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公开(公告)号:US20190055196A1
公开(公告)日:2019-02-21
申请号:US16108230
申请日:2018-08-22
Applicant: AbbVie Inc.
Inventor: Maria A. Argiriadi , Eric C. Breinlinger , Kevin P. Cusack , Adrian D. Hobson , Dominique Potin , Martine Barth , Jerome Amaudrut , Olivia Poupardin , Laurent Mounier , Michael E. Kort
IPC: C07D209/08 , C07D231/56 , C07D235/16 , C07D471/04 , C07D235/06 , C07D405/14 , C07D491/107 , C07D401/06 , C07D405/12 , C07D401/14 , C07D403/10 , C07D401/10 , C07D209/18 , C07D209/14 , C07D491/10 , C07D405/10 , C07D487/04
Abstract: The invention provides compounds of Formula (I) pharmaceutically acceptable salts, thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological conditions.
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公开(公告)号:US10273238B2
公开(公告)日:2019-04-30
申请号:US15852179
申请日:2017-12-22
Applicant: AbbVie Inc.
Inventor: Eric C. Breinlinger , Andrew Burchat , Justin Dietrich , Michael Friedman , David Ihle , David Kinsman , Kelly Mullen , Augustine Osuma , Anil Vasudevan , Noel S. Wilson
IPC: C07D487/04 , C07D519/00 , C07D498/04
Abstract: The disclosure provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the disclosure are useful for treating immunological and oncological conditions.
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公开(公告)号:US20160362370A1
公开(公告)日:2016-12-15
申请号:US15176309
申请日:2016-06-08
Applicant: AbbVie Inc.
Inventor: Maria A. Argiriadi , Eric C. Breinlinger , Kevin P. Cusack , Adrian D. Hobson , Dominique Potin , Martine Barth , Jerome Amaudrut , Olivia Poupardin , Laurent Mounier , Michael E. Kort
IPC: C07D209/08 , C07D403/10 , C07D401/14 , C07D405/12 , C07D231/56 , C07D491/107 , C07D405/14 , C07D235/06 , C07D471/04 , C07D487/04 , C07D401/10 , C07D401/06
CPC classification number: C07D209/08 , C07D209/14 , C07D209/18 , C07D231/56 , C07D235/06 , C07D235/16 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/10 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/107
Abstract: The invention provides compounds of Formula (I) pharmaceutically acceptable salts, thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological conditions.
Abstract translation: 其药学上可接受的盐,其中所述变量在本文中定义。 本发明的化合物可用于治疗免疫学病症。
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公开(公告)号:US20160304517A1
公开(公告)日:2016-10-20
申请号:US15130362
申请日:2016-04-15
Applicant: AbbVie Inc.
Inventor: Eric C. Breinlinger , Phil B. Cox , Jerome Daanen , Justin Dietrich , Stevan Djuric , Amanda W. Dombrowski , Kristine E. Frank , Michael M. Friedman , Arthur Gomtsyan , Huan-Qui Li , Kenton Longenecker , Augustine Osuma , Ann Marie Rowley , Robert Schmidt , Anil Vasudevan , Noel Wilson
IPC: C07D471/04 , C07D491/147 , C07D491/22 , C07D498/04 , C07D471/18 , C07D471/14 , C07D498/22 , C07D498/14 , C07D498/20 , C07D487/04 , C07D519/00
CPC classification number: C07D471/04 , C07D471/14 , C07D471/18 , C07D487/04 , C07D491/147 , C07D491/22 , C07D498/04 , C07D498/14 , C07D498/18 , C07D498/20 , C07D498/22 , C07D519/00
Abstract: The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.
Abstract translation: 本发明提供三环杂环化合物,药学上可接受的盐,前药,生物活性代谢物,立体异构体和异构体,其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号:US20210130293A1
公开(公告)日:2021-05-06
申请号:US16654141
申请日:2019-10-16
Applicant: AbbVie Inc.
Inventor: Maria A. Argiriadi , Eric C. Breinlinger , Kevin P. Cusack , Adrian D. Hobson , Dominique Potin , Martine Barth , Jerome Amaudrut , Olivia Poupardin , Laurent Mounier , Michael E. Kort
IPC: C07D209/08 , C07D401/10 , C07D403/10 , C07D401/14 , C07D405/12 , C07D401/06 , C07D491/107 , C07D405/14 , C07D235/06 , C07D471/04 , C07D487/04 , C07D231/56 , C07D235/16 , C07D405/10 , C07D491/10 , C07D209/14 , C07D209/18
Abstract: The invention provides compounds of Formula (I) pharmaceutically acceptable salts, thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological conditions.
