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17 条记录 (耗时 0.018 秒)

    Anticancer drug-chitosan complex forming self-aggregates and preparation method thereof
    4.
    发明授权
    Anticancer drug-chitosan complex forming self-aggregates and preparation method thereof 失效
    形成自聚集体的抗癌药物 - 壳聚糖复合物及其制备方法

    公开(公告)号：US07511023B2

    公开(公告)日：2009-03-31

    申请号：US10473629

    申请日：2002-08-14

    申请人： Ick Chan Kwon ,  In-San Kim ,  Seo Young Jeong ,  Hesson Chung ,  Yong Woo Cho ,  Yoen Ju Son ,  Chong Rae Park ,  Sang Bong Seo

    发明人： Ick Chan Kwon ,  In-San Kim ,  Seo Young Jeong ,  Hesson Chung ,  Yong Woo Cho ,  Yoen Ju Son ,  Chong Rae Park ,  Sang Bong Seo

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： A61K31/704 ,  A61K47/61 ,  A61K47/6907

    摘要： The present invention relates to an anticancer drug-chitosan complex forming self-aggregates and the preparation method thereof. More precisely, the present invention relates to the anticancer drug-chitosan complex forming self-aggregates in aqueous media composed of a hydrophobic anticancer agent and a hydrophilic chitosan, and the preparation method thereof. The anticancer drug-chitosan complex of the present invention not only works selectively against target tumor tissue but also continues to release the medicine over a long period of time. Besides, the anticancer drug-chitosan complex could have greater amount of drug by adding the anticancer drug into self-aggregates, which is generally limited by chemical bond. Therefore, the anticancer drug-chitosan complex of the present invention can be effectively used for the cancer chemotherapy.

    摘要翻译： 本发明涉及形成自聚集体的抗癌药物 - 壳聚糖复合物及其制备方法。 更准确地说，本发明涉及在由疏水性抗癌剂和亲水性壳聚糖组成的水性介质中形成自聚集体的抗癌药物 - 壳聚糖复合物及其制备方法。 本发明的抗癌药物 - 壳聚糖复合物不仅对目标肿瘤组织有选择性的作用，而且还能够长时间地释放药物。 此外，抗癌药物 - 壳聚糖复合物可以通过将抗癌药物加入自聚集体中而具有更大量的药物，其通常受化学键的限制。 因此，本发明的抗癌药物 - 壳聚糖复合物可以有效地用于癌症化疗。

    Composition for solubilization of paclitaxel and preparation method thereof
    6.
    发明申请
    Composition for solubilization of paclitaxel and preparation method thereof 有权
    紫杉醇溶解组合物及其制备方法

    公开(公告)号：US20060104999A1

    公开(公告)日：2006-05-18

    申请号：US10521669

    申请日：2003-07-18

    申请人： Hesson Chung ,  Seo-Young Jeong ,  Ick-Chan Kwon ,  Yeong-Taek Park ,  In-Hyun Lee ,  Soon-Hong Yuk ,  Young-Wook Choi ,  Jae-Hyung Park ,  Jin-Wook Chung

    发明人： Hesson Chung ,  Seo-Young Jeong ,  Ick-Chan Kwon ,  Yeong-Taek Park ,  In-Hyun Lee ,  Soon-Hong Yuk ,  Young-Wook Choi ,  Jae-Hyung Park ,  Jin-Wook Chung

    IPC分类号： A61K9/00

    CPC分类号： A61K31/337 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/107 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  A61K2300/00

    摘要： The present invention relates to a paclitaxel composition and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4˜90% by weight of at least one selected from the monoglycerides, 0.01˜90% by weight of at least one oil and 0.01˜20% by weight of paclitaxel. Also the present invention relates to a paclitaxel composition including emulsifiers and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4˜90% by weight of at least one selected from the monoglycerides, 0.01˜90% by weight of at least one oil, 0.01˜90% by weight of at least one emulsifier and 0.01˜20% by weight of paclitaxel. The composition of the present invention is an effective paclitaxel delivery system since the composition solubilizes paclitaxel, does not form aggregates after being dispersed in water, adsorbs well on the intestinal wall, and therefore has high bioavailability.

    摘要翻译： 本发明涉及紫杉醇组合物及其制备方法，其中所述组合物包含4〜90重量％的选自单酸甘油酯，0.01〜90重量％的至少一种油和0.01〜20重量％的至少一种 紫杉醇的重量％。 本发明还涉及包含乳化剂的紫杉醇组合物及其制备方法来溶解紫杉醇，其中所述组合物包含4〜90重量％的选自单酸甘油酯，0.01〜90重量％的至少一种油， 0.01〜90重量％的至少一种乳化剂和0.01〜20重量％的紫杉醇。 本发明的组合物是有效的紫杉醇递送系统，因为组合物溶解紫杉醇，在分散于水中后不形成聚集体，在肠壁上吸附良好，因此具有高的生物利用度。

    PHARMACEUTICAL COMPOSITION COMPRISING GINGER EXTRACT OR SHOGAOL
    8.
    发明申请
    PHARMACEUTICAL COMPOSITION COMPRISING GINGER EXTRACT OR SHOGAOL 有权
    包括葫芦提取物或SHOGAOL的药物组合物

    公开(公告)号：US20110229590A1

    公开(公告)日：2011-09-22

    申请号：US13130009

    申请日：2009-11-13

    申请人： Sun-Yeou Kim ,  Sang-Keun Ha ,  Jong-Hoon Ryu ,  Myung-Sook Oh ,  Seo-Young Jeong

    发明人： Sun-Yeou Kim ,  Sang-Keun Ha ,  Jong-Hoon Ryu ,  Myung-Sook Oh ,  Seo-Young Jeong

    IPC分类号： A61K36/906 ,  A61K31/12 ,  A61P25/00 ,  A61P25/16

    CPC分类号： A61K31/12 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/322 ,  A23V2250/21

    摘要： The present invention provides a pharmaceutical composition for preventing or treating learning disorders, memory disorders, Parkinson's disease, or ischemic cerebrovascular disease, which comprises a ginger extract or shogaol; and a pharmaceutically acceptable carrier. And also, the present invention provides a food composition for improving learning disorders or memory disorders or alleviating the symptoms of learning disorders or memory disorders which comprises a ginger extract or shogaol as an active ingredient, or a food composition for improving learning or memory which comprises a ginger extract or shogaol as an active ingredient.

    摘要翻译： 本发明提供了一种用于预防或治疗学习障碍，记忆障碍，帕金森病或缺血性脑血管疾病的药物组合物，其包含姜提取物或shogaol; 和药学上可接受的载体。 而且，本发明提供了一种用于改善学习障碍或记忆障碍或减轻学习障碍或记忆障碍症状的食物组合物，其包含姜提取物或shogaol作为活性成分，或用于改善学习或记忆的食物组合物，其包含 姜提取物或shogaol作为活性成分。