公开(公告)号：US20230184767A1

公开(公告)日：2023-06-15

申请号：US17926474

申请日：2021-05-19

Applicant: The Board of Trustees of the University of Illinois ,  Universidad Nacional de La Plata ,  Consejo Nacional de Investigaciones Cientificas y Tecnicas

Inventor： Yi Lu ,  Ana Sol Peinetti ,  Omar Azzaroni

IPC: G01N33/569 ,  G01N33/53 ,  G01N33/543 ,  G01N27/327 ,  G01N27/333

CPC classification number: G01N33/56983 ,  G01N33/5308 ,  G01N33/5438 ,  G01N27/3276 ,  G01N27/333

Abstract: Methods of detecting presence of a virus in a sample are provided, the method including contacting the sample with a solid state nanopore comprising a plurality of virus-specific aptamers and measuring a current-voltage curve in the solid state nanopore, wherein a decrease in the current indicates presence of the virus in the sample. Solid state nanopores comprising a plurality of virus-specific aptamers covalently linked to the interior of the solid state nanopore are also provided. Membranes including a plurality of solid state nanopores including a plurality of covalently attached virus-specific aptamers and kits and systems with a membrane including a plurality of solid state nanopores including a plurality of covalently attached virus-specific aptamers are also provided.

公开(公告)号：US20220398426A1

公开(公告)日：2022-12-15

申请号：US17607970

申请日：2020-09-10

Applicant: IONQ, INC. ,  Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet)

Inventor： Carla Alejandra Gimenez ,  Guillermo Daniel REPIZO ,  Federico Alberto PEREYRA BONNET ,  Lucía Ana CURTI ,  Franco GOYTIA ,  Maria Eugenia FARÍAS

IPC: G06N3/00 ,  G06N10/40

Abstract: Provided herein are novel Class 2 Type II and Type V CRISPR-Cas RNA-guided endonucleases, e.g. Cas9 and Cas12 endonucleases, and systems comprising the same. Provided also are methods of making, and methods of use thereof. Exemplary methods of use include modifying target DNAs and detecting targeting DNAs, useful for therapeutic and diagnostic applications. Some of the diagnostic applications may utilise the collateral nuclease activity of an enzyme bound to a target sequence.

公开(公告)号：US20220220177A1

公开(公告)日：2022-07-14

申请号：US17280541

申请日：2019-09-26

Applicant: UNIVERSIDAD NACIONAL DEL LITORAL ,  CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) ,  UNIVERSDAD NACIONAL DE GENERAL SAN MARTIN

Inventor： Marcos OGGERO-EBERHARDT ,  Maria de los Milagros BURGI-FISSOLO ,  Aquiles DORELLA ,  Gabriela I. APARICIO ,  Marina ETCHEVERRIGARAY ,  Camila SCORTICATI ,  Ricardo KRATJE

IPC: C07K14/505 ,  C12N15/85 ,  A61P25/28

Abstract: A modified human erythropoietin with an increased plasma half-life, with an erythropoietic activity of less than 0.5% in relation to a native erythropoietin, which maintains the neuroprotective and neuroplastic capacity, which comprises the mutation of at least one of the binding sites the homodimeric or heterodimeric receptor by incorporating consensus sites for N-glycosylation.

公开(公告)号：US20200325557A1

公开(公告)日：2020-10-15

申请号：US16766247

申请日：2018-11-23

Applicant: CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS CONICET ,  UNIVERSIDAD NACIONAL DE CUYO

Inventor： Mario Humberto RODRIGUEZ ,  Alexander Cristian RESENTERA BEIZA ,  Gustavo Daniel ROSALES

IPC: C22B26/12 ,  C22B3/08 ,  C01D15/04

Abstract: Pyrometallurgic process for obtaining lithium compounds and intermediates, the process being characterized by comprising the steps of a) contacting lithium aluminosilicate particles with at least a fluorine solid compound, b) heating until a temperature of 25 to 900° C. obtaining a solid mixture and c) carrying out at least a leaching process of the mixture in step b).

