公开(公告)号：US20250161350A1

公开(公告)日：2025-05-22

申请号：US18842461

申请日：2023-03-03

Applicant: UNIVERSITY OF PITTSBURGH- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Shilpa Sant ,  Akhil Pravinkumar Patel ,  Vinayak Sant ,  Kerry McGarr Empey ,  Jessica L. Kosanovich

IPC: A61K33/24 ,  A61K9/00 ,  A61K9/14 ,  A61P31/14

Abstract: The invention relates to shape-specific cerium oxide nanoparticles (CNPs). methods of preparing CNPs. and methods of using CNPs to treat and/or inhibit and/or reduce and/or reverse the complications of respiratory syncytial virus (RSV) disease and other infections that cause pathologic immune responses. through the balance of favorable immunomodulation and reduced lung immunopathology. CNPs have the capability to switch between Ce3+ and Ce4+ oxidation states (e.g., to scavenge reactive oxygen species). The shape-specific CNPs are synthesized into various shapes and sizes. These properties offer an opportunity to utilize CNPs to modulate macrophage phenotypes along the spectrum of M1 and M2 phenotypes to combat RSV infection and other infections that cause pathologic immune responses.

公开(公告)号：US20250143716A1

公开(公告)日：2025-05-08

申请号：US18937726

申请日：2024-11-05

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Jason Y. Lee ,  Cyrus J. Darvish ,  Timothy K. Chung

IPC: A61B17/122 ,  A61B17/00 ,  A61B17/32 ,  A61B17/3201 ,  A61B90/00

Abstract: A system for use in connection with a blood vessel includes a proximal section including a control system and a distal section. The distal section has connected thereto an application device configure to apply one or more ligating clips to the blood vessel to mechanically ligate the blood vessel. The application system is in connection with the control system. The distal section further has connected thereto a cutting device which is configured to mechanically cut tissue, including the blood vessel (for example, after compressive force is applied to the vessel via one or the one or more ligating clips).

公开(公告)号：US12294124B2

公开(公告)日：2025-05-06

申请号：US17659672

申请日：2022-04-19

Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  UNITED STATES DEPATMENT OF ENERGY

Inventor： Peng K. Chen ,  Jacob Lorenzi Poole ,  Paul R. Ohodnicki ,  Thomas D. Brown ,  Kirk R. Gerdes ,  Michael P. Buric

IPC: H01M8/0444 ,  H01M8/02 ,  H01M8/0432 ,  H01M8/12 ,  H01M8/2425

Abstract: A method of monitoring operation of a reactor system includes causing a chemical reaction to occur within an assembly of the reactor system, and measuring a chemical composition of one or more reactants of the chemical reaction with spatial resolution at a plurality of points along a path within the assembly using a sensor system structured to implement distributed sensing. The sensor system includes an optical fiber sensing member provided at least partially within the assembly, wherein the optical fiber sensing member comprises a functionalized optical fiber based sensor device structured to exhibit a change in one or more optical properties in response to changes in the chemical composition of the one or more reactants.

公开(公告)号：US12290640B2

公开(公告)日：2025-05-06

申请号：US16660691

申请日：2019-10-22

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education

Inventor： Eric A. Nofzinger ,  Jeffrey J. Schirm

IPC: A61M21/02 ,  A61B17/00 ,  A61F7/00 ,  A61F7/02 ,  A61F7/10 ,  A61H9/00 ,  A61M19/00 ,  A61M21/00 ,  A61N1/04 ,  A61N5/06

Abstract: Methods, systems and devices for reducing anxiety, including increasing relaxation and/or calm. In some variations these methods may include reducing anxiety, increase relaxation and/or calm by non-invasive temperature regulation of the frontal cortex prior to and/or during sleep. The subject may have an anxiety disorder, or may not have a diagnosed anxiety disorder.

公开(公告)号：US12283654B2

公开(公告)日：2025-04-22

申请号：US18100722

申请日：2023-01-24

Applicant: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Prashant N. Kumta ,  Partha Saha ,  Moni Kanchan Datta ,  Ayyakkannu Manivannan

IPC: H01M10/054 ,  C01B19/00 ,  C01G39/00 ,  C01G39/06 ,  H01M4/02 ,  H01M4/58 ,  H01M10/052

Abstract: The invention relates to Chevrel-phase materials and methods of preparing these materials utilizing a precursor approach. The Chevrel-phase materials are useful in assembling electrodes, e.g., cathodes, for use in electrochemical cells, such as rechargeable batteries. The Chevrel-phase materials have a general formula of Mo6Z8 (Z=sulfur) or Mo6Z18-yZ2y (Z1=sulfur; Z2=selenium), and partially cuprated Cu1Mo6S8 as well as partially de-cuprated Cu1-xMgxMo6S8 and the precursors have a general formula of MxMo6Z8 or MxMo6Z18-yZ2y, M=Cu. The cathode containing the Chevrel-phase material in accordance with the invention can be combined with a magnesium-containing anode and an electrolyte.

