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公开(公告)号：US12220213B2
公开(公告)日：2025-02-11
申请号：US16987851
申请日：2020-08-07
Applicant: Apple Inc.
Inventor： Erno H. Klaassen , Wren Nancy Dougherty , Richard C. Kimoto , Ravi K. Narasimhan , Thomas J. Sullivan , Stephen J. Waydo , Todd K. Whitehurst , Santiago Quijano , Derek Park-Shing Young , Zijing Zeng
Abstract: Methods and devices for obtaining a blood pressure measurement of a subject measure a transit time of a blood pulse of the subject. A method includes sensing, with a pulse ejection sensor of a wrist-worn device, ejection of blood from the left ventricle. Arrival of a resulting blood pressure pulse at the wrist is sensed via a pulse arrival sensor of the wrist-worn device. A transit time of the blood pressure pulse from the left ventricle to the wrist is determined. A relative blood pressure value of the subject is determined based on the transit time. A reference absolute blood pressure value associated with the relative blood pressure value is received. An absolute blood pressure value for the relative blood pressure value is determined based on the reference absolute blood pressure value and the relative blood pressure value.
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公开(公告)号：US11918324B2
公开(公告)日：2024-03-05
申请号：US16990650
申请日：2020-08-11
Applicant: Apple Inc.
Inventor： Thomas J. Sullivan , Wren Nancy Dougherty , Richard C. Kimoto , Erno Klaassen , Ravi K. Narasimhan , Stephen J. Waydo , Todd K. Whitehurst , Derek Park-Shing Young , Santiago Quijano , Zijing Zeng
CPC classification number: A61B5/02125 , A61B5/14551 , A61B5/282 , A61B5/681 , A61B5/6824 , A61B5/02416 , A61B5/053
Abstract: A pulse transit time is measured non-invasively and used to calculate a blood pressure value. A method of determining one or more blood pressure values includes propagating an alternating drive current through a thorax of a subject via electrodes located on a wrist-worn device. Resulting voltage levels of the subject are sensed by the wrist-worn device. The voltage levels are processed to detect when a volume of blood is ejected from the left ventricle. Output from a pulse arrival sensor coupled to the wrist-worn device is processed to detect when a blood pressure pulse generated by ejection of the volume of blood from the left ventricle arrives at the wrist. A pulse transit time (PTT) for transit of the blood pressure pulse from the left ventricle to the wrist is calculated. One or more blood pressure values for the subject are determined based on the PTT.
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公开(公告)号：US20220254984A1
公开(公告)日：2022-08-11
申请号：US17730841
申请日：2022-04-27
Applicant: Apple Inc.
Inventor： Chin San Han , German A. Alvarez , Santiago Quijano , Stuart W. Wenzel
IPC: H01L41/113 , H01L41/047 , A61B5/00 , H01L41/083 , H01L41/08 , G01L1/16 , A61B5/11 , G01L1/20
Abstract: Disclosed herein are monitoring systems and sensors for physiological measurements. The sensors can be multi-element piezo sensors capable of generating multiple electrical signals, whereby the monitoring systems can receive the multiple electrical signals to analyze the user's vital signs along multiple regions of the user's body. In some examples, the piezo sensor can include one or more corrugations, such as peaks and valleys, to create localized regions with increased mechanical response to force. The sensitivity and resolution of the piezo sensor can be enhanced by further locating electrode sections at the corrugations, where the electrode sections can be electrically isolated and independently operable from other electrode sections. Traces electrically connecting an electrode section to, e.g., an off-panel controller can be routed over and/or around other electrode sections by including an insulator to electrically insulate from the other electrode sections, or by using vias to route through one or more layers.
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4.发明申请公开(公告)号：US20170340219A1
公开(公告)日：2017-11-30
申请号：US15681024
申请日：2017-08-18
Applicant: Apple, Inc.
