公开(公告)号：US20190257698A1

公开(公告)日：2019-08-22

申请号：US16216995

申请日：2018-12-11

申请人： Lan Yang ,  Fang-Jie Shu ,  Xuefeng Jiang ,  Guangming Zhao

发明人： Lan Yang ,  Fang-Jie Shu ,  Xuefeng Jiang ,  Guangming Zhao

IPC分类号： G01K11/32 ,  G02B1/04 ,  G02B6/32 ,  G01K11/26

摘要： A microprobe is provided that includes a microsphere optical resonator operatively coupled to a nanoscatterer. The microsphere optical resonator includes a back surface and a front surface opposite the front surface. The front surface is configured to receive a focused laser beam, and the nanoscatterer is positioned adjacent to the back surface.

公开(公告)号：US08704155B2

公开(公告)日：2014-04-22

申请号：US12966785

申请日：2010-12-13

申请人： Lina He ,  Jiangang Zhu ,  Sahin Kaya Ozdemir ,  Lan Yang ,  Da-Ren Chen

发明人： Lina He ,  Jiangang Zhu ,  Sahin Kaya Ozdemir ,  Lan Yang ,  Da-Ren Chen

IPC分类号： G01J9/00

CPC分类号： G01N21/7746

摘要： Detection of individual objects using a light source and a whispering gallery mode (WGM) resonator. Light from the whispering gallery mode (WGM) resonator is analyzed. The presence of an object is determined based on mode splitting associated with the light received by the photodetector. For example, the presence of the object may be determined based on the distance between two whispering gallery modes and/or the linewidths of the two modes in a transmission spectrum. Alternatively, the presence of the object may be determined based on a beat frequency that is determined based on a heterodyne beat signal produced by combining split laser modes in the received light from a WGM microcavity laser.

摘要翻译： 使用光源和耳语画廊模式（WGM）谐振器检测各个物体。 分析了来自耳语堂模式（WGM）谐振器的光。 基于与由光电检测器接收的光相关联的模式分割来确定对象的存在。 例如，可以基于两个耳语画廊模式之间的距离和/或发送频谱中的两种模式的线宽来确定对象的存在。 或者，可以基于基于通过在来自WGM微腔激光器的接收光中组合分割激光模式而产生的外差拍频确定的拍频来确定对象的存在。

公开(公告)号：US08623682B2

公开(公告)日：2014-01-07

申请号：US13618774

申请日：2012-09-14

申请人： Chien-Kai Chung ,  Ta-Cheng Hsu ,  Jung-Min Hwang ,  Min-Hsun Hsieh ,  Ya-Lan Yang ,  De-Shan Kuo ,  Tsun-Kai Ko ,  Chien-Fu Shen ,  Ting-Chia Ko ,  Schang-Jing Hon

发明人： Chien-Kai Chung ,  Ta-Cheng Hsu ,  Jung-Min Hwang ,  Min-Hsun Hsieh ,  Ya-Lan Yang ,  De-Shan Kuo ,  Tsun-Kai Ko ,  Chien-Fu Shen ,  Ting-Chia Ko ,  Schang-Jing Hon

IPC分类号： H01L21/00

CPC分类号： H01L33/005 ,  H01L21/02057 ,  H01L21/3043 ,  H01L33/0095

摘要： A method of manufacturing a light-emitting device comprising the steps of cutting a substrate by a laser beam to form a cavity in the substrate and generate a by-product directly on the substrate by the cutting, and removing the by-product by a chemical solution containing an acid under a predetermined cleaning temperature.

摘要翻译： 一种制造发光器件的方法，包括以下步骤：通过激光束切割衬底以在衬底中形成空腔，并通过切割直接在衬底上产生副产物，并通过化学物质除去副产物 溶液在预定的清洁温度下含有酸。

公开(公告)号：US20130153960A1

公开(公告)日：2013-06-20

申请号：US13328944

申请日：2011-12-16

申请人： Hsiao-Lan Yang

发明人： Hsiao-Lan Yang

IPC分类号： H01L23/525 ,  H01L21/768

CPC分类号： H01L27/11206 ,  H01L21/76895 ,  H01L21/823431 ,  H01L21/823475 ,  H01L23/5252 ,  H01L27/101 ,  H01L27/115 ,  H01L29/66484 ,  H01L29/66795 ,  H01L2924/0002 ,  H01L2924/00

摘要： A device includes a substrate, isolation regions at a surface of the substrate, and a semiconductor region over a top surface of the isolation regions. A conductive feature is disposed over the top surface of the isolation regions, wherein the conductive feature is adjacent to the semiconductor region. A dielectric material is disposed between the conductive feature and the semiconductor region. The dielectric material, the conductive feature, and the semiconductor region form an anti-fuse.

公开(公告)号：US08425904B2

公开(公告)日：2013-04-23

申请号：US13587644

申请日：2012-08-16

申请人： Jonathan A. Terrett ,  Sarah L. Pogue ,  Kristopher Toy ,  Lan Yang ,  Chetana Rao-Naik ,  Bingliang Chen

发明人： Jonathan A. Terrett ,  Sarah L. Pogue ,  Kristopher Toy ,  Lan Yang ,  Chetana Rao-Naik ,  Bingliang Chen

IPC分类号： A61K39/395 ,  A61K39/00

CPC分类号： C07K16/30 ,  A61K39/39558 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/80 ,  C07K2317/92 ,  A61K2300/00

摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.

