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公开(公告)号：US12156991B2
公开(公告)日：2024-12-03
申请号：US16590636
申请日：2019-10-02
Applicant: AMGEN INC.
Inventor： Christian Plambech , Matias Melander
Abstract: Injection systems for drug delivery are disclosed. A system may include a container filled or fillable with a drug, a stopper movably disposed in the container, a plunger, an energy source outputting a force, a mechanical linkage operable to transmit the force output by the energy source to the plunger to cause the plunger to act on the stopper to expel the drug from the container, and a trigger member. The system may have pre-injection state where the trigger member inhibits actuation of the mechanical linkage, an injection state where the trigger member permits actuation of the mechanical linkage, and a post-injection state where the plunger is stationarily positioned in an end-of-dose position. The system may be designed to limit the number of components included in various force transmission loops present in the pre-injection, injection, and/or post-injection states.
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公开(公告)号：US12102808B2
公开(公告)日：2024-10-01
申请号：US17036556
申请日：2020-09-29
Applicant: AMGEN INC.
Inventor： Christian Plambech , Matias Melander , Bjarke Lykke Ludvig Svendsen , Joshua Jay Dudman , Michael Sorensen , Margaux Frances Boyaval , Avon Kuo
CPC classification number: A61M5/3157 , A61M5/2033 , A61M5/3204 , A61M2205/581
Abstract: Drug delivery devices and related arrangements are disclosed. A drug delivery device may include a housing having an opening, a drug storage container including a delivery member with an insertion end configured to extend at least partially through the opening, and a plunger. A drive mechanism may be included for driving the plunger in a distal direction to expel a drug from the drug storage container through the delivery member upon activation. The drug delivery device may additionally include a guard moveably disposed adjacent to the opening and operably coupled to the drive mechanism for activation of the drive mechanism. A lock may be selectively engageable with the guard to limit movement of the guard in the proximal direction. An indicator may be coupled to the drive mechanism to generate an audible signal during drug delivery, and to cease generating the audible signal when drug delivery is complete.
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公开(公告)号：US20210346596A1
公开(公告)日：2021-11-11
申请号：US17277533
申请日：2019-10-15
Applicant: AMGEN INC.
Inventor： Jakob Halkjaer Pedersen , Matias Melander , Christian Plambech , Adam B. McCullough , Rasmus Ohlenschlager
Abstract: An approach for assembling a platform drug delivery device includes providing a set of base components and identifying, based on at least one desired characteristic of the platform drug delivery device, a rear sub-assembly for the drug delivery device from a group of rear sub-assemblies. The identified rear sub-assembly is selected, and a front sub-assembly is identified based on the at least one desired characteristic from a group of front sub-assemblies. The identified front-assembly is selected, and the drug delivery device is assembled using the set of base components, the rear sub-assembly, and the front sub-assembly.
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公开(公告)号：US20240424223A1
公开(公告)日：2024-12-26
申请号：US18696203
申请日：2022-10-05
Applicant: AMGEN INC.
Inventor： Emil Gram Spork , Matias Melander , Alexandre Gegelashvili , Yangkun Song , Thomas Peter Sonderby
IPC: A61M5/32
Abstract: A drug delivery device includes a housing having proximal and distal ends and a longitudinal axis extending therebetween, an injection assembly at least partially disposed within the housing at or near the proximal end, a shield slidably coupled with the housing, a drive assembly operably coupled with the injection assembly and the shield, and a cap. The injection assembly includes a needle or a cannula. The shield is positionable in an extended position in which at least a proximal end thereof extends a distance beyond the proximal end of the housing. The drive assembly is engageable to deliver a medicament via the injection assembly. The cap is removably coupled with at least one of the shield or the housing and is adapted to limit movement of the shield when coupled with the shield and/or the housing such that the drive assembly is restricted from delivering the medicament via the injection assembly.