Inventor： Thomas J. Sullivan , Wren Nancy Dougherty , Richard C. Kimoto , Erno Klaassen , Ravi Narasimhan , Stephen J. Waydo , Todd K. Whitehurst , Derek Park-Shing Young , Santiago Quijano , Zijing Zeng
IPC: A61B5/021 , A61B5/0408 , A61B5/00 , A61B5/1455 , A61B5/024 , A61B5/053
CPC classification number: A61B5/02125 , A61B5/02416 , A61B5/04085 , A61B5/053 , A61B5/14551 , A61B5/681 , A61B5/6824
Abstract: Wrist-worn devices and related methods measure a pulse transit time non-invasively and calculate a blood pressure value using the pulse transit time. A wrist-worn device include a wrist-worn elongate band, at least four EKG or ICG electrodes coupled to the wrist-worn device for detecting a ventricular ejection of a heart, a photo-plethysmogram (PPG) sensor coupled to the wrist-worn device for detecting arrival of a blood pressure pulse at the user's wrist, and a controller configured to calculate a pulse transit time (PTT) for the blood pressure pulse. The controller calculates one or more blood pressure values for the user based on the PTT.
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公开(公告)号：US20200367760A1
公开(公告)日：2020-11-26
申请号：US16987851
申请日：2020-08-07
Applicant: Apple Inc.
Inventor： Erno H. Klaassen , Wren Nancy Dougherty , Richard C. Kimoto , Ravi K. Narasimhan , Thomas J. Sullivan , Stephen J. Waydo , Todd K. Whitehurst , Santiago Quijano , Derek Park-Shing Young , Zijing Zeng
Abstract: Methods and devices for obtaining a blood pressure measurement of a subject measure a transit time of a blood pulse of the subject. A method includes sensing, with a pulse ejection sensor of a wrist-worn device, ejection of blood from the left ventricle. Arrival of a resulting blood pressure pulse at the wrist is sensed via a pulse arrival sensor of the wrist-worn device. A transit time of the blood pressure pulse from the left ventricle to the wrist is determined. A relative blood pressure value of the subject is determined based on the transit time. A reference absolute blood pressure value associated with the relative blood pressure value is received. An absolute blood pressure value for the relative blood pressure value is determined based on the reference absolute blood pressure value and the relative blood pressure value.
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Patent Agency Ranking
公开(公告)号：US10779738B2
公开(公告)日：2020-09-22
申请号：US15681024
申请日：2017-08-18
Applicant: Apple Inc.
Inventor： Thomas J. Sullivan , Wren Nancy Dougherty , Richard C. Kimoto , Erno Klaassen , Ravi Narasimhan , Stephen J. Waydo , Todd K. Whitehurst , Derek Park-Shing Young , Santiago Quijano , Zijing Zeng
IPC: A61B5/021 , A61B5/0408 , A61B5/1455 , A61B5/00 , A61B5/024 , A61B5/053
Abstract: Wrist-worn devices and related methods measure a pulse transit time non-invasively and calculate a blood pressure value using the pulse transit time. A wrist-worn device include a wrist-worn elongate band, at least four EKG or ICG electrodes coupled to the wrist-worn device for detecting a ventricular ejection of a heart, a photo-plethysmogram (PPG) sensor coupled to the wrist-worn device for detecting arrival of a blood pressure pulse at the user's wrist, and a controller configured to calculate a pulse transit time (PTT) for the blood pressure pulse. The controller calculates one or more blood pressure values for the user based on the PTT.
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公开(公告)号：US20170340209A1
公开(公告)日：2017-11-30
申请号：US15680931
申请日：2017-08-18
Applicant: Apple, Inc.
Inventor： Erno H. Klaassen , Wren Nancy Dougherty , Richard C. Kimoto , Ravi Narasimhan , Thomas J. Sullivan , Stephen J. Waydo , Todd K. Whitehurst , Santiago Quijano , Derek Park-Shing Young , Zijing Zeng
Abstract: The present invention provides non-invasive devices, methods, and systems for determining a pressure of blood within a cardiovascular system of a user, the cardiovascular system including a heart and the user having a wrist covered by skin. More particularly, the present invention discloses a variety of wrist-worn devices having a variety of sensors configured to non-invasively engage the skin on the wrist of the user for sensing a variety of user signals from the cardiovascular system of the user. Generally, approaches disclosed herein may passively track blood pressure values without any interaction required on the part of the user or may allow for on demand or point measurements of blood pressure values by having a user actively interact with the sensors of the wrist-worn device. Approaches disclosed herein further allow for absolute blood pressure values to be determined directly without the requirement for any periodic calibrations or for relative blood pressure values to be tracked so as to provide relative blood pressure indices.
