公开(公告)号：US20230381114A1

公开(公告)日：2023-11-30

申请号：US18201559

申请日：2023-05-24

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyuk KIM ,  Chaeyeon Song ,  Joonho Choi

IPC: A61K9/51 ,  A61K31/728 ,  A61K8/02

CPC classification number: A61K9/5192 ,  A61K31/728 ,  A61K8/0241 ,  A61K2800/413

Abstract: The present disclosure relates to a method for preparing hyaluronic acid nanoparticle and to hyaluronic acid nanoparticle prepared by the method. In one aspect of the present disclosure, the method for preparing hyaluronic acid nanoparticle can minimize the size of the hyaluronic acid nanoparticle, and the hyaluronic acid nanoparticle prepared by the method has low viscosity characteristics and is excellent in spreadability, and can penetrate the stratum corneum evenly when applied to the skin.

公开(公告)号：US11896640B2

公开(公告)日：2024-02-13

申请号：US16742812

申请日：2020-01-14

Applicant: AMOREPACIFIC CORPORATION

Inventor： Juewon Kim ,  Si Young Cho ,  Hyungsu Kim ,  Wonseok Park ,  Joonho Choi ,  Dong Hyun Kim ,  Jaewon You ,  Miyoung Park

IPC: A61K36/82 ,  A23L33/105 ,  A61K8/97 ,  A61Q19/02 ,  A61Q19/08

CPC classification number: A61K36/82 ,  A23L33/105 ,  A61K8/97 ,  A61Q19/02 ,  A61Q19/08 ,  A61K2800/782

Abstract: Disclosed is to provide a composition for skin-whitening or preventing or improving skin wrinkles, comprising a green tea extract which has modified amounts of ingredients. More specifically, the extract and composition according to one aspect of the present disclosure are derived from natural plants that cause less irritation to the skin and are eco-friendly, thus they are safe, and thereby the extract and composition can exhibit excellent effects of effectively inhibiting melanin production and tyrosinase activity and preventing or improving skin whitening, and can exhibit excellent effects of effectively inhibiting the expression of MMP-1 and preventing or improving skin wrinkles.

公开(公告)号：US11382900B2

公开(公告)日：2022-07-12

申请号：US16805202

申请日：2020-02-28

Applicant: AMOREPACIFIC CORPORATION

Inventor： Gyeyoung Choi ,  Hyunjin Nam ,  Miyoung Park ,  Kyoungmi Jung ,  Jihae Lee ,  Chang Soon Choi ,  Youngho Park ,  Jong Hwa Roh ,  Eunsil Park ,  Jaehong Park ,  Kwanghyun Shin ,  Byoung Young Woo ,  Kiwha Lee ,  Wonkyung Cho ,  Joonho Choi

IPC: A61K31/44 ,  A61K9/00 ,  A61K9/06

Abstract: Disclosed is a method for preventing or treating sleep disorders using TRPV1 receptor antagonist, (R)—N-[1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-3-(2-propyl-6-trifluoromethyl-pyridin-3-yl)-acrylamide. The method of the present invention can effectively and safely prevent or treat sleep disorders accompanying pruritus caused by atopic dermatitis.

公开(公告)号：US10479763B2

公开(公告)日：2019-11-19

申请号：US15325349

申请日：2016-02-15

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young Woo ,  Ki-Wha Lee ,  Kwang-Hyun Shin ,  Miyoung Park ,  Kyoungmi Jung ,  Joonho Choi ,  Gyeyoung Choi ,  Wonkyung Cho ,  Young-Ho Park

IPC: C07C303/42 ,  C07C303/36 ,  C07C311/08 ,  C07C303/44 ,  C07D213/56 ,  C07B57/00 ,  C07C63/06

Abstract: The present specification relates to a chiral resolution method of a stereoisomer mixture, comprising a step of mixing a stereoisomer mixture of compounds, in which an amine group is bound to an asymmetric carbon atom, with a chiral auxiliary and salt-forming auxiliary compound, wherein the chiral auxiliary is an O,O′-diacyltartaric acid derivative, more specifically, a 2,3-dibenzoyl-tartaric acid or O,O′-di-p-toluoyl tartaric acid, the salt-forming auxiliary compound is mandelic acid or camphorsulfonic acid, and an optical isomer having a high level of optical purity can be obtained by using the method. Therefore, according to one aspect of the present invention, the method can be useful in pharmaceutical or cosmetic field when preparing an optical isomer having a high optical purity.

