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1.发明授权Identification of virulence associated regions RD1 and RD5 leading to improve vaccine of M. bovis BCG and M. microti 失效鉴定毒力相关区域RD1和RD5，导致改进牛分枝杆菌BCG和M. microti的疫苗公开(公告)号：US08747866B2
公开(公告)日：2014-06-10
申请号：US12923432
申请日：2010-09-21
申请人： Stewart Cole , Alexander S. Pym , Roland Brosch , Priscille Brodin , Laleh Majlessi , Caroline Demangel , Claude LeClerc
发明人： Stewart Cole , Alexander S. Pym , Roland Brosch , Priscille Brodin , Laleh Majlessi , Caroline Demangel , Claude LeClerc
CPC分类号： A61K39/04 , A61K39/00 , A61K2039/522 , A61K2039/523 , C07K14/35 , C12N1/36 , C12Q1/689 , G01N33/5695
摘要： The present invention relates to a strain of M. bovis BCG or M. microti, wherein said strain has integrated part or all of the RD1 region responsible for enhanced immunogenicity of the tubercle bacilli, especially the ESAT-6 and CFP-10 genes. These strains will be referred as the M. bovis BCG::RD1 or M. microti::RD1 strains and are useful as a new improved vaccine for preventing tuberculosis and as a therapeutical product enhancing the stimulation of the immune system for the treatment of bladder cancer.
摘要翻译： 本发明涉及牛分枝杆菌BCG或微生物菌株，其中所述菌株具有整合部分或全部RD1区域，其负责增强结核杆菌的免疫原性，特别是ESAT-6和CFP-10基因。 这些菌株将被称为牛分枝杆菌BCG :: RD1或M. microti :: RD1菌株，并且可用作预防结核病的新改良疫苗，并且作为增强刺激免疫系统以治疗膀胱的治疗产品 癌症。
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2.发明申请DELETED SEQUENCES IN M. BOVIS BCG/M. BOVIS OR M. TUBERCULOSIS, METHOD FOR DETECTING MYCOBACTERIA USING SAID SEQUENCES AND VACCINES 审中-公开M.BVVIS BCG / M中的删除序列。 BOVIS或M.TUBERCULOSIS，使用确定序列和疫苗检测MYCOBACTERIA的方法公开(公告)号：US20130164749A1
公开(公告)日：2013-06-27
申请号：US13693940
申请日：2012-12-04
IPC分类号： C12Q1/68
摘要： The invention concerns the isolation of nucleotide and peptide sequences in particular for differentiating, in diagnostic terms, an immunisation resulting from BCG vaccination of an infection by M. tuberculosis. Said sequences are either M. bovis BCG/M. bovis specific or M. tuberculosis specific. The invention also concerns a method for detecting said sequences, a method for detecting antibodies generated by the products expressing said sequences as well as kits for implementing said methods. Finally, the invention concerns novel vaccines.