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公开(公告)号：US12219877B2
公开(公告)日：2025-02-04
申请号：US17730841
申请日：2022-04-27
Applicant: Apple Inc.
Inventor： Chin San Han , German A. Alvarez , Santiago Quijano , Stuart W. Wenzel
IPC: H01L41/113 , A61B5/00 , A61B5/11 , G01L1/16 , G01L1/20 , H10N30/00 , H10N30/30 , H10N30/50 , H10N30/87 , A61B5/0205
Abstract: Disclosed herein are monitoring systems and sensors for physiological measurements. The sensors can be multi-element piezo sensors capable of generating multiple electrical signals, whereby the monitoring systems can receive the multiple electrical signals to analyze the user's vital signs along multiple regions of the user's body. In some examples, the piezo sensor can include one or more corrugations, such as peaks and valleys, to create localized regions with increased mechanical response to force. The sensitivity and resolution of the piezo sensor can be enhanced by further locating electrode sections at the corrugations, where the electrode sections can be electrically isolated and independently operable from other electrode sections. Traces electrically connecting an electrode section to, e.g., an off-panel controller can be routed over and/or around other electrode sections by including an insulator to electrically insulate from the other electrode sections, or by using vias to route through one or more layers.
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公开(公告)号：US11349063B2
公开(公告)日：2022-05-31
申请号：US15986643
申请日：2018-05-22
Applicant: Apple Inc.
Inventor： Chin San Han , German A. Alvarez , Santiago Quijano , Stuart W. Wenzel
IPC: H01L41/113 , H01L41/047 , A61B5/00 , H01L41/083 , H01L41/08 , G01L1/16 , A61B5/11 , G01L1/20 , A61B5/0205
Abstract: Disclosed herein are monitoring systems and sensors for physiological measurements. The sensors can be multi-element piezo sensors capable of generating multiple electrical signals, whereby the monitoring systems can receive the multiple electrical signals to analyze the user's vital signs along multiple regions of the user's body. In some examples, the piezo sensor can include one or more corrugations, such as peaks and valleys, to create localized regions with increased mechanical response to force. The sensitivity and resolution of the piezo sensor can be enhanced by further locating electrode sections at the corrugations, where the electrode sections can be electrically isolated and independently operable from other electrode sections. Traces electrically connecting an electrode section to, e.g., an off-panel controller can be routed over and/or around other electrode sections by including an insulator to electrically insulate from the other electrode sections, or by using vias to route through one or more layers.
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10.发明申请公开(公告)号：US20200367767A1
公开(公告)日：2020-11-26
申请号：US16990650
申请日：2020-08-11
Applicant: Apple Inc.
Inventor： Thomas J. Sullivan , Wren Nancy Dougherty , Richard C. Kimoto , Erno Klaassen , Ravi K. Narasimhan , Stephen J. Waydo , Todd K. Whitehurst , Derek Park-Shing Young , Santiago Quijano , Zijing Zeng
IPC: A61B5/021 , A61B5/0408 , A61B5/1455 , A61B5/00
Abstract: A pulse transit time is measured non-invasively and used to calculate a blood pressure value. A method of determining one or more blood pressure values includes propagating an alternating drive current through a thorax of a subject via electrodes located on a wrist-worn device. Resulting voltage levels of the subject are sensed by the wrist-worn device. The voltage levels are processed to detect when a volume of blood is ejected from the left ventricle. Output from a pulse arrival sensor coupled to the wrist-worn device is processed to detect when a blood pressure pulse generated by ejection of the volume of blood from the left ventricle arrives at the wrist. A pulse transit time (PTT) for transit of the blood pressure pulse from the left ventricle to the wrist is calculated. One or more blood pressure values for the subject are determined based on the PTT.
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