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公开(公告)号：US09254258B2
公开(公告)日：2016-02-09
申请号：US12991321
申请日：2009-05-14
IPC分类号： A61K9/51 , A61K9/00 , C12N5/071 , A61K31/7105 , B82Y5/00 , A61K9/127 , A61K48/00 , C12N15/11
CPC分类号： A61K9/1273 , A61K9/0019 , A61K31/713 , A61K48/0041 , C12N15/111 , C12N2320/32
摘要： The present invention provides a composition comprising vesicles and encapsulated within the vesicles, nucleic acid comprising less than 1000 nucleotides, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block.Methods of forming vesicles and methods of delivering nucleic acid, in particular, iRNA into cells, are also provided.
摘要翻译： 本发明提供包含囊泡并包封在囊泡内的组合物，其包含小于1000个核苷酸的核酸，其中囊泡包含具有亲水和疏水嵌段的两亲性嵌段共聚物。 还提供了形成囊泡的方法和将核酸，特别是将iRNA递送到细胞中的方法。
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公开(公告)号：US20110151013A1
公开(公告)日：2011-06-23
申请号：US12991321
申请日：2009-05-14
IPC分类号： A61K9/51 , A61K9/00 , C12N5/071 , A61K31/7105 , B82Y5/00
CPC分类号： A61K9/1273 , A61K9/0019 , A61K31/713 , A61K48/0041 , C12N15/111 , C12N2320/32
摘要： The present invention provides a composition comprising vesicles and encapsulated within the vesicles, nucleic acid comprising less than 1000 nucleotides, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block.Methods of forming vesicles and methods of delivering nucleic acid, in particular, iRNA into cells, are also provided.
摘要翻译： 本发明提供包含囊泡并包封在囊泡内的组合物，其包含小于1000个核苷酸的核酸，其中囊泡包含具有亲水和疏水嵌段的两亲嵌段共聚物。 还提供了形成囊泡的方法和将核酸，特别是将iRNA递送到细胞中的方法。
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公开(公告)号：US09732142B2
公开(公告)日：2017-08-15
申请号：US12991330
申请日：2009-05-14
IPC分类号： C07K16/00 , A61K9/127 , C08F290/00 , C08F293/00 , C08L53/00 , A61K39/00
CPC分类号： C07K16/00 , A61K9/1273 , A61K2039/505 , C08F290/00 , C08F293/005 , C08L53/00 , C08L2666/02
摘要： The present invention concerns a composition comprising vesicles and encapsulated within the vesicles, an antibody, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block.Methods of delivering the above compositions into cells are also described.
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公开(公告)号：US20110111036A1
公开(公告)日：2011-05-12
申请号：US12991330
申请日：2009-05-14
IPC分类号： A61K39/395 , A61K9/00 , A61K9/14 , C12N5/071 , B82Y5/00
CPC分类号： C07K16/00 , A61K9/1273 , A61K2039/505 , C08F290/00 , C08F293/005 , C08L53/00 , C08L2666/02
摘要： The present invention concerns a composition comprising vesicles and encapsulated within the vesicles, an antibody, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block.Methods of delivering the above compositions into cells are also described.
摘要翻译： 本发明涉及包含泡囊并包封在囊泡内的组合物，抗体，其中囊泡包含具有亲水和疏水嵌段的两亲性嵌段共聚物。 还描述了将上述组合物递送到细胞中的方法。
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公开(公告)号：US10525004B2
公开(公告)日：2020-01-07
申请号：US12991349
申请日：2009-05-14
申请人： Giuseppe Battaglia
发明人： Giuseppe Battaglia
IPC分类号： A61K9/00 , A61K9/127 , A61K47/32 , A61K47/34 , C08F293/00
摘要： The present invention relates to composition comprising vesicles and associated with the vesicles, a chemical agent, for use in a method of treatment by therapy wherein the chemical agent is delivered trans- and/or intra-epithelially to a human or animal body, wherein the constructs comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block.Methods for forming the composition are also provided.
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公开(公告)号：US20110150941A1
公开(公告)日：2011-06-23
申请号：US12991349
申请日：2009-05-14
申请人： Giuseppe Battaglia
发明人： Giuseppe Battaglia
IPC分类号： A61K9/00 , C12N5/00 , A61K31/4164 , A61P31/04
CPC分类号： A61K9/0014 , A61K9/1273 , A61K47/32 , A61K47/34 , C08F293/005 , C08F2438/01
摘要： The present invention relates to composition comprising vesicles and associated with the vesicles, a chemical agent, for use in a method of treatment by therapy wherein the chemical agent is delivered trans- and/or intra-epithelially to a human or animal body, wherein the constructs comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block.Methods for forming the composition are also provided.
摘要翻译： 本发明涉及包含囊泡并与泡囊相关的组合物，化学试剂，用于通过治疗方法治疗，其中化学试剂被递送和/或上皮外递送至人或动物体，其中 构建体包含具有亲水和疏水嵌段的两亲性嵌段共聚物。 还提供了用于形成组合物的方法。
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