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公开(公告)号:US20200255423A1
公开(公告)日:2020-08-13
申请号:US16654219
申请日:2019-10-16
Applicant: AbbVie Inc.
Inventor: Maria A. Argiriadi , Eric C. Breinlinger , Ellen Yulin Tsai Chien , Marlon D. Cowart , Kristine E. Frank , Michael M. Friedman , David J. Hardee , J. Martin Herold , Huaqing Liu , Wei Qiu , Marc J. Scanio , Michael R. Schrimpf , Thomas R. Vargo , Stacy A. Van Epps , Matthew P. Webster , Andrew J. Little , Matthew H. Katcher , Theresa A. Dunstan , David A. Schiedler
IPC: C07D471/04 , C07D487/04
Abstract: Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4a, R4b, X1, X2, X3, X4, X5, and n are as defined herein, pharmaceutical compositions comprising same, and methods of preparation and use.
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公开(公告)号:US20190276450A1
公开(公告)日:2019-09-12
申请号:US16299485
申请日:2019-03-12
Applicant: AbbVie Inc.
Inventor: Maria A. Argiriadi , Eric C. Breinlinger , Ellen Yulin Tsai Chien , Marlon D. Cowart , Kristine E. Frank , Michael M. Friedman , David J. Hardee , J. Martin Herold , Huaqing Liu , Wei Qiu , Marc J. Scanio , Michael R. Schrimpf , Thomas R. Vargo , Stacy A. Van Epps , Matthew P. Webster , Andrew J. Little , Matthew H. Katcher
IPC: C07D471/04
Abstract: Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4a, R4b, X1, X2, X3, X4, X5, and n are as defined herein, pharmaceutical compositions comprising same, and methods of preparation and use.
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公开(公告)号:US20180215764A1
公开(公告)日:2018-08-02
申请号:US15852179
申请日:2017-12-22
Applicant: AbbVie Inc.
Inventor: Eric C. Breinlinger , Andrew Burchat , Justin D. Dietrich , Michael Friedman , David Ihle , David Kinsman , Kelly Mullen , Augustine T. Osuma , Anil Vasudevan , Noel S. Wilson
IPC: C07D487/04 , C07D519/00 , C07D498/04
CPC classification number: C07D487/04 , C07D498/04 , C07D519/00
Abstract: The disclosure provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the disclosure are useful for treating immunological and oncological conditions.
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公开(公告)号:US09856253B2
公开(公告)日:2018-01-02
申请号:US15130362
申请日:2016-04-15
Applicant: AbbVie Inc.
Inventor: Eric C. Breinlinger , Phil B. Cox , Justin Dietrich , Kristine E. Frank , Michael M. Friedman , Huan-Qui Li , Kenton Longenecker , Augustine Osuma , Ann Marie Rowley , Anil Vasudevan , Noel Wilson
IPC: C07D227/00 , C07D471/04 , C07D471/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/18 , C07D498/20 , C07D498/22 , C07D519/00 , C07D471/18 , C07D491/147 , C07D491/22
CPC classification number: C07D471/04 , C07D471/14 , C07D471/18 , C07D487/04 , C07D491/147 , C07D491/22 , C07D498/04 , C07D498/14 , C07D498/18 , C07D498/20 , C07D498/22 , C07D519/00
Abstract: The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.
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公开(公告)号:US10106501B2
公开(公告)日:2018-10-23
申请号:US15176309
申请日:2016-06-08
Applicant: AbbVie Inc.
Inventor: Maria A. Argiriadi , Eric C. Breinlinger , Kevin P. Cusack , Adrian D. Hobson , Dominique Potin , Martine Barth , Jerome Amaudrut , Olivia Poupardin , Laurent Mounier , Michael E. Kort
IPC: C07D209/08 , C07D401/10 , C07D403/10 , C07D401/14 , C07D405/12 , C07D401/06 , C07D491/107 , C07D405/14 , C07D235/06 , C07D471/04 , C07D487/04 , C07D231/56 , C07D235/16 , C07D405/10 , C07D491/10 , C07D209/14 , C07D209/18
Abstract: The invention provides compounds of Formula (I) pharmaceutically acceptable salts, thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological conditions.
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