公开(公告)号：US20180328948A1

公开(公告)日：2018-11-15

申请号：US16037150

申请日：2018-07-17

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  CONICET (CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS) ,  INSTITUT JEAN PAOLI & IRENE CALMETTES ,  UNIVERSITÉ D'AIX-MARSEILLE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Inventor： Juan IOVANNA ,  Virginia PASQUINELLI ,  Maria Madgalena GHERARDI ,  Hector Eduardo CHULUYAN ,  Ana Inès ROVETTA ,  Delfina PENA ,  Véronica Edith GARCIA

IPC: G01N33/68 ,  C12N5/078 ,  G01N33/569 ,  C07K14/35

CPC classification number: G01N33/6893 ,  C07K14/35 ,  C12N5/0634 ,  G01N33/5695 ,  G01N2333/35 ,  G01N2333/57

Abstract: The present invention concerns a composition comprising at least three peptides derived from Mycobacterium tuberculosis antigen Rv2626c, its use in the diagnostic of latently infected Mycobacterium tuberculosis (LTBI) subjects, corresponding methods of use and kits.

公开(公告)号：US20170298267A1

公开(公告)日：2017-10-19

申请号：US15392754

申请日：2016-12-28

Applicant: CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET)

Inventor： Silvia Nair GOYANES ,  Norma Beatriz DACCORSO ,  Joana Elisa TASQUE

IPC: C09K8/80 ,  C08K3/041 ,  C08K3/00 ,  C08K3/04

CPC classification number: C09K8/80 ,  C08F6/008 ,  C08K3/00 ,  C08K3/04 ,  C08K3/041 ,  C08K3/34 ,  C08K2201/011 ,  C09K8/685 ,  C09K8/887 ,  C09K2208/10 ,  C08L25/06 ,  C08L25/14

Abstract: The present invention relates to new materials composed of reticulate polymer loaded with micro- or nano-loads which result in particles or microparticles to be used in fracking muds for secondary extraction of gas and oil.

公开(公告)号：US09657298B2

公开(公告)日：2017-05-23

申请号：US14360054

申请日：2012-11-22

Applicant: CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) ,  INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA (INTA) ,  INIS BIOTECH LLC

Inventor： Gabriela Cynthia Soto, Sr. ,  Nicolas Daniel Ayub ,  Lorena Maria Setten

IPC: A01N63/00 ,  C12N1/20 ,  C12P19/34 ,  C07H21/04 ,  C12N15/78 ,  C07K14/21 ,  C12N9/02 ,  C12R1/39

CPC classification number: C12N15/78 ,  A01N63/00 ,  C07K14/21 ,  C12N9/0095 ,  C12N9/0097 ,  C12R1/39

Abstract: Recombinant bacterial strains comprising heterologous nif genes in its genome, and capable of fixing nitrogen. The strain may be, for example, a recombinant Pseudomonas fluorescens strain comprising heterologous nif genes in its genome. An inoculum and a method for increasing plant productivity are further described.

公开(公告)号：US09457096B2

公开(公告)日：2016-10-04

申请号：US13843766

申请日：2013-03-15

Applicant: CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

Inventor： David Klatzmann ,  Eliane Piaggio ,  Hugo Lujan

IPC: C12Q1/00 ,  A61K38/28 ,  C07K14/62 ,  A61K38/00 ,  A01N25/00 ,  C07K14/605 ,  A61K38/27 ,  A61K38/26 ,  A61P5/06 ,  A61P3/10 ,  A61P7/12 ,  A61K45/00 ,  A61K47/00 ,  A61K39/00 ,  A61K47/42 ,  C07K14/44 ,  A61K47/48 ,  A61K39/39 ,  A61Q19/00

CPC classification number: A61K47/646 ,  A61K38/00 ,  A61K38/2013 ,  A61K38/2066 ,  A61K38/26 ,  A61K38/27 ,  A61K38/28 ,  A61K38/29 ,  A61K39/39 ,  A61K47/42 ,  A61K47/64 ,  A61P3/10 ,  A61Q19/00 ,  C07K14/44 ,  C07K2319/02 ,  C07K2319/21 ,  Y02A50/491

Abstract: The invention provides compositions for oral delivery and methods of treatment using VSP carriers, such as Giardia sp. variable surface proteins (VSP), to deliver therapeutic agents. VSP drug carriers can be combined with bioactive peptides, e.g., insulin, glucagon, or hGH, and be administered orally or mucosally. VSP carriers are resistant to acidic pHs and to proteolytic degradation and protect therapeutic agents from degradation in the gastrointestinal tract.

