和结合到所述杆的流体导管子组件。 流体导管子组件输送并返回用于低温冷却的冷却流体。 流体导管子组件包括用于提供用于低温消融的热交换表面的轴; 牢固地连接到所述轴的壳体; 以及绝缘元件，其与所述轴的内表面可滑动地接合并且可滑动地与所述杆接合。 冷冻手术探针组件包括一个可调节的滑动装置，其包括牢固地附接到所述绝缘管的滑动器组件，用于沿着所述轴可滑动地引导绝缘管; 以及可操作地连接到滑块组件的按钮组件，用于允许使用者致动滑块组件以提供相对于轴的绝缘管的期望调节。 手柄组件围绕壳体定位。

公开(公告)号：US20080147055A1

公开(公告)日：2008-06-19

申请号：US11613054

申请日：2006-12-19

申请人： Thach Duong ,  Jenny C. Liu ,  Jay J. Eum

发明人： Thach Duong ,  Jenny C. Liu ,  Jay J. Eum

IPC分类号： A61B18/18 ,  F16L9/18 ,  B23K15/06 ,  B23Q3/00

CPC分类号： A61B18/02 ,  A61B2018/0262 ,  F16L9/18 ,  F16L59/065 ,  F16L59/14

摘要： A vacuum insulation tube assembly which is utilized as a component in a cryosurgical probe. The vacuum insulation tube assembly includes an inner tube; and, an outer tube concentrically positioned about the inner tube. The outer tube is securely soldered at end portions of the inner tube and forms a vacuum space between the inner tube and the outer tube. The vacuum tube assemblies may be conveniently mass produced using a special fixture.

摘要翻译： 一种真空绝热管组件，用作冷冻手术探头中的组件。 真空绝热管组件包括内管; 以及围绕内管同心定位的外管。 外管在内管的端部牢固地焊接，并在内管和外管之间形成真空空间。 真空管组件可以使用特殊的夹具方便地批量生产。

公开(公告)号：US07189228B2

公开(公告)日：2007-03-13

申请号：US11116873

申请日：2005-04-28

申请人： Jay J. Eum ,  Thach Duong ,  Paul LaPine

发明人： Jay J. Eum ,  Thach Duong ,  Paul LaPine

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/0046 ,  A61B2018/0262

摘要： The detachable cryosurgical probe includes a disposable probe assembly and a reusable probe assembly. The disposable probe assembly includes a breakaway collar which, when twisted away, activates a finger lock element which provides release of the disposable probe assembly from the reusable probe assembly. Additional features include a safety valve assembly for impeding cryogenic working fluid flow when the disposable probe assembly is detached from the reusable probe assembly and an electrical confirmation assembly for providing electrical confirmation that the disposable probe assembly is connected. Other embodiments include a sliding mechanism that allows for selectively positioning of the vacuum tube relative to the shaft to create an ice ball of the desired size and configuration.

摘要翻译： 可拆卸的冷冻手术探针包括一次性探针组件和可重复使用的探针组件。 一次性探针组件包括分离套环，当被扭转时，该开口套环激活手指锁定元件，其提供一次性探针组件从可重复使用的探针组件的释放。 另外的特征包括一个安全阀组件，用于当一次性探头组件与可重复使用的探头组件分离时阻止低温工作流体流动;以及电气确认组件，用于提供一次性探头组件连接的电气确认。 其它实施例包括允许真空管相对于轴选择性定位以产生所需尺寸和构造的冰球的滑动机构。

公开(公告)号：US20120239018A1

公开(公告)日：2012-09-20

申请号：US13481557

申请日：2012-05-25

申请人： SHENGHAO BAO ,  JAY J. EUM

发明人： SHENGHAO BAO ,  JAY J. EUM

IPC分类号： A61B18/02

CPC分类号： A61B18/0218 ,  A61B5/0008 ,  A61B5/01 ,  A61B8/0841 ,  A61B8/085 ,  A61B8/0858 ,  A61B8/4254 ,  A61B8/4263 ,  A61B8/4416 ,  A61B8/5223 ,  A61B8/5238 ,  A61B8/5253 ,  A61B8/546 ,  A61B18/02 ,  A61B34/10 ,  A61B2017/00274 ,  A61B2018/00011 ,  A61B2018/00511 ,  A61B2018/00529 ,  A61B2018/00547 ,  A61B2018/00744 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00982 ,  A61B2034/104 ,  A61B2090/378

