公开(公告)号：US11912760B2

公开(公告)日：2024-02-27

申请号：US17350763

申请日：2021-06-17

Applicant: PHAROSGEN CO., LTD

Inventor： Youngro Byun ,  Ha Kyeong Lee ,  So Young Choi ,  So Ra Park ,  Se Ra Lee ,  Seung Il Baek

IPC: A61K39/395 ,  A61K39/00 ,  G01N33/53 ,  A61K49/00 ,  C07K16/46 ,  C07K16/00 ,  C07K16/18 ,  G01N33/68 ,  A61P35/00

CPC classification number: C07K16/18 ,  A61P35/00 ,  G01N33/68 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92

Abstract: Described herein are doppel-targeting molecules (e.g., antibodies) useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

公开(公告)号：US20220267422A1

公开(公告)日：2022-08-25

申请号：US17350763

申请日：2021-06-17

Applicant: PHAROSGEN CO., LTD

Inventor： Youngro BYUN ,  Ha Kyeong LEE ,  So Young CHOI ,  So Ra PARK ,  Se Ra LEE ,  Seung Il BAEK

IPC: C07K16/18 ,  G01N33/68 ,  A61P35/00

Abstract: Described herein are doppel-targeting molecules (e.g., antibodies) useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

公开(公告)号：US20180185498A1

公开(公告)日：2018-07-05

申请号：US15690157

申请日：2017-08-29

Applicant: Pharosgen Co., Ltd.

Inventor： Sang-Yoon KIM ,  Youngro Byun ,  Seung Woo Chung

IPC: A61K47/55

CPC classification number: A61K47/551 ,  A61B18/02 ,  A61K31/337 ,  A61K31/65 ,  A61K38/14 ,  A61K45/06 ,  A61K47/542 ,  A61K47/545 ,  A61K47/60 ,  A61K47/61 ,  A61K47/643 ,  A61K47/65 ,  A61N1/403 ,  A61N5/062 ,  A61N7/02 ,  A61N2005/067 ,  A61N2007/0004

Abstract: Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce apoptosis, amplify apoptosis, and treat cancer.

公开(公告)号：US09775914B2

公开(公告)日：2017-10-03

申请号：US14796219

申请日：2015-07-10

Applicant: PHAROSGEN CO., LTD.

Inventor： Sang-Yoon Kim ,  Youngro Byun ,  Seung Woo Chung

IPC: A61K47/48 ,  A61K31/65 ,  A61K31/337 ,  A61K45/06 ,  A61N1/40 ,  A61K38/14 ,  A61B18/02 ,  A61N7/00 ,  A61N5/067 ,  A61N5/06 ,  A61N7/02

CPC classification number: A61K47/551 ,  A61B18/02 ,  A61K31/337 ,  A61K31/65 ,  A61K38/14 ,  A61K45/06 ,  A61K47/542 ,  A61K47/545 ,  A61K47/60 ,  A61K47/61 ,  A61K47/643 ,  A61K47/65 ,  A61N1/403 ,  A61N5/062 ,  A61N7/02 ,  A61N2005/067 ,  A61N2007/0004

Abstract: Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce apoptosis, amplify apoptosis, and treat cancer.

公开(公告)号：US10357572B2

公开(公告)日：2019-07-23

申请号：US15690157

申请日：2017-08-29

Applicant: Pharosgen Co., Ltd.

Inventor： Sang-Yoon Kim ,  Youngro Byun ,  Seung Woo Chung

IPC: A61N1/40 ,  A61N5/06 ,  A61N7/00 ,  A61N7/02 ,  A61B18/02 ,  A61K31/65 ,  A61K38/14 ,  A61K45/06 ,  A61K47/54 ,  A61K47/55 ,  A61K47/60 ,  A61K47/61 ,  A61K47/64 ,  A61K47/65 ,  A61N5/067 ,  A61K31/337

Abstract: Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce apoptosis, amplify apoptosis, and treat cancer.

公开(公告)号：US10202459B2

公开(公告)日：2019-02-12

申请号：US15363103

申请日：2016-11-29

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  UNIVERSITY OF ULSAN ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  PHAROSGEN

Inventor： Youngro Byun ,  In San Kim ,  Ahmed Al-Hilal Taslim ,  Sang-Yoon Kim ,  Ye Ji Jang

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/28 ,  A61K31/727 ,  G01N33/574 ,  G01N33/68 ,  C07K14/705 ,  C12N15/113 ,  A61K47/54

Abstract: Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

公开(公告)号：US20170260278A1

公开(公告)日：2017-09-14

申请号：US15450272

申请日：2017-03-06

Applicant: SEOUL NATIONAL UNIVERSITY ,  UNIVERSITY OF ULSAN ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  PHAROSGEN

Inventor： Youngro Byun ,  In San Kim ,  Ahmed Al-Hilal Taslim ,  Sang-Yoon Kim ,  Ye Ji Jang

IPC: C07K16/28

CPC classification number: C07K16/2872 ,  A01K2217/075 ,  A01K2227/105 ,  A61K47/55 ,  A61K47/554 ,  A61K47/61 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/30 ,  C07K2317/70 ,  C07K2317/73 ,  C07K2317/76 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/3515 ,  C12Q1/68 ,  G01N33/57492 ,  G01N33/6893 ,  G01N2333/705

Abstract: Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.