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公开(公告)号：US20250033971A1
公开(公告)日：2025-01-30
申请号：US18913675
申请日：2024-10-11
Inventor： Alexandra Ros , Mohammad Towshif Rabbani , Christoph Schmidt
IPC: C01B32/172 , B03C5/02
Abstract: Systems & methods for sorting single-walled carbon nanotubes (SWNTs) using an iDEP-based sorting device. The device includes an inlet channel with a constriction and the inlet channel splits into multiple different channels after the constriction—the multiple channels includes a center channel and at least one side channel. A sample is introduced into the iDEP sorting device containing a plurality of SWNTs of different lengths suspended in a fluid. An electrical field is applied to the sample between a first electrode in the center channel and a second electrodes at a proximal end of the inlet channel. The applied electrical field causes longer SWNTs to move towards the side channels while the shorter SWNTs move towards the center channel. Accordingly, a first plurality of shorter SWNTs is then collected from the center channel and a second plurality of longer SWNTs is collected from the at least one side channel.
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公开(公告)号：US10969350B2
公开(公告)日：2021-04-06
申请号：US16616189
申请日：2018-05-22
Inventor： Alexandra Ros , Daihyun Kim , Austin Echelmeier , Jorvani Cruz Villarreal , Ana Egatz-Gomez , Sebastian Quintana
IPC: F16K11/02 , G01N23/20025 , B33Y80/00 , B01L3/02 , B01L3/00
Abstract: Methods and systems are provided for serial femtosecond crystallography for reducing the vast amount of waste of injected crystals practiced with traditional continuous flow injections. A micrometer-scale 3-D printed water-in-oil droplet generator device includes an oil phase inlet channel, an aqueous phase inlet channel, a droplet flow outlet channel, and two embedded non-contact electrodes. The inlet and outlet channels are connected internally at a junction. The electrodes comprise gallium metal injected within the 3-D printed device. Voltage across the electrodes generates water-in-oil droplets, determines a rate for a series of droplets, or triggers a phase shift in the droplets. An external trigger generates the droplets based on the frequency of an XFEL utilized in droplet detection, thereby synchronizing a series of droplets with x-ray pulses for efficient crystal detection. The generated droplets can be coupled to an SFX with XFEL experiment compatible with common liquid injector such as a GDVN.
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公开(公告)号：US12145849B2
公开(公告)日：2024-11-19
申请号：US17722106
申请日：2022-04-15
Inventor： Alexandra Ros , Mohammad Towshif Rabbani , Christoph Schmidt
IPC: C01B32/172 , B03C5/02
Abstract: Systems & methods for sorting single-walled carbon nanotubes (SWNTs) using an iDEP-based sorting device. The device includes an inlet channel with a constriction and the inlet channel splits into multiple different channels after the constriction—the multiple channels includes a center channel and at least one side channel. A sample is introduced into the iDEP sorting device containing a plurality of SWNTs of different lengths suspended in a fluid. An electrical field is applied to the sample between a first electrode in the center channel and a second electrodes at a proximal end of the inlet channel. The applied electrical field causes longer SWNTs to move towards the side channels while the shorter SWNTs move towards the center channel. Accordingly, a first plurality of shorter SWNTs is then collected from the center channel and a second plurality of longer SWNTs is collected from the at least one side channel.
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公开(公告)号：US11485632B2
公开(公告)日：2022-11-01
申请号：US17497675
申请日：2021-10-08
Inventor： Alexandra Ros , John Spence , Diandra Doppler , Garrett Nelson , Richard Kirian , Reza Nazari , Ana Egatz-Gomez , Mukul Sonker , Mohammad Rabbani
Abstract: A microfluidic device for use in a serial crystallography apparatus includes a modular 3D-printed nozzle having an inlet, an outlet, and a first snap engagement feature. The microfluidic device further includes a modular 3D-printed fiber holder having an outlet and a second snap engagement feature. The first snap engagement feature is configured to engage the second snap engagement feature to removably couple the nozzle to the fiber holder. The outlet of the fiber holder is aligned with the inlet of the nozzle when the first snap engagement feature is coupled to the second snap engagement feature.
