公开(公告)号：US20140257423A1

公开(公告)日：2014-09-11

申请号：US13508968

申请日：2011-05-31

申请人： Sven-Erik Hedberg ,  Nils Holmstrom ,  Karin Jarverud

发明人： Sven-Erik Hedberg ,  Nils Holmstrom ,  Karin Jarverud

IPC分类号： A61N1/368

CPC分类号： A61N1/368 ,  A61N1/3622 ,  A61N1/3682 ,  A61N1/3684

摘要： The present invention relates generally to implantable medical devices and more particularly to systems and methods for stimulating a heart of a patient. A first ventricle is activated by delivering stimulation to at least one stimulation site, a point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the first ventricle is estimated and a first activation time interval substantially corresponding to the time interval required for at least one depolarization wave to travel from the stimulation site in the first ventricle to the AV node using the estimated point of time for arrival of the depolarization wave and a point of time for delivery of stimulation is computed. Thereafter, the other ventricle is stimulated by delivering stimulation to at least one stimulation site. A point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the other ventricle is then estimated and a second activation time interval substantially corresponding to the time required for at least one depolarization wave to travel from the stimulation site in the other ventricle to the AV node using the estimated arrival of the depolarization wave and the point of time for delivery of stimulation is computed. Based on these activation time intervals and a difference between the intervals, a pacing therapy can be determined, wherein the first ventricle is paced prior to activation of the other ventricle if the activation time difference indicates that the first activation time interval is longer than the second activation time interval and the other ventricle is paced prior to activation of the first ventricle if the activation time difference indicates that the second activation time interval is longer than the first activation time interval.

摘要翻译： 本发明一般涉及可植入医疗装置，更具体地涉及用于刺激患者心脏的系统和方法。 通过向至少一个刺激部位递送刺激来激活第一脑室，估计到达在第一脑室刺激产生的至少一个去极化波的AV节点的时间点，并且基本对应于 计算使用去极化波的到达的估计时间点和用于递送刺激的时间点的至少一个去极化波从第一脑室的刺激部位行进到AV节点所需的时间间隔。 此后，通过将刺激递送至至少一个刺激部位刺激另一个心室。 然后估计到达AV节点对于在另一个心室中的刺激产生的至少一个去极化波的时间点，并且基本对应于至少一个去极化波从刺激行进所需的时间的第二激活时间间隔 计算使用去极化波的估计到达和输送刺激的时间点在AV节点的另一脑室中的位置。 基于这些激活时间间隔和间隔之间的差异，可以确定起搏治疗，其中如果激活时间差指示第一激活时间间隔长于第二心室第二激活时间间隔，则第一心室在另一心室激活之前起搏 如果所述激活时间差指示所述第二激活时间间隔长于所述第一激活时间间隔，则所述激活时间间隔和所述另一个心室在所述第一心室激活之前起步。

公开(公告)号：US08626313B2

公开(公告)日：2014-01-07

申请号：US12298218

申请日：2006-04-25

申请人： Tom Eriksson ,  Kenth Nilsson ,  Sven-Erik Hedberg

发明人： Tom Eriksson ,  Kenth Nilsson ,  Sven-Erik Hedberg

IPC分类号： A61N1/00 ,  A61B5/00 ,  G01L7/00

CPC分类号： A61N1/056 ,  A61B5/0215 ,  A61N1/0565 ,  A61N1/36542 ,  A61N1/36564 ,  G01L9/0026 ,  G01L9/08 ,  H01L41/087 ,  H01L41/1132

摘要： In a piezoelectric sensor, a method for the manufacture thereof, and an implantable lead embodying such a piezoelectric sensor, a layer of piezoelectric material, having aligned, polarized dipoles, is applied to a tubular supporting substrate, the layer of piezoelectric material having at least one electrode at an outer surface thereof and at least one electrode at an inner surface thereof. The piezoelectric material is applied on the inner circumference of the tubular supporting substrate.