摘要翻译： 本发明涉及分离核苷酸和肽序列，特别是用于在诊断方面鉴别由结核分枝杆菌感染引起的BCG接种引起的免疫。 所述序列是牛分枝杆菌BCG / M。 牛结核特异性或结核分枝杆菌特异性。 本发明还涉及一种用于检测所述序列的方法，用于检测表达所述序列的产物产生的抗体的方法以及用于实现所述方法的试剂盒。 最后，本发明涉及新型疫苗。
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3.发明申请Identification of virulence associated regions RD1 and RD5 leading to improve vaccine of M. bovis BCG and M. microti 失效鉴定毒力相关区域RD1和RD5，导致改进牛分枝杆菌BCG和M. microti的疫苗公开(公告)号：US20120189662A1
公开(公告)日：2012-07-26
申请号：US12923432
申请日：2010-09-21
申请人： Stewart Cole , Alexander S. Pym , Roland Brosch , Priscille Brodin , Laleh Majlessi , Caroline Demangel , Claude LeClerc
发明人： Stewart Cole , Alexander S. Pym , Roland Brosch , Priscille Brodin , Laleh Majlessi , Caroline Demangel , Claude LeClerc
IPC分类号： A61K39/04 , C12N15/74 , A61K35/74 , A61P37/04 , A61P35/00 , C12Q1/68 , C12P21/00 , C07H21/04 , C12N1/21 , A61P31/06
CPC分类号： A61K39/04 , A61K39/00 , A61K2039/522 , A61K2039/523 , C07K14/35 , C12N1/36 , C12Q1/689 , G01N33/5695
摘要： The present invention relates to a strain of M. bovis BCG or M. microti, wherein said strain has integrated part or all of the RD1 region responsible for enhanced immunogenicity of the tubercle bacilli, especially the ESAT-6 and CFP-10 genes. These strains will be referred as the M. bovis BCG::RD1 or M. microti::RD1 strains and are useful as a new improved vaccine for preventing tuberculosis and as a therapeutical product enhancing the stimulation of the immune system for the treatment of bladder cancer.
摘要翻译： 本发明涉及牛分枝杆菌BCG或微生物菌株，其中所述菌株具有整合部分或全部RD1区域，其负责增强结核杆菌的免疫原性，特别是ESAT-6和CFP-10基因。 这些菌株将被称为牛分枝杆菌BCG :: RD1或M. microti :: RD1菌株，并且可用作预防结核病的新改良疫苗，并且作为增强刺激免疫系统以治疗膀胱的治疗产品 癌症。
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4.发明授权Delete sequence in M. tuberculosis, method for detecting mycobacteria using these sequences and vaccines 有权删除结核分枝杆菌中的序列，使用这些序列和疫苗检测分枝杆菌的方法公开(公告)号：US07977047B2
公开(公告)日：2011-07-12
申请号：US10505405
申请日：2003-02-25
申请人： Stewart Cole , Roland Brosch , Stephen Gordon , Karin Eiglmeier , Thierry Garnier , Glyn Hewinson
发明人： Stewart Cole , Roland Brosch , Stephen Gordon , Karin Eiglmeier , Thierry Garnier , Glyn Hewinson
CPC分类号： G01N33/5695 , A61K39/00 , C07K14/35 , C12Q1/689 , C12Q2600/156
摘要： The present invention is the identification of a nucleotide sequence which make it possible in particular to distinguish an infection resulting from the vast majority of Mycobacterium tuberculosis strains from an infection resulting from Mycobacterium africanum, Mycobacterium canetti, Mycobacterium microti, Mycobacterium bovis, Mycobacterium bovis BCG. The subject of the present invention is also a method for detecting the sequences in question by the products of expression of these sequences and the kits for carrying out these methods. Finally, the subject of the present invention is novel vaccines.
