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22 条记录 (耗时 0.02 秒)

    Method of treatment using an anticoagulant polypeptide
    2.
    发明授权
    Method of treatment using an anticoagulant polypeptide 失效
    使用抗凝血多肽的治疗方法

    公开(公告)号：US5179081A

    公开(公告)日：1993-01-12

    申请号：US693063

    申请日：1991-05-01

    申请人： Akio Iwasaki ,  Makoto Suda ,  Yushi Saino

    发明人： Akio Iwasaki ,  Makoto Suda ,  Yushi Saino

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/18

    CPC分类号： C07K14/4721 ,  C07K16/18 ,  A61K38/00

    摘要： A polypeptide having an amino acid sequence as shown in FIG. 1 and its preparation method are disclosed. A DNA fragment capable of coding CPBII polypeptide (human placenta-derived coagulation inhibitor) is first obtained from the human placental cDNA library by using a CPBII-specific antibody as a probe. Then, microorganism cells are transformed by the use of a recombinant plasmid incorporated with the DNA fragment, allowing the resultant transformant to express the CPBII gene, to finally obtain a CPBII-like polypeptide. The polypeptide of this invention exhibits strong anticoagulation activities, and useful for an active component of anticoagulation medicines and preventin in vivo blood coagulation.

    摘要翻译： 具有如图1所示的氨基酸序列的多肽。 1及其制备方法。 首先通过使用CPBII特异性抗体作为探针从人胎盘cDNA文库中获得能够编码CPBII多肽（人胎盘来源的凝血抑制剂）的DNA片段。 然后，通过使用掺入DNA片段的重组质粒转化微生物细胞，使得到的转化体表达CPBII基因，最终获得CPBII样多肽。 本发明的多肽表现出强的抗凝活性，对抗凝药物的活性成分和体内血液凝固有效。

    Microorganism capable of microbially decomposing chloro-, methylthio- and methoxy-triazine agrichemicals
    5.
    发明授权
    Microorganism capable of microbially decomposing chloro-, methylthio- and methoxy-triazine agrichemicals 有权
    微生物能够微量分解氯，甲硫基和甲氧基三嗪农药

    公开(公告)号：US08168420B2

    公开(公告)日：2012-05-01

    申请号：US12513573

    申请日：2007-11-20

    申请人： Kazuhiro Takagi ,  Kunihiko Fujii ,  Naoki Harada ,  Akio Iwasaki

    发明人： Kazuhiro Takagi ,  Kunihiko Fujii ,  Naoki Harada ,  Akio Iwasaki

    IPC分类号： C12N1/20 ,  C02F3/34 ,  A62D3/02

    CPC分类号： B09C1/10 ,  A62D3/02 ,  A62D2101/26 ,  C02F3/34 ,  C02F2101/306 ,  C12R1/01 ,  Y10S435/822

    摘要： Disclosed are: a novel microorganism which can decompose a methylthiotriazine compound (particularly, simetryn, dimethametryn, prometryn), a chlorotriazine compound (particularly, simazine, atrazine, propazine) and a methoxytriazine compound (particularly, simeton, atraton, prometon) which have been frequently used as agrichemicals or the like; and a method for decomposing a methylthiotriazine compound, a chlorotriazine compound and/or a methoxytriazine compound by using the microorganism. Specifically disclosed are: a novel bacterium Nocardioides sp. strain MTD22 which is capable of decomposing a methylthiotriazine compound, a chlorotriazine compound and a methoxytriazine compound; and a method for decomposing a methylthiotriazine compound, a chlorotriazine compound and/or a methoxytriazine compound, particularly simetryn, dimethametryn, prometryn, simazine, atrazine, propazine, simeton, atraton and/or prometon, by using the microorganism.