摘要翻译： 在压电传感器中，其制造方法以及体现这种压电传感器的可植入引线，具有排列的极化偶极子的压电材料层被施加到管状支撑衬底，压电材料层至少具有 一个电极在其外表面和至少一个电极在其内表面。 压电材料被施加在管状支撑衬底的内圆周上。

公开(公告)号：US08532774B1

公开(公告)日：2013-09-10

申请号：US13545794

申请日：2012-07-10

申请人： Sven-Erik Hedberg ,  Tomas Svensson ,  Kjell Noren ,  Stuart Rosenberg ,  Kyungmoo Ryu ,  Edward Karst

发明人： Sven-Erik Hedberg ,  Tomas Svensson ,  Kjell Noren ,  Stuart Rosenberg ,  Kyungmoo Ryu ,  Edward Karst

IPC分类号： A61N1/37

CPC分类号： A61N1/36521 ,  A61B5/042 ,  A61B5/0538 ,  A61N1/3686 ,  A61N1/3702

摘要： The present invention provides methods for detecting phrenic nerve stimulation. A pacing module is instructed to deliver pacing pulses having a predetermined pulse amplitude and/or width within the refractory period of the left ventricle. The pacing pulses are repeatedly delivered during a number of cardiac cycles and wherein the pacing pulses are delivered at different delays relative to an onset of the refractory period of the left ventricle in different cardiac cycles. Impedance signals are measured in time windows synchronized with the delivery of pacing pulses in the refractory period of the left ventricle using at least one electrode configuration. At least one impedance signal is gathered from each time window, aggregated impedance signals are created using the impedance signals from the different time windows, and the aggregated impedance signals are analyzed to detect PNS.

摘要翻译： 本发明提供了检测膈神经刺激的方法。 指示起搏模块在左心室的不应期内输送具有预定脉搏幅度和/或宽度的起搏脉冲。 起搏脉冲在多个心动周期期间重复递送，并且其中起搏脉冲相对于在不同心脏周期中的左心室的不应期的开始以不同的延迟递送。 使用至少一个电极配置，在与左心室的不应期中的起搏脉冲的递送同步的时间窗口中测量阻抗信号。 从每个时间窗口收集至少一个阻抗信号，使用来自不同时间窗口的阻抗信号创建聚合阻抗信号，并分析聚合阻抗信号以检测PNS。

公开(公告)号：US08359095B2

公开(公告)日：2013-01-22

申请号：US12442742

申请日：2006-09-25

申请人： Sven-Erik Hedberg ,  Patrik Malmberg ,  Leif Lychou ,  Jürgen Kerstna

发明人： Sven-Erik Hedberg ,  Patrik Malmberg ,  Leif Lychou ,  Jürgen Kerstna

IPC分类号： A61N1/365 ,  A61N1/372

CPC分类号： A61N1/36585 ,  A61N1/025 ,  A61N1/3682 ,  A61N1/37247 ,  A61N1/37252 ,  G06F19/00 ,  G16H40/40

摘要： In a medical system and a method for operating such a system, the system includes an implantable medical device of a patient, a programmer device, and an extracorporeal stress equipment adapted to exert a physiological stress on the patient, for automatically determining settings of a sensor for sensing a physiological parameter of the patient or for automatically determining a pacing setting of the device over a broad range of workloads of the equipment. The ingoing units and/or devices of the medical system, i.e. the implantable medical device of the patient, the programmer device, and the extracorporeal stress equipment, communicate bi-directionally with each other and form a closed loop.

摘要翻译： 在用于操作这种系统的医疗系统和方法中，系统包括患者的可植入医疗装置，编程器装置和适于对患者施加生理压力的体外应力装置，用于自动确定传感器的设置 用于感测患者的生理参数或用于在设备的广泛工作负载上自动确定设备的起搏设置。 医疗系统的进入单元和/或装置，即患者的可植入医疗装置，编程器装置和体外应力设备彼此双向地通信并形成闭环。

公开(公告)号：US20120089035A1

公开(公告)日：2012-04-12

申请号：US13271548

申请日：2011-10-12

申请人： KARIN JÄRVERUD ,  Kenth Nilsson ,  Sven-Erik Hedberg

发明人： KARIN JÄRVERUD ,  Kenth Nilsson ,  Sven-Erik Hedberg

IPC分类号： A61N1/368 ,  A61B5/0245

CPC分类号： A61N1/3627 ,  A61B5/1107 ,  A61B5/6869 ,  A61B2562/0219 ,  A61N1/36514 ,  A61N1/36578

摘要： In a system and method for monitoring cardiac synchrony in a human heart, a first sensor is positioned at a first cardiac wall location that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and measures the cardiac wall movements at the first cardiac wall location and a second sensor is positioned at a second cardiac wall location that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and measures the cardiac wall movements at the second cardiac wall location. A lead arrangement conducts respective output signals from the first and second sensors to processing circuitry that processes the first and second sensor output signals to produce a synchronization signal therefrom indicative of synchrony in the respective valve plane movements at the first and second cardiac wall locations.

