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公开(公告)号：US07381734B2
公开(公告)日：2008-06-03
申请号：US11186870
申请日：2005-07-22
申请人： Sarah Elizabeth Lively , Bohdan Waszkowycz , Martin James Harrison , Christopher Neil Farthing , Keith Michael Johnson
发明人： Sarah Elizabeth Lively , Bohdan Waszkowycz , Martin James Harrison , Christopher Neil Farthing , Keith Michael Johnson
IPC分类号： A61K31/445 , A61K31/381 , A61K31/428 , C07D211/08 , C07D211/20 , C07D333/56 , C07D277/30 , C07D277/82 , C07D333/68 , C07D401/12 , C07D417/12 , C07C233/00
CPC分类号： C07D417/12 , A61K31/165 , A61K31/277 , A61K31/381 , A61K31/426 , C07C237/22 , C07C255/58 , C07C271/22 , C07C271/66 , C07C2601/08 , C07D209/08 , C07D209/12 , C07D211/26 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/55 , C07D215/38 , C07D233/24 , C07D277/30 , C07D277/40 , C07D277/46 , C07D277/54 , C07D277/82 , C07D295/135 , C07D295/185 , C07D307/54 , C07D307/81 , C07D317/46 , C07D317/60 , C07D333/38 , C07D333/60 , C07D333/66 , C07D333/68 , C07D401/06 , C07D401/12 , C07D403/06 , C07D409/06 , C07D417/06
摘要： Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents.
摘要翻译： 其中R 5，R 6a，各X，L，Cy和Lp的式（I）化合物如说明书中所定义，是可用作抗炎剂的类胰蛋白酶抑制剂。
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公开(公告)号：US07067516B2
公开(公告)日：2006-06-27
申请号：US10432365
申请日：2001-12-12
申请人： Sarah Elizabeth Lively , Martin James Harrison , Neil Jason Naylor , Christopher Neil Farthing , Bohdan Waszkowycz
发明人： Sarah Elizabeth Lively , Martin James Harrison , Neil Jason Naylor , Christopher Neil Farthing , Bohdan Waszkowycz
IPC分类号： A61K31/381 , A61K31/428 , C07D277/30 , C07D277/82 , C07D333/68 , C07D401/12 , C07D417/12
CPC分类号： C07D273/00 , A61K31/381 , A61K31/428 , C07B2200/07 , C07C237/42 , C07C2601/14 , C07C2602/08 , C07D209/08 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/56 , C07D213/61 , C07D213/73 , C07D233/64 , C07D277/30 , C07D277/40 , C07D277/46 , C07D277/52 , C07D277/68 , C07D277/82 , C07D307/54 , C07D307/79 , C07D333/36 , C07D333/60 , C07D333/66 , C07D333/68 , C07D333/78 , C07D401/12 , C07D409/04 , C07D409/12 , C07D417/12 , C07D417/14 , C07D495/04
摘要： Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents.
摘要翻译： 其中R 5，R 6a，各X，L，Cy和Lp的式（I）化合物如说明书中所定义，是可用作抗炎剂的类胰蛋白酶抑制剂。
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公开(公告)号：US06916957B2
公开(公告)日：2005-07-12
申请号：US10148174
申请日：2000-12-13
申请人： Sarah Elizabeth Lively , Bohdan Waszkowycz , Martin James Harrison , Christopher Neil Farthing , Keith Michael Johnson
发明人： Sarah Elizabeth Lively , Bohdan Waszkowycz , Martin James Harrison , Christopher Neil Farthing , Keith Michael Johnson
IPC分类号： C07C237/36 , C07C237/42 , C07C255/60 , C07D209/08 , C07D209/30 , C07D209/34 , C07D209/42 , C07D211/26 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/53 , C07D213/56 , C07D213/61 , C07D213/73 , C07D213/74 , C07D213/82 , C07D215/38 , C07D217/04 , C07D217/06 , C07D231/56 , C07D233/54 , C07D235/06 , C07D241/24 , C07D273/00 , C07D277/28 , C07D277/30 , C07D277/40 , C07D277/46 , C07D277/52 , C07D277/64 , C07D277/68 , C07D277/82 , C07D295/135 , C07D295/185 , C07D307/54 , C07D307/79 , C07D317/68 , C07D333/36 , C07D333/38 , C07D333/60 , C07D333/68 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D413/14 , C07D417/06 , C07D417/12 , C07D487/04 , C07C233/64 , A61K31/16
CPC分类号： C07D217/04 , C07B2200/07 , C07C237/36 , C07C237/42 , C07C255/60 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07D209/08 , C07D209/30 , C07D209/34 , C07D209/42 , C07D211/26 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/53 , C07D213/56 , C07D213/61 , C07D213/73 , C07D213/74 , C07D213/82 , C07D215/38 , C07D217/06 , C07D231/56 , C07D233/64 , C07D235/06 , C07D241/24 , C07D273/00 , C07D277/28 , C07D277/30 , C07D277/40 , C07D277/46 , C07D277/52 , C07D277/64 , C07D277/68 , C07D277/82 , C07D295/135 , C07D295/185 , C07D307/54 , C07D307/79 , C07D317/68 , C07D333/36 , C07D333/38 , C07D333/60 , C07D333/68 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D413/14 , C07D417/06 , C07D417/12 , C07D487/04
摘要： Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents.
