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公开(公告)号：US6165790A
公开(公告)日：2000-12-26
申请号：US433694
申请日：1999-11-03
IPC分类号： C12N15/09 , A61K31/7088 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P3/10 , A61P35/00 , A61P43/00 , C07H21/04 , C12N15/113 , C12Q1/68 , C12N15/00 , C12P19/34
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/01137 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for inhibiting the expression of PI3 kinase p55 gamma. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PI3 kinase p55 gamma. Methods of using these compounds for inhibition of PI3 kinase p55 gamma expression and for treatment of diseases associated with expression of PI3 kinase p55 gamma are provided.
摘要翻译： 提供反义化合物，组合物和方法用于抑制PI3激酶p55γ的表达。 组合物包含靶向编码PI3激酶p55γ的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物抑制PI3激酶p55γ表达和治疗与PI3激酶p55γ表达相关的疾病的方法。
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公开(公告)号：US06165728A
公开(公告)日：2000-12-26
申请号：US444053
申请日：1999-11-19
申请人： Donna T. Ward , Lex M. Cowsert
发明人： Donna T. Ward , Lex M. Cowsert
IPC分类号： A61K38/00 , C12N15/113 , C07H21/04 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of nck-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding nck-2. Methods of using these compounds for modulation of nck-2 expression and for treatment of diseases associated with expression of nck-2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节nck-2的表达。 组合物包含靶向编码nck-2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节nck-2表达和治疗与nck-2表达相关的疾病的方法。
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公开(公告)号：US06426221B1
公开(公告)日：2002-07-30
申请号：US09920663
申请日：2001-08-01
申请人： Donna T. Ward , Lex M. Cowsert
发明人： Donna T. Ward , Lex M. Cowsert
IPC分类号： C12Q168
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6876 , C12Q2600/158 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of RIP2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding RIP2. Methods of using these compounds for modulation of RIP2 expression and for treatment of diseases associated with expression of RIP2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节RIP2的表达。 组合物包含靶向编码RIP2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节RIP2表达和治疗与RIP2表达相关疾病的方法。
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公开(公告)号：US6010906A
公开(公告)日：2000-01-04
申请号：US358382
申请日：1999-07-21
申请人： Donna T. Ward , Lex M. Cowsert
发明人： Donna T. Ward , Lex M. Cowsert
IPC分类号： C12N15/09 , A61K31/7088 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P43/00 , C07H21/00 , C12N15/113 , C07H21/04 , C12N15/00 , C12Q1/68
CPC分类号： C12N15/1137 , C12Y207/12002 , A61K38/00 , C12N2310/315 , C12N2310/318 , C12N2310/3181 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Jun N-terminal Kinase Kinase-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Jun N-terminal Kinase Kinase-1. Methods of using these compounds for modulation of Jun N-terminal Kinase Kinase-1 expression and for treatment of diseases associated with expression of Jun N-terminal Kinase Kinase-1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节JunN-末端激酶激酶-1的表达。 组合物包含靶向编码JunN-末端激酶激酶-1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节JunN-末端激酶激酶-1表达和治疗与Jun N-末端激酶激酶-1表达有关的疾病的方法。
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公开(公告)号：US06168950A
公开(公告)日：2001-01-02
申请号：US09359756
申请日：1999-07-23
申请人： Brett P. Monia , William Gaarde , Donna T. Ward , Lex M. Cowsert
发明人： Brett P. Monia , William Gaarde , Donna T. Ward , Lex M. Cowsert
IPC分类号： C07T2104
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/3341 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MEKK1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK1. Methods of using these compounds for modulation of MEKK1 expression and for treatment of diseases associated with expression of MEKK1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节MEKK1的表达。 组合物包含靶向编码MEKK1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节MEKK1表达和治疗与MEKK1表达相关的疾病的方法。