    摘要翻译： 公开了一种可以分解甲基硫代三嗪化合物（特别是西米特，二甲基丙烯酸甲酯，prometryn），氯代三嗪化合物（特别是西马拉嗪，莠去津，丙嗪）和甲氧基三嗪化合物（特别是西蒙特，阿特拉津，普罗特酮）的新型微生物， 经常用作农药等; 以及通过使用微生物分解甲基硫代三嗪化合物，氯代三嗪化合物和/或甲氧基三嗪化合物的方法。 具体公开的是：新型细菌诺卡氏菌属 能够分解甲基硫代三嗪化合物，氯代三嗪化合物和甲氧基三嗪化合物的菌株MTD22; 以及通过使用该微生物分解甲基硫代三嗪化合物，氯代三嗪化合物和/或甲氧基三嗪化合物，特别是西蒙特，二甲基丙烯酸，衍生物，西马拉平，莠去津，丙嗪，西蒙，阿特拉津和/或前导子的方法。

    Process for production of antibiotics and novel antibiotics produced thereby
    6.
    发明授权
    Process for production of antibiotics and novel antibiotics produced thereby 失效
    生产抗生素的方法和由此生产的新型抗生素

    公开(公告)号：US4425430A

    公开(公告)日：1984-01-10

    申请号：US281898

    申请日：1981-07-09

    申请人： Akio Iwasaki ,  Takeo Deushi ,  Isamu Watanabe ,  Toshihito Mori

    发明人： Akio Iwasaki ,  Takeo Deushi ,  Isamu Watanabe ,  Toshihito Mori

    IPC分类号： C07H15/224 ,  C12P19/48 ,  A01N63/02 ,  C12R1/01

    CPC分类号： C07H15/224 ,  C12P19/48 ,  C12R1/01 ,  Y10S435/822

    摘要： A process for producing an antibiotic, which comprises cultivating an antibiotic KA-6606-producing strain of an genus Saccharopolyspora in a nutrient culture medium, isolating the antibiotic KA-6606-containing substance from the culture broth, and separating from the resulting antibiotic KA-6606-containing substance at least one antibiotic selected from the group consisting of antibiotic KA-6606 VII, KA-6606 VIII, KA-6606 IX, KIA-6606 X, KA-6606 XI, KA-6606 XII, KA-6606 XIII, KA-6606 XIV, KA-6606 XV, KIA-6606 XVI and KA-6606 XVII; and novel antibiotics KA-6606 XII, XIII and XV to XVII.

    摘要翻译： 一种生产抗生素的方法，其包括在营养培养基中培养产生抗生素KA-6606的产酵菌属菌株，从培养液中分离含抗生素KA-6606的物质，并从得到的抗生素KA- 含有6606的物质，选自抗生素KA-6606 VII，KA-6606 VIII，KA-6606 IX，KIA-6606X，KA-6606 XI，KA-6606 XII，KA-6606 XIII， KA-6606 XIV，KA-6606 XV，KIA-6606 XVI和KA-6606 XVII; 和新型抗生素KA-6606 XII，XIII和XV至XVII。

    Movable backing system
    7.
    发明授权
    Movable backing system 失效
    可移动支撑系统

    公开(公告)号：US5590829A

    公开(公告)日：1997-01-07

    申请号：US495653

    申请日：1995-10-18

    申请人： Akitoshi Masamura ,  Yuichi Kimura ,  Akio Iwasaki

    发明人： Akitoshi Masamura ,  Yuichi Kimura ,  Akio Iwasaki

    IPC分类号： B23K9/035 ,  B23K37/06 ,  B23K37/02

    CPC分类号： B23K37/06

    摘要： A movable backing system enables it to continuously, easily perform full penetration welding along a weld line in a confined space, irrespective of the length, configuration and other factors of a weld zone. A weld backing, which has a backing member disposed on the side facing a workpiece and cooling means disposed inside the weld backing for cooling the backing member, is so supported on a wheeled carriage as to be movable toward the workpiece. The weld backing is provided with follower elements which are always in contact with the underside of the workpiece and which turn following the movement of the workpiece to keep a predetermined gap between the underside of the workpiece and the weld backing so that desired bead thickness can be obtained. The wheeled carriage is moved synchronously with the movement of the welder to continuously perform full penetration welding.

