专利检索 ap:("Alessandra Bartolozzi" OR "Todd Bosanac" OR "Zhidong Chen" OR "Stephane De Lombaert" OR "John D. Huber" OR "Weimin Liu" OR "Ho Yin Lo" OR "Pui Leng Loke" OR "Doris Riether" OR "Heather Tye" OR "Lifen Wu" OR "Renee M. Zindell") AND inv:"Renee M. Zindell" 第 1 页

1.

发明授权
Oxadiazole inhibitors of leukotriene production 有权

公开(公告)号：US08580829B2

公开(公告)日：2013-11-12

申请号：US13215654

申请日：2011-08-23

申请人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Tina Marie Morwick , Peter Allen Nemoto , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell

发明人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Tina Marie Morwick , Peter Allen Nemoto , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell

IPC分类号： A01N43/82 , A61K31/41

CPC分类号： C07D413/14 , A61K31/4245 , C07D413/10 , C07D417/14

摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

2.

发明授权
Oxadiazole inhibitors of leukotriene production 有权
标题翻译：恶二唑抑制剂生产白三烯

公开(公告)号：US08580825B2

公开(公告)日：2013-11-12

申请号：US13237106

申请日：2011-09-20

申请人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell

发明人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell

IPC分类号： A01N43/40 , A61K31/44

CPC分类号： C07D413/14

摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 5如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

3.

发明授权
Oxadiazole inhibitors of leukotriene production 有权
标题翻译：恶二唑抑制剂生产白三烯

公开(公告)号：US08658661B2

公开(公告)日：2014-02-25

申请号：US13208582

申请日：2011-08-12

申请人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Ho Yin Lo , Pui Leng Loke , Weimin Liu , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell

发明人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Ho Yin Lo , Pui Leng Loke , Weimin Liu , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell

IPC分类号： A01N43/54 , A61K31/505

CPC分类号： C07D413/14 , C07D413/10 , C07D417/14 , C07D471/04 , C07D498/04

摘要： The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1 -R 5如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

4.

发明授权
Oxadiazole inhibitors of leukotriene production 有权
标题翻译：恶二唑抑制剂生产白三烯

公开(公告)号：US08575201B2

公开(公告)日：2013-11-05

申请号：US13237112

申请日：2011-09-20

申请人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin W. Liu , Pui Leng Loke , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell

发明人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin W. Liu , Pui Leng Loke , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell

IPC分类号： A01N43/40 , A61K31/44

CPC分类号： C07D413/14

摘要： The present invention relates to compounds of formula (I) and (IA): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

摘要翻译： 本发明涉及式（I）和（IA）化合物及其药学上可接受的盐，其中R 1 -R 5如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

5.

发明授权
Heterocyclic compounds as inhibitors of leukotriene production 有权
标题翻译：杂环化合物作为白三烯生产的抑制剂

公开(公告)号：US09174980B2

公开(公告)日：2015-11-03

申请号：US13752640

申请日：2013-01-29

申请人： Alessandra Bartolozzi , Zhidong Chen , Jonathon Alan Dines , Ho Yin Lo , Pui Leng Loke , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell

发明人： Alessandra Bartolozzi , Zhidong Chen , Jonathon Alan Dines , Ho Yin Lo , Pui Leng Loke , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell

IPC分类号： C07D403/10 , A61K31/404 , C07D471/04 , C07D409/14 , C07D413/14 , C07D403/14 , C07D417/14 , C07D413/10 , C07D417/10 , C07D405/14 , C07D401/14 , C07D401/12

CPC分类号： C07D471/04 , A61K31/404 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14

摘要： The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R7, A and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1 -R 7，A和HET如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

6.

