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公开(公告)号：US20140045274A1
公开(公告)日：2014-02-13
申请号：US13776631
申请日：2013-02-25
申请人： Alessandra Luchini Kunkel , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M. Dunlap , Alexis Patanarut
发明人： Alessandra Luchini Kunkel , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M. Dunlap , Alexis Patanarut
IPC分类号： G01N1/40
CPC分类号： G01N1/405 , B01D15/00 , B01D15/02 , B01D15/34 , B01D15/3804 , B01D15/3861 , B01J20/26 , B01J20/261 , B01J20/264 , B01J20/265 , B01J2220/54 , B82Y15/00 , G01N33/54313 , G01N33/545 , Y10T436/255
摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
摘要翻译： 描述从溶液中收集分析物的捕获颗粒和使用它们的方法。 捕获颗粒由具有允许分析物进入捕获颗粒的孔径的聚合物基质构成。 当对颗粒施加刺激时，捕获颗粒的孔径是可变的，允许改变颗粒的孔径，使得目标分析物保留在颗粒内。 捕获颗粒的聚合物基质由具有结构单体和亲和单体的共聚物制成，亲和单体具有将分析物吸引到捕获颗粒的性质。 捕获颗粒可用于分离和鉴定混合物中存在的分析物。 它们也可用于保护在收获时通常会降解的分析物，并将低分析物浓缩在液体中的丰度低。
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公开(公告)号：US09383299B2
公开(公告)日：2016-07-05
申请号：US13776631
申请日：2013-02-25
申请人： Alessandra Luchini Kunkel , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M Dunlap , Alexis Patanarut
发明人： Alessandra Luchini Kunkel , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M Dunlap , Alexis Patanarut
IPC分类号： B01D39/16 , G01N1/40 , B01D15/00 , B01D15/02 , B01D15/38 , B01J20/26 , B82Y15/00 , B01D15/34
CPC分类号： G01N1/405 , B01D15/00 , B01D15/02 , B01D15/34 , B01D15/3804 , B01D15/3861 , B01J20/26 , B01J20/261 , B01J20/264 , B01J20/265 , B01J2220/54 , B82Y15/00 , G01N33/54313 , G01N33/545 , Y10T436/255
摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
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公开(公告)号：US08382987B2
公开(公告)日：2013-02-26
申请号：US12194371
申请日：2008-08-19
申请人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M Dunlap , Alexis Patanarut
发明人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M Dunlap , Alexis Patanarut
IPC分类号： B01D39/16
CPC分类号： G01N1/405 , B01D15/00 , B01D15/02 , B01D15/34 , B01D15/3804 , B01D15/3861 , B01J20/26 , B01J20/261 , B01J20/264 , B01J20/265 , B01J2220/54 , B82Y15/00 , G01N33/54313 , G01N33/545 , Y10T436/255
摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
摘要翻译： 描述从溶液中收集分析物的捕获颗粒和使用它们的方法。 捕获颗粒由具有允许分析物进入捕获颗粒的孔径的聚合物基质构成。 当对颗粒施加刺激时，捕获颗粒的孔径是可变的，允许改变颗粒的孔径，使得目标分析物保留在颗粒内。 捕获颗粒的聚合物基质由具有结构单体和亲和单体的共聚物制成，亲和单体具有将分析物吸引到捕获颗粒的性质。 捕获颗粒可用于分离和鉴定混合物中存在的分析物。 它们也可用于保护在收获时通常会降解的分析物，并将低分析物浓缩在液体中的丰度低。
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公开(公告)号：US20090087346A1
公开(公告)日：2009-04-02
申请号：US12194371
申请日：2008-08-19
申请人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M. Dunlap , Alexis Patanarut
发明人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M. Dunlap , Alexis Patanarut
CPC分类号： G01N1/405 , B01D15/00 , B01D15/02 , B01D15/34 , B01D15/3804 , B01D15/3861 , B01J20/26 , B01J20/261 , B01J20/264 , B01J20/265 , B01J2220/54 , B82Y15/00 , G01N33/54313 , G01N33/545 , Y10T436/255
摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
摘要翻译： 描述从溶液中收集分析物的捕获颗粒和使用它们的方法。 捕获颗粒由具有允许分析物进入捕获颗粒的孔径的聚合物基质构成。 当对颗粒施加刺激时，捕获颗粒的孔径是可变的，允许改变颗粒的孔径，使得目标分析物保留在颗粒内。 捕获颗粒的聚合物基质由具有结构单体和亲和单体的共聚物制成，亲和单体具有将分析物吸引到捕获颗粒的性质。 捕获颗粒可用于分离和鉴定混合物中存在的分析物。 它们也可用于保护在收获时通常会降解的分析物，并将低分析物浓缩在液体中的丰度低。
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公开(公告)号：US20120164749A1
公开(公告)日：2012-06-28
申请号：US12194360
申请日：2008-08-19
申请人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Caterina Longo , Virginia Espina , Alexis Patanarut
发明人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Caterina Longo , Virginia Espina , Alexis Patanarut
IPC分类号： G01N1/18 , C08F220/56 , B82Y40/00
CPC分类号： G01N33/5432 , G01N33/5436 , Y10T428/2989 , Y10T428/2998 , Y10T436/25375
摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
摘要翻译： 描述从溶液中收集分析物的捕获颗粒和使用它们的方法。 捕获颗粒由具有允许分析物进入捕获颗粒的孔径的聚合物基质构成。 当对颗粒施加刺激时，捕获颗粒的孔径是可变的，允许改变颗粒的孔径，使得目标分析物保留在颗粒内。 捕获颗粒的聚合物基质由具有结构单体和亲和单体的共聚物制成，亲和单体具有将分析物吸引到捕获颗粒的性质。 捕获颗粒可用于分离和鉴定混合物中存在的分析物。 它们也可用于保护在收获时通常会降解的分析物，并将低分析物浓缩在液体中的丰度低。
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公开(公告)号：US08497137B2
公开(公告)日：2013-07-30
申请号：US12194360
申请日：2008-08-19
申请人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Caterina Longo , Virginia Espina , Alexis Patanarut
发明人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Caterina Longo , Virginia Espina , Alexis Patanarut
IPC分类号： G01N33/545
CPC分类号： G01N33/5432 , G01N33/5436 , Y10T428/2989 , Y10T428/2998 , Y10T436/25375
摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
摘要翻译： 描述从溶液中收集分析物的捕获颗粒和使用它们的方法。 捕获颗粒由具有允许分析物进入捕获颗粒的孔径的聚合物基质构成。 当对颗粒施加刺激时，捕获颗粒的孔径是可变的，允许改变颗粒的孔径，使得目标分析物保留在颗粒内。 捕获颗粒的聚合物基质由具有结构单体和亲和单体的共聚物制成，亲和单体具有将分析物吸引到捕获颗粒的性质。 捕获颗粒可用于分离和鉴定混合物中存在的分析物。 它们也可用于保护在收获时通常会降解的分析物，并将低分析物浓缩在液体中的丰度低。
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公开(公告)号：US08133881B2
公开(公告)日：2012-03-13
申请号：US11179801
申请日：2005-07-13
申请人： Travis Mickle , Thomas Piccariello , James Scott Moncrief , Nancy Johnston Boerth , Barney Bishop
发明人： Travis Mickle , Thomas Piccariello , James Scott Moncrief , Nancy Johnston Boerth , Barney Bishop
CPC分类号： A61K9/0019 , A61K31/706 , A61K47/549
摘要： The invention provides a “street-safe” version of a controlled substance that permits the therapeutically beneficial effects of the substance while reducing or eliminating the euphoric effects that lead to substance abuse. The invention provides pharmaceutical compositions comprising a controlled substance and a carbohydrate covalently bound to said controlled substance in a manner that renders said controlled substance pharmacologically inactive or substantially diminishes its activity and methods of using the same.
摘要翻译： 本发明提供了一种“街道安全”的受控物质版本，其允许物质的治疗有益效果，同时减少或消除导致药物滥用的欣快效应。 本发明提供药物组合物，其包含受控物质和与所述受控物质共价结合的碳水化合物，使得所述受控物质在药理学上无活性或显着降低其活性及其使用方法。
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公开(公告)号：US07700561B2
公开(公告)日：2010-04-20
申请号：US11400304
申请日：2006-04-10
申请人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
发明人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
IPC分类号： A61K38/00 , A61K51/00 , A61K31/785 , G01N33/53 , G01N33/00
CPC分类号： A61K31/165 , A61K47/542 , C07C237/06 , Y10S436/901 , Y10T436/173845
摘要： The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
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公开(公告)号：US07674774B2
公开(公告)日：2010-03-09
申请号：US12201982
申请日：2008-08-29
申请人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
发明人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
IPC分类号： A61K38/00 , A61K51/00 , A61K31/785 , G01N33/53 , G01N33/00
CPC分类号： A61K31/165 , A61K47/542 , C07C237/06 , Y10S436/901 , Y10T436/173845
摘要： The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
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公开(公告)号：US07671031B2
公开(公告)日：2010-03-02
申请号：US12202159
申请日：2008-08-29
申请人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
发明人： Travis Mickle , Suma Krishnan , Barney Bishop , Christopher Lauderback , James Scott Moncrief , Robert Oberlender , Thomas Piccariello , Bernhard J. Paul , Christopher A. Verbicky
IPC分类号： A61K38/00 , A61K51/00 , A61K31/785 , G01N33/53 , G01N33/00
CPC分类号： A61K31/165 , A61K47/542 , C07C237/06 , Y10S436/901 , Y10T436/173845
摘要： The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
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