摘要翻译： 本发明是鉴定可以特别区分绝大多数结核分枝杆菌菌株感染从非洲分枝杆菌，Cancobacterium canetti，Mycobacterium microti，牛分枝杆菌，牛分枝杆菌BCG得到的感染。 本发明的主题也是通过这些序列的表达产物和用于实施这些方法的试剂盒来检测所讨论的序列的方法。 最后，本发明的主题是新型疫苗。
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5.发明授权DNA sequence of the LTR region of human immunodeficiency virus type 1 (HIV-1) 失效人类免疫缺陷病毒1型（HIV-1）的LTR区的DNA序列公开(公告)号：US07232654B1
公开(公告)日：2007-06-19
申请号：US08308219
申请日：1994-09-19
申请人： Jean-Claude Chermann , Solange Chamaret , Claudine Axler-Blin , Francoise Rey , Marie-Therese Nugeyre , Jacques Gruest, legal representative , Charles Dauguet , Willy Rozenbaum , Christine Rouzioux , Francois Brun-Vezinet , Luc Montagnier , Francoise Barre-Sinoussi , Pierre Tiollais , Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Stewart Cole , Oliver Danos , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
CPC分类号： C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus Type 1 (HIV-1) to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates tot he DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译： 本发明属于淋巴结病毒病毒领域，已被指定为1型HIV（1型）免疫缺陷病毒（HIV-1），用于检测与获得性免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在 通过使用DNA片段或由所述DNA片段编码的肽。 本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。
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6.发明申请Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a bac-based DNA library. application to the detection of mycobacteria 失效使用基于bac的DNA文库从分枝杆菌的基因组分离感兴趣的多核苷酸的方法。 应用于检测分枝杆菌公开(公告)号：US20050250104A1
公开(公告)日：2005-11-10
申请号：US10802796
申请日：2004-03-18
CPC分类号： C12Q1/689 , C07K14/35 , C12N15/1072 , C12Q1/6809
摘要： The present invention is directed to a method for isolating a polynucleotide of interest that is present or is expressed in a genome of a first mycobacterium strain and that is absent or altered in a genome of a second mycobacterium strain which is different from the first mycobacterium strain using a bacterial artificial chromosome (BAC) vector. The invention further relates to a polynucleotide isolated by this method and recombinant BAC vector used in this method. In addition the present invention comprises method and kit for detecting the presence of a mycobacteria in a biological sample.
摘要翻译： 本发明涉及分离在第一分枝杆菌菌株的基因组中存在或表达的目的多核苷酸的方法，并且在与第一分枝杆菌菌株不同的第二分枝杆菌菌株的基因组中不存在或改变 使用细菌人造染色体（BAC）载体。 本发明还涉及通过该方法分离的多核苷酸和用于该方法的重组BAC载体。 此外，本发明包括用于检测生物样品中分枝杆菌存在的方法和试剂盒。
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7.发明授权Method for detecting mycobacteria using deleted sequences in M. bovis BCG/M. bovis or tuberculosis 有权使用牛分枝杆菌BCG / M中缺失的序列检测分枝杆菌的方法。 牛或结核病公开(公告)号：US08357493B2
公开(公告)日：2013-01-22
申请号：US10980194
申请日：2004-11-04
摘要： The invention concerns the isolation of nucleotide and peptide sequences in particular for differentiating, in diagnostic terms, an immunization resulting from BCG vaccination of an infection by M. tuberculosis. Said sequences are either M. bovis BCG/M. bovis specific or M. tuberculosis specific. The invention also concerns a method for detecting said sequences, a method for detecting antibodies generated by the products expressing said sequences as well as kits for implementing said methods. Finally, the invention concerns novel vaccines.
摘要翻译： 本发明涉及分离核苷酸和肽序列，特别是用于在诊断方面鉴别由结核分枝杆菌感染引起的BCG接种引起的免疫。 所述序列是牛分枝杆菌BCG / M。 牛结核特异性或结核分枝杆菌特异性。 本发明还涉及一种用于检测所述序列的方法，用于检测表达所述序列的产物产生的抗体的方法以及用于实现所述方法的试剂盒。 最后，本发明涉及新型疫苗。
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8.发明授权Comparative mycobacterial geneomics as a tool for identifying targets for the diagnosis, prophylaxis or treatment of mycobacterioses 失效比较分枝杆菌基因组学作为确定分枝杆菌诊断，预防或治疗目标的工具公开(公告)号：US07538206B2
公开(公告)日：2009-05-26
申请号：US10468356
申请日：2002-02-22
申请人： Stewart Cole
发明人： Stewart Cole
CPC分类号： C12N15/1089 , A61K39/00 , A61K2039/505 , C07K14/345 , C07K14/35 , C12Q1/689
摘要： The present invention is directed to a method of selection of purified nucleotidic sequences or polynucleotides encoding proteins or part of proteins carrying at least an essential function for the survival or the virulence of mycobacterium species by a comparative genomic analysis of the sequence of the genome of M. tuberculosis aligned on the genome sequence of M. leprae and M. tuberculosis and M. leprae marker polypeptides of nucleotides encoding the polypeptides, and methods for using the nucleotides and the encoded polypeptides are disclosed.
