公开(公告)号：US07460911B2

公开(公告)日：2008-12-02

申请号：US11004758

申请日：2004-12-03

申请人： Gregoire Cosendai ,  Ytizhak Zilberman ,  Doug Kuschner ,  Anne Marie Ripley ,  Ruth Turk ,  Jane Burridge ,  Scott V. Notley ,  Ross Davis ,  Morten Hansen ,  Lee Jay Mandell ,  Joseph H. Schulman ,  Robert Dan Dell ,  John C. Gord

发明人： Gregoire Cosendai ,  Ytizhak Zilberman ,  Doug Kuschner ,  Anne Marie Ripley ,  Ruth Turk ,  Jane Burridge ,  Scott V. Notley ,  Ross Davis ,  Morten Hansen ,  Lee Jay Mandell ,  Joseph H. Schulman ,  Robert Dan Dell ,  John C. Gord

IPC分类号： A61N1/08

CPC分类号： A61B5/07 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/4519 ,  A61B5/4528 ,  A61B2560/0219 ,  A61B2562/08 ,  A61F2/72 ,  A61F2002/5058 ,  A61F2002/704 ,  A61F2002/705 ,  A61N1/37205 ,  A61N1/37211 ,  A61N1/37252 ,  A61N1/37288 ,  A61N1/3787

摘要： A system and method that facilitates stimulating neural pathways, e.g., muscles and/or associated nerves, of a patient's body for the purpose of therapeutic medical treatment by rehabilitating weakened muscles and using neuroplasticity to retrain sequential muscle movements and/or to provide the ability to directly deliver functional motor movements. Use of the present invention is of particular value for treating a patient following a stroke. More particularly, such systems are characterized by a plurality of discrete devices, preferably battery powered but may alternatively include RF-powered devices as well or in combination, configured for implanting within a patient's body via injection, each device being configured to affect a parameter, e.g., via nerve and/or muscle stimulation and/or to sense a body parameter, e.g., temperature, O2 content, physical position, electrical potential, etc., that operate under control of a system controller that coordinates the sequential stimulation via wireless commands to the implanted devices.

摘要翻译： 一种系统和方法，其有助于刺激患者身体的神经通路，例如肌肉和/或相关神经，以通过康复弱化的肌肉并使用神经可塑性来重新训练顺序的肌肉运动和/或提供 直接提供功能运动。 本发明的使用对于治疗中风后的患者是特别有价值的。 更具体地，这样的系统的特征在于多个分立的装置，优选地是电池供电的，但也可以包括RF供电的装置，或者组合地被配置用于经由注射植入到患者体内，每个装置被配置成影响参数， 例如经由神经和/或肌肉刺激和/或感测在通过无线命令协调顺序刺激的系统控制器的控制下操作的身体参数，例如温度，O 2含量，物理位置，电位等 到植入的装置。

公开(公告)号：US07513257B2

公开(公告)日：2009-04-07

申请号：US11187290

申请日：2005-07-21

申请人： Joseph H. Schulman ,  Robert Dan Dell ,  John C. Gord

发明人： Joseph H. Schulman ,  Robert Dan Dell ,  John C. Gord

IPC分类号： A61B19/00 ,  A61N1/08

CPC分类号： A61N1/37211 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/07 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/4519 ,  A61B5/4528 ,  A61B2560/0219 ,  A61B2562/08 ,  A61F2/72 ,  A61F2002/5058 ,  A61F2002/704 ,  A61F2002/705 ,  A61N1/37205 ,  A61N1/37252 ,  A61N1/37288 ,  A61N1/3787

摘要： A system for monitoring and/or affecting parameters of a patient's body and more particularly to such a system comprised of a system control unit (SCU) and one or more other devices, preferably battery-powered, implanted in the patient's body, i.e., within the envelope defined by the patient's skin. Each such implanted device is configured to be monitored and/or controlled by the SCU via a wireless communication channel. In accordance with the invention, the SCU comprises a programmable unit capable of (1) transmitting commands to at least some of a plurality of implanted devices and (2) receiving data signal from at least some of those implanted devices. In accordance with a preferred embodiment, the system operates in closed loop fashion whereby the commands transmitted by the SCU are dependent, in part, on the content of the data signals received by the SCU.

