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1.发明授权Metabolic engineering of lipid metabolism by improving fatty acid binding and transport 有权通过改善脂肪酸结合和转运来代谢脂质代谢工程公开(公告)号：US08252973B2
公开(公告)日：2012-08-28
申请号：US13107558
申请日：2011-05-13
IPC分类号： C12N15/82
CPC分类号： C12N9/90 , C12N15/8247
摘要： CHI like fatty acid binding proteins and genes, recombinant cells and organisms, methods of metabolic pathway engineering to improve lipid production in cells, Crystal structures of CHI like fatty acid binding proteins, methods of engineering CHI like fatty acid binding proteins and systems thereof are provided.
摘要翻译： CHI如脂肪酸结合蛋白和基因，重组细胞和生物体，代谢途径工程方法，以改善细胞中的脂质生成，提供CHI类脂肪酸结合蛋白的晶体结构，工程化CHI如脂肪酸结合蛋白的方法及其系统 。
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2.发明申请METABOLIC ENGINEERING OF LIPID METABOLISM BY IMPROVING FATTY ACID BINDING AND TRANSPORT 有权通过改善脂肪酸结合和运输来代谢脂肪代谢的代谢工程公开(公告)号：US20110223667A1
公开(公告)日：2011-09-15
申请号：US13107558
申请日：2011-05-13
IPC分类号： C12N5/10
CPC分类号： C12N9/90 , C12N15/8247
摘要： CHI like fatty acid binding proteins and genes, recombinant cells and organisms, methods of metabolic pathway engineering to improve lipid production in cells, Crystal structures of CHI like fatty acid binding proteins, methods of engineering CHI like fatty acid binding proteins and systems thereof are provided.
摘要翻译： CHI如脂肪酸结合蛋白和基因，重组细胞和生物体，代谢途径工程方法，以改善细胞中的脂质生成，提供CHI类脂肪酸结合蛋白的晶体结构，工程化CHI如脂肪酸结合蛋白的方法及其系统 。
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公开(公告)号：US20100317030A1
公开(公告)日：2010-12-16
申请号：US12690079
申请日：2010-01-19
申请人： Joseph P. Noel , Jean-Luc Ferrer , Joseph Jez , Mike Austin , Marianne Bowman
发明人： Joseph P. Noel , Jean-Luc Ferrer , Joseph Jez , Mike Austin , Marianne Bowman
IPC分类号： G01N33/573 , C07H21/04 , C12N9/00
CPC分类号： C12N9/1029 , C12N9/1037
摘要： The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acids encoding such non-native polyketide synthases. Also disclosed are methods of predicting the activity and/or substrated specificity of putative polyketide synthase, methods of identifying potential polyketide synthase substrates, and methods of identifying potential polyketide synthase inhibitors.
摘要翻译： 本发明包括结晶聚酮化合物合成酶，具有所述结晶聚酮化合物合酶的结构坐标的分离的非天然聚酮化合物合酶和编码这种非天然聚酮化合物合酶的核酸。 还公开了预测推定的聚酮化合物合酶的活性和/或底物特异性的方法，鉴定潜在的聚酮化合物合成酶底物的方法以及鉴定潜在的聚酮化合物合酶抑制剂的方法。
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4.发明授权Structure of the farnesoid X receptor ligand binding domain and methods of use therefor 失效法呢酯X受体配体结合域的结构及其用途公开(公告)号：US07647217B2
公开(公告)日：2010-01-12
申请号：US10535042
申请日：2003-11-14
申请人： Michael R Downes , Mark A. Verdicia , Joseph P. Noel , Ronald M. Evans , Lindsey J. Bowman , Marianne Bowman
发明人： Michael R Downes , Mark A. Verdicia , Joseph P. Noel , Ronald M. Evans , Lindsey J. Bowman , Marianne Bowman
CPC分类号： C07K14/70567 , C07K2299/00 , G01N33/743 , G01N2500/00 , G06F19/16 , G06F19/706
摘要： The present invention provides compositions comprising the ligand binding domain (LBD) of a farnesoid X receptor (FXR) in crystalline form. In alternative embodiments, the LBD of FXR is complexed with a ligand therefor. There are provided high resolution structures of FXR complexed with a novel high affinity agonist, fexaramine. The discovered structure of a FXR LBD provides the first three-dimensional view of the structural basis for FXR ligand binding. The present invention further provides a computer for producing a three-dimensional representation of FXR or a complex thereof, and a computer for determining at least a portion of the structure coordinates of FXR or a complex thereof. The present invention further provides methods of using this structural information to predict molecules capable of binding to FXR; to identify compounds with agonist, antagonist or partial agonist activity for FXR; and to determine whether a test compound is capable of binding to the LBD of FXR. The present invention further provides compositions comprising compounds identified by such invention methods.