发明授权
Compounds which selectively modulate the CB2 receptor 有权

公开(公告)号：US08372874B2

公开(公告)日：2013-02-12

申请号：US12564133

申请日：2009-09-22

申请人： Alessandra Bartolozzi , Eugene Richard Hickey , Doris Riether , Lifen Wu , Renee M. Zindell , Monika Ermann

发明人： Alessandra Bartolozzi , Eugene Richard Hickey , Doris Riether , Lifen Wu , Renee M. Zindell , Monika Ermann

IPC分类号： A61K31/4196 , A61K31/42 , A61K31/422 , C07D261/14 , C07D249/14

CPC分类号： C07D413/12 , C07D249/14 , C07D261/14 , C07D405/12 , C07D413/04 , C07D413/14

摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

7.

发明授权
Heterocyclic compounds which modulate the CB2 receptor 有权
标题翻译：调节CB2受体的杂环化合物

公开(公告)号：US08889670B2

公开(公告)日：2014-11-18

申请号：US13147432

申请日：2010-02-16

申请人： Alessandra Bartolozzi , Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , Lifen Wu , Renee M. Zindell

发明人： Alessandra Bartolozzi , Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , Lifen Wu , Renee M. Zindell

IPC分类号： A61K31/4545 , C07D211/60 , C07D401/12 , C07D405/04 , C07D413/12 , C07D417/12 , C07D417/14

CPC分类号： C07D413/12 , C07D211/60 , C07D401/12 , C07D405/04 , C07D417/12 , C07D417/14

摘要： Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

摘要翻译： 公开了调节CB2受体的化合物。根据本发明的化合物与CB2受体结合并且是激动剂，并且可用于治疗炎症。作为激动剂的那些化合物另外可用于治疗疼痛。

8.

发明授权
Therapeutic uses of compounds which selectively modulate the CB2 receptor 有权
标题翻译：选择性调节CB2受体的化合物的治疗用途

公开(公告)号：US08349871B2

公开(公告)日：2013-01-08

申请号：US13238054

申请日：2011-09-21

申请人： Alessandra Bartolozzi , Angela Berry , Eugene Richard Hickey , Doris Riether , Achim Sauer , David Smith Thomson , Lifen Wu , Renee M. Zindell , Patricia Amouzegh , Nigel James Blumire , Stephen Peter East , Monika Ermann , Someina Khor , Innocent Mushi

发明人： Alessandra Bartolozzi , Angela Berry , Eugene Richard Hickey , Doris Riether , Achim Sauer , David Smith Thomson , Lifen Wu , Renee M. Zindell , Patricia Amouzegh , Nigel James Blumire , Stephen Peter East , Monika Ermann , Someina Khor , Innocent Mushi

IPC分类号： A61K31/454 , A61K31/4196 , A61K31/422 , A61K31/42 , A61K31/427 , C07D401/12 , C07D285/135 , C07D261/14 , C07D249/14 , C07D277/46 , C07D277/62

CPC分类号： C07D413/12 , C07D249/14 , C07D261/14 , C07D405/12 , C07D413/04 , C07D413/14

摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

摘要翻译： 公开了式（I）的化合物。根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。作为激动剂的那些化合物另外可用于治疗疼痛。

9.

发明授权
Compounds which selectively modulate the CB2 receptor 有权
标题翻译：选择性调节CB2受体的化合物

公开(公告)号：US08735430B2

公开(公告)日：2014-05-27

申请号：US13627149

申请日：2012-09-26

申请人： Alessandra Bartolozzi , Eugene Richard Hickey , Doris Riether , Lifen Wu , Renee M. Zindell , Nigel James Blumire , Monika Ermann , Edward Thomas Glenn , Someina Khor , Przemyslaw Zawadzki

发明人： Alessandra Bartolozzi , Eugene Richard Hickey , Doris Riether , Lifen Wu , Renee M. Zindell , Nigel James Blumire , Monika Ermann , Edward Thomas Glenn , Someina Khor , Przemyslaw Zawadzki

IPC分类号： C07D261/14 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14

CPC分类号： C07D413/12 , C07D261/14 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14

摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

摘要翻译： 公开了式（I）的化合物。根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。作为激动剂的那些化合物另外可用于治疗疼痛。