-
1.发明公开公开(公告)号：US20230338535A1
公开(公告)日：2023-10-26
申请号：US18343349
申请日：2023-06-28
发明人： Andrea Pfeifer , Andreas Muhs , Wendy Galpern
CPC分类号： A61K39/4637 , A61K39/4611 , A61K9/1271 , A61K2039/55555 , A61K2039/54 , A61K2039/545 , A61K2039/55572 , A61K2039/55561 , A61K2039/57
摘要： Methods for inducing a sustained immune response against phosphorylated Tau in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist, a helper T-cell epitope, a lipidated CpG oligonucleotide, and a Tau phosphopeptide presented on the surface of the liposome to thereby obtain the sustained immune response.
-
公开(公告)号：US20230257433A1
公开(公告)日：2023-08-17
申请号：US18171498
申请日：2023-02-20
发明人： Elizabeth Anne Ramsburg , Donata De Marco , Chakkumkal Anish , Charlotte Sadaka , Jaap Goudsmit , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , David Hickman , Nicolas Piot , Saroj Raj Ghimire
CPC分类号： C07K14/4711 , A61K39/0007 , A61K9/1271 , A61K2039/627 , A61K2039/55561 , A61K2039/55572 , A61K2039/6018 , A61K2039/55516
摘要： Methods for inducing an immune response against tau protein in a subject suffering from a neurodegenerative disease, disorder or condition, such as Alzheimer's Disease, are described. The methods include administering a liposomal priming composition containing tau peptides, preferably phosphorylated tau peptides, and a conjugate boosting composition containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier.
-
公开(公告)号：US11591377B2
公开(公告)日：2023-02-28
申请号：US16856400
申请日：2020-04-23
发明人： Elizabeth Anne Ramsburg , Donata De Marco , Chakkumkal Anish , Charlotte Sadaka , Jaap Goudsmit , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , David Hickman , Nicolas Piot , Saroj Raj Ghimire
摘要： Methods for inducing an immune response against tau protein in a subject suffering from a neurodegenerative disease, disorder or condition, such as Alzheimer's Disease, are described. The methods include administering a liposomal priming composition containing tau peptides, preferably phosphorylated tau peptides, and a conjugate boosting composition containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier.
-
公开(公告)号：US11124552B2
公开(公告)日：2021-09-21
申请号：US16169215
申请日：2018-10-24
发明人： Elizabeth Anne Ramsburg , Donata De Marco , Charlotte Sadaka , Jaap Goudsmit , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , Nicolas Piot , Saroj Raj Ghimire
摘要： Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.
-
公开(公告)号：US20230381108A1
公开(公告)日：2023-11-30
申请号：US18316829
申请日：2023-05-12
发明人： Andrea Pfeifer , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , Nicolas Piot , Saroj Raj Ghimire , Elizabeth Anne Ramsburg , Donata De Marco , Charlotte Sadaka
CPC分类号： A61K9/1271 , A61P25/28 , A61K39/0007 , A61K2039/545 , A61K2039/627 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/6018 , A61K2039/55516
摘要： Methods for inducing anti-phosphorylated Tau antibodies without inducing a severe adverse event in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist and a Tau phosphopeptide presented on the surface of the liposome.
-
公开(公告)号：US11958889B2
公开(公告)日：2024-04-16
申请号：US16757621
申请日：2018-10-24
发明人： Elizabeth Anne Ramsburg , Donata de Marco , Charlotte Sadaka , Jaap Goudsmit , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , David Hickman , Nicolas Piot , Saroj Raj Ghimire
CPC分类号： C07K14/4711 , A61K9/127 , A61K9/1271 , A61K38/1709 , A61K39/0007 , A61K39/39 , A61P25/28 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/6018 , A61K2039/627
摘要： Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.
-
公开(公告)号：US11684576B2
公开(公告)日：2023-06-27
申请号：US16785011
申请日：2020-02-07
发明人： Andrea Pfeifer , Andreas Muhs , Maria Pihlgren Bosch , Marija Vukicevic Verhille , Nicolas Piot , Saroj Raj Ghimire , Elizabeth Anne Ramsburg , Donata De Marco , Charlotte Sadaka
CPC分类号： A61K9/1271 , A61K39/0007 , A61P25/28 , A61K2039/545 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/6018 , A61K2039/627
摘要： Methods for inducing anti-phosphorylated Tau antibodies without inducing a severe adverse event in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist and a Tau phosphopeptide presented on the surface of the liposome.
-
公开(公告)号：US20240270829A1
公开(公告)日：2024-08-15
申请号：US18395150
申请日：2023-12-22
申请人： AC Immune SA
发明人： Andrea Pfeifer , Andreas Muhs , Rime Madani , Pavel Vasilyevich Belichenko , William Charles Mobley
CPC分类号： C07K16/18 , A61K39/0007 , A61K2039/55555 , A61K2039/6018
摘要： The present invention provides means for treating, alleviating and preventing amyloid-related pathology in young to middle-aged subjects with Down's syndrome (DS). In particular, the present invention provides antigenic peptide fragments derived from amyloid protein or amyloid-like protein for use in the preventive treatment of amyloid-related pathology in young to middle-aged subjects with Down's syndrome.
-
公开(公告)号：US20210139572A1
公开(公告)日：2021-05-13
申请号：US17067100
申请日：2020-10-09
申请人： AC Immune SA , Genentech, Inc.
摘要： The invention provides anti-Tau antibodies and methods of using the same.
-
公开(公告)号：US11352419B2
公开(公告)日：2022-06-07
申请号：US17067100
申请日：2020-10-09
申请人： AC Immune SA , Genentech, Inc.
摘要： The invention provides anti-Tau antibodies and methods of using the same.
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.019 秒)
