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公开(公告)号：US09919029B2
公开(公告)日：2018-03-20
申请号：US14906747
申请日：2014-07-25
Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT PASTEUR DE LILLE , UNIVERSITE DE LILLE 1 SCIENCES ET TECHNOLOGIES , ETH ZURICH , UNIVERSIDAD DE LA REPUBLICA
Inventor： Wolf-Dietrich Hardt , Patrick Kaiser , Jean-Claude Sirard , Christophe Carnoy , Delphine Fougeron , Jose Alejandro Chabalgoity , Natalia Munoz
IPC: A61K38/16 , A61K31/505 , A61K31/42 , A61K31/43 , A61K45/06 , A61K31/635
CPC classification number: A61K38/164 , A61K31/42 , A61K31/43 , A61K31/505 , A61K31/635 , A61K45/06 , Y02A50/402 , Y02A50/475 , Y02A50/481 , A61K2300/00
Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial infections. In particular, the present invention relates to a Toll-like receptor (TLR) agonist for use in a method for the treatment of a bacterial infection in a subject in need thereof wherein the TLR agonist is administered to the subject in combination with at least one antibiotic.
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公开(公告)号：US20220313802A1
公开(公告)日：2022-10-06
申请号：US17610388
申请日：2020-05-11
Applicant: NEW YORK UNIVERSITY , INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA (INTA) , UNIVERSIDAD DE LA REPUBLICA
Inventor： Fernando GONI , Thomas WISNIEWSKI , Lucia YIM , Jose Alejandro CHABALGOITY , Analia ELISEI
Abstract: The present disclosure is directed to a multi-species prion protein or peptide thereof, and vaccine compositions comprising the same that are useful for the vaccination and treatment of mammalian subjects at risk of having or having prion disease. Also disclosed herein are isolated proteins and peptides, polymers, vaccines, animal bait or feed, antibodies, and methods of inhibiting the onset of or treating a prion disease.
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公开(公告)号：US20220098609A1
公开(公告)日：2022-03-31
申请号：US16956526
申请日：2018-12-20
Applicant: INSTITUTO NACIONAL DE INVESTIGACIÓN AGROPECUARIA , UNIVERSIDAD DE LA REPUBLICA , CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECHNICAS , ESTACION EXPERIMENTAL AGROINDUSTRIAL OBISPO COLOMBRES
Inventor： Julio Omar BORSANI CAMBÓN , Esteban CASARETTO DE GREGORIO , Juan Pablo GALLINO MALCUORI , Andrea Luciana FLEITAS BELAMENDIA , Maria Victoria BONNECARRÈRE MARTINEZ , Atilio Pedro CASTAGNARO , Esteban Mariano PARDO , Sabina VIDAL MACCHI
IPC: C12N15/82 , C07K14/415
Abstract: The invention relates to methods for improving abiotic stress tolerance (and/or yield) in plants, including enhanced drought tolerance. It discloses nucleic acid constructs comprising the isolated polynucleotides, transgenic plants expressing the same, and methods of using the same for increasing abiotic stress tolerance (and/or yield).
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公开(公告)号：US20240055013A1
公开(公告)日：2024-02-15
申请号：US17766172
申请日：2020-10-02
Inventor： Francisco Cervantes Constantino , Tom Francart , Jonas Vanthornhout
IPC: G10L21/0364 , G06F3/01
CPC classification number: G10L21/0364 , G06F3/011
Abstract: A method of estimating speech intelligibility is disclosed. The method comprises the steps of providing at least a first time-dependent signal derived from a first auditory stimulus and a corresponding first measured EEG response; comparing at least part of the first signal with at least part of the first measured EEG response in order to determine a signal-response latency difference; comparing the signal-response latency difference to a reference value; and deriving a measure of speech intelligibility based on the comparison of the signal-response latency difference and the reference value.
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公开(公告)号：US11561201B2
公开(公告)日：2023-01-24
申请号：US16646396
申请日：2018-10-30
Applicant: UNIVERSIDAD DE LA REPUBLICA
Inventor： Nicolás Benech , Gustavo Grinspan , Sofía Aguiar , Carlos Negreira
IPC: G01N29/07 , G01N29/52 , A61B5/01 , A61B5/00 , G01C3/02 , G01K13/00 , G01L5/00 , G01N29/24 , G01N29/42 , G01N29/44
Abstract: The invention comprises a device and method to estimate the elasticity of soft elastic solids from surface wave measurements. The method is non-destructive, reliable and repeatable. The final device is low-cost and portable. It is based in audio-frequency shear wave propagation in elastic soft solids. Within this frequency range, shear wavelength is centimeter sized. Thus, the experimental data is usually collected in the near-field of the source. Therefore, an inversion algorithm taking into account near-field effects was developed for use with the device. Example applications are shown in beef samples, tissue mimicking materials and in vivo skeletal muscle of healthy volunteers.
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Patent Agency Ranking
公开(公告)号：US09328163B2
公开(公告)日：2016-05-03
申请号：US14037973
申请日：2013-09-26
Applicant: INSTITUT PASTEUR , INSTITUTO DE INVESTIGACIONES BIOLOGICAS CLEMENTE ESTABLE , FACULTAD DE MEDICINA, UNIVERSIDAD DE LA REPUBLICA , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventor： Luis Barbeito , Mariana Pehar , Patricia Cassina , Pedro M. Alzari
IPC: C07K16/22 , A61K39/395 , C07K14/475 , C07K14/48 , A61K38/00
CPC classification number: C07K16/22 , A61K38/00 , A61K39/3955 , C07K14/475 , C07K14/48
Abstract: The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that bind to these modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.