摘要： A cryosurgical system for assisting an operator in placing and operating cryosurgical probes in the prostate of a human patient. The cryosurgical system includes a computer system being programmed with software capable of performing the following steps: a) capturing a plurality of transverse views of the prostate; b) capturing a sagittal view of the prostate; c) outlining the capsule of the prostate, the urethra and the rectal wall of the patient with the assistance of the operator, utilizing the captured plurality of transverse views and the captured sagittal view; d) constructing a 3-dimensional model of the prostate, the urethra and the rectal wall utilizing the outlines of step c), above; and, e) utilizing the 3-dimensional model of the prostate, the urethra and the rectal wall to determine i) the number of cryosurgical probes to be utilized; ii) probe settings; and, iii) probe placement positions. The resultant ice thus produced by the cryosurgical probes is optimized for a specific patient.

摘要翻译： 一种用于帮助操作者将冷冻手术探针置于和操作人类前列腺的冷冻手术系统。 所述冷冻手术系统包括用软件编程的计算机系统，所述软件能够执行以下步骤：a）捕获前列腺的多个横向视图; b）捕获前列腺的矢状视图; c）在操作者的帮助下，使用所捕获的多个横向视图和所述被捕获的矢状视图概述前列腺的胶囊，患者的尿道和直肠壁; d）利用上述步骤c）的轮廓构建前列腺，尿道和直肠壁的3维模型; 和e）利用前列腺，尿道和直肠壁的三维模型来确定i）要使用的冷冻手术探针的数量; ii）探针设置; 和iii）探测放置位置。 由冷冻手术探针产生的所得到的冰针对特定患者进行了优化。

公开(公告)号：US20080154253A1

公开(公告)日：2008-06-26

申请号：US12025619

申请日：2008-02-04

申请人： SANFORD D. DAMASCO ,  Thach Duong ,  Jawahar M. Ali ,  David J. Battles ,  Paul W. Mikus ,  Jay J. Eum

发明人： SANFORD D. DAMASCO ,  Thach Duong ,  Jawahar M. Ali ,  David J. Battles ,  Paul W. Mikus ,  Jay J. Eum

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B8/08 ,  A61B34/10 ,  A61B90/11 ,  A61B90/37 ,  A61B2017/00084 ,  A61B2017/00274 ,  A61B2017/3411 ,  A61B2018/00547 ,  A61B2090/378

摘要： The system for providing computer guided ablation of tissue of a patient includes an ablative surgical computer system and a set of surgical devices. The ablative surgical computer system includes a guidance module for providing a treatment guidance plan to an operator; and, a treatment module for acquiring and processing surgical device output data, for optimally controlling treatment parameters and providing feedback information to the operator based on the treatment guidance plan. The set of surgical devices includes at least one ablative device for providing ablation of the treatment region based on the treatment parameters and operator input; and, at least one temperature sensing device for acquiring temperature data from the treatment region and providing a temperature sensing device output signal. The temperature sensing device output signal is a portion of the surgical device output data. The treatment guidance plan is utilized for placing the ablative device and the temperature sensing device into the treatment region.