摘要翻译： 一种用于监测和/或影响患者身体的参数的系统，更具体地涉及由系统控制单元（SCU）和一个或多个其它装置（优选由电池供电的）组成的系统，其被植入患者体内，即，在 由病人皮肤定义的信封。 每个这样的植入装置被配置为经由无线通信信道由SCU监视和/或控制。 根据本发明，SCU包括能够（1）向多个植入装置中的至少一些发送命令的可编程单元，以及（2）从至少某些植入装置接收数据信号。 根据优选实施例，系统以闭环方式操作，由此由SCU发送的命令部分地取决于由SCU接收的数据信号的内容。

公开(公告)号：US07114502B2

公开(公告)日：2006-10-03

申请号：US10719715

申请日：2003-11-21

申请人： Joseph H. Schulman ,  Robert Dan Dell ,  John C. Gord

发明人： Joseph H. Schulman ,  Robert Dan Dell ,  John C. Gord

IPC分类号： A61B19/00

CPC分类号： A61N1/3787 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/07 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/4519 ,  A61B2560/0219 ,  A61B2562/08 ,  A61F2/72 ,  A61F2002/5058 ,  A61F2002/704 ,  A61F2002/705 ,  A61N1/37205 ,  A61N1/37217 ,  A61N1/37223 ,  A61N1/37288

摘要： A device configured for implanting beneath a patient's skin for the purpose of tissue, e.g., nerve or muscle, stimulation and/or parameter monitoring and/or data communication. Devices in accordance with the invention are comprised of a sealed housing, typically having an axial dimension of less than 60 mm and a lateral dimension of less than 6 mm, having a non-circular, e.g., an oval or polygon shaped, cross-section containing a power source for powering electronic circuitry within including a controller, an address storage means, a data signal receiver and an input/output transducer. When used as a stimulator, such a device is useful in a wide variety of applications to stimulate nerves and associated neural pathways. Alternatively, devices of the present invention are configurable to monitor a biological parameter. Furthermore, a placement structure is shown for facilitating placement of the implantable device proximate to neural/muscular tissue.

摘要翻译： 一种被配置为植入患者皮肤下面以用于组织例如神经或肌肉，刺激和/或参数监测和/或数据通信的装置。 根据本发明的装置包括通常具有小于60mm的轴向尺寸和小于6mm的横向尺寸的密封外壳，其具有非圆形例如椭圆形或多边形横截面 包括用于为包括控制器，地址存储装置，数据信号接收器和输入/输出换能器的电子电路供电的电源。 当用作刺激剂时，这种装置可用于各种应用以刺激神经和相关的神经通路。 或者，本发明的装置可配置为监测生物参数。 此外，示出了放置结构，以便于将可植入装置置于靠近神经/肌肉组织的位置。

公开(公告)号：US06564807B1

公开(公告)日：2003-05-20

申请号：US09677384

申请日：2000-09-30

申请人： Joseph H. Schulman ,  Robert Dan Dell ,  John C. Gord

发明人： Joseph H. Schulman ,  Robert Dan Dell ,  John C. Gord

IPC分类号： A61B1900

CPC分类号： A61N1/37211 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/07 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/4519 ,  A61B5/4528 ,  A61B2560/0219 ,  A61B2562/08 ,  A61F2/72 ,  A61F2002/5058 ,  A61F2002/704 ,  A61F2002/705 ,  A61N1/37205 ,  A61N1/37252 ,  A61N1/37288 ,  A61N1/3787

摘要： A system for monitoring and/or affecting parameters of a patient's body and more particularly to such a system comprised of a system control unit (SCU) and one or more other devices, preferably battery-powered, implanted in the patient's body, i.e., within the envelope defined by the patient's skin. Each such implanted device is configured to be monitored and/or controlled by the SCU via a wireless communication channel. In accordance with the invention, the SCU comprises a programmable unit capable of (1) transmitting commands to at least some of a plurality of implanted devices and (2) receiving data signal from at least some of those implanted devices. In accordance with a preferred embodiment, the system operates in closed loop fashion whereby the commands transmitted by the SCU are dependent, in part, on the content of the data signals received by the SCU.