摘要翻译： 本发明提供了包含结晶形式的法呢甾X受体（FXR）的配体结合结构域（LBD）的组合物。 在替代实施方案中，FXR的LBD与其配体复合。 提供了与新型高亲和力激动剂fexaramine复合的FXR的高分辨率结构。 所发现的FXR LBD的结构提供了FXR配体结合的结构基础的第一个三维视图。 本发明还提供一种用于产生FXR或其复数的三维表示的计算机，以及用于确定FXR的结构坐标的至少一部分或其复合体的计算机。 本发明还提供使用该结构信息来预测能够结合FXR的分子的方法; 识别FXR激动剂，拮抗剂或部分激动剂活性的化合物; 并确定测试化合物是否能够结合FXR的LBD。 本发明还提供包含通过本发明方法鉴定的化合物的组合物。
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5.发明授权Structure of the farnesoid X receptor ligand binding domain and methods of use therefor 失效法呢酯X受体配体结合域的结构及其用途公开(公告)号：US08212006B2
公开(公告)日：2012-07-03
申请号：US12686347
申请日：2010-01-12
申请人： Michael R. Downes , Mark A. Verdicia , Joseph P. Noel , Ronald M. Evans , Lindsey J. Bowman , Marianne Bowman
发明人： Michael R. Downes , Mark A. Verdicia , Joseph P. Noel , Ronald M. Evans , Lindsey J. Bowman , Marianne Bowman
CPC分类号： C07K14/70567 , C07K2299/00 , G01N33/743 , G01N2500/00 , G06F19/16 , G06F19/706
摘要： The present invention provides compositions comprising the ligand binding domain (LBD) of a farnesoid X receptor (FXR) in crystalline form. In alternative embodiments, the LBD of FXR is complexed with a ligand therefor. There are provided high resolution structures of FXR complexed with a novel high affinity agonist fexaramine. The discovered structure of a FXR LBD provides the first three-dimensional view of the structural basis for FXR ligand binding. The present invention further provides a computer for producing a time-dimensional representation of FXR or a complex thereof, and a computer for determining at least a portion of the structure coordinates of FXR or a complex thereof. The present invention further provides methods of using this structural information to predict molecules capable of binding to FXR; to identify compounds with agonist, antagonist or partial agonist activity for FXR; and to determine whether a test compound is capable of binding to the LBD of FXR. The present invention further provides compositions comprising compounds identified by such invention methods.
摘要翻译： 本发明提供了包含结晶形式的法呢甾X受体（FXR）的配体结合结构域（LBD）的组合物。 在替代实施方案中，FXR的LBD与其配体复合。 提供了与新型高亲和力激动剂福沙康胺复合的FXR的高分辨率结构。 所发现的FXR LBD的结构提供了FXR配体结合的结构基础的第一个三维视图。 本发明还提供一种用于产生FXR或其复数的时间维度表示的计算机，以及用于确定FXR或其复数的结构坐标的至少一部分的计算机。 本发明还提供使用该结构信息来预测能够结合FXR的分子的方法; 识别FXR激动剂，拮抗剂或部分激动剂活性的化合物; 并确定测试化合物是否能够结合FXR的LBD。 本发明还提供包含通过本发明方法鉴定的化合物的组合物。
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公开(公告)号：US20070298438A1
公开(公告)日：2007-12-27
申请号：US11748424
申请日：2007-05-14
申请人： Joseph Noel , Jean-Luc Ferrer , Joseph Jez , Mike Austin , Marianne Bowman
发明人： Joseph Noel , Jean-Luc Ferrer , Joseph Jez , Mike Austin , Marianne Bowman
IPC分类号： G01N33/573 , C07H21/00 , C12N9/00
CPC分类号： C12N9/1029 , C12N9/1037
摘要： The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acids encoding such non-native polyketide synthases. Also disclosed are methods of predicting the activity and/or substrated specificity of putative polyketide synthase, methods of identifying potential polyetide synthase substrates, and methods of identifying potential polyketide synthase inhibitors.