公开(公告)号：US12178837B2

公开(公告)日：2024-12-31

申请号：US18520281

申请日：2023-11-27

Applicant: AMOREPACIFIC CORPORATION

Inventor： Juewon Kim ,  Si Young Cho ,  Hyungsu Kim ,  Wonseok Park ,  Joonho Choi ,  Dong Hyun Kim ,  Jaewon You ,  Miyoung Park

IPC: A61K36/82 ,  A23L33/105 ,  A61K8/97 ,  A61Q19/02 ,  A61Q19/08

Abstract: Disclosed is to provide a composition for skin-whitening or preventing or improving skin wrinkles, comprising a green tea extract which has modified amounts of ingredients. More specifically, the extract and composition according to one aspect of the present disclosure are derived from natural plants that cause less irritation to the skin and are eco-friendly, thus they are safe, and thereby the extract and composition can exhibit excellent effects of effectively inhibiting melanin production and tyrosinase activity and preventing or improving skin whitening, and can exhibit excellent effects of effectively inhibiting the expression of MMP-1 and preventing or improving skin wrinkles.

公开(公告)号：US11998633B2

公开(公告)日：2024-06-04

申请号：US17289382

申请日：2019-10-16

Applicant: Amorepacific Corporation

Inventor： Wonkyung Cho ,  Kwanghyun Shin ,  Joonho Choi ,  Kiwha Lee ,  Jong Hwa Roh ,  Miyoung Park ,  Youngho Park ,  Eunsil Park ,  Jaehong Park ,  Byoung Young Woo ,  Min Soo Kim ,  Eun Sol Ha

IPC: A61K9/08 ,  A61K9/06 ,  A61K31/44 ,  A61K47/10 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61K9/00

CPC classification number: A61K9/06 ,  A61K31/44 ,  A61K47/10 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61K9/0014

Abstract: One aspect of the present disclosure relates to a sol-gel composition enabling reversible sol-gel transition and, more specifically, to a sol-gel composition of which the viscosity changes by external physical force so that reversible sol-gel transition is performed.

公开(公告)号：US12059412B2

公开(公告)日：2024-08-13

申请号：US16976140

申请日：2019-03-21

Applicant: Amorepacific Corporation

Inventor： Joonho Choi ,  Wonkyung Cho ,  Jong Hwa Roh ,  Kwanghyun Shin ,  Byoung Young Woo ,  Min Soo Kim ,  Miyoung Park ,  Youngho Park ,  Eunsil Park ,  Jaehong Park ,  Kiwha Lee

IPC: A61K31/44 ,  A61K9/00 ,  A61K31/79 ,  A61K47/32

CPC classification number: A61K31/44 ,  A61K9/0014 ,  A61K47/32

Abstract: One aspect of the present disclosure relates to a pharmaceutical composition, containing (R)-N-[1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-3-(2-propyl-6-trifluoromethyl-pyridin-3-yl)-acrylamide as a first ingredient and containing a vinylpyrrolidone-based polymer as a second ingredient. The composition of one aspect of the present disclosure has a formulation characteristic in which the crystal formation of a compound represented by chemical formula 1 is delayed for a long time.

公开(公告)号：US11878008B2

公开(公告)日：2024-01-23

申请号：US16805381

申请日：2020-02-28

Applicant: AMOREPACIFIC CORPORATION

Inventor： Gyeyoung Choi ,  Hyunjin Nam ,  Miyoung Park ,  Kyoungmi Jung ,  Jihae Lee ,  Chang Soon Choi ,  Youngho Park ,  Jong Hwa Roh ,  Eunsil Park ,  Jaehong Park ,  Kwanghyun Shin ,  Byoung Young Woo ,  Kiwha Lee ,  Wonkyung Cho ,  Joonho Choi

IPC: A61P17/04 ,  A61K31/44 ,  A61K9/00

CPC classification number: A61K31/44 ,  A61K9/0014 ,  A61P17/04

Abstract: Disclosed is a method for preventing or treating atopic dermatitis using TRPV1 receptor antagonist. More specifically, it may be possible to prevent and/or treat the atopic dermatitis without any side effects such as an increase in body temperature, epidermal atrophy, and the like by percutaneously administrating a composition for external use on the skin containing the TRPV1 receptor antagonist.