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公开(公告)号：US06348315B1
公开(公告)日：2002-02-19
申请号：US09425585
申请日：1999-10-22
申请人： Andreas Plückthun , Jozef Hanes , Lutz Jermutus
发明人： Andreas Plückthun , Jozef Hanes , Lutz Jermutus
IPC分类号： C12Q168
CPC分类号： C12N15/1041 , C07K16/00
摘要： The present invention relates to methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules. The method of the present invention is particularly characterized by an in vitro translation step under conditions that allow formation of polysomes in the presence of antisense oligonucleotides complementary to the tag-coding sequence of ssrA-RNA. The present invention further relates to kits that are useful for carrying out the method of the invention.
摘要翻译： 本发明涉及用于鉴定与靶分子相互作用的编码（多）肽的核酸分子的方法。 在允许在与ssrA-RNA的标签编码序列互补的反义寡核苷酸存在下形成多核糖体的条件下，本发明的方法的特征在于体外翻译步骤。 本发明还涉及可用于实施本发明方法的试剂盒。
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公开(公告)号：US06589741B2
公开(公告)日：2003-07-08
申请号：US09953321
申请日：2001-09-14
申请人： Andreas Plückthun , Jozef Hanes , Lutz Jermutus
发明人： Andreas Plückthun , Jozef Hanes , Lutz Jermutus
IPC分类号： C12Q168
CPC分类号： C12N15/1041 , C07K16/00
摘要： The present invention relates to methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules. The method of the present invention is particularly characterized by an in vitro translation step under conditions that allow formation of polysomes in the presence of antisense oligonucleotides complementary to the tag-coding sequence of ssrA-RNA. The present invention further relates to kits that are useful for carrying out the method of the invention.
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公开(公告)号：US20050065327A1
公开(公告)日：2005-03-24
申请号：US10891972
申请日：2004-07-15
申请人： Phillip Monk , Lutz Jermutus , Celia Shorrock , Ralph Minter
发明人： Phillip Monk , Lutz Jermutus , Celia Shorrock , Ralph Minter
IPC分类号： A61P1/00 , A61P11/06 , A61P17/00 , A61P19/04 , A61P35/00 , A61P37/00 , A61P37/08 , C07K16/24 , C12N15/13 , C07H21/04
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S514/826 , Y10S514/883
摘要： Specific binding members, in particular human anti-IL-13 antibody molecules and especially those which neutralise IL-13 activity. Methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, including asthma, atopic dermatitis, allergic rhinitis,.fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译： 特异性结合成员，特别是人抗IL-13抗体分子，特别是中和IL-13活性的那些。 用于诊断或治疗IL-13相关疾病的方法，包括哮喘，特应性皮炎，过敏性鼻炎，纤维化，炎性肠病和霍奇金淋巴瘤。
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公开(公告)号：US20120052060A1
公开(公告)日：2012-03-01
申请号：US12941677
申请日：2010-11-08
IPC分类号： A61K39/395 , C07H21/00 , C12P21/00 , G01N33/53 , C12N1/19 , A61P37/08 , C12N5/10 , C12N1/21 , A61P37/06 , A61P11/06 , A61P11/00 , A61P35/00 , C07K16/24 , C12N7/01
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S514/826 , Y10S514/883
摘要： Specific binding members, in particular human anti-IL-13 antibody molecules and especially those which neutralise IL-13 activity. Methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, including asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译： 特异性结合成员，特别是人抗IL-13抗体分子，特别是中和IL-13活性的那些。 用于诊断或治疗IL-13相关疾病（包括哮喘，特应性皮炎，过敏性鼻炎，纤维化，炎性肠病和霍奇金淋巴瘤）的抗IL-13抗体分子的方法。
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公开(公告)号：US20070134246A1
公开(公告)日：2007-06-14
申请号：US11700711
申请日：2007-01-30
申请人： Steven Ledbetter , Celia Hart , Robert Holgate , Lutz Jermutus , Catriona Buchanan , Alexander Duncan , Donna Finch
发明人： Steven Ledbetter , Celia Hart , Robert Holgate , Lutz Jermutus , Catriona Buchanan , Alexander Duncan , Donna Finch
IPC分类号： A61K39/395 , C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , A61P13/12 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
摘要翻译： 本发明涉及抗体分子，特别是结合转化生长因子β（TGFβ）的抗体分子及其用途。 更具体地，本发明涉及结合并优选中和TGFbeta1，TGFbeta2和TGFbeta3，所谓的“泛特异性”抗体分子的抗体分子，以及这种抗体分子的用途。 本发明中优选的实施方案是抗体分子，无论是全抗体（例如IgG，如IgG1或IgG4）还是抗体片段（例如scFv，Fab，dAb）。