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Patent Agency Ranking
公开(公告)号：US11904143B2
公开(公告)日：2024-02-20
申请号：US16609466
申请日：2018-06-04
Applicant: AMGEN INC.
Inventor： Adam B. McCullough , Ronald Forster , Joseph Michael Iglesias , Matias Melander , Rasmus Øhlenschlaeger , Christian Plambech , Lars Stenholt , Bjarke Lykke Ludvig Svendsen
CPC classification number: A61M5/3145 , A61M5/20 , A61M5/31583 , A61M2005/3143
Abstract: An injector includes a housing having a syringe assembly and an actuating mechanism at least partially disposed within the housing. The syringe assembly includes a syringe barrel that stores a medicament to be injected into a user, a needle assembly, and a filter member disposed adjacent to the needle assembly. The actuating mechanism is operatively coupled to the syringe assembly and includes a torque spring that exerts a torque to urge the medicament through the filter member to be injected into the user. The actuating mechanism further includes a damper mechanism that exerts an opposing force to dampen the motion exerted by the torque spring.
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公开(公告)号：US20240390599A1
公开(公告)日：2024-11-28
申请号：US18789085
申请日：2024-07-30
Applicant: AMGEN INC.
Inventor： Christian Plambech , Matias Melander , Bjarke Lykke Ludvig Svendsen , Joshua Jay Dudman , Michael Sorensen , Margaux Frances Boyaval , Avon Kuo
Abstract: Drug delivery devices and related arrangements are disclosed. A drug delivery device may include a housing having an opening, a drug storage container including a delivery member with an insertion end configured to extend at least partially through the opening, and a plunger. A drive mechanism may be included for driving the plunger in a distal direction to expel a drug from the drug storage container through the delivery member upon activation. The drug delivery device may additionally include a guard moveably disposed adjacent to the opening and operably coupled to the drive mechanism for activation of the drive mechanism. A lock may be selectively engageable with the guard to limit movement of the guard in the proximal direction. An indicator may be coupled to the drive mechanism to generate an audible signal during drug delivery, and to cease generating the audible signal when drug delivery is complete.
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公开(公告)号：US11878149B2
公开(公告)日：2024-01-23
申请号：US17036129
申请日：2020-09-29
Applicant: AMGEN INC.
Inventor： Emil Finkelstein , Soren Forbech Skall , Lars Eilertsen , Matias Melander , Jan Jensen
CPC classification number: A61M5/31536 , A61M5/20 , A61M5/3137 , A61M5/3157 , A61M5/3204 , A61M2205/581 , A61M2205/582
Abstract: A drug delivery device may include a housing defining a longitudinal axis and having an opening and a drug storage container including a delivery member having an insertion end configured to extend at least partially through the opening during a delivery state. The device may also include plunger moveable toward the distal end of the drug storage container to expel a drug from the drug storage container through the delivery member, the plunger including a body portion having an inner wall defining an axial chamber and an outer wall cooperating with the inner wall to define a body thickness. The device may further include a plunger biasing member disposed at least partially within the axial chamber, the plunger biasing member configured to urge the plunger toward the distal end of the drug storage container.
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公开(公告)号：US20210093793A1
公开(公告)日：2021-04-01
申请号：US17036129
申请日：2020-09-29
Applicant: AMGEN INC.
Inventor： Emil Finkelstein , Soren Forbech Skall , Lars Eilertsen , Matias Melander , Jan Jensen
IPC: A61M5/315
Abstract: A drug delivery device may include a housing defining a longitudinal axis and having an opening and a drug storage container including a delivery member having an insertion end configured to extend at least partially through the opening during a delivery state. The device may also include plunger moveable toward the distal end of the drug storage container to expel a drug from the drug storage container through the delivery member, the plunger including a body portion having an inner wall defining an axial chamber and an outer wall cooperating with the inner wall to define a body thickness. The device may further include a plunger biasing member disposed at least partially within the axial chamber, the plunger biasing member configured to urge the plunger toward the distal end of the drug storage container.
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