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公开(公告)号:US20170360306A1
公开(公告)日:2017-12-21
申请号:US15507659
申请日:2015-09-08
Applicant: Apple, Inc.
Inventor: Ravi Narasimhan , Zijing Zeng , Richard C. Kimoto , Erno Klaassen , Thomas J. Sullivan , Derek Park-Shing Young , Todd K. Whitehurst
Abstract: The present invention generally relates to blood pressure monitoring. In some embodiments, methods and devices of measuring a mean arterial pressure are provided and/or monitoring blood pressure changes. A wrist-worn device may include a plurality of sensors backed by a plurality of actuators. Subsets of the plurality of sensors may be selectively actuateable against a wrist of a user using one or more of the plurality of actuators. A preferred sensor and location may be identified based on pressure signals received from each of the sensors. In some embodiments, devices may use a fluid bladder coupled with piezoelectric film sensors. A fluid bladder pressure sensor may be used to calibrate the piezoelectric film signal to provide a static and dynamic pressure reading. In yet another embodiment, a mean arterial pressure may be calculated by processing a swept pressure signal obtained as a sensor is swept through different heights.
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公开(公告)号:US20210041287A1
公开(公告)日:2021-02-11
申请号:US16930125
申请日:2020-07-15
Applicant: Apple Inc.
Inventor: Henry Rimminen , Ali M. Amin , Timothy L. Weadon , Yindar Chuo , Zijing Zeng , Erno Klaassen
IPC: G01H11/08 , A61B5/00 , H01L41/047 , H01L41/113 , A61B5/08 , A61B5/0205
Abstract: A sensor system includes a sensor stack, a differential amplifier, an analog-to-digital converter, and a processor. The sensor stack includes a piezoelectric material having a first side opposing a second side, a first electrode connected to the first side, and a second electrode connected to the second side. The differential amplifier is coupled to the first and second electrodes and is configured to generate a differential output indicative of vibrations sensed by the piezoelectric material. The analog-to-differential converter is configured to digitize the differential output. The processor is configured to identify a type of biological vibration included in the digitized differential output.
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3.
公开(公告)号:US20200367767A1
公开(公告)日:2020-11-26
申请号:US16990650
申请日:2020-08-11
Applicant: Apple Inc.
Inventor: Thomas J. Sullivan , Wren Nancy Dougherty , Richard C. Kimoto , Erno Klaassen , Ravi K. Narasimhan , Stephen J. Waydo , Todd K. Whitehurst , Derek Park-Shing Young , Santiago Quijano , Zijing Zeng
IPC: A61B5/021 , A61B5/0408 , A61B5/1455 , A61B5/00
Abstract: A pulse transit time is measured non-invasively and used to calculate a blood pressure value. A method of determining one or more blood pressure values includes propagating an alternating drive current through a thorax of a subject via electrodes located on a wrist-worn device. Resulting voltage levels of the subject are sensed by the wrist-worn device. The voltage levels are processed to detect when a volume of blood is ejected from the left ventricle. Output from a pulse arrival sensor coupled to the wrist-worn device is processed to detect when a blood pressure pulse generated by ejection of the volume of blood from the left ventricle arrives at the wrist. A pulse transit time (PTT) for transit of the blood pressure pulse from the left ventricle to the wrist is calculated. One or more blood pressure values for the subject are determined based on the PTT.
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公开(公告)号:US11918324B2
公开(公告)日:2024-03-05
申请号:US16990650
申请日:2020-08-11
Applicant: Apple Inc.
Inventor: Thomas J. Sullivan , Wren Nancy Dougherty , Richard C. Kimoto , Erno Klaassen , Ravi K. Narasimhan , Stephen J. Waydo , Todd K. Whitehurst , Derek Park-Shing Young , Santiago Quijano , Zijing Zeng
CPC classification number: A61B5/02125 , A61B5/14551 , A61B5/282 , A61B5/681 , A61B5/6824 , A61B5/02416 , A61B5/053
Abstract: A pulse transit time is measured non-invasively and used to calculate a blood pressure value. A method of determining one or more blood pressure values includes propagating an alternating drive current through a thorax of a subject via electrodes located on a wrist-worn device. Resulting voltage levels of the subject are sensed by the wrist-worn device. The voltage levels are processed to detect when a volume of blood is ejected from the left ventricle. Output from a pulse arrival sensor coupled to the wrist-worn device is processed to detect when a blood pressure pulse generated by ejection of the volume of blood from the left ventricle arrives at the wrist. A pulse transit time (PTT) for transit of the blood pressure pulse from the left ventricle to the wrist is calculated. One or more blood pressure values for the subject are determined based on the PTT.
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5.
公开(公告)号:US20170340219A1
公开(公告)日:2017-11-30
申请号:US15681024
申请日:2017-08-18
Applicant: Apple, Inc.