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公开(公告)号：US07709453B2
公开(公告)日：2010-05-04
申请号：US10852630
申请日：2004-05-24
申请人： Donna T. Ward , Andrew T. Watt
发明人： Donna T. Ward , Andrew T. Watt
CPC分类号： C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/10 , C12N2320/50 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the RNAi pathway. The compositions comprise oligonucleotides, targeted to nucleic acid molecules encoding EIF2C2. Methods of using these compounds for modulation of RNA interference as well as EIF2C2 expression and for diagnosis and treatment of disease associated with expression of EIF2C2 are provided. Also provided are compounds, compositions and methods for modulating the expression of DDX36. The compositions comprise oligonucleotides, targeted to nucleic acid encoding DDX36. Methods of using these compounds for modulation of DDX36 expression and for diagnosis and treatment of diseases and conditions associated with expression of DDX36 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节RNAi途径。 组合物包含靶向编码EIF2C2的核酸分子的寡核苷酸。 提供了使用这些化合物调节RNA干扰以及EIF2C2表达以及用于诊断和治疗与EIF2C2表达相关的疾病的方法。 还提供了用于调节DDX36表达的化合物，组合物和方法。 组合物包含针对编码DDX36的核酸的寡核苷酸。 提供了使用这些化合物调制DDX36表达和用于诊断和治疗与DDX36表达相关的疾病和病症的方法。
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公开(公告)号：US20120316220A1
公开(公告)日：2012-12-13
申请号：US13364477
申请日：2012-02-02
申请人： Donna T. Ward , Jason Rhodes
发明人： Donna T. Ward , Jason Rhodes
CPC分类号： C12N15/113 , A01K67/0333 , A01N25/002 , A01N57/16 , A61K48/00 , C12N15/1131 , C12N15/85 , C12N15/86 , C12N2310/14 , C12N2320/00 , C12N2320/30 , C12N2320/32 , C12N2710/14043
摘要： Provided herein are methods and compositions for modulating gene expression in insects by administering a composition comprising an RNA effector molecule and a delivery agent. Methods are provided for controlling pest populations by inhibiting insect growth, development, survival, reproduction and/or viability. Also provided herein are methods for treating or preventing disease in an insect caused by a pathogen or by external factors (e.g., pollution, environment, stress, weather, etc.).
摘要翻译： 本文提供了通过施用包含RNA效应分子和递送剂的组合物来调节昆虫中基因表达的方法和组合物。 提供了通过抑制昆虫生长，发育，存活，繁殖和/或生存力来控制害虫种群的方法。 本文还提供了用于治疗或预防由病原体引起的昆虫疾病或外部因素（例如污染，环境，压力，天气等）的疾病的方法。
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公开(公告)号：US06448080B1
公开(公告)日：2002-09-10
申请号：US09791211
申请日：2001-02-23
申请人： Donna T. Ward , Andrew T. Watt
发明人： Donna T. Ward , Andrew T. Watt
IPC分类号： C12Q168
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of WRN. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding WRN. Methods of using these compounds for modulation of WRN expression and for treatment of diseases associated with expression of WRN are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节WRN的表达。 组合物包含靶向编码WRN的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节WRN表达和治疗与WRN表达相关的疾病的方法。
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公开(公告)号：US08513400B2
公开(公告)日：2013-08-20
申请号：US12642534
申请日：2009-12-18
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C07F9/65586 , A61K38/00 , C07F9/65616 , C12N15/113 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α and/or HIF2α are provided.
摘要翻译： 提供化合物，组合物和方法用于调节HIF1α和/或HIF2α的表达。 组合物包含针对编码HIF1α和HIF2α的核酸的寡核苷酸。 提供了使用这些化合物调节HIF1α和/或HIF2α表达以及用于诊断和治疗与HIF1α和/或HIF2α的表达相关的疾病的方法。
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公开(公告)号：US20110190370A1
公开(公告)日：2011-08-04
申请号：US12642534
申请日：2009-12-18
IPC分类号： A61K31/7088 , C07H21/04 , A61P35/00 , C12N5/00
CPC分类号： C07F9/65586 , A61K38/00 , C07F9/65616 , C12N15/113 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α and/or HIF2α are provided.
摘要翻译： 提供化合物，组合物和方法用于调节HIF1α和/或HIF2α的表达。 组合物包含针对编码HIF1α和HIF2α的核酸的寡核苷酸。 提供了使用这些化合物调节HIF1α和/或HIF2α表达以及用于诊断和治疗与HIF1α和/或HIF2α的表达相关的疾病的方法。
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