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公开(公告)号：US11918324B2
公开(公告)日：2024-03-05
申请号：US16990650
申请日：2020-08-11
Applicant: Apple Inc.
Inventor： Thomas J. Sullivan , Wren Nancy Dougherty , Richard C. Kimoto , Erno Klaassen , Ravi K. Narasimhan , Stephen J. Waydo , Todd K. Whitehurst , Derek Park-Shing Young , Santiago Quijano , Zijing Zeng
CPC classification number: A61B5/02125 , A61B5/14551 , A61B5/282 , A61B5/681 , A61B5/6824 , A61B5/02416 , A61B5/053
Abstract: A pulse transit time is measured non-invasively and used to calculate a blood pressure value. A method of determining one or more blood pressure values includes propagating an alternating drive current through a thorax of a subject via electrodes located on a wrist-worn device. Resulting voltage levels of the subject are sensed by the wrist-worn device. The voltage levels are processed to detect when a volume of blood is ejected from the left ventricle. Output from a pulse arrival sensor coupled to the wrist-worn device is processed to detect when a blood pressure pulse generated by ejection of the volume of blood from the left ventricle arrives at the wrist. A pulse transit time (PTT) for transit of the blood pressure pulse from the left ventricle to the wrist is calculated. One or more blood pressure values for the subject are determined based on the PTT.
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2.发明申请公开(公告)号：US20170340219A1
公开(公告)日：2017-11-30
申请号：US15681024
申请日：2017-08-18
Applicant: Apple, Inc.
Inventor： Thomas J. Sullivan , Wren Nancy Dougherty , Richard C. Kimoto , Erno Klaassen , Ravi Narasimhan , Stephen J. Waydo , Todd K. Whitehurst , Derek Park-Shing Young , Santiago Quijano , Zijing Zeng
IPC: A61B5/021 , A61B5/0408 , A61B5/00 , A61B5/1455 , A61B5/024 , A61B5/053
CPC classification number: A61B5/02125 , A61B5/02416 , A61B5/04085 , A61B5/053 , A61B5/14551 , A61B5/681 , A61B5/6824
Abstract: Wrist-worn devices and related methods measure a pulse transit time non-invasively and calculate a blood pressure value using the pulse transit time. A wrist-worn device include a wrist-worn elongate band, at least four EKG or ICG electrodes coupled to the wrist-worn device for detecting a ventricular ejection of a heart, a photo-plethysmogram (PPG) sensor coupled to the wrist-worn device for detecting arrival of a blood pressure pulse at the user's wrist, and a controller configured to calculate a pulse transit time (PTT) for the blood pressure pulse. The controller calculates one or more blood pressure values for the user based on the PTT.
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公开(公告)号：US12220213B2
公开(公告)日：2025-02-11
申请号：US16987851
申请日：2020-08-07
Applicant: Apple Inc.
Inventor： Erno H. Klaassen , Wren Nancy Dougherty , Richard C. Kimoto , Ravi K. Narasimhan , Thomas J. Sullivan , Stephen J. Waydo , Todd K. Whitehurst , Santiago Quijano , Derek Park-Shing Young , Zijing Zeng
Abstract: Methods and devices for obtaining a blood pressure measurement of a subject measure a transit time of a blood pulse of the subject. A method includes sensing, with a pulse ejection sensor of a wrist-worn device, ejection of blood from the left ventricle. Arrival of a resulting blood pressure pulse at the wrist is sensed via a pulse arrival sensor of the wrist-worn device. A transit time of the blood pressure pulse from the left ventricle to the wrist is determined. A relative blood pressure value of the subject is determined based on the transit time. A reference absolute blood pressure value associated with the relative blood pressure value is received. An absolute blood pressure value for the relative blood pressure value is determined based on the reference absolute blood pressure value and the relative blood pressure value.
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公开(公告)号：US10702171B2
公开(公告)日：2020-07-07
申请号：US15507659
申请日：2015-09-08
Applicant: Apple Inc.
Inventor： Ravi Narasimhan , Zijing Zeng , Richard C. Kimoto , Erno Klaassen , Thomas J. Sullivan , Derek Park-Shing Young , Todd K. Whitehurst
Abstract: The present invention generally relates to blood pressure monitoring. In some embodiments, methods and devices of measuring a mean arterial pressure are provided and/or monitoring blood pressure changes. A wrist-worn device may include a plurality of sensors backed by a plurality of actuators. Subsets of the plurality of sensors may be selectively actuateable against a wrist of a user using one or more of the plurality of actuators. A preferred sensor and location may be identified based on pressure signals received from each of the sensors. In some embodiments, devices may use a fluid bladder coupled with piezoelectric film sensors. A fluid bladder pressure sensor may be used to calibrate the piezoelectric film signal to provide a static and dynamic pressure reading. In yet another embodiment, a mean arterial pressure may be calculated by processing a swept pressure signal obtained as a sensor is swept through different heights.
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公开(公告)号：US20170281024A1
公开(公告)日：2017-10-05
申请号：US15507607
申请日：2015-09-08
Applicant: Apple, Inc.
Inventor： Ravi Narasimhan , Richard C. Kimoto , Thomas J. Sullivan , Todd K. Whitehurst , Derek Park-shing Young , Zijing Zeng , Erno Klaassen
CPC classification number: A61B5/02125 , A61B5/024 , A61B5/02416 , A61B5/11 , A61B5/1102 , A61B5/681 , A61B5/6824
Abstract: Wrist-worn devices and related methods measure a pulse transit time non-invasively and calculate a blood pressure value using the pulse transit time. A wrist-worn device includes an accelerometer, a photo-plethysmogram (PPG) or a pulse pressure sensor, and a controller. The PPG or the pulse pressure sensor coupled to the wrist-worn device for detecting an arrival of a blood pressure pulse at the user's wrist. The controller is configured to process output signals from the accelerometer to detect when the blood pressure pulse is propagated from the left ventricle of the user's heart, process a signal from the PPG or the pulse pressure sensor to detect when the blood pressure pulse arrives at the wrist, calculate a pulse transit time (PTT) for propagation of the blood pressure pulse from the left ventricle to the wrist, and generate one or more blood pressure values for the user based on the PTT.
