公开(公告)号：US20170342027A1

公开(公告)日：2017-11-30

申请号：US15325349

申请日：2016-02-15

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young WOO ,  Ki-Wha LEE ,  Kwang-Hyun SHIN ,  Miyoung PARK ,  Kyoungmi JUNG ,  Joonho CHOI ,  Gyeyoung CHOI ,  Wonkyung CHO ,  Young-Ho PARK

IPC: C07C303/42 ,  C07C63/06 ,  C07B57/00 ,  C07C311/08 ,  C07C303/36

CPC classification number: C07C303/42 ,  C07B57/00 ,  C07B2200/07 ,  C07C63/06 ,  C07C303/36 ,  C07C303/44 ,  C07C311/08 ,  C07D213/56

Abstract: The present specification relates to a chiral resolution method of a stereoisomer mixture, comprising a step of mixing a stereoisomer mixture of compounds, in which an amine group is bound to an asymmetric carbon atom, with a chiral auxiliary and salt-forming auxiliary compound, wherein the chiral auxiliary is an O,O′-diacyltartaric acid derivative, more specifically, a 2,3-dibenzoyl-tartaric acid or O,O′-di-p-toluoyl tartaric acid, the salt-forming auxiliary compound is mandelic acid or camphorsulfonic acid, and an optical isomer having a high level of optical purity can be obtained by using the method. Therefore, according to one aspect of the present invention, the method can be useful in pharmaceutical or cosmetic field when preparing an optical isomer having a high optical purity.

公开(公告)号：US20230095813A1

公开(公告)日：2023-03-30

申请号：US17935949

申请日：2022-09-28

Applicant: AMOREPACIFIC CORPORATION

Inventor： Changyong MOON ,  Su Hwan KIM ,  Jihae LEE ,  Kyoungmi JUNG ,  Wonkyung CHO ,  Wanki KIM ,  Jong Hwa ROH ,  Chan WOONG PARK

IPC: A61K31/197 ,  A61K31/198 ,  A61K31/455 ,  A61P25/00 ,  A61K9/20 ,  A61K9/48 ,  A61K9/14 ,  A61K9/16 ,  A61K9/00 ,  A23L33/15 ,  A23L33/175

Abstract: The present disclosure relates to a composition for improving sleep quality, including γ-aminobutyric acid (GABA) or a salt, hydrate or solvate thereof; and at least one of arginine, niacin, and salts, hydrates and solvates thereof. The composition for improving sleep quality may improve the sleep quality by increasing melatonin secretion. In addition, in another aspect, the present disclosure provides a composition for alleviating stress, including γ-aminobutyric acid (GABA) or a salt, hydrate or solvate thereof; and at least one of arginine, niacin, and salts, hydrates and solvates thereof.

公开(公告)号：US20240180993A1

公开(公告)日：2024-06-06

申请号：US18442847

申请日：2024-02-15

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyunjin NAM ,  Juewon KIM ,  Miyoung PARK ,  Kyoungmi JUNG ,  Jinoh CHUNG ,  Gyeyoung CHOI ,  Wanki KIM

IPC: A61K36/82 ,  A23L2/52 ,  A23L33/00 ,  A23L33/105 ,  A61K9/00 ,  A61K31/353 ,  A61P7/00 ,  A61P11/16

CPC classification number: A61K36/82 ,  A23L2/52 ,  A23L33/105 ,  A23L33/40 ,  A61K9/0056 ,  A61K31/353 ,  A61P7/00 ,  A61P11/16 ,  A23V2002/00 ,  A61K2236/33 ,  A61K2236/331 ,  A61K2236/333

Abstract: An aspect of the present disclosure relates to a composition for improving respiratory health exposed to particulate matter, which contains a green tea extract, a green tea polysaccharide and a green tea flavonol as active ingredients. The composition provided in an aspect of the present disclosure can improve respiratory health damaged by exposure to particulate matter by enhancing the effect of preventing adsorption of particulate matter to bronchial epithelial cells and activating the cilia of bronchial epithelial cells. The composition provided in an aspect of the present disclosure may decrease blood heavy metal level.

公开(公告)号：US20210379136A1

公开(公告)日：2021-12-09

申请号：US17341868

申请日：2021-06-08

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyunjin NAM ,  Juewon KIM ,  Miyoung PARK ,  Kyoungmi JUNG ,  Jinoh CHUNG ,  Gyeyoung CHOI ,  Wanki KIM

IPC: A61K36/82 ,  A61P11/16 ,  A61P7/00 ,  A61K31/353 ,  A61K9/00 ,  A23L33/00 ,  A23L33/105 ,  A23L2/52

Abstract: An aspect of the present disclosure relates to a composition for improving respiratory health exposed to particulate matter, which contains a green tea extract, a green tea polysaccharide and a green tea flavonol as active ingredients. The composition provided in an aspect of the present disclosure can improve respiratory health damaged by exposure to particulate matter by enhancing the effect of preventing adsorption of particulate matter to bronchial epithelial cells and activating the cilia of bronchial epithelial cells. The composition provided in an aspect of the present disclosure may decrease blood heavy metal level.