Abstract translation: 本发明描述了神经营养因子经历翻译后修饰，并且这些翻译后修饰介导神经营养蛋白的促凋亡和/或前神经突活性。 这些翻译后修饰特别包括硝化和构象不同二聚体的形成，以及异构低聚物如四聚体和八聚体。 本发明还涉及与这种修饰的神经营养因子竞争的化合物，以及与这些修饰的神经营养蛋白结合的化合物。 因此，本发明提供了用于治疗涉及慢性疼痛和/或神经元损失的病症或疾病的有用试剂。
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公开(公告)号：US11618903B2
公开(公告)日：2023-04-04
申请号：US16956526
申请日：2018-12-20
Applicant: INSTITUTO NACIONAL DE INVESTIGACIÓN AGROPECUARIA , UNIVERSIDAD DE LA REPUBLICA , CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS , ESTACION EXPERIMENTAL AGROINDUSTRIAL OBISPO COLOMBRES
Inventor： Julio Omar Borsani Cambón , Esteban Casaretto De Gregorio , Juan Pablo Gallino Malcuori , Andrea Luciana Fleitas Belamendia , Maria Victoria Bonnecarrère Martinez , Atilio Pedro Castagnaro , Esteban Mariano Pardo , Sabina Vidal Macchi
IPC: C12N15/82 , C07K14/415
Abstract: The invention relates to methods for improving abiotic stress tolerance (and/or yield) in plants, including enhanced drought tolerance. It discloses nucleic acid constructs comprising the isolated polynucleotides, transgenic plants expressing the same, and methods of using the same for increasing abiotic stress tolerance (and/or yield).
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公开(公告)号：US20200271624A1
公开(公告)日：2020-08-27
申请号：US16646396
申请日：2018-10-30
Applicant: UNIVERSIDAD DE LA REPUBLICA
Inventor： Nicolás BENECH , Gustavo GRINSPAN , Sofía AGUIAR , Carlos NEGREIRA
IPC: G01N29/07 , G01N29/24 , G01N29/42 , G01N29/44 , G01N29/52 , G01K13/00 , G01L5/00 , G01C3/02 , A61B5/00 , A61B5/01
Abstract: The invention comprises a device and method to estimate the elasticity of soft elastic solids from surface wave measurements. The method is non-destructive, reliable and repeatable. The final device is low-cost and portable. It is based in audio-frequency shear wave propagation in elastic soft solids. Within this frequency range, shear wavelength is centimeter sized. Thus, the experimental data is usually collected in the near-field of the source. Therefore, an inversion algorithm taking into account near-field effects was developed for use with the device. Example applications are shown in beef samples, tissue mimicking materials and in vivo skeletal muscle of healthy volunteers
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9.发明申请METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF BACTERIAL INFECTIONS 有权用于治疗细菌感染的方法和药物组合物公开(公告)号：US20160151453A1
公开(公告)日：2016-06-02
申请号：US14906747
申请日：2014-07-25
Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT PASTEUR DE LILLE , UNIVERSITÉ DE LILLE 1 SCIENCES ET TECHNOLOGIES , ETH ZURICH , UNIVERSIDAD DE LA REPUBLICA
Inventor： Wolf-Dietrich HARDT , Patrick KAISER , Jean-Claude SIRARD , Christophe CARNOY , Delphine FOUGERON , Jose Alejandro CHABALGOITY , Natalia MUNOZ
IPC: A61K38/16 , A61K31/505 , A61K31/42 , A61K31/43
CPC classification number: A61K38/164 , A61K31/42 , A61K31/43 , A61K31/505 , A61K31/635 , A61K45/06 , Y02A50/402 , Y02A50/475 , Y02A50/481 , A61K2300/00
Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial infections. In particular, the present invention relates to a Toll-like receptor (TLR) agonist for use in a method for the treatment of a bacterial infection in a subject in need thereof wherein the TLR agonist is administered to the subject in combination with at least one antibiotic.
Abstract translation: 本发明涉及用于治疗细菌感染的方法和药物组合物。 特别地，本发明涉及用于治疗有需要的受试者的细菌感染的方法中的Toll样受体（TLR）激动剂，其中将TLR激动剂与至少一种 抗生素。
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公开(公告)号：US20150313991A1
公开(公告)日：2015-11-05
申请号：US14651093
申请日：2013-12-09
Applicant: UNIVERSIDAD DE LA REPUBLICA DE URUGUAY
Inventor： Fernando Amaury FERREIRA CHIESA , Leonora QUIRICI VALADAN , Maria Ines BESSIO PRATO , Luis Fernando SILVEIRA GONZALEZ
CPC classification number: A61K39/08 , A61K39/09 , A61K39/092 , A61K39/39 , A61K2039/55511 , A61K2039/55577
Abstract: The invention relates to the composition, preparation and use of a formulation as an adjuvant for human or animal use, said formulation comprising at least one bile acid or salts thereof and saponin, in order to enhance the immune response against an antigen, which may or may not be well defined, including but not limited to bacterins, antigens and antigenic preparations that are viral, bacterial or parasitic, and antigens associated with diseases such as different types of cancer. The antigens used can be isolated from pathogens, as well as products resulting from enzymatic or chemical modification, synthetic or recombinant antigens, or mixtures of the same.
Abstract translation: 本发明涉及作为人或动物使用佐剂的制剂的组成，制备和用途，所述制剂包含至少一种胆汁酸或其盐和皂苷，以增强针对抗原的免疫应答，其可以或 可能不是很好地定义，包括但不限于细菌，抗原和病毒，细菌或寄生虫的抗原制剂，以及与疾病如不同类型的癌症相关的抗原。 所用的抗原可以从病原体中分离，以及由酶或化学修饰产生的产物，合成或重组抗原或其混合物。
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