公开(公告)号：US20250115644A1

公开(公告)日：2025-04-10

申请号：US18816891

申请日：2024-08-27

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Jason Lohmueller

IPC: C07K14/36 ,  A61K35/17 ,  A61K38/00 ,  A61K39/00 ,  A61P35/00 ,  A61P35/02 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C07K16/30

Abstract: A chimeric antigen receptor is disclosed that includes: (a) an extracellular high affinity streptavidin; (b) a hinge domain from CD8; (c) a CD28 transmembrane domain; (d) an intracellular 4-1BB and/or CD28 signaling domain; and (e) an intracellular CD3 zeta signaling domain, wherein (a)-(e) are in N-terminal to C-terminal order. Nucleic acids encoding this chimeric antigen receptor, and T and natural killer (NK) cells transformed with this chimeric antigen receptor are also disclosed. The use of this chimeric antigen receptor for the treatment of tumors is also disclosed.

公开(公告)号：US12266445B2

公开(公告)日：2025-04-01

申请号：US18625784

申请日：2024-04-03

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education

Inventor： Srinivas C. Chennubhotla ,  Filippo Pullara ,  Samantha A. Furman

IPC: G16H30/40 ,  G06F18/23 ,  G16H10/40 ,  G16H30/20

Abstract: A method of characterizing cellular phenotypes includes receiving multi-parameter cellular and sub-cellular imaging data for a number of tissue samples from a number of patients or a number of multicellular in vitro models, performing cellular segmentation on the multi-parameter cellular and sub-cellular imaging data to create segmented multi-parameter cellular and sub-cellular imaging data, and performing recursive decomposition on the segmented multi-parameter cellular and subcellular imaging data to identify a plurality of computational phenotypes. The recursive decomposition includes a plurality of levels of decomposition with each level of decomposition including soft/probabilistic clustering and spatial regularization, and each cell in the segmented multi-parameter cellular and subcellular imaging data is probabilistically assigned to one or more of the plurality of computational phenotypes.

公开(公告)号：US20250099650A1

公开(公告)日：2025-03-27

申请号：US18975525

申请日：2024-12-10

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Stephen F. Badylak ,  Julie Anne Phillippi ,  Thomas G. Gleason ,  George R. Fercana, JR.

IPC: A61L27/36 ,  A61K35/12 ,  A61L27/22 ,  A61L27/50 ,  A61L27/52 ,  C07K14/745 ,  C07K14/75

Abstract: Provided herein are methods of making an ECM gel from vascular tissue. Also provided herein are ECM compositions prepared from vascular tissue, and methods of use of those compositions, for example in treatment of aneurysms, and for vascularization or re-vascularization.

公开(公告)号：US20250090731A1

公开(公告)日：2025-03-20

申请号：US18968598

申请日：2024-12-04

Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： PRASHANT N. KUMTA ,  SUNG JAE CHUNG ,  PARTHA SAHA ,  OLEG VELIKOKHATNYI ,  MONI KANCHAN DATTA ,  DAE HO HONG ,  DA-TREN CHOU

IPC: A61L31/02 ,  A61L31/14 ,  C22C33/10 ,  C22C38/00 ,  C22C38/04 ,  C22C38/14 ,  C22C45/02

Abstract: The invention relates to biodegradable iron alloy-containing compositions for use in preparing medical devices. In addition, biodegradable crystalline and amorphous compositions of the invention exhibit properties that make them suitable for use as medical devices for implantation into a body of a patient. The compositions include elemental iron, and one or more elements selected from manganese, magnesium, zirconium, zinc and calcium. The compositions can be prepared using a high energy milling technique. The resulting compositions and the devices formed therefrom are useful in various surgical procedures, such as but not limited to orthopedic, craniofacial, tracheal, and cardiovascular.

公开(公告)号：US20250090106A1

公开(公告)日：2025-03-20

申请号：US18294504

申请日：2022-08-01

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Michael Schnetz ,  Aman Mahajan ,  David Danks

IPC: A61B5/00 ,  A61B5/021

Abstract: Methods are disclosed for generating a target mean arterial pressure (MAP) for a patient during a surgery. In some implementations, the disclosed methods include calculating the target MAP based on the age, biological sex, emergent surgery status, and American Society of Anesthesiology (ASA) physical status (PS) class of the patient, and a predetermined intraoperative hypotension (IOH) risk benchmark. Treating the patient to maintain a MAP at or above the target MAP during the surgery reduces a risk of IOH during the surgery, a risk of administering an unnecessary therapy to avoid IOH during the surgery; and a risk of not administering a therapeutic MAP-decreasing action during the surgery. In some implementations, the method further comprises conducting the surgery on the patient and treating the patient to maintain the MAP of the patient at or above the target MAP during the surgery. Also provided are systems for implementing the disclosed methods.