摘要翻译： 在用于监测人心脏心脏同步的系统和方法中，第一传感器位于第一心脏壁位置，该第一心脏壁位置受到与心脏的纵向轴线的纵向瓣膜平面运动有关的运动，并且测量心脏壁移动 在第一心脏壁位置处，并且第二传感器定位在第二心脏壁位置处，所述第二心脏壁位置受到与沿着心脏的纵向轴线的纵向瓣膜平面运动相关的运动，并且测量第二心脏壁位置处的心脏壁运动。 引线装置将来自第一和第二传感器的相应输出信号传导到处理电路，处理电路处理第一和第二传感器输出信号以产生同步信号，表示在第一和第二心脏壁位置处的各个阀平面运动中的同步。

公开(公告)号：US20100268102A1

公开(公告)日：2010-10-21

申请号：US12808041

申请日：2007-12-19

申请人： Andreas Blomqvist ,  Nils Holmstöm ,  Sven-Erik Hedberg ,  Malin Öhlander

发明人： Andreas Blomqvist ,  Nils Holmstöm ,  Sven-Erik Hedberg ,  Malin Öhlander

IPC分类号： A61B5/0472

CPC分类号： A61N1/36521 ,  A61B5/0456 ,  A61B5/053 ,  A61B5/0538 ,  A61N1/3622 ,  A61N1/3684

摘要： In an implantable heart monitoring device and a monitoring method, an impedance is measured across at least part of an atrium, such that variation of the impedance is related to the volume change of the atrium. Values are stored at different occasions that indicate the rate of change of the measured impedance. The stored values are determined such that, when the device is used in a living being, the variation of the stored values will be related to the variation of the speed with which the atrium is filled with blood during the atrial diastole.

摘要翻译： 在可植入心脏监测装置和监测方法中，跨越心房的至少一部分测量阻抗，使得阻抗的变化与心房的体积变化相关。 值存储在指示测量阻抗的变化率的不同场合。 确定所存储的值，使得当在生物体中使用该装置时，存储值的变化将与在心房舒张期期间心房充满血液的速度的变化相关。

公开(公告)号：US20100099994A1

公开(公告)日：2010-04-22

申请号：US12528160

申请日：2007-02-28

申请人： Nils Holmström ,  Andreas Blomqvist ,  Berit Larsson ,  Karin Järverud ,  Sven-Erik Hedberg

发明人： Nils Holmström ,  Andreas Blomqvist ,  Berit Larsson ,  Karin Järverud ,  Sven-Erik Hedberg

IPC分类号： A61B5/02

CPC分类号： A61B5/1107 ,  A61B5/0051 ,  A61B5/4519 ,  A61B5/6869 ,  A61N1/36578

摘要： An implantable heart analyzing device has a housing and a control circuit located within said housing. The control circuit generates an output signal adapted to actuate an activator, which is able to make a wall of the heart deflect or vibrate. The control circuit also communicates with a sensor, which can be identical with the activator, with which the movement of the heart wall can be sensed. The control circuit executes a procedure that involves the generation of an output signal and sensing a corresponding sensor signal, and to be able to derive information concerning the tension of the heart wall. An implantable heart analyzing includes the aforementioned heart analyzing device, as well as the activator and the sensor. The heart analyzing device and the system implement a method that results in generation of the aforementioned information concerning the tension of the heart wall.