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公开(公告)号：US07947273B2
公开(公告)日：2011-05-24
申请号：US11821880
申请日：2007-06-25
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S514/826 , Y10S514/883
摘要： Specific binding members, in particular human anti-IL-13 antibody molecules and especially those which neutralise IL-13 activity. Methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, including asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译： 特异性结合成员，特别是人抗IL-13抗体分子，特别是中和IL-13活性的那些。 用于诊断或治疗IL-13相关疾病（包括哮喘，特应性皮炎，过敏性鼻炎，纤维化，炎性肠病和霍奇金淋巴瘤）的抗IL-13抗体分子的方法。
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公开(公告)号：US09315575B2
公开(公告)日：2016-04-19
申请号：US12941677
申请日：2010-11-08
IPC分类号： A61K39/395 , C07K16/24 , A61K39/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S514/826 , Y10S514/883
摘要： Specific binding members, in particular human anti-IL-13 antibody molecules and especially those which neutralise IL-13 activity. Methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, including asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译： 特异性结合成员，特别是人抗IL-13抗体分子，特别是中和IL-13活性的那些。 用于诊断或治疗IL-13相关疾病（包括哮喘，特应性皮炎，过敏性鼻炎，纤维化，炎性肠病和霍奇金淋巴瘤）的抗IL-13抗体分子的方法。
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公开(公告)号：US20120237496A1
公开(公告)日：2012-09-20
申请号：US13378764
申请日：2010-06-21
申请人： Joerg Birkenfeld , Andrea Eicker , Per-Ola Freskgard , Claudia Gotzberger-Schad , Joanna Grudzinska , Ulrich Haupts , Josi Innig , Christoph Mahlert , Andreas Scheidig , Michael Strerath , Jan Tebbe , Johan Per-Wallin , Nina Wobst , Carl Innes Webster , Lutz Jermutus
发明人： Joerg Birkenfeld , Andrea Eicker , Per-Ola Freskgard , Claudia Gotzberger-Schad , Joanna Grudzinska , Ulrich Haupts , Josi Innig , Christoph Mahlert , Andreas Scheidig , Michael Strerath , Jan Tebbe , Johan Per-Wallin , Nina Wobst , Carl Innes Webster , Lutz Jermutus
IPC分类号： A61K38/48 , C12N9/96 , C12N5/10 , A61P25/28 , C12N1/19 , C12N15/63 , C12N15/57 , C12N9/64 , C12N1/15
CPC分类号： C12N9/6494 , A61K38/00 , C12Y304/24011
摘要： The present invention relates to polypeptides comprising protease variants of wild type human neprilysin having an altered specificity and/or activity. In particular the present invention relates to polypeptides comprising protease variants derived from human neprilysin having an increased specificity and/or activity against certain substrates, in particular against amyloid beta.
摘要翻译： 本发明涉及包含具有改变的特异性和/或活性的野生型人体炎蛋白的蛋白酶变体的多肽。 特别地，本发明涉及包含衍生自人尼泊金的蛋白酶变体的多肽，其具有针对某些底物，特别是针对淀粉样β的特异性和/或活性增加。
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公开(公告)号：US07829090B2
公开(公告)日：2010-11-09
申请号：US10564647
申请日：2004-07-15
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S514/826 , Y10S514/883
摘要： Specific binding members, in particular human anti-IL-13 antibody molecules and especially those which neutralise IL-13 activity. Methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, including asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译： 特异性结合成员，特别是人抗IL-13抗体分子，特别是中和IL-13活性的那些。 用于诊断或治疗IL-13相关疾病（包括哮喘，特应性皮炎，过敏性鼻炎，纤维化，炎性肠病和霍奇金淋巴瘤）的抗IL-13抗体分子的方法。
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公开(公告)号：US20090123478A1
公开(公告)日：2009-05-14
申请号：US11821880
申请日：2007-06-25
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , C12N5/00 , C12P21/00 , G01N33/53 , A61P11/06 , A61P17/00 , A61P35/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S514/826 , Y10S514/883
摘要： Specific binding members, in particular human anti-IL-13 antibody molecules and especially those which neutralise IL-13 activity. Methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, including asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.
摘要翻译： 特异性结合成员，特别是人抗IL-13抗体分子，特别是中和IL-13活性的那些。 用于诊断或治疗IL-13相关疾病（包括哮喘，特应性皮炎，过敏性鼻炎，纤维化，炎性肠病和霍奇金淋巴瘤）的抗IL-13抗体分子的方法。
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