Abstract translation: 本发明提供用于口服递送的组合物和使用VSP载体的治疗方法，例如贾第虫属 可变表面蛋白（VSP），以递送治疗剂。 VSP药物载体可与生物活性肽例如胰岛素，胰高血糖素或hGH组合，并口服或粘膜给药。 VSP载体对酸性pH和蛋白水解降解具有抗性，并保护治疗剂免于胃肠道中的降解。

公开(公告)号：US20160220612A1

公开(公告)日：2016-08-04

申请号：US14916963

申请日：2014-09-05

Applicant: CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) ,  ASOCIACION CIVIL DE ESTUDIOS SUPERIORES ,  INIS BIOTECH LLC

Inventor： Guillermo Daniel MAZZOLINI ,  Mariana Gabriela GARCIA ,  Juan BAYO

IPC: A61K35/28 ,  C12N5/077

CPC classification number: A61K35/28 ,  C12N5/0668 ,  C12N5/0669 ,  C12N2501/20 ,  C12N2501/40 ,  C12N2501/998 ,  C12N2502/99

Abstract: The present application is directed to compositions and methods for treating a subject with cancer and/or increasing migration of a mesenchymal stromal cells (MSCs) stimulated with a recombinant autocrine motility factor (rAMF) to a tumor or a tumor cell, e.g. hepatocellular carcinoma (HCC). In addition, methods for increasing adhesion of MSCs to endothelial cells with rAMF are disclosed. In some embodiments, the MSCs comprise a therapeutic agent, e.g., an anti-tumor agent.

Abstract translation: 本申请涉及用癌症治疗受试者和/或增加用重组自分泌运动因子（rAMF）刺激的间充质基质细胞（MSC）向肿瘤或肿瘤细胞例如移植的组合物和方法。 肝细胞癌（HCC）。 此外，公开了通过rAMF增加MSC对内皮细胞粘附的方法。 在一些实施方案中，MSC包含治疗剂，例如抗肿瘤剂。

公开(公告)号：US20160038582A1

公开(公告)日：2016-02-11

申请号：US14780677

申请日：2014-03-25

Applicant: CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) ,  UNIVERSIDAD NACIONAL DE LA PLATA ,  INIS BIOTECH LLC

Inventor： Daniela HOZBOR ,  Daniela BOTTERO ,  María Emelia GAILLARD ,  Eugenia ZURITA ,  Maximiliano OMAZABAL ,  Darío FLORES ,  Agustina ERREA ,  Griselda MORENO ,  Martin RUMBO ,  Erika BARTEL ,  Celina CASTUMA

IPC: A61K39/02

CPC classification number: A61K39/099 ,  A61K39/0018 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55544 ,  A61K2039/70

Abstract: A vaccine for the prevention of infections with Bordetella, comprising at least outer membrane vesicles (OMVs) of B. parapertussis, excipients and/or adjuvants. Bordetella may be, for example, B. pertussis or B. parapertussis. The vaccine can comprise adjuvants, for example, aluminum hydroxide and other immunogens such as tetanus toxoid, diphtheria toxoid, or combinations thereof.In another preferred embodiment, the vaccine for the prevention of infections with Bordetella comprises at least outer membrane vesicles (OMVs) of B. pertussis and the lipopolysaccharide of B. parapertussis, excipients and/or adjuvants. The vaccine can comprise between 3 to 20 μg per dose of OMVs from B. pertussis and between the amount equivalent to 107 and 1010 bacteria per dose of lipopolysaccharide of B. parapertussis. The adjuvant can be aluminum hydroxide and other immunogens such as tetanus toxoid, diphtheria toxoid, or combinations thereof. The Tdap vaccine exhibits cross activity.

Abstract translation: 用于预防博德特氏杆菌感染的疫苗，其至少包含副百日咳杆菌的外膜囊泡（OMV），赋形剂和/或佐剂。 博德特氏菌可以是例如百日咳博德特氏菌或副百日咳杆菌。 疫苗可以包含佐剂，例如氢氧化铝和其它免疫原，例如破伤风类毒素，白喉类毒素或其组合。 在另一个优选的实施方案中，用于预防博德特氏菌感染的疫苗至少包含百日咳杆菌的外膜囊泡（OMV）和副百日咳杆菌的脂多糖，赋形剂和/或佐剂。 该疫苗可以包含3至20μg/剂量的来自百日咳百日咳杆菌的OMV，相当于每剂量百草枯二聚体的107和1010细菌的量。 佐剂可以是氢氧化铝和其它免疫原，例如破伤风类毒素，白喉类毒素或其组合。 Tdap疫苗显示交叉活性。