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公开(公告)号：US07074934B2
公开(公告)日：2006-07-11
申请号：US10296245
申请日：2001-06-12
申请人： Sarah Elizabeth Lively , Bohdan Waszkowycz , Martin James Harrison , Christopher Neil Farthing , Keith Michael Johnson
发明人： Sarah Elizabeth Lively , Bohdan Waszkowycz , Martin James Harrison , Christopher Neil Farthing , Keith Michael Johnson
IPC分类号： C07D211/08 , C07D211/20 , C07D333/56 , C07C233/00 , A61K31/445
CPC分类号： C07D417/12 , A61K31/165 , A61K31/277 , A61K31/381 , A61K31/426 , C07C237/22 , C07C255/58 , C07C271/22 , C07C271/66 , C07C2601/08 , C07D209/08 , C07D209/12 , C07D211/26 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/55 , C07D215/38 , C07D233/24 , C07D277/30 , C07D277/40 , C07D277/46 , C07D277/54 , C07D277/82 , C07D295/135 , C07D295/185 , C07D307/54 , C07D307/81 , C07D317/46 , C07D317/60 , C07D333/38 , C07D333/60 , C07D333/66 , C07D333/68 , C07D401/06 , C07D401/12 , C07D403/06 , C07D409/06 , C07D417/06
摘要： Compounds of formula (I) where R2, each X, L, Y, Cy, Lp, D and n are as defined in the specification, are serine protease inhibitors useful as antithrombotic agents.
摘要翻译： 其中R 2，X，L，Y，Cy，Lp，D和n如说明书中所定义的式（I）化合物是用作抗血栓形成剂的丝氨酸蛋白酶抑制剂。
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公开(公告)号：US07157585B2
公开(公告)日：2007-01-02
申请号：US11126309
申请日：2005-05-11
申请人： Sarah Elizabeth Lively , Bohdan Waszkowycz , Martin James Harrison , Christopher Neil Farthing , Keith Michael Johnson
发明人： Sarah Elizabeth Lively , Bohdan Waszkowycz , Martin James Harrison , Christopher Neil Farthing , Keith Michael Johnson
IPC分类号： C07D277/62 , A61K31/425 , C07C233/64 , A61K31/16
CPC分类号： C07D217/04 , C07B2200/07 , C07C237/36 , C07C237/42 , C07C255/60 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07D209/08 , C07D209/30 , C07D209/34 , C07D209/42 , C07D211/26 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/53 , C07D213/56 , C07D213/61 , C07D213/73 , C07D213/74 , C07D213/82 , C07D215/38 , C07D217/06 , C07D231/56 , C07D233/64 , C07D235/06 , C07D241/24 , C07D273/00 , C07D277/28 , C07D277/30 , C07D277/40 , C07D277/46 , C07D277/52 , C07D277/64 , C07D277/68 , C07D277/82 , C07D295/135 , C07D295/185 , C07D307/54 , C07D307/79 , C07D317/68 , C07D333/36 , C07D333/38 , C07D333/60 , C07D333/68 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D413/14 , C07D417/06 , C07D417/12 , C07D487/04
摘要： Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents.
摘要翻译： 其中R 5，R 6a，各X，L，Cy和Lp的式（I）化合物如说明书中所定义，是可用作抗炎剂的类胰蛋白酶抑制剂。
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