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31 条记录 (耗时 0.061 秒)

    Targeting vector-phospholipid conjugates
    1.
    发明授权
    Targeting vector-phospholipid conjugates 有权
    靶向载体 - 磷脂缀合物

    公开(公告)号：US07985402B2

    公开(公告)日：2011-07-26

    申请号：US11954130

    申请日：2007-12-11

    申请人： Philippe Bussat ,  Samir Cherkaoui ,  Hong (Helen) Fan ,  Bernard Lamy ,  Palaniappa Nanjappan ,  Radhakrishna K. Pillai ,  Sibylle Pochon ,  Bo Song ,  Rolf E. Swenson

    发明人： Philippe Bussat ,  Samir Cherkaoui ,  Hong (Helen) Fan ,  Bernard Lamy ,  Palaniappa Nanjappan ,  Radhakrishna K. Pillai ,  Sibylle Pochon ,  Bo Song ,  Rolf E. Swenson

    IPC分类号： A61K49/00 ,  A61B8/00

    CPC分类号： A61K49/227 ,  C07K14/00 ,  C07K14/52 ,  Y02A50/58

    摘要： Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.

    摘要翻译： 提供具有高KDR结合亲和力的肽载体和用于制备此类载体的方法。 肽载体可以与磷脂结合并包含在超声造影剂组合物中。 这样的超声造影剂在治疗和诊断方法中是特别有用的，例如在成像含KDR组织和评估和治疗与肿瘤病症相关的血管生成过程中。 本发明还提供大规模生产高纯度二聚体和单体肽磷脂共轭物以及用于形成缀合物的前体材料的方法。 本发明还提供了大规模生产含有非常低水平的TFA的高纯度肽磷脂缀合物的方法。

    Medical Imaging System Based on a Targeted Contrast Agent
    7.
    发明申请
    Medical Imaging System Based on a Targeted Contrast Agent 失效
    基于目标对比剂的医学成像系统

    公开(公告)号：US20080139942A1

    公开(公告)日：2008-06-12

    申请号：US11885723

    申请日：2006-03-03

    申请人： Emmanuel Gaud ,  Peter Frinking ,  Nicolas Rognin ,  Sibylle Pochon ,  Nathalie Biolluz ,  Marcel Arditi

    发明人： Emmanuel Gaud ,  Peter Frinking ,  Nicolas Rognin ,  Sibylle Pochon ,  Nathalie Biolluz ,  Marcel Arditi

    IPC分类号： A61B8/00

    CPC分类号： A61K49/223 ,  Y10S128/916

    摘要： A medical imaging system is proposed. The system includes means for providing a plurality of echo signals indicative of a response of a body part to a plurality of ultrasound pulsed waves having different acoustic pressures, the body part including a tissue being perfused with a contrast agent, and means for discriminating in the echo signals a contribution of a first type of contrast agent from a contribution of a second type of contrast agent and/or of the tissue, at least one harmonic component of the contribution of the first type of contrast agent having an acoustic power changing according to a first dependency law on the acoustic pressure and the at least one harmonic component of the contribution of the second type of contrast agent and/or of the tissue having an acoustic power changing according to at least one second dependency law on the acoustic pressure, wherein the means for discriminating includes means for significantly reducing the at least one harmonic component of the contribution of the second type of contrast agent and/or of the tissue with respect to the at least one harmonic component of the contribution of the first type of contrast agent according to the corresponding dependency laws.

    摘要翻译： 提出了一种医学成像系统。 该系统包括用于提供指示体部分对具有不同声压的多个超声脉冲波的响应的多个回波信号的装置，身体部分包括用造影剂灌注的组织，以及用于在 回波信号是来自第二类型的造影剂和/或组织的贡献的第一类型的造影剂的贡献，第一类型的造影剂的贡献的至少一个谐波分量具有根据 第二类造影剂和/或组织的声压和至少一个谐波分量的第一依赖规律具有根据至少一个第二依赖规律改变的声功率对声压，其中 用于鉴别的装置包括用于显着减少第二类型c的贡献的至少一个谐波分量的装置 根据相应的依赖规律相对于第一类型造影剂的贡献的至少一个谐波分量的组织和/或组织。

    Fibrin-binding peptides and conjugates thereof
    10.
    发明授权
    Fibrin-binding peptides and conjugates thereof 有权
    纤维蛋白结合肽及其缀合物

    公开(公告)号：US08466107B2

    公开(公告)日：2013-06-18

    申请号：US13598811

    申请日：2012-08-30

    申请人： Philippe Bussat ,  Bernard Lamy ,  Edmund R. Marinelli ,  Sibylle Pochon ,  Bo Song ,  Rolf E. Swenson

    发明人： Philippe Bussat ,  Bernard Lamy ,  Edmund R. Marinelli ,  Sibylle Pochon ,  Bo Song ,  Rolf E. Swenson

    IPC分类号： A61K38/36

    CPC分类号： A61K49/14 ,  A61K49/0043 ,  A61K49/0056 ,  A61K49/085 ,  A61K49/124 ,  C07K7/06 ,  G01N33/532 ,  G01N33/574 ,  G01N33/86 ,  G01N2500/04

    摘要： Fibrin-binding peptides having high binding affinity and excellent physical characteristics compared to previously known fibrin-binding peptides are provided. These fibrin-binding peptides may be conjugated to a detectable label or a therapeutic agent and used to detect and facilitate treatment of pathological conditions associated with the presence of fibrin such as thrombic, angiogenic and neoplastic conditions. These peptides may be used in imaging processes such as MRI, ultrasound and nuclear medicine imaging (e.g. PET, scintigraphic imaging, etc.). The peptides may also be used therapeutically. The present invention also provides processes and methods for making and using such peptides and conjugates thereof.

    摘要翻译： 提供了与先前已知的纤维蛋白结合肽相比具有高结合亲和力和优异物理特性的纤维蛋白结合肽。 这些纤维蛋白结合肽可以缀合到可检测标记或治疗剂，并用于检测和促进治疗与血纤维蛋白如血栓形成和血管生成和肿瘤状况有关的病理状况。 这些肽可以用于诸如MRI，超声和核医学成像（例如PET，闪烁照相成像等）的成像过程中。 肽也可以在治疗上使用。 本发明还提供了制备和使用这些肽及其缀合物的方法和方法。