    摘要翻译： PCT No.PCT / JP93 / 00093 Sec。 371 1995年10月18日第 102（e）日期1995年10月18日PCT提交1993年1月27日PCT公布。 公开号WO94 / 16856 日期1994年8月4日可移动支承系统使其能够连续地，容易地在密闭空间内沿着焊接线进行全穿透焊接，而与焊接区域的长度，构造和其他因素无关。 具有设置在面向工件的一侧的背衬构件和设置在焊接背衬内部以冷却背衬构件的冷却装置的焊接背衬被支撑在轮式滑架上以朝向工件移动。 焊接背衬设置有随动元件，其随动件与工件的下侧接触，并随着工件的移动而转动，以保持工件的下侧与焊接背衬之间的预定的间隙，使得期望的焊道厚度可以为 获得。 轮式滑架与焊机的运动同步移动，以连续进行全焊接。

    Fortimicin aminoglycosides, process for production thereof, and use thereof
    8.
    发明授权
    Fortimicin aminoglycosides, process for production thereof, and use thereof 失效
    百古霉素氨基糖苷类，其制备方法及其用途

    公开(公告)号：US4255421A

    公开(公告)日：1981-03-10

    申请号：US85058

    申请日：1979-10-12

    申请人： Isamu Watanabe ,  Akio Iwasaki ,  Toshihito Mori

    发明人： Isamu Watanabe ,  Akio Iwasaki ,  Toshihito Mori

    IPC分类号： C07H15/224 ,  A61K31/71 ,  C07H15/22

    CPC分类号： C07H15/224

    摘要： Novel aminoglycosides of the following formula ##STR1## wherein R.sub.1 and R.sub.2 are identical or different and each represents a hydrogen atom or a methyl group, R.sub.3 represents a hydrogen atom or an optionally substituted aminoacyl group having 2 to 4 carbon atoms in the acyl moiety, and when all of R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms, the methylamino group at the 4-position is not oriented trans to the hydroxyl groups at the 3- and 5-positions; and acid addition salts thereof, which are useful as antibiotics; and process for producing compounds containing the same.

    摘要翻译： 下列通式的新型氨基糖苷类其中R 1和R 2相同或不同，各自表示氢原子或甲基，R 3表示酰基部分中的氢原子或任选取代的具有2至4个碳原子的氨基酰基， 当R 1，R 2和R 3全部为氢原子时，4-位上的甲基氨基不反向在3-和5-位羟基上; 和其酸加成盐，其可用作抗生素; 以及制备含有该化合物的化合物的方法。

    Cassette loading device
    9.
    发明授权
    Cassette loading device 失效
    纸盒装载装置

    公开(公告)号：US4775904A

    公开(公告)日：1988-10-04

    申请号：US898316

    申请日：1986-08-20

    申请人： Takashi Kimura ,  Akio Iwasaki ,  Akira Tomitaka

    发明人： Takashi Kimura ,  Akio Iwasaki ,  Akira Tomitaka

    IPC分类号： G11B15/675 ,  G11B15/00

    CPC分类号： G11B15/67565

    摘要： A cassette loading device having a cassette holding member arranged to be shiftable between a first position in which the cassette is attachable and detachable and a second position in which the cassette is stayed in a state of allowing use of a recording medium disposed within the cassette; to limit the movement of a cassette pushing member when the holding member is in the first position; and to remove the limitation when the holding member is in the second position.

    摘要翻译： 一种盒式装载装置，其具有盒保持构件，该盒保持构件布置成可在盒可附接和可拆卸的第一位置与盒子在允许使用设置在盒内的记录介质的状态下停留的第二位置之间移动; 当所述保持构件处于所述第一位置时，限制所述盒推动构件的移动; 并且当保持构件处于第二位置时消除限制。