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公开(公告)号：US20050053973A1
公开(公告)日：2005-03-10
申请号：US10840723
申请日：2004-05-05
申请人： Joost Kolkman , Willem Stemmer , Per-Ola Freskgard
发明人： Joost Kolkman , Willem Stemmer , Per-Ola Freskgard
CPC分类号： C07K1/047 , G01N33/6878
摘要： Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or immuno-domains, selected monomer and/or immuno-domains, multimers and/or selected multimers to allow their selection. Compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.
摘要翻译： 提供用于鉴定具有所需性质的离散单体结构域和免疫结构域的方法。 还提供了用于从两个或更多个选定的离散单体域产生多聚物的方法，以及用于鉴定具有所需性质的多聚物的方法。 还提供呈现系统，其呈现分立的单体和/或免疫结构域，选择的单体和/或免疫结构域，多聚体和/或选择的多聚体以允许其选择。 表达一个或多个文库成员的组合物，文库和细胞以及试剂盒和整合体系也包括在本发明中。
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公开(公告)号：US20050048512A1
公开(公告)日：2005-03-03
申请号：US10693056
申请日：2003-10-24
申请人： Joost Kolkman , Willem Stemmer , Per-Ola Freskgard
发明人： Joost Kolkman , Willem Stemmer , Per-Ola Freskgard
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/543
CPC分类号： G01N33/6845 , A61K47/62 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , C07K1/047 , C40B30/04 , C40B40/10
摘要： Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or immuno-domains, selected monomer and/or immuno-domains, multimers and/or selected multimers to allow their selection. Compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.
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公开(公告)号：US20050221384A1
公开(公告)日：2005-10-06
申请号：US10966064
申请日：2004-10-15
申请人： Joost Kolkman , Willem Stemmer , Per-Ola Freskgard
发明人： Joost Kolkman , Willem Stemmer , Per-Ola Freskgard
IPC分类号： G01N33/53 , C07B61/00 , C07K1/04 , C07K14/47 , C12N15/09 , C12Q1/02 , C12Q1/68 , C40B30/04 , C40B40/10 , G01N33/68 , G01N37/00 , G01N33/543
CPC分类号： C40B30/04 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , C07K1/047 , C40B40/10 , G01N33/6845
摘要： Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or immuno-domains, selected monomer and/or immuno-domains, multimers and/or selected multimers to allow their selection. Compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.
摘要翻译： 提供用于鉴定具有所需性质的离散单体结构域和免疫结构域的方法。 还提供了用于从两个或更多个选定的离散单体域产生多聚物的方法，以及用于鉴定具有所需性质的多聚物的方法。 还提供呈现系统，其呈现分立的单体和/或免疫结构域，选择的单体和/或免疫结构域，多聚体和/或选择的多聚体以允许其选择。 表达一个或多个文库成员的组合物，文库和细胞以及试剂盒和整合体系也包括在本发明中。
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公开(公告)号：US20050089932A1
公开(公告)日：2005-04-28
申请号：US10871602
申请日：2004-06-17
申请人： Joost Kolkman , Willem Stemmer , Per-Ola Freskgard
发明人： Joost Kolkman , Willem Stemmer , Per-Ola Freskgard
IPC分类号： C07K7/08 , G01N33/53 , G01N33/543
CPC分类号： C07K7/06 , C07K14/485 , C07K14/705 , C07K2319/00 , C12N15/1037 , C40B40/02 , C40B50/06 , G01N33/6878 , G01N33/84 , G01N33/92 , G01N2333/4718 , G01N2333/4724 , G01N2333/71
摘要： Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or immuno-domains, selected monomer and/or immuno-domains, multimers and/or selected multimers to allow their selection. Compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.
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公开(公告)号：US20140120095A1
公开(公告)日：2014-05-01
申请号：US13848826
申请日：2013-03-22
申请人： Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS , Diane VAN HOORICK
发明人： Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS , Diane VAN HOORICK
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/31
摘要： Bispecific binding molecules, in particular immunoglobulin single variable domains such as VHHs and domain antibodies, comprising a VEGF-binding component and a DII4-binding component in one molecule. Pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF- and DII4-mediated effects on angiogenesis. Nucleic acids encoding the bispecific binding molecules, host cells and methods for preparing same.
摘要翻译： 双特异性结合分子，特别是免疫球蛋白单可变结构域，例如VHH和结构域抗体，其在一个分子中包含VEGF结合组分和DII4结合组分。 含有它们的药物组合物及其在治疗与VEGF和DII4介导的血管生成作用相关的疾病中的用途。 编码双特异性结合分子的核酸，宿主细胞及其制备方法。
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公开(公告)号：US20110318366A1
公开(公告)日：2011-12-29
申请号：US13024174
申请日：2011-02-09
申请人： Karen CROMIE , Bruno DOMBRECHT , Seth ETTENBERG , Joost KOLKMAN , Jing LI , Kris MEERSCHAERT , David Raymond STOVER , Jingxin ZHANG
发明人： Karen CROMIE , Bruno DOMBRECHT , Seth ETTENBERG , Joost KOLKMAN , Jing LI , Kris MEERSCHAERT , David Raymond STOVER , Jingxin ZHANG
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02 , C07K16/28
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2316/95 , C07K2317/22 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： The present invention relates to amino acid sequences that are directed against TRAIL cell surface receptor 2 (herein also “DR5”), as well as to compounds or constructs thereof, and in particular proteins and polypeptides and nucleotides that encode them (referred to herein in their entirety as “NB agents”) and fragments thereof, and pharmaceutically effective variants thereof, and their use in the diagnosis and treatment of DR5 associated diseases and disorders.