摘要翻译： 用于提供患者的组织的计算机引导消融的系统包括烧蚀性外科手术计算机系统和一组手术装置。 烧蚀外科计算机系统包括用于向操作者提供治疗指导计划的引导模块; 以及用于获取和处理手术装置输出数据的治疗模块，用于根据治疗指导计划最佳地控制治疗参数并向操作者提供反馈信息。 该组手术装置包括至少一个消融装置，用于基于治疗参数和操作员输入提供治疗区域的消融; 以及至少一个用于从处理区域获取温度数据并提供温度感测装置输出信号的温度感测装置。 温度感测装置输出信号是手术装置输出数据的一部分。 治疗指导计划用于将消融装置和温度感测装置放置在治疗区域中。

公开(公告)号：US06702846B2

公开(公告)日：2004-03-09

申请号：US10091112

申请日：2002-02-28

申请人： Paul W. Mikus ,  William G. Moseley ,  Jay J. Eum

发明人： Paul W. Mikus ,  William G. Moseley ,  Jay J. Eum

IPC分类号： A61F206

CPC分类号： A61F2/88 ,  A61F2/95 ,  A61F2002/048 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2002/9517 ,  A61F2250/0039 ,  A61M27/008

摘要： A stent system and method for use in the prostate gland. The stent is made of a shape memory alloy such as nitinol, and has a low temperature martensite state, with a martensite transition temperature below body temperature, and a high temperature austenite state, with an austenite transition temperature at or above body temperature, and a memorized shape in the high temperature austenite state which is a helical coil of diameter large enough to hold the prostatic urethra open. The stent is used to heat the prostate and is left in the prostatic urethra while the prostate heals. After the prostate is substantially healed, the stent is cooled to its martensite state and is easily removed from the urethra.

摘要翻译： 用于前列腺的支架系统和方法。 该支架由镍钛诺镍等形状记忆合金制成，具有马氏体转变温度低于体温的低温马氏体状态和奥氏体转变温度在体温以上的高温奥氏体状态， 在高温奥氏体状态下记忆形状，其为直径足够大以容纳前列腺尿道打开的螺旋线圈。 支架用于加热前列腺，并在前列腺治疗时留在前列腺尿道。 在前列腺基本上愈合之后，支架被冷却到其马氏体状态，并且容易地从尿道中移出。

公开(公告)号：US6146378A

公开(公告)日：2000-11-14

申请号：US272889

申请日：1999-03-19

申请人： Paul W. Mikus ,  Jay J. Eum

发明人： Paul W. Mikus ,  Jay J. Eum

IPC分类号： A61B19/00 ,  A61B1/00 ,  A61B17/00 ,  A61B17/32 ,  A61B17/34 ,  A61B17/42 ,  A61B18/02 ,  A61M25/08 ,  A61B18/18

CPC分类号： A61B18/02 ,  A61B2017/00292 ,  A61B2017/4216 ,  A61B2018/0212 ,  A61B2090/034 ,  A61B2090/0463 ,  A61B2090/378

摘要： A placement guide for positioning ablation devices within a human body is disclosed. The placement guide comprise an outer catheter and an inner tubular member disposed within a lumen of the outer catheter. When a stop on the inner tubular member engages a seat on the outer catheter, a distal projection of the inner tubular member extends from the distal end of the outer catheter. While monitoring the position of the inner tubular member through an endoscope inserted in its lumen, a clinician positions the distal projection within a human body for optimal ablation. After securing the outer catheter in position, the inner tubular member is withdrawn and replaced with an ablation device which is inserted distally within the outer catheter lumen until a stop on the ablation device engages the seat on the outer catheter wherein a distal projection of the ablation device extends from the distal end of the outer catheter. Because the distal projection of the inner tubular member has a length substantially identical to that of the inner tubular member, the ablation device may be positioned for optimal ablation.

摘要翻译： 公开了一种用于将消融装置定位在人体内的放置引导件。 放置引导件包括外导管和设置在外导管的内腔内的内管状构件。 当内管状构件上的止动件与外导管上的座接合时，内管状构件的远端突出部从外导管的远端延伸。 在通过插入其管腔中的内窥镜监测内管状构件的位置的同时，临床医生将远侧突出物定位在人体内以进行最佳消融。 在将外导管固定就位之后，内管状构件被取出并且被切除装置替代，该消融装置向远端插入外导管内腔中直到消融装置上的止动件接合外导管上的座，其中消融的远侧突出部 装置从外导管的远端延伸。 因为内部管状构件的远侧突出部具有与内部管状构件的长度基本相同的长度，所以可以定位消融装置以实现最佳消融。