摘要翻译： 本发明包括结晶聚酮化合物合成酶，具有所述结晶聚酮化合物合酶的结构坐标的分离的非天然聚酮化合物合酶和编码这种非天然聚酮化合物合酶的核酸。 还公开了预测推定的聚酮化合物合酶的活性和/或底色特异性的方法，鉴定潜在的多肽合酶底物的方法，以及鉴定潜在的聚酮化合物合酶抑制剂的方法。
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7.发明申请Metabolic engineering of lipid metabolism by improving fatty acid binding and transport 审中-公开通过改善脂肪酸结合和转运来代谢脂质代谢工程公开(公告)号：US20090158468A1
公开(公告)日：2009-06-18
申请号：US11879026
申请日：2007-07-13
CPC分类号： C12N9/90 , C12N15/8247
摘要： CHI like fatty acid binding proteins and genes, recombinant cells and organisms, methods of metabolic pathway engineering to improve lipid production in cells, Crystal structures of CHI like fatty acid binding proteins, methods of engineering CHI like fatty acid binding proteins and systems thereof are provided.
摘要翻译： CHI如脂肪酸结合蛋白和基因，重组细胞和生物体，代谢途径工程方法，以改善细胞中的脂质生成，提供CHI类脂肪酸结合蛋白的晶体结构，工程化CHI如脂肪酸结合蛋白的方法及其系统 。
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公开(公告)号：US07217557B1
公开(公告)日：2007-05-15
申请号：US10031918
申请日：2000-07-27
申请人： Joseph P. Noel , Jean-Luc Ferrer , Joseph Jez , Mike Austin , Marianne Bowman
发明人： Joseph P. Noel , Jean-Luc Ferrer , Joseph Jez , Mike Austin , Marianne Bowman
IPC分类号： C12N9/88
CPC分类号： C12N9/1029 , C12N9/1037
摘要： The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acids encoding such non-native polyketide synthases. Also disclosed are methods of predicting the activity and/or substrate specificity of putative polyketide synthase, methods of identifying potential polyketide synthase substrates, and methods of identifying potential polyketide synthase inhibitors.
摘要翻译： 本发明包括结晶聚酮化合物合成酶，具有所述结晶聚酮化合物合酶的结构坐标的分离的非天然聚酮化合物合酶和编码这种非天然聚酮化合物合酶的核酸。 还公开了预测推定的聚酮化合物合成酶的活性和/或底物特异性的方法，鉴定潜在的聚酮化合物合酶底物的方法，以及鉴定潜在的聚酮化合物合酶抑制剂的方法。
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9.发明申请STRUCTURE OF THE FARNESOID X RECEPTOR LIGAND BINDING DOMAIN AND METHODS OF USE THEREFOR 失效FARNESOID X受体配体结合域的结构及其使用方法公开(公告)号：US20110018866A1
公开(公告)日：2011-01-27
申请号：US12686347
申请日：2010-01-12
申请人： Michael R. Downes , Mark A. Verdicia , Joseph P. Noel , Ronald M. Evans , Lindsey J. Bowman , Marianne Bowman
发明人： Michael R. Downes , Mark A. Verdicia , Joseph P. Noel , Ronald M. Evans , Lindsey J. Bowman , Marianne Bowman
IPC分类号： C07C229/44 , C07K14/72 , A61K38/16 , A61K31/216 , C07D317/58 , A61K31/36 , C07J9/00 , A61K31/575 , C07D261/08 , A61K31/42 , G06G7/58 , G06T15/00
CPC分类号： C07K14/70567 , C07K2299/00 , G01N33/743 , G01N2500/00 , G06F19/16 , G06F19/706
摘要： The present invention provides compositions comprising the ligand binding domain (LBD) of a farnesoid X receptor (FXR) in crystalline form. In alternative embodiments, the LBD of FXR is complexed with a ligand therefor. There are provided high resolution structures of FXR complexed with a novel high affinity agonist fexaramine. The discovered structure of a FXR LBD provides the first three-dimensional view of the structural basis for FXR ligand binding. The present invention further provides a computer for producing a time-dimensional representation of FXR or a complex thereof, and a computer for determining at least a portion of the structure coordinates of FXR or a complex thereof. The present invention further provides methods of using this structural information to predict molecules capable of binding to FXR; to identify compounds with agonist, antagonist or partial agonist activity for FXR; and to determine whether a test compound is capable of binding to the LBD of FXR. The present invention further provides compositions comprising compounds identified by such invention methods.