Inventor: Thomas J. Sullivan , Wren Nancy Dougherty , Richard C. Kimoto , Erno Klaassen , Ravi Narasimhan , Stephen J. Waydo , Todd K. Whitehurst , Derek Park-Shing Young , Santiago Quijano , Zijing Zeng
IPC: A61B5/021 , A61B5/0408 , A61B5/00 , A61B5/1455 , A61B5/024 , A61B5/053
CPC classification number: A61B5/02125 , A61B5/02416 , A61B5/04085 , A61B5/053 , A61B5/14551 , A61B5/681 , A61B5/6824
Abstract: Wrist-worn devices and related methods measure a pulse transit time non-invasively and calculate a blood pressure value using the pulse transit time. A wrist-worn device include a wrist-worn elongate band, at least four EKG or ICG electrodes coupled to the wrist-worn device for detecting a ventricular ejection of a heart, a photo-plethysmogram (PPG) sensor coupled to the wrist-worn device for detecting arrival of a blood pressure pulse at the user's wrist, and a controller configured to calculate a pulse transit time (PTT) for the blood pressure pulse. The controller calculates one or more blood pressure values for the user based on the PTT.
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公开(公告)号:US10779738B2
公开(公告)日:2020-09-22
申请号:US15681024
申请日:2017-08-18
Applicant: Apple Inc.
Inventor: Thomas J. Sullivan , Wren Nancy Dougherty , Richard C. Kimoto , Erno Klaassen , Ravi Narasimhan , Stephen J. Waydo , Todd K. Whitehurst , Derek Park-Shing Young , Santiago Quijano , Zijing Zeng
IPC: A61B5/021 , A61B5/0408 , A61B5/1455 , A61B5/00 , A61B5/024 , A61B5/053
Abstract: Wrist-worn devices and related methods measure a pulse transit time non-invasively and calculate a blood pressure value using the pulse transit time. A wrist-worn device include a wrist-worn elongate band, at least four EKG or ICG electrodes coupled to the wrist-worn device for detecting a ventricular ejection of a heart, a photo-plethysmogram (PPG) sensor coupled to the wrist-worn device for detecting arrival of a blood pressure pulse at the user's wrist, and a controller configured to calculate a pulse transit time (PTT) for the blood pressure pulse. The controller calculates one or more blood pressure values for the user based on the PTT.
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公开(公告)号:US10517489B2
公开(公告)日:2019-12-31
申请号:US15507607
申请日:2015-09-08
Applicant: Apple Inc.
Inventor: Ravi Narasimhan , Richard C. Kimoto , Thomas J. Sullivan , Todd K. Whitehurst , Derek Park-shing Young , Zijing Zeng , Erno Klaassen
Abstract: Wrist-worn devices and related methods measure a pulse transit time non-invasively and calculate a blood pressure value using the pulse transit time. A wrist-worn device includes an accelerometer, a photo-lethysmogram (PPG) or a pulse pressure sensor, and a controller. The PPG or the pulse pressure sensor coupled to the wrist-worn device for detecting an arrival of a blood pressure pulse at the user's wrist. The controller is configured to process output signals from the accelerometer to detect when the blood pressure pulse is propagated from the left ventricle of the user's heart, process a signal from the PPG or the pulse pressure sensor to detect when the blood pressure pulse arrives at the wrist, calculate a pulse transit time (PTT) for propagation of the blood pressure pulse from the left ventricle to the wrist, and generate one or more blood pressure values for the user based on the PTT.
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公开(公告)号:US10702171B2
公开(公告)日:2020-07-07
申请号:US15507659
申请日:2015-09-08
Applicant: Apple Inc.
Inventor: Ravi Narasimhan , Zijing Zeng , Richard C. Kimoto , Erno Klaassen , Thomas J. Sullivan , Derek Park-Shing Young , Todd K. Whitehurst
Abstract: The present invention generally relates to blood pressure monitoring. In some embodiments, methods and devices of measuring a mean arterial pressure are provided and/or monitoring blood pressure changes. A wrist-worn device may include a plurality of sensors backed by a plurality of actuators. Subsets of the plurality of sensors may be selectively actuateable against a wrist of a user using one or more of the plurality of actuators. A preferred sensor and location may be identified based on pressure signals received from each of the sensors. In some embodiments, devices may use a fluid bladder coupled with piezoelectric film sensors. A fluid bladder pressure sensor may be used to calibrate the piezoelectric film signal to provide a static and dynamic pressure reading. In yet another embodiment, a mean arterial pressure may be calculated by processing a swept pressure signal obtained as a sensor is swept through different heights.
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公开(公告)号:US20170281024A1
公开(公告)日:2017-10-05
申请号:US15507607
申请日:2015-09-08
Applicant: Apple, Inc.
Inventor: Ravi Narasimhan , Richard C. Kimoto , Thomas J. Sullivan , Todd K. Whitehurst , Derek Park-shing Young , Zijing Zeng , Erno Klaassen
CPC classification number: A61B5/02125 , A61B5/024 , A61B5/02416 , A61B5/11 , A61B5/1102 , A61B5/681 , A61B5/6824
Abstract: Wrist-worn devices and related methods measure a pulse transit time non-invasively and calculate a blood pressure value using the pulse transit time. A wrist-worn device includes an accelerometer, a photo-plethysmogram (PPG) or a pulse pressure sensor, and a controller. The PPG or the pulse pressure sensor coupled to the wrist-worn device for detecting an arrival of a blood pressure pulse at the user's wrist. The controller is configured to process output signals from the accelerometer to detect when the blood pressure pulse is propagated from the left ventricle of the user's heart, process a signal from the PPG or the pulse pressure sensor to detect when the blood pressure pulse arrives at the wrist, calculate a pulse transit time (PTT) for propagation of the blood pressure pulse from the left ventricle to the wrist, and generate one or more blood pressure values for the user based on the PTT.
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