利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

25 条记录 (耗时 0.034 秒)

    Smart hydrogel particles for biomarker harvesting
    5.
    发明授权
    Smart hydrogel particles for biomarker harvesting 有权
    用于生物标志物收获的智能水凝胶颗粒

    公开(公告)号：US08497137B2

    公开(公告)日：2013-07-30

    申请号：US12194360

    申请日：2008-08-19

    申请人： Alessandra Luchini ,  Lance Liotta ,  Emanuel Petricoin ,  Barney Bishop ,  Caterina Longo ,  Virginia Espina ,  Alexis Patanarut

    发明人： Alessandra Luchini ,  Lance Liotta ,  Emanuel Petricoin ,  Barney Bishop ,  Caterina Longo ,  Virginia Espina ,  Alexis Patanarut

    IPC分类号： G01N33/545

    CPC分类号： G01N33/5432 ,  G01N33/5436 ,  Y10T428/2989 ,  Y10T428/2998 ,  Y10T436/25375

    摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.

    摘要翻译： 描述从溶液中收集分析物的捕获颗粒和使用它们的方法。 捕获颗粒由具有允许分析物进入捕获颗粒的孔径的聚合物基质构成。 当对颗粒施加刺激时，捕获颗粒的孔径是可变的，允许改变颗粒的孔径，使得目标分析物保留在颗粒内。 捕获颗粒的聚合物基质由具有结构单体和亲和单体的共聚物制成，亲和单体具有将分析物吸引到捕获颗粒的性质。 捕获颗粒可用于分离和鉴定混合物中存在的分析物。 它们也可用于保护在收获时通常会降解的分析物，并将低分析物浓缩在液体中的丰度低。

    Smart Hydrogel Particles for Biomarker Harvesting
    6.
    发明申请
    Smart Hydrogel Particles for Biomarker Harvesting 有权
    用于生物标记收获的智能水凝胶颗粒

    公开(公告)号：US20120164749A1

    公开(公告)日：2012-06-28

    申请号：US12194360

    申请日：2008-08-19

    申请人： Alessandra Luchini ,  Lance Liotta ,  Emanuel Petricoin ,  Barney Bishop ,  Caterina Longo ,  Virginia Espina ,  Alexis Patanarut

    发明人： Alessandra Luchini ,  Lance Liotta ,  Emanuel Petricoin ,  Barney Bishop ,  Caterina Longo ,  Virginia Espina ,  Alexis Patanarut

    IPC分类号： G01N1/18 ,  C08F220/56 ,  B82Y40/00

    CPC分类号： G01N33/5432 ,  G01N33/5436 ,  Y10T428/2989 ,  Y10T428/2998 ,  Y10T436/25375

    摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.

    摘要翻译： 描述从溶液中收集分析物的捕获颗粒和使用它们的方法。 捕获颗粒由具有允许分析物进入捕获颗粒的孔径的聚合物基质构成。 当对颗粒施加刺激时，捕获颗粒的孔径是可变的，允许改变颗粒的孔径，使得目标分析物保留在颗粒内。 捕获颗粒的聚合物基质由具有结构单体和亲和单体的共聚物制成，亲和单体具有将分析物吸引到捕获颗粒的性质。 捕获颗粒可用于分离和鉴定混合物中存在的分析物。 它们也可用于保护在收获时通常会降解的分析物，并将低分析物浓缩在液体中的丰度低。

    Biomarker isolation and use thereof to characterize physiological state
    8.
    发明授权
    Biomarker isolation and use thereof to characterize physiological state 有权
    生物标志物分离及其用于表征生理状态

    公开(公告)号：US07794952B2

    公开(公告)日：2010-09-14

    申请号：US11639414

    申请日：2006-12-15

    申请人： Lance Liotta ,  Emanuel Petricoin

    发明人： Lance Liotta ,  Emanuel Petricoin

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6848 ,  G01N33/57415 ,  G01N33/57449 ,  G01N2333/4703 ,  G01N2333/976 ,  G01N2400/02

    摘要： The present invention relates to compositions and methods for characterizing the physiological state of a living system, including cells, tissues, organs, and whole organisms. The methods involve capturing biomarkers from the living system, and correlating their presence or absence to a physiological state. The biomarkers can be captured from the system, and then detected using any suitable analytical system to determine their presence or absence. In one embodiment, the invention relates to a method of detecting a polypeptide biomarker in a blood serum or plasma sample obtained from a single subject with an affinity ligand which is capable of binding to a plurality of different polypeptide biomarkers derived from the same parental molecule.

    摘要翻译： 本发明涉及用于表征生物体系的生理状态的组合物和方法，包括细胞，组织，器官和整个生物体。 该方法涉及从生物系统捕获生物标志物，并将其存在或不存在与生理状态相关联。 生物标志物可以从系统中捕获，然后使用任何合适的分析系统进行检测以确定其存在或不存在。 在一个实施方案中，本发明涉及一种检测从单个受试者获得的血清或血浆样品中的多肽生物标志物的方法，该亲和配体能够结合来自同一亲本分子的多种不同的多肽生物标志物。

    Biomarker isolation and use thereof to characterize physiological state
    9.
    发明申请
    Biomarker isolation and use thereof to characterize physiological state 有权
    生物标志物分离及其用于表征生理状态

    公开(公告)号：US20070275483A1

    公开(公告)日：2007-11-29

    申请号：US11639414

    申请日：2006-12-15

    申请人： Lance Liotta ,  Emanuel Petricoin

    发明人： Lance Liotta ,  Emanuel Petricoin

    IPC分类号： G01N33/53 ,  C12Q1/68

    CPC分类号： G01N33/6848 ,  G01N33/57415 ,  G01N33/57449 ,  G01N2333/4703 ,  G01N2333/976 ,  G01N2400/02

    摘要： The present invention relates to compositions and methods for characterizing the physiological state of a living system, including cells, tissues, organs, and whole organisms. The methods involve capturing biomarkers from the living system, and correlating their presence or absence to a physiological state. The biomarkers can be captured from the system, and then detected using any suitable analytical system to determine their presence or absence. In one embodiment, the invention relates to a method of detecting a polypeptide biomarker in a blood serum or plasma sample obtained from a single subject with an affinity ligand which is capable of binding to a plurality of different polypeptide biomarkers derived from the same parental molecule.

    摘要翻译： 本发明涉及用于表征生物体系的生理状态的组合物和方法，包括细胞，组织，器官和整个生物体。 该方法涉及从生物系统捕获生物标志物，并将其存在或不存在与生理状态相关联。 生物标志物可以从系统中捕获，然后使用任何合适的分析系统进行检测以确定其存在或不存在。 在一个实施方案中，本发明涉及一种检测从单个受试者获得的血清或血浆样品中的多肽生物标志物的方法，该亲和配体能够结合来自同一亲本分子的多种不同的多肽生物标志物。