摘要翻译： 本发明涉及一种选择纯化的核苷酸序列或多核苷酸的方法，所述纯化的核苷酸序列或多核苷酸通过对M基因组序列的比较基因组分析来编码蛋白质或至少携带至关重要功能的蛋白质的存活或毒力的蛋白质或部分蛋白质 公开了在编码多肽的核苷酸编码多肽的核黄素和结核分枝杆菌的基因组序列和M.leprae标记多肽上的结核病，以及使用该核苷酸和编码多肽的方法。
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9.发明申请Mycolactone locus: an assembly line for producing novel polyketides, therapeutic and prophylactic uses 审中-公开霉酚酸酯基因座：用于生产新型聚酮化合物的组装线，治疗和预防用途公开(公告)号：US20060024806A1
公开(公告)日：2006-02-02
申请号：US11175689
申请日：2005-07-07
申请人： Timothy Stinear , Stewart Cole , Peter Leadlay , Pamela Small , Paul Johnson , Grant Jenkin , John Davies , Stephen Haydock
发明人： Timothy Stinear , Stewart Cole , Peter Leadlay , Pamela Small , Paul Johnson , Grant Jenkin , John Davies , Stephen Haydock
CPC分类号： C12N15/52
摘要： The present invention relates to Mycobacterium ulcerans virulence plasmid, pMUM001 and particularly to a cluster of genes carried by this plasmid that encode polyketide synthases (PKSs) and polyketide-modifying enzymes necessary and sufficient for mycolactone biosynthesis. More particularly this invention is directed to novel purified or isolated polypeptides, the polynucleotides encoding such polypeptides, processes for production of such polypeptides, antibodies generated against these polypeptides, the use of such polynucleotides and polypeptides in Diagnostic methods, kits, vaccines, therapy and for the production of mycolactone derivatives or novel polyketides by combinatorial synthesis.
摘要翻译： 本发明涉及溃疡分枝杆菌毒力质粒pMUM001，特别涉及由该质粒携带的编码聚酮内酯合成酶（PKS）和聚酮化合物修饰酶的基因簇，其对于霉酚酸内酯生物合成是必需和足够的。 更具体地说，本发明涉及新的纯化或分离的多肽，编码这些多肽的多核苷酸，产生此类多肽的方法，针对这些多肽产生的抗体，在诊断方法，试剂盒，疫苗，治疗中用于此类多核苷酸和多肽 通过组合合成生产莫考内酯衍生物或新型聚酮化合物。
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公开(公告)号：US06991904B2
公开(公告)日：2006-01-31
申请号：US10259678
申请日：2002-09-30
CPC分类号： C12Q1/689 , C07K14/35 , C12N15/1072 , C12Q1/6809
摘要： A method for isolating a polynucleotide of interest that is present in the genome of a first mycobacterium strain and/or is expressed by the first mycobacterium strain, where the polynucleotide of interest is also absent or altered in the genome of a second mycobacterium strain and/or is not expressed in the second mycobacterium. The method includes (a) contacting the genomic DNA of the first mycobacterium strain under hybridizing conditions with the DNA of a least one clone that belongs to a bacterial artificial chromosome (BAC) genomic DNA library of the second mycobacterium strain, and (b) isolating the polynucleotide of interest that does not form a hybrid with the DNA of the second mycobacterium strain. This invention further pertains to a Mycobacterium tuberculosis strain H37Rv genomic DNA library, as well as a Mycobacterium bovis BCG strain Pasteur genomic DNA library, and the recombinant BAC vectors that belong to those genomic DNA libraries. This invention also relates to mycobacterial nucleic acids, and methods and kits for using these nucleic acids to detect mycobacteria in a biological sample.
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