公开(公告)号：US20130028904A1

公开(公告)日：2013-01-31

申请号：US13587500

申请日：2012-08-16

申请人： Jonathan A. Terrett ,  Sarah L. Pogue ,  Kristopher Toy ,  Lan Yang ,  Chetana Rao-Naik ,  Bingliang Chen

发明人： Jonathan A. Terrett ,  Sarah L. Pogue ,  Kristopher Toy ,  Lan Yang ,  Chetana Rao-Naik ,  Bingliang Chen

IPC分类号： C07K16/30 ,  A61P35/00 ,  A61K39/395

CPC分类号： C07K16/30 ,  A61K39/39558 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/80 ,  C07K2317/92 ,  A61K2300/00

摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.

公开(公告)号：US08188235B2

公开(公告)日：2012-05-29

申请号：US12480991

申请日：2009-06-09

申请人： Arvind Rajpal ,  Madhav Devalaraja ,  Kristopher Toy ,  Lan Yang ,  Haichun Huang ,  Jun Zhang ,  Peter Brams ,  Brigitte Devaux ,  David B. Passmore

发明人： Arvind Rajpal ,  Madhav Devalaraja ,  Kristopher Toy ,  Lan Yang ,  Haichun Huang ,  Jun Zhang ,  Peter Brams ,  Brigitte Devaux ,  David B. Passmore

IPC分类号： C07K16/00 ,  C07K16/24 ,  C07K16/46

CPC分类号： C07K16/248 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/92

摘要： Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.

摘要翻译： 提供了结合人IL-6的抗体及其抗原结合部分。 还提供了编码此类抗体和抗原结合部分的核酸，制备此类抗体和抗原结合部分的方法，包含此类抗体或抗原结合部分的组合物，以及此类抗体或抗原结合部分的用途。

公开(公告)号：US20110262448A1

公开(公告)日：2011-10-27

申请号：US12681215

申请日：2008-09-29

申请人： Jonathan A. TERRETT ,  Sarah L. Pogue ,  Kristopher Toy ,  Lan Yang ,  Chetana Rao-Naik ,  Bingliang Chen

发明人： Jonathan A. TERRETT ,  Sarah L. Pogue ,  Kristopher Toy ,  Lan Yang ,  Chetana Rao-Naik ,  Bingliang Chen

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61K39/44 ,  C07K16/18

CPC分类号： C07K16/30 ,  A61K39/39558 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/80 ,  C07K2317/92 ,  A61K2300/00

摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.

摘要翻译： 本公开提供以高亲和力特别是人单克隆抗体特异性结合间皮素的分离的单克隆抗体。 优选地，所述抗体结合人间皮素。 在某些实施方案中，抗体能够内化成表达间皮素的细胞或能够介导抗原依赖性细胞毒性。 本发明还提供可以抑制间皮素与卵巢癌抗原CA125的结合的抗间皮素抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了使用本公开的抗间皮素抗体检测间皮素的方法以及用于治疗癌症的方法，诸如间皮瘤，胰腺癌和卵巢癌。

公开(公告)号：US08043878B2

公开(公告)日：2011-10-25

申请号：US12379561

申请日：2009-02-25

申请人： Ta-Cheng Hsu ,  Jung-Min Hwang ,  Min-Hsun Liu ,  Ya-Lan Yang ,  De-Shan Kuo ,  Tsun-Kai Ko ,  Chien-Fu Shen ,  Ting-Chia Ko ,  Schang-Jing Hon

发明人： Ta-Cheng Hsu ,  Jung-Min Hwang ,  Min-Hsun Liu ,  Ya-Lan Yang ,  De-Shan Kuo ,  Tsun-Kai Ko ,  Chien-Fu Shen ,  Ting-Chia Ko ,  Schang-Jing Hon

IPC分类号： H01L21/00

CPC分类号： H01L33/0095

摘要： A method for manufacturing a light-emitting device comprising the steps of cutting a light-emitting unit by a laser beam, and cleaning the light-emitting unit by an acid solution to remove by-products resulted from the laser cutting.

摘要翻译： 一种发光装置的制造方法，其特征在于，包括以下步骤：用激光束切割发光单元，用酸溶液清洗发光单元，除去激光切割产生的副产物。

公开(公告)号：US07811845B2

公开(公告)日：2010-10-12

申请号：US11602199

申请日：2006-11-21

申请人： Ta-Cheng Hsu ,  Jung-Min Hwang ,  Min-Hsun Hsieh ,  Ya-Lan Yang

发明人： Ta-Cheng Hsu ,  Jung-Min Hwang ,  Min-Hsun Hsieh ,  Ya-Lan Yang

IPC分类号： H01L21/00

CPC分类号： H01L33/0095

摘要： A method for manufacturing a light-emitting device comprising the steps of cutting a light-emitting unit by a laser beam, and cleaning the light-emitting unit by an acid solution to remove by-products resulted from the laser cutting.

摘要翻译： 一种发光装置的制造方法，其特征在于，包括以下步骤：用激光束切割发光单元，用酸溶液清洗发光单元，除去激光切割所产生的副产物。