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Patent Agency Ranking
公开(公告)号：US11980480B2
公开(公告)日：2024-05-14
申请号：US17821433
申请日：2022-08-22
Applicant: Apple Inc.
Inventor： Chad A. Bossetti , Thomas J. Sullivan , Xiaoyu Guo , Paras Samsukha , Anirban Chatterjee
CPC classification number: A61B5/6844 , A61B5/24 , A61B5/681 , A61B5/7203 , A61B5/7228 , A61B5/7475 , A61B5/30 , A61B5/304
Abstract: Detecting user contact with one or more electrodes of a physiological signal sensor can be used to ensure physiological signals measured by the physiological signal sensor meet waveform characteristics (e.g., of a clinically accurate physiological signal). In some examples, a mobile and/or wearable device can comprise sensing circuitry, stimulation circuitry, and processing circuitry. The stimulation circuit can drive one or more stimulation signals on one or more electrodes, the resulting signal(s) can be measured (e.g., by the sensing circuitry), and the processing circuitry can determine whether a user is in contact with the electrode(s). Additionally or alternatively, in some examples, mobile and/or wearable device can comprise saturation detection circuitry, and the processing circuitry can determine whether the sensing circuitry is saturated.
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公开(公告)号：US11633114B2
公开(公告)日：2023-04-25
申请号：US15578624
申请日：2016-06-16
Applicant: Apple Inc.
Inventor： Tobias J. Harrison-Noonan , Richard H. Koch , Habib S. Karaki , Richard C. Kimoto , R. Keith Montgomery , Thomas J. Sullivan
IPC: A61B5/022 , A61B5/0235 , A61B5/00
Abstract: A low-profile blood pressure measurement system and methods of use are disclosed. The system includes an expandable member or structure that has a multi-compartment structure and/or is mounted on a rigid surface or structure. The system is incorporated into a portable multi-function device, or is configured to communicate with a portable multi-function device.
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公开(公告)号：US11419550B2
公开(公告)日：2022-08-23
申请号：US16565090
申请日：2019-09-09
Applicant: Apple Inc.
Inventor： Chad A. Bossetti , Thomas J. Sullivan , Xiaoyu Guo , Paras Samsukha , Anirban Chatterjee
Abstract: Detecting user contact with one or more electrodes of a physiological signal sensor can be used to ensure physiological signals measured by the physiological signal sensor meet waveform characteristics (e.g., of a clinically accurate physiological signal). In some examples, a mobile and/or wearable device can comprise sensing circuitry, stimulation circuitry, and processing circuitry. The stimulation circuit can drive one or more stimulation signals on one or more electrodes, the resulting signal(s) can be measured (e.g., by the sensing circuitry), and the processing circuitry can determine whether a user is in contact with the electrode(s). Additionally or alternatively, in some examples, mobile and/or wearable device can comprise saturation detection circuitry, and the processing circuitry can determine whether the sensing circuitry is saturated.
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公开(公告)号：US20170360306A1
公开(公告)日：2017-12-21
申请号：US15507659
申请日：2015-09-08
Applicant: Apple, Inc.
Inventor： Ravi Narasimhan , Zijing Zeng , Richard C. Kimoto , Erno Klaassen , Thomas J. Sullivan , Derek Park-Shing Young , Todd K. Whitehurst
Abstract: The present invention generally relates to blood pressure monitoring. In some embodiments, methods and devices of measuring a mean arterial pressure are provided and/or monitoring blood pressure changes. A wrist-worn device may include a plurality of sensors backed by a plurality of actuators. Subsets of the plurality of sensors may be selectively actuateable against a wrist of a user using one or more of the plurality of actuators. A preferred sensor and location may be identified based on pressure signals received from each of the sensors. In some embodiments, devices may use a fluid bladder coupled with piezoelectric film sensors. A fluid bladder pressure sensor may be used to calibrate the piezoelectric film signal to provide a static and dynamic pressure reading. In yet another embodiment, a mean arterial pressure may be calculated by processing a swept pressure signal obtained as a sensor is swept through different heights.
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10.发明申请公开(公告)号：US20200367767A1
公开(公告)日：2020-11-26
申请号：US16990650
申请日：2020-08-11
Applicant: Apple Inc.
Inventor： Thomas J. Sullivan , Wren Nancy Dougherty , Richard C. Kimoto , Erno Klaassen , Ravi K. Narasimhan , Stephen J. Waydo , Todd K. Whitehurst , Derek Park-Shing Young , Santiago Quijano , Zijing Zeng
IPC: A61B5/021 , A61B5/0408 , A61B5/1455 , A61B5/00
Abstract: A pulse transit time is measured non-invasively and used to calculate a blood pressure value. A method of determining one or more blood pressure values includes propagating an alternating drive current through a thorax of a subject via electrodes located on a wrist-worn device. Resulting voltage levels of the subject are sensed by the wrist-worn device. The voltage levels are processed to detect when a volume of blood is ejected from the left ventricle. Output from a pulse arrival sensor coupled to the wrist-worn device is processed to detect when a blood pressure pulse generated by ejection of the volume of blood from the left ventricle arrives at the wrist. A pulse transit time (PTT) for transit of the blood pressure pulse from the left ventricle to the wrist is calculated. One or more blood pressure values for the subject are determined based on the PTT.
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