摘要翻译： 可植入心脏分析装置具有壳体和位于所述壳体内的控制电路。 控制电路产生适于致动激活器的输出信号，其能够使心脏的壁发生偏转或振动。 控制电路还与传感器通信，传感器可以与激活器相同，通过该传感器可以感测心脏壁的移动。 控制电路执行涉及生成输出信号并感测相应的传感器信号的过程，并且能够得出关于心壁的张力的信息。 可植入心脏分析包括上述心脏分析装置，以及活化剂和传感器。 心脏分析装置和系统实施导致产生上述关于心脏壁张力的信息的方法。

公开(公告)号：US20100041970A1

公开(公告)日：2010-02-18

申请号：US12532186

申请日：2007-11-27

申请人： Sven-Erik Hedberg ,  Andreas Blomqvist ,  Karin Järverud ,  Karin Ljungström ,  Leif Lindkvist ,  Urban Lönn ,  Nils Holmström

发明人： Sven-Erik Hedberg ,  Andreas Blomqvist ,  Karin Järverud ,  Karin Ljungström ,  Leif Lindkvist ,  Urban Lönn ,  Nils Holmström

IPC分类号： A61B5/1459

CPC分类号： A61N1/3702 ,  A61B5/14542 ,  A61B5/1459 ,  A61N1/056 ,  A61N1/36557

摘要： An implantable medical device has an oxygen sensor adapted to measure the level of oxygen in oxygenized blood, and to generate an oxygen measurement signal in dependence of the level of oxygen. The oxygen sensor is adapted to perform measurements inside the heart, of blood entering the left atrium of a patient's heart. The obtained oxygen measurement signal is compared to a predetermined threshold level and an indication signal is generated in dependence of the comparison. The, indication signal is indicative of the lung functionality of the patient.

摘要翻译： 可植入医疗装置具有适于测量氧合血液中的氧气水平的氧传感器，并且根据氧气水平产生氧测量信号。 氧传感器适于在心脏内进行血液进入患者心脏左心房的血液。 将获得的氧测量信号与预定阈值电平进行比较，并根据比较产生指示信号。 该指示信号表示患者的肺功能。

公开(公告)号：US20090187426A1

公开(公告)日：2009-07-23

申请号：US12301691

申请日：2006-05-31

申请人： Jürgen Kerstna ,  Patrik Malmberg ,  Sven-Erik Hedberg ,  Leif Lychou

发明人： Jürgen Kerstna ,  Patrik Malmberg ,  Sven-Erik Hedberg ,  Leif Lychou

IPC分类号： G06Q50/00 ,  G06F17/30

CPC分类号： A61N1/37282 ,  G06F19/3418 ,  G06Q50/24

摘要： Functions of a clinician's workstation, which is a part of an implantable medical system that also includes an implantable medical device, are dynamically adapted dependent on collected patient data and/or collected data relating to operation of the implantable medical device. The adaptation can take place based on instructions provided to the workstation from a server, that is supplied with the collected data, and that processes the collected data to produce the instructions.

摘要翻译： 根据收集的患者数据和/或与可植入医疗装置的操作相关的收集数据，临床医生工作站的功能也是植入式医疗系统的一部分，其也包括可植入医疗装置。 适应可以基于从服务器提供给工作站的指令进行，该指令被提供给所收集的数据，并且处理收集的数据以产生指令。

公开(公告)号：US20080319498A1

公开(公告)日：2008-12-25

申请号：US11658981

申请日：2004-08-31

申请人： Sven-Erik Hedberg

发明人： Sven-Erik Hedberg

IPC分类号： A61N1/365 ,  A61B5/02

CPC分类号： A61B5/686 ,  A61B5/02405 ,  A61B5/0472 ,  A61B5/1107 ,  A61B5/6869 ,  A61B2562/0219

摘要： In a method and implantable medical apparatus for detecting diastolic heart failure (DHF), and a pacemaker embodying such an apparatus, movement of the valve plane of the heart is measured and analyzed to identify a slowing of the movement of the valve plane as an indication of a DHF state of the heart. A signal indicative of this DHF state is emitted and, in the pacemaker, is used to control the administration of a pacing pulse therapy to the heart.

摘要翻译： 在用于检测舒张性心力衰竭（DHF）的方法和可植入医疗装置中，以及体现这种装置的起搏器，测量和分析心脏瓣膜平面的运动，以识别阀平面的运动减慢作为指示 的DHF状态的心脏。 发出指示该DHF状态的信号，并且在起搏器中用于控制对心脏的起搏脉冲治疗的施用。