-
公开(公告)号：US6096312A
公开(公告)日：2000-08-01
申请号：US999631
申请日：1998-01-22
申请人： Norio Nakamura , Kamon Shirakawa , Tomokazu Matsusue , Shigekazu Nagata , Man Sung Co , Maximiliano Vasquez
发明人： Norio Nakamura , Kamon Shirakawa , Tomokazu Matsusue , Shigekazu Nagata , Man Sung Co , Maximiliano Vasquez
IPC分类号： A61K38/00 , A61P31/18 , C07K16/28 , A61K39/395 , C07K14/525 , C07K16/00
CPC分类号： C07K16/2875 , C07K16/2878 , A61K2039/505 , A61K38/00 , C07K2317/24
摘要： An agent for preventing or treating AIDS which contains as its effective component an anti-Fas ligand antibody, and the method for preventing and treating AIDS by using such drug.
摘要翻译： 用于预防或治疗AIDS的药物，其含有抗Fas配体抗体作为其有效成分，以及通过使用该药物来预防和治疗AIDS的方法。
-
公开(公告)号：US07977461B2
公开(公告)日：2011-07-12
申请号：US11912757
申请日：2006-04-28
申请人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
发明人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
IPC分类号： C12P21/08
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
摘要翻译： 本发明提供具有以下特征的抗体，其活性片段或其衍生物：a）其特异性结合人血小板膜糖蛋白VI（GPVI）; b）激活血小板和/或在体内诱导血小板减少症的功能低; 和c）它通过与血小板接触至少部分地消耗血小板膜上的GPVI。
-
公开(公告)号：US20090092612A1
公开(公告)日：2009-04-09
申请号：US11912757
申请日：2006-04-28
申请人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
发明人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , C12N15/11 , C12P21/04
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
-
公开(公告)号：US08389692B2
公开(公告)日：2013-03-05
申请号：US13095098
申请日：2011-04-27
申请人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
发明人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
IPC分类号： C12P21/08
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
-
公开(公告)号：US20110217318A1
公开(公告)日：2011-09-08
申请号：US13095098
申请日：2011-04-27
申请人： HIROSHI TAKAYAMA , KAMON SHIRAKAWA , SHOJI FURUSAKO , YOSHITAKA HOSAKA , TOMOKAZU MATSUSUE , KATSUKI NAITOH , YUMI HOTTA , TETSUSHI KAWAHARA , MOTOYASU HONDA
发明人： HIROSHI TAKAYAMA , KAMON SHIRAKAWA , SHOJI FURUSAKO , YOSHITAKA HOSAKA , TOMOKAZU MATSUSUE , KATSUKI NAITOH , YUMI HOTTA , TETSUSHI KAWAHARA , MOTOYASU HONDA
IPC分类号： A61K39/395 , C12N15/63 , C12N5/071 , C12P21/02 , C07K16/28 , C07H21/00 , A61P7/02 , C07K19/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
摘要翻译： 本发明提供具有以下特征的抗体，其活性片段或其衍生物：a）其特异性结合人血小板膜糖蛋白VI（GPVI）; b）激活血小板和/或在体内诱导血小板减少症的功能低; 和c）它通过与血小板接触至少部分地消耗血小板膜上的GPVI。
-
公开(公告)号：US20090041783A1
公开(公告)日：2009-02-12
申请号：US11816233
申请日：2006-01-27
申请人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara
发明人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , C07K14/00 , A61P43/00 , G01N33/566 , C12N15/11 , C12P21/04
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
摘要翻译： 本发明提供具有以下特征的抗体，其活性片段或其衍生物：a）其特异性结合人血小板膜糖蛋白VI（GPVI）; b）激活血小板和/或在体内诱导血小板减少症的功能低; 和c）它通过与血小板接触至少部分地消耗血小板膜上的GPVI。
-
公开(公告)号：US20070032637A1
公开(公告)日：2007-02-08
申请号：US10503486
申请日：2002-09-12
申请人： Shigeyuki Yokoyama , Hideo Ogiso , Mikako Shirouzu , Osamu Nureki , Ryuichiro Ishitani , Kazuki Saito , Tomokazu Matsusue , Naoki Nakao , Hiroyuki Muramatsu , Mikihiko Shinozaki
发明人： Shigeyuki Yokoyama , Hideo Ogiso , Mikako Shirouzu , Osamu Nureki , Ryuichiro Ishitani , Kazuki Saito , Tomokazu Matsusue , Naoki Nakao , Hiroyuki Muramatsu , Mikihiko Shinozaki
CPC分类号： C07K16/2863 , A61K2039/505 , C07K14/485 , C07K14/71 , C07K16/22 , C07K2299/00 , C07K2317/32 , C07K2317/34
摘要： The present invention relates to a crystal of a complex of an epidermal growth factor (EGF) and an epidermal growth factor receptor (EGFR), a crystal of a complex of EGFR and a substance regulating EGFR activity, structure coordinates of these crystals, a method for screening for the substance regulating EGFR activity, a method for designing the substance regulating EGFR activity, a method for designing an EGFR variant or an EGF variant, a method for producing an EGFR variant or an EGF variant and an EGF variant or an EGFR variant obtainable by such method, a method for designing an epitope using the structure coordinates of the EGF-EGFR complex, a method for producing an anti-EGFR antibody or an anti-EGF antibody and an antibody obtainable by such method, a polypeptide or a salt thereof comprising a region that forms an EGFR dimerization site, and the like.
摘要翻译： 本发明涉及表皮生长因子（EGF）和表皮生长因子受体（EGFR）的复合物的晶体，EGFR复合物的结晶和调节EGFR活性的物质，这些晶体的结构坐标，方法 用于筛选调节EGFR活性的物质，设计调节EGFR活性的物质的方法，设计EGFR变体或EGF变体的方法，产生EGFR变体或EGF变体和EGF变体或EGFR变体的方法 可以通过这种方法获得使用EGF-EGFR复合物的结构座标设计表位的方法，抗EGFR抗体或抗EGF抗体的制备方法和可通过这种方法获得的抗体，多肽或盐 其包含形成EGFR二聚化位点的区域等。
-
8.发明授权Anti-Fas ligand antibody and assay method using the anti-Fas ligand antibody 失效抗Fas配体抗体和使用抗Fas配体抗体的测定方法
公开(公告)号：US6114507A
公开(公告)日：2000-09-05
申请号：US649100
申请日：1996-05-17
CPC分类号： C07K16/2875 , A61K38/00 , C07K2317/24 , C07K2317/34 , C07K2319/00
摘要： An anti-Fas ligand antibody capable of suppressing Fas ligand-induced apoptosis to a high degree, especially humanized antibodies having less antigenecity to human, and a method for assaying the Fas ligand in human body fluid utilizing such an antibody.Measurement of the Fas ligand in human body fluid would be useful for elucidation of hepatitis B, hepatitis C, HIV infections and the like, and for prediction and diagnosis of pathological conditions associated with such diseases.
摘要翻译： 能够高度抑制Fas配体诱导的凋亡的抗Fas配体抗体，特别是对人具有较小抗原性的人源化抗体，以及利用这种抗体测定人体液体中的Fas配体的方法。 人体液体中Fas配体的测定可用于阐明乙型肝炎，丙型肝炎，艾滋病毒感染等，以及与这些疾病相关的病理状况的预测和诊断。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.019 秒)