摘要翻译： 本发明提供了包含结晶形式的法呢甾X受体（FXR）的配体结合结构域（LBD）的组合物。 在替代实施方案中，FXR的LBD与其配体复合。 提供了与新型高亲和力激动剂福沙康胺复合的FXR的高分辨率结构。 所发现的FXR LBD的结构提供了FXR配体结合的结构基础的第一个三维视图。 本发明还提供一种用于产生FXR或其复数的时间维度表示的计算机，以及用于确定FXR或其复数的结构坐标的至少一部分的计算机。 本发明还提供使用该结构信息来预测能够结合FXR的分子的方法; 识别FXR激动剂，拮抗剂或部分激动剂活性的化合物; 并确定测试化合物是否能够结合FXR的LBD。 本发明还提供包含通过本发明方法鉴定的化合物的组合物。
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10.发明申请Structure of the farnesoid x receptor ligand binding domain and methods of use therefor 失效法呢基x受体配体结合域的结构及其使用方法公开(公告)号：US20060194949A1
公开(公告)日：2006-08-31
申请号：US10535042
申请日：2003-11-14
申请人： Michael Downes , Mark Verdicia , Joseph Noel , Ronald Evans , Lindsey Bowman , Marianne Bowman
发明人： Michael Downes , Mark Verdicia , Joseph Noel , Ronald Evans , Lindsey Bowman , Marianne Bowman
IPC分类号： G06F19/00 , C07K14/705
CPC分类号： C07K14/70567 , C07K2299/00 , G01N33/743 , G01N2500/00 , G06F19/16 , G06F19/706
摘要： The present invention provides compositions comprising the ligand binding domain (LBD) of a farnesoid X receptor (FXR) in crystalline form. In alternative embodiments, the LBD of FXR is complexed with a ligand therefor. There are provided high resolution structures of FXR complexed with a novel high affinity agonist, fexaramine. The discovered structure of a FXR LBD provides the first three-dimensional view of the structural basis for FXR ligand binding. The present invention further provides a computer for producing a three-dimensional representation of FXR or a complex thereof, and a computer for determining at least a portion of the structure coordinates of FXR or a complex thereof. The present invention further provides methods of using this structural information to predict molecules capable of binding to FXR; to identify compounds with agonist, antagonist or partial agonist activity for FXR; and to determine whether a test compound is capable of binding to the LBD of FXR. The present invention further provides compositions comprising compounds identified by such invention methods.
摘要翻译： 本发明提供了包含结晶形式的法呢甾X受体（FXR）的配体结合结构域（LBD）的组合物。 在替代实施方案中，FXR的LBD与其配体复合。 提供了与新型高亲和力激动剂fexaramine复合的FXR的高分辨率结构。 所发现的FXR LBD的结构提供了FXR配体结合的结构基础的第一个三维视图。 本发明还提供一种用于产生FXR或其复数的三维表示的计算机，以及用于确定FXR的结构坐标的至少一部分或其复合体的计算机。 本发明还提供使用该结构信息来预测能够结合FXR的分子的方法; 识别FXR激动剂，拮抗剂或部分激动剂活性的化合物; 并确定测试化合物是否能够结合FXR的LBD。 本发明还提供包含通过本发明方法鉴定的化合物的组合物。
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