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公开(公告)号：USD676481S1
公开(公告)日：2013-02-19
申请号：US29416764
申请日：2012-03-27
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公开(公告)号：USD676900S1
公开(公告)日：2013-02-26
申请号：US29416768
申请日：2012-03-27
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公开(公告)号：USD676887S1
公开(公告)日：2013-02-26
申请号：US29404428
申请日：2011-10-20
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4.发明授权公开(公告)号：US08222002B2
公开(公告)日：2012-07-17
申请号：US12792064
申请日：2010-06-02
CPC分类号： G01N33/6896 , A61K31/7088 , A61K48/00 , C07K16/18 , C07K2317/21 , C07K2317/622 , G01N2333/4709 , G01N2800/2821
摘要： A human anti-amyloid β peptide (hereinafter referred to as “Aβ”) antibody that binds to Aβ to thereby inhibit aggregation of Aβ molecules, and a fragment of said antibody are provided. The antibody and a fragment thereof according to the present invention, comprising a variable region of a human-derived anti-Aβ antibody, strongly reacts with Aβ to thereby inhibit its aggregation and hence may be used as a medicament for the prophylaxis and treatment of Alzheimer dementia.
摘要翻译： 人类抗淀粉样蛋白 与A＆bgr结合的肽（以下称为“A＆bgr”）抗体; 从而抑制A＆bgr的聚集; 分子和所述抗体的片段。 根据本发明的抗体及其片段，其包含人衍生的抗A＆Bgr的可变区; 抗体与A＆bgr强烈反应; 从而抑制其聚集，因此可以用作预防和治疗阿尔茨海默氏痴呆的药物。
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公开(公告)号：USD626599S1
公开(公告)日：2010-11-02
申请号：US29356739
申请日：2010-03-02
申请人： Junichi Ogawa , Atsushi Tani , Toshihiro Nakashima
设计人： Junichi Ogawa , Atsushi Tani , Toshihiro Nakashima
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公开(公告)号：US07342106B2
公开(公告)日：2008-03-11
申请号：US10527823
申请日：2003-09-10
CPC分类号： C07K16/24 , C07K2317/21 , C07K2317/622 , C07K2317/64 , C07K2317/76
摘要： A substance effective for treating immunopathy where MCP-1 is involved is provided. scFv having a high affinity to human MCP-1 was obtained using phage antibody technique. Based on information of VH chain and VL chain obtained from said scFv, a human anti-human MCP-1 antibody and a human anti-human MCP-1 antibody fragment are obtained. Said antibody and antibody fragment are expected to be useful as a medicament for treating inflammation and immunopathy caused by MCP-1.
摘要翻译： 提供了有效治疗涉及MCP-1的免疫病的物质。 使用噬菌体抗体技术获得对人MCP-1具有高亲和力的scFv。 基于从所述scFv获得的VH链和VL链的信息，获得人抗人MCP-1抗体和人抗人MCP-1抗体片段。 预期所述抗体和抗体片段可用作治疗由MCP-1引起的炎症和免疫病症的药物。
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公开(公告)号：US07241873B2
公开(公告)日：2007-07-10
申请号：US10489866
申请日：2002-09-25
申请人： Toshimitsu Uede , Shigeyuki Kon , Nobuchika Yamamoto , Hirofumi Higuchi , Masaharu Torikai , Yoshiyuki Tokieda , Toshihiro Nakashima , Hiroaki Maeda
发明人： Toshimitsu Uede , Shigeyuki Kon , Nobuchika Yamamoto , Hirofumi Higuchi , Masaharu Torikai , Yoshiyuki Tokieda , Toshihiro Nakashima , Hiroaki Maeda
CPC分类号： C07K14/52 , A61K39/00 , A61K2039/505 , C07K16/24 , C07K16/2842 , C07K16/2848 , C07K2317/34
摘要： A recombinant antibody in which at least the constant regions in the heavy chain and the light chain have been converted into human-origin regions and which inhibits the binding of an integrin recognizing the RGD sequence to osteopontin or its fragment and inhibits the binding of an integrin recognizing the SVVYGLR sequence or a sequence corresponding thereto to osteopontin or its fragment. This antibody is useful as a remedy for autoimmune diseases and a remedy for rheumatism or rheumatoid arthritis. Thus, a method of treating autoimmune diseases, rheumatism or rheumatoid arthritis is provided. This osteopontin antibody is useful in a diagnostic for rheumatism and a method of diagnosing rheumatism too.
摘要翻译： 重组抗体，其中至少重链和轻链中的恒定区已转化为人源区，并且抑制识别RGD序列的整联蛋白与骨桥蛋白或其片段的结合并抑制整联蛋白的结合 识别SVVYGLR序列或与骨桥蛋白或其片段相应的序列。 该抗体可用作自身免疫性疾病的补救剂和风湿病或类风湿性关节炎的治疗剂。 因此，提供了治疗自身免疫疾病，风湿病或类风湿性关节炎的方法。 该骨桥蛋白抗体可用于风湿病的诊断和风湿病的诊断方法。
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公开(公告)号：US20060240012A1
公开(公告)日：2006-10-26
申请号：US10526072
申请日：2003-08-28
CPC分类号： C07K16/248 , A61K2039/505 , C07K16/005 , C07K2317/21 , C07K2317/622 , C07K2317/73
摘要： A substance effective for treating immunopathy where interleukin 6 (IL-6) is involved is provided. A human anti-human IL-6 antibody and a human anti-human IL-6 antibody fragment having a high affinity to human IL-6 were obtained using phage antibody technique. Said antibody and antibody fragment are expected to be useful as a medicament for treating inflammation and immunopathy caused by IL-6.
摘要翻译： 提供了有效治疗涉及白介素6（IL-6）的免疫病的物质。 使用噬菌体抗体技术获得对人IL-6具有高亲和力的人抗人IL-6抗体和人抗人IL-6抗体片段。 预期所述抗体和抗体片段可用作治疗由IL-6引起的炎症和免疫疾病的药物。
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公开(公告)号：US07482436B2
公开(公告)日：2009-01-27
申请号：US10526072
申请日：2003-08-28
IPC分类号： C07K16/24
CPC分类号： C07K16/248 , A61K2039/505 , C07K16/005 , C07K2317/21 , C07K2317/622 , C07K2317/73
摘要： A substance effective for treating immunopathy where interleukin 6 (IL-6) is involved is provided. A human anti-human IL-6 antibody and a human anti-human IL-6 antibody fragment having a high affinity to human IL-6 were obtained using phage antibody technique. The antibody and antibody fragment are expected to be useful as a medicament for treating inflammation and immunopathy caused by IL-6.
摘要翻译： 提供了有效治疗涉及白介素6（IL-6）的免疫病的物质。 使用噬菌体抗体技术获得对人IL-6具有高亲和力的人抗人IL-6抗体和人抗人IL-6抗体片段。 预期抗体和抗体片段可用作治疗由IL-6引起的炎症和免疫病症的药物。
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公开(公告)号：USD570837S1
公开(公告)日：2008-06-10
申请号：US29263297
申请日：2006-07-20
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