公开(公告)号：US06185452B2

公开(公告)日：2001-02-06

申请号：US09030106

申请日：1998-02-25

申请人： Joseph H. Schulman ,  Robert Dan Dell ,  John C. Gord

发明人： Joseph H. Schulman ,  Robert Dan Dell ,  John C. Gord

IPC分类号： A61N130

CPC分类号： A61B5/0031 ,  A61B5/053 ,  A61B5/07 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/4519 ,  A61B2560/0219 ,  A61B2560/063 ,  A61B2562/08 ,  A61F2/72 ,  A61F2002/5058 ,  A61F2002/704 ,  A61F2002/705 ,  A61N1/37205 ,  A61N1/3787

摘要： A device configured for implanting beneath a patient's skin for the purpose of tissue, e.g., nerve or muscle, stimulation and/or parameter monitoring and/or data communication. Devices in accordance with the invention are comprised of a sealed housing, typically having an axial dimension of less than 60 mm and a lateral dimension of less than 6 mm, containing a power source for powering electronic circuitry within including a controller, an address storage means, a data signal receiver and an input/output transducer. When used as a stimulator, such a device is useful in a wide variety of applications to stimulate nerves and associated neural pathways, e.g., to decrease or relieve pain, stimulate specific muscles or organs to better carry out a body function (e.g., to exercise weak or unconditioned muscles or to control urinary incontinence), and the like. Alternatively, devices of the present invention are configurable to monitor a biological parameter or to operate as a transponder to retransmit received command messages.

摘要翻译： 一种被配置为植入患者皮肤下面以用于组织例如神经或肌肉，刺激和/或参数监测和/或数据通信的装置。 根据本发明的装置包括通常具有小于60mm的轴向尺寸和小于6mm的横向尺寸的密封壳体，其包含用于为包括控制器的电子电路供电的电源，地址存储装置 ，数据信号接收器和输入/输出换能器。 当用作刺激器时，这种装置可用于各种应用以刺激神经和相关神经通路，例如减轻或缓解疼痛，刺激特定的肌肉或器官以更好地进行身体功能（例如运动 弱或无条件肌肉或控制尿失禁）等。 或者，本发明的装置可配置为监测生物参数或作为应答器操作以重新发送所接收的命令消息。

公开(公告)号：US6067474A

公开(公告)日：2000-05-23

申请号：US126615

申请日：1998-07-31

申请人： Joseph H. Schulman ,  Robert Dan Dell ,  Alfred E. Mann ,  Michael A. Faltys

发明人： Joseph H. Schulman ,  Robert Dan Dell ,  Alfred E. Mann ,  Michael A. Faltys

IPC分类号： A61F2/02 ,  A61F2/18 ,  A61F11/00 ,  A61N1/08 ,  A61N1/36 ,  A61N1/375 ,  A61N1/378 ,  H01M2/10 ,  H01M4/02 ,  H01M6/10 ,  H01M10/04 ,  H01M10/34 ,  H01M10/46 ,  H02J7/00 ,  H02J7/02 ,  H02J17/00 ,  A61N1/34

CPC分类号： A61N1/08 ,  A61N1/36032 ,  A61N1/375 ,  A61N1/3787 ,  H01M10/0436 ,  H01M10/46 ,  H01M4/02 ,  H02J7/025 ,  H01M10/345 ,  H01M2/1022 ,  H01M2/1066 ,  H01M2004/025 ,  H01M6/10

摘要： An implantable system, such as a neural stimulator or a cochlear implant system, includes a rechargeable battery configuration having improved recharging and lifetime characteristics. The battery is housed within the implant's case and has first and second electrode plates. Each electrode plate has a plurality of slits that extend across a substantial portion of the plate's surface area. The slits in the electrode plates reduce the magnitude of eddy currents induced in the plates by external ac magnetic fields allowing faster battery recharging times. Alternatively, the electrode plates are wrapped in a spiral configuration such that, in the plane of the spiral, the electrode plates have a small cross-sectional area and no closed current loops. Additionally, the implant device may be housed in a case formed of a high-resistivity material and a circuit included in the implant device is configured to avoid large current loops that would result in eddy current heating. As a backup option, the circuitry of the implant device may optionally be powered from an external battery that inductively couples energy to the same coil that is used to charge the internal battery. In one embodiment, the implantable system is partitioned into first and second implantable cases, each having electrical circuitry therein, and only one having a rechargeable power source therein, facilitating its subsequent replacement for repair or upgrading purposes. The two cases are coupled together when the system is in use. Coupling is achieved either magnetically and/or with a detachable electrical cable. In one embodiment, power is transferred from one implant case to the other using a 3-phase transmission scheme.

