公开(公告)号：US09550773B2

公开(公告)日：2017-01-24

申请号：US14684871

申请日：2015-04-13

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Doris Stoermer ,  Joseph F. Dellaria, Jr. ,  David T. Amos ,  Bernhard M. Zimmermann ,  Luke T. Dressel ,  Jason D. Bonk ,  Matthew R. Radmer

IPC: C07D471/04 ,  C07D471/14 ,  A61K31/341 ,  A61K31/351 ,  A61K31/437 ,  A61K31/445

CPC classification number: C07D471/04 ,  A61K31/341 ,  A61K31/351 ,  A61K31/435 ,  A61K31/437 ,  A61K31/445 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并喹啉，吡啶和萘啶环体系（特别是喹啉，四氢喹啉，吡啶，[1,5]萘啶，[1,5]四氢萘并噻嗪）在1位被环状取代基取代的药物组合物 公开了制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：US20150259270A1

公开(公告)日：2015-09-17

申请号：US14434981

申请日：2013-10-09

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Steven J. Martin ,  Luke T. Dressel ,  Aaron E. Hutt ,  Eric A. Schotz ,  Terence D. Spawn ,  Miguel A. Guerra ,  Tatsuo Fukushi ,  Jeremy A. Miller ,  Christopher M. Geise ,  James A. McDonell

IPC: C07C45/58 ,  C07C17/26

CPC classification number: C07C45/58 ,  C07C17/00 ,  C07C17/093 ,  C07C17/26 ,  C07C19/16

Abstract: A method of making α,ω-diiodoperfluoroalkanes includes combining: diatomic iodine, at least one perfluoroalkylene oxide represented by the formula wherein Rf represents a perfluoroalkyl group; and at least one of: a) a first metallic compound comprising nickel, and a second metallic compound comprising molybdenum that is compositionally different from the first metallic compound; or b) a metallic alloy comprising from 50 to 70 percent by weight of nickel and from 20 to 40 percent by weight of molybdenum, based on the total weight of the metallic alloy, thereby producing at least one product represented by the formula I(CF2)nI, wherein n independently represents an integer in the range of from 1 to 11. The total weight of the at least one product wherein n is 3 or greater exceeds the total weight of the at least one product wherein n is 1 or 2 by a factor of at least 4.

Abstract translation: 制备α，ω-二碘全氟烷烃的方法包括组合：双原子碘，至少一种由下式表示的全氟氧化烯，其中Rf表示全氟烷基; 和至少一种：a）包含镍的第一金属化合物和包含与第一金属化合物成分不同的钼的第二金属化合物; 或b）金属合金，其包含基于金属合金的总重量的50-70重量％的镍和20至40重量％的钼，由此产生至少一种由式I表示的产物（CF 2 ）nI，其中n独立地表示1至11范围内的整数。其中n为3或更大的至少一种产物的总重量超过至少一种产物的总重量，其中n为1或2，其中n为1或2， 至少4的因素。

公开(公告)号：US09006264B2

公开(公告)日：2015-04-14

申请号：US14021197

申请日：2013-09-09

Applicant: 3M Innovative Properties Company

Inventor： Doris Stoermer ,  Joseph F. Dellaria, Jr. ,  David T. Amos ,  Bernhard M. Zimmermann ,  Luke T. Dressel ,  Jason D. Bonk

IPC: C07D471/04 ,  A61K31/341 ,  A61K31/351 ,  A61K31/437 ,  A61K31/445 ,  C07D471/14

CPC classification number: C07D471/04 ,  A61K31/341 ,  A61K31/351 ,  A61K31/435 ,  A61K31/437 ,  A61K31/445 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并喹啉，吡啶和萘啶环体系（特别是喹啉，四氢喹啉，吡啶，[1,5]萘啶，[1,5]四氢萘并噻嗪）在1位被环状取代基取代的药物组合物 公开了制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：US20180222906A1

公开(公告)日：2018-08-09

申请号：US15948594

申请日：2018-04-09

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Doris Stoermer ,  Joseph F. Dellaria, Jr. ,  David T. Amos ,  Bernhard M. Zimmermann ,  Luke T. Dressel ,  Jason D. Bonk ,  Matthew R. Radmer

IPC: C07D471/04 ,  C07D471/14

CPC classification number: C07D471/04 ,  A61K31/341 ,  A61K31/351 ,  A61K31/435 ,  A61K31/437 ,  A61K31/445 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