摘要翻译： 本发明涉及针对TRAIL细胞表面受体2（本文还称为“DR5”）的氨基酸序列以及编码它们的化合物或构建体，特别是编码它们的蛋白质和多肽和核苷酸（在本文中称为 其整体作为“NB剂”）及其片段及其药学上有效的变体，以及它们在诊断和治疗DR5相关疾病和病症中的用途。
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公开(公告)号：US20110172398A1
公开(公告)日：2011-07-14
申请号：US12894989
申请日：2010-09-30
申请人： Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS , Diane VAN HOORICK
发明人： Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS , Diane VAN HOORICK
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/31
摘要： Bispecific binding molecules, in particular immunoglobulin single variable domains such as VHHs and domain antibodies, comprising a VEGF-binding component and a Dll4-binding component in one molecule. Pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF- and Dll4-mediated effects on angiogenesis. Nucleic acids encoding the bispecific binding molecules, host cells and methods for preparing same.
摘要翻译： 双特异性结合分子，特别是免疫球蛋白单可变结构域，例如VHH和结构域抗体，其在一个分子中包含VEGF结合组分和Dll4结合组分。 含有该组合物的药物组合物及其用于治疗与VEGF和Dll4介导的血管生成作用相关的疾病。 编码双特异性结合分子的核酸，宿主细胞及其制备方法。
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公开(公告)号：US20100204052A1
公开(公告)日：2010-08-12
申请号：US12456516
申请日：2009-06-16
CPC分类号： C07K1/047 , C07K7/06 , C07K14/485 , C07K14/705 , C07K2319/00 , C12N15/1037 , C12N15/1044 , C40B40/02 , C40B50/06 , G01N33/6845 , G01N33/6878 , G01N33/84 , G01N33/92 , G01N2333/4718 , G01N2333/4724 , G01N2333/71
摘要： The present invention provides thrombospondin, thyroglobulin and trfoil/PD monomer domains and multimers comprising the monomer domains are provided. Methods, compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.
摘要翻译： 本发明提供了血小板反应蛋白，甲状腺球蛋白和三叶形/ PD单体结构域和包含单体结构域的多聚体。 表达一个或多个文库成员的方法，组合物，文库和细胞以及试剂盒和整合体系也包括在本发明中。
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公开(公告)号：US20060234299A1
公开(公告)日：2006-10-19
申请号：US11281256
申请日：2005-11-16
申请人： Willem Stemmer , Martin Vogt , Joost Kolkman , Josh Silverman , Candace Swimmer
发明人： Willem Stemmer , Martin Vogt , Joost Kolkman , Josh Silverman , Candace Swimmer
IPC分类号： C40B40/10
CPC分类号： C07K14/485 , C07K1/047 , C07K2319/70 , G01N33/6845 , G01N2333/485 , G01N2333/70546 , G01N2500/04
摘要： Specific monomer domains and multimers comprising the monomer domains are provided. Methods, compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.
摘要翻译： 提供了包含单体域的特异性单体域和多聚物。 表达一个或多个文库成员的方法，组合物，文库和细胞以及试剂盒和整合体系也包括在本发明中。
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公开(公告)号：US20060223114A1
公开(公告)日：2006-10-05
申请号：US11281245
申请日：2005-11-16
申请人： Willem Stemmer , Martin Vogt , Joost Kolkman , Josh Silverman
发明人： Willem Stemmer , Martin Vogt , Joost Kolkman , Josh Silverman
IPC分类号： C40B40/10
CPC分类号： C07K1/047 , C07K7/06 , C07K14/485 , C07K14/705 , C07K2319/00 , C12N15/1037 , C12N15/1044 , C40B40/02 , C40B50/06 , G01N33/6845 , G01N33/6878 , G01N33/84 , G01N33/92 , G01N2333/4718 , G01N2333/4724 , G01N2333/71
摘要： The present invention provides thrombospondin, thyroglobulin and trfoil/PD monomer domains and multimers comprising the monomer domains are provided. Methods, compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.
摘要翻译： 本发明提供了血小板反应蛋白，甲状腺球蛋白和三叶形/ PD单体结构域和包含单体结构域的多聚体。 表达一个或多个文库成员的方法，组合物，文库和细胞以及试剂盒和整合体系也包括在本发明中。
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