摘要翻译： 诸如神经刺激器或人工耳蜗植入系统的可植入系统包括具有改善的再充电和寿命特性的可再充电电池配置。 电池容纳在植入物壳体内并具有第一和第二电极板。 每个电极板具有延伸穿过板的表面区域的大部分的多个狭缝。 电极板中的狭缝通过外部交流磁场减小板中感应的涡流的大小，从而允许更快的电池充电时间。 或者，电极板被卷绕成螺旋构造，使得在螺旋的平面中，电极板具有小的横截面积并且没有闭合电流环路。 另外，植入装置可以容纳在由高电阻率材料形成的壳体中，并且包括在植入装置中的电路被配置为避免将导致涡流加热的大电流环路。 作为备用选项，植入装置的电路可以可选地由外部电池供电，外部电池将能量耦合到用于对内部电池充电的相同线圈。 在一个实施例中，可植入系统被划分成第一和第二可植入壳体，每个壳体具有电路，并且只有一个在其中具有可再充电的电源，便于其随后的修理或升级目的的更换。 当系统使用时，这两种情况耦合在一起。 通过磁性和/或可拆卸电缆实现耦合。 在一个实施例中，使用3相传输方案将功率从一个植入壳体传送到另一个。

公开(公告)号：US6164284A

公开(公告)日：2000-12-26

申请号：US48827

申请日：1998-03-25

申请人： Joseph H. Schulman ,  Robert Dan Dell ,  John C. Gord

发明人： Joseph H. Schulman ,  Robert Dan Dell ,  John C. Gord

IPC分类号： A61B5/00 ,  A61B5/053 ,  A61B5/07 ,  A61B19/00 ,  A61F2/50 ,  A61F2/70 ,  A61F2/72 ,  A61N1/372 ,  A61N1/378

CPC分类号： A61N1/37211 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/07 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/4519 ,  A61B5/4528 ,  A61B2560/0219 ,  A61B2562/08 ,  A61F2/72 ,  A61F2002/5058 ,  A61F2002/704 ,  A61F2002/705 ,  A61N1/37205 ,  A61N1/37252 ,  A61N1/37288 ,  A61N1/3787

摘要： A system for monitoring and/or affecting parameters of a patient's body and more particularly to such a system comprised of a system control unit (SCU) and one or more other devices, preferably battery-powered, implanted in the patient's body, i.e., within the envelope defined by the patient's skin. Each such implanted device is configured to be monitored and/or controlled by the SCU via a wireless communication channel. In accordance with the invention, the SCU comprises a programmable unit capable of (1) transmitting commands to at least some of a plurality of implanted devices and (2) receiving data signal from at least some of those implanted devices. In accordance with a preferred embodiment, the system operates in closed loop fashion whereby the commands transmitted by the SCU are dependent, in part, on the content of the data signals received by the SCU. In accordance with the invention, a preferred SCU is similarly implemented as a device capable of being implanted beneath a patient's skin, preferably having an axial dimension of less than 60 mm and a lateral dimension of less than 6 mm. Wireless communication between the SCU and the implanted devices is preferably implemented via a modulated sound signal, AC magnetic field, RF signal, or electric conduction.

摘要翻译： 一种用于监测和/或影响患者身体的参数的系统，更具体地涉及由系统控制单元（SCU）和一个或多个其它装置（优选由电池供电的）组成的系统，其被植入患者体内，即，在 由病人皮肤定义的信封。 每个这样的植入装置被配置为经由无线通信信道由SCU监视和/或控制。 根据本发明，SCU包括能够（1）向多个植入装置中的至少一些发送命令的可编程单元，以及（2）从至少某些植入装置接收数据信号。 根据优选实施例，系统以闭环方式操作，由此由SCU发送的命令部分地取决于由SCU接收的数据信号的内容。 根据本发明，优选的SCU类似地实施为能够植入患者皮肤下方的装置，优选具有小于60mm的轴向尺寸和小于6mm的横向尺寸。 优选地，经由调制声音信号，AC磁场，RF信号或电传导来实现SCU与植入装置之间的无线通信。