公开(公告)号：US20170129891A1

公开(公告)日：2017-05-11

申请号：US15412850

申请日：2017-01-23

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Doris Stoermer ,  Joseph F. Dellaria, JR. ,  David T. Amos ,  Bernhard M. Zimmermann ,  Luke T. Dressel ,  Jason D. Bonk ,  Matthew R. Radmer

IPC: C07D471/04 ,  C07D471/14

CPC classification number: C07D471/04 ,  A61K31/341 ,  A61K31/351 ,  A61K31/435 ,  A61K31/437 ,  A61K31/445 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

公开(公告)号：US20150218162A1

公开(公告)日：2015-08-06

申请号：US14684871

申请日：2015-04-13

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Doris Stoermer ,  Joseph F. Dellaria, JR. ,  David T. Amos ,  Bernhard M. Zimmermann ,  Luke T. Dressel ,  Jason D. Bonk ,  Matthew R. Radmer

IPC: C07D471/04 ,  C07D471/14

CPC classification number: C07D471/04 ,  A61K31/341 ,  A61K31/351 ,  A61K31/435 ,  A61K31/437 ,  A61K31/445 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并喹啉，吡啶和萘啶环体系（特别是喹啉，四氢喹啉，吡啶，[1,5]萘啶，[1,5]四氢萘并噻嗪）在1位被环状取代基取代的药物组合物 公开了制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：US09938275B2

公开(公告)日：2018-04-10

申请号：US15412850

申请日：2017-01-23

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Doris Stoermer ,  Joseph F. Dellaria, Jr. ,  David T. Amos ,  Bernhard M. Zimmermann ,  Luke T. Dressel ,  Jason D. Bonk ,  Matthew R. Radmer

IPC: C07D471/04 ,  C07D471/14

CPC classification number: C07D471/04 ,  A61K31/341 ,  A61K31/351 ,  A61K31/435 ,  A61K31/437 ,  A61K31/445 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

公开(公告)号：US09212119B2

公开(公告)日：2015-12-15

申请号：US14434981

申请日：2013-10-09

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Steven J. Martin ,  Luke T. Dressel ,  Aaron E. Hutt ,  Eric A. Schotz ,  Terence D. Spawn ,  Miguel A. Guerra ,  Tatsuo Fukushi ,  Jeremy A. Miller ,  Christopher M. Geise ,  James A. McDonell

IPC: C07C21/18 ,  C07C45/58 ,  C07C17/26 ,  C07C17/093

CPC classification number: C07C45/58 ,  C07C17/00 ,  C07C17/093 ,  C07C17/26 ,  C07C19/16

Abstract: A method of making α,ω-diiodoperfluoroalkanes includes combining: diatomic iodine, at least one perfluoroalkylene oxide represented by the formula wherein Rf represents a perfluoroalkyl group; and at least one of: a) a first metallic compound comprising nickel, and a second metallic compound comprising molybdenum that is compositionally different from the first metallic compound; or b) a metallic alloy comprising from 50 to 70 percent by weight of nickel and from 20 to 40 percent by weight of molybdenum, based on the total weight of the metallic alloy, thereby producing at least one product represented by the formula I(CF2)nI, wherein n independently represents an integer in the range of from 1 to 11. The total weight of the at least one product wherein n is 3 or greater exceeds the total weight of the at least one product wherein n is 1 or 2 by a factor of at least 4.

Abstract translation: 制备α，ω-二碘全氟烷烃的方法包括组合：双原子碘，至少一种由下式表示的全氟氧化烯，其中Rf表示全氟烷基; 和至少一种：a）包含镍的第一金属化合物和包含与第一金属化合物成分不同的钼的第二金属化合物; 或b）金属合金，其包含基于金属合金的总重量的50-70重量％的镍和20至40重量％的钼，由此产生至少一种由式I表示的产物（CF 2 ）nI，其中n独立地表示1至11范围内的整数。其中n为3或更大的至少一种产物的总重量超过至少一种产物的总重量，其中n为1或2，其中n为1或2， 至少4的因素。

公开(公告)号：US20140011777A1

公开(公告)日：2014-01-09

申请号：US14021197

申请日：2013-09-09

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Doris Stoermer ,  Joseph F. Dellaria, Jr. ,  David T. Amos ,  Bernhard M. Zimmermann ,  Luke T. Dressel ,  Jason D. Bonk

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61K31/341 ,  A61K31/351 ,  A61K31/435 ,  A61K31/437 ,  A61K31/445 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并喹啉，吡啶和萘啶环体系（特别是喹啉，四氢喹啉，吡啶，[1,5]萘啶，[1,5]四氢萘并噻嗪）在1位被环状取代基取代的药物组合物 公开了制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。