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公开(公告)号:US20250064984A1
公开(公告)日:2025-02-27
申请号:US18949585
申请日:2024-11-15
Applicant: The University of Bristol
Inventor: Moin Ahson Saleem-Uddin , Gavin Iain Welsh
Abstract: The present invention provides an adeno-associated virus (AAV) vector gene therapy for use in treating a monogenic form of nephrotic syndrome, wherein the AAV vector comprises a NS-associated transgene and minimal nephrin promoter NPHS1 or podocin promoter NPHS2.
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公开(公告)号:US20250032336A1
公开(公告)日:2025-01-30
申请号:US18580111
申请日:2022-07-15
Applicant: The University of Bristol
Inventor: Mojtaba Dorri , Alberto Gambaruto
Abstract: A hood comprising: a barrier defining an interior space for receiving the head of a patient and an opening through which the head may enter and leave the interior space, the barrier being arranged to prevent the transmission of aerosol particles through the barrier; a suction port arranged to remove air from the interior space of the hood; an access hole within the barrier, arranged to allow a person external to the barrier to access the interior space; and an air jet arranged to propel air across the access hole in order to inhibit the transmission of aerosols through the access hole.
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公开(公告)号:US12121593B2
公开(公告)日:2024-10-22
申请号:US17348048
申请日:2021-06-15
Applicant: The University of Bristol
Inventor: Moin Ahson Saleem-Uddin , Gavin Iain Welsh , Wen Yi Ding
CPC classification number: A61K48/005 , C12N15/86 , C12N2750/14143 , C12N2830/48 , C12N2830/50
Abstract: The application provides gene therapies for treating monogenic forms of nephrotic syndrome.
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公开(公告)号:US20240085631A1
公开(公告)日:2024-03-14
申请号:US18370785
申请日:2023-09-20
Applicant: PsiQuantum, Corp. , The University of Bristol
Inventor: Damien Bonneau , Mark Thompson
CPC classification number: G02B6/2861 , G02B6/262 , H01P9/00
Abstract: An optical device includes a first multi-mode waveguide, a first optical coupler coupled to the first multi-mode waveguide, the first coupler being tapered and curved, and a first single-mode waveguide having a first end coupled to the first optical coupler. The optical device maybe used in an optical delay device. A method of propagating light in a first multi-mode waveguide toward a first optical coupler, propagating the light in the first optical coupler toward a first single-mode waveguide, the first optical coupler being tapered and curved, and propagating the light along the first single-mode waveguide is also disclosed.
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公开(公告)号:US11821903B2
公开(公告)日:2023-11-21
申请号:US16644926
申请日:2018-09-06
Applicant: The University of Bristol
Inventor: Derek Neil Woolfson , William Michael Dawson , Guto Glyn Rhys , David Arne Scott , Jordan Michael Fletcher , Christopher Robin Wells Wood
CPC classification number: G01N33/6845 , G01N21/6428 , G01N33/5308
Abstract: A sensor array comprising at least two sensors, wherein each sensor comprises a protein barrel and a reporter dye; wherein the protein barrel defines a lumen; the reporter dye is bound to the lumen reversibly; and wherein the protein barrel is different in structure in the at least two sensors.
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公开(公告)号:US20230365922A1
公开(公告)日:2023-11-16
申请号:US18245560
申请日:2021-09-17
Applicant: The University of Bristol
Inventor: Alistair William Poole , Xioajuan Zhao
CPC classification number: C12N5/0068 , C12M25/14 , C12N5/0644
Abstract: The invention provides a method for generating platelets or platelet-like particles comprising passing a source material comprising one or more cells through a micro-passage to produce a passaged material comprising platelets or platelet-like particles. The invention also provides platelets and platelet-like particles produced using the method and uses thereof.
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公开(公告)号:US11667638B2
公开(公告)日:2023-06-06
申请号:US16326615
申请日:2017-08-17
Applicant: The University of Bristol
Inventor: Timothy Charles Gallagher , Hugo Rego Campello
IPC: C07D471/18 , B01J31/18 , B01J31/24
CPC classification number: C07D471/18 , B01J31/1815 , B01J31/1825 , B01J31/2409
Abstract: Disclosed are novel analogs of cytisine, a process for their preparation, pharmaceutical compositions containing them, and their use in the prevention of or treatment of CNS disorders including addictive disorders.
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公开(公告)号:US20220333077A1
公开(公告)日:2022-10-20
申请号:US17760658
申请日:2020-09-21
Applicant: The University of Bristol
Inventor: Timothy James Satchwell , Ashley Mark Toye , Marjolein Meinders
Abstract: A method of making an erythroid cell comprising elevated levels of a target protein or polypeptide, the method comprising: a) provision of an erythroid progenitor which is able to express the target protein or polypeptide; b) expression of the target protein or polypeptide; and c) maturation of the erythroid progenitor into the erythroid cell; wherein during maturation of the erythroid progenitor into the erythroid cell, the target protein or polypeptide is configured and/or inhibited such that ubiquitination of the target protein or polypeptide is hindered or prevented. Erythroid cells, pharmaceutical compositions and methods of use related thereto, and a method of screening for proteins or polypeptides degraded by ubiquitination during maturation of an erythroid progenitor are also provided.
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公开(公告)号:US11150221B2
公开(公告)日:2021-10-19
申请号:US16612951
申请日:2018-05-24
Inventor: Akinori Tamura , Satoshi Kanno , Paul Wilcox , Anthony Croxford , Chenghuan Zhong
IPC: G01N29/04 , G01N21/17 , G01N21/954 , G01N29/24
Abstract: Provided is a sensor system which can detect a thickness reduction, a crack, or the like of a pipe or a container covered with a thick coating member through ultrasonic inspection without attachment and detachment of the coating member. A sensor system used for nondestructive inspection includes a sensor attached to a surface of an inspection target, a sensor coil that is electrically connected to the sensor via a first cable, a first electromagnetic wave blocking member that is disposed between the surface of the inspection target and the sensor coil, a sensor side coil that is disposed to face the sensor coil with a gap and is coupled to the sensor coil through electromagnetic induction, and a probe side coil that is disposed to be separated from the sensor side coil and is electrically connected to the sensor side coil via a second cable.
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公开(公告)号:US20210060174A1
公开(公告)日:2021-03-04
申请号:US16644354
申请日:2018-09-07
Applicant: THE UNIVERSITY OF BRISTOL
Inventor: Adam Willis PERRIMAN , Robert Christopher DELLER , Wenjin XIAO , Thomas Iain Phillip GREEN , Benjamin Michael CARTER , Graham John DAY , Rosalia Cuahtecontzi DELINT
Abstract: There is provided a phospholipid composition which is a bilayer or micelle comprising at least one embedded protein-polymer surfactant conjugate comprising an anchor protein, wherein the anchor protein is a cationised protein or an anionised protein, the composition characterised in that the anchor protein is: a) an active enzyme; orb) is a protein which does not comprise a —CH2C(O)NCH3(CH2)3NCH3)2H+ linker covalently bonded to an amino acid side chain.
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