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Patent Agency Ranking
公开(公告)号：US20220332583A1
公开(公告)日：2022-10-20
申请号：US17722106
申请日：2022-04-15
Inventor： Alexandra Ros , Mohammad Towshif Rabbani , Christoph Schmidt
IPC: C01B32/172 , C01B32/162
Abstract: Systems & methods for sorting single-walled carbon nanotubes (SWNTs) using an iDEP-based sorting device. The device includes an inlet channel with a constriction and the inlet channel splits into multiple different channels after the constriction—the multiple channels includes a center channel and at least one side channel. A sample is introduced into the iDEP sorting device containing a plurality of SWNTs of different lengths suspended in a fluid. An electrical field is applied to the sample between a first electrode in the center channel and a second electrodes at a proximal end of the inlet channel. The applied electrical field causes longer SWNTs to move towards the side channels while the shorter SWNTs move towards the center channel. Accordingly, a first plurality of shorter SWNTs is then collected from the center channel and a second plurality of longer SWNTs is collected from the at least one side channel.
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公开(公告)号：US12123840B2
公开(公告)日：2024-10-22
申请号：US18504091
申请日：2023-11-07
Inventor： Alexandra Ros , Daihyun Kim , Austin Echelmeier , Jorvani Cruz Villarreal , Ana Egatz-Gomez , Sebastian Quintana
IPC: G01N23/20025 , B01L3/00 , B01L3/02 , B33Y80/00
CPC classification number: G01N23/20025 , B01L3/0241 , B01L3/50273 , B33Y80/00 , B01L2300/0867 , G01N2223/602
Abstract: Methods and systems are provided for serial femtosecond crystallography for reducing the vast amount of waste of injected crystals practiced with traditional continuous flow injections. A micrometer-scale 3-D printed water-in-oil droplet generator device includes an oil phase inlet channel, an aqueous phase inlet channel, a droplet flow outlet channel, and two embedded non-contact electrodes. The inlet and outlet channels are connected internally at a junction. The electrodes comprise gallium metal injected within the 3-D printed device. Voltage across the electrodes generates water-in-oil droplets, determines a rate for a series of droplets, or triggers a phase shift in the droplets. An external trigger generates the droplets based on the frequency of an XFEL utilized in droplet detection, thereby synchronizing a series of droplets with x-ray pulses for efficient crystal detection. The generated droplets can be coupled to an SFX with XFEL experiment compatible with common liquid injector such as a GDVN.
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公开(公告)号：US12017924B2
公开(公告)日：2024-06-25
申请号：US18296501
申请日：2023-04-06
Inventor： Ana Egatz-Gomez , Alexandra Ros
CPC classification number: C01F17/36 , B01J19/0013 , B01J19/126 , C01F17/265 , C09K11/025 , C09K11/7773 , B01J2219/00033 , B01J2219/00141 , B01J2219/00162 , B01J2219/00166 , B82Y30/00 , B82Y40/00 , C01P2004/38 , C01P2004/64 , C01P2006/60
Abstract: Synthesizing upconverting nanoparticles includes heating a precursor solution comprising one or more rare earth salts, an alkali metal salt or alkaline earth salt, and a solvent comprising a plasticizer in a microwave reactor to yield a product mixture, and cooling the product mixture to yield the upconverting nanoparticles. Core-shell upconverting nanoparticles are synthesized by combining the upconverting nanoparticles with a precursor solution comprising one or more rare earth salts, an alkali metal salt or alkaline earth salt, and a solvent comprising a plasticizer to yield a nanoparticle mixture, heating the nanoparticle mixture in a microwave reactor to yield a product mixture, and cooling the product mixture to yield the core-shell upconverting nanoparticles.
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公开(公告)号：US11867644B2
公开(公告)日：2024-01-09
申请号：US17220357
申请日：2021-04-01
Inventor： Alexandra Ros , Daihyun Kim , Austin Echelmeier , Jorvani Cruz Villarreal , Ana Egatz-Gomez , Sebastian Quintana
IPC: G01N23/20025 , B33Y80/00 , B01L3/02 , B01L3/00
CPC classification number: G01N23/20025 , B01L3/0241 , B01L3/50273 , B33Y80/00 , B01L2300/0867 , G01N2223/602
Abstract: Methods and systems are provided for serial femtosecond crystallography for reducing the vast amount of waste of injected crystals practiced with traditional continuous flow injections. A micrometer-scale 3-D printed water-in-oil droplet generator device includes an oil phase inlet channel, an aqueous phase inlet channel, a droplet flow outlet channel, and two embedded non-contact electrodes. The inlet and outlet channels are connected internally at a junction. The electrodes comprise gallium metal injected within the 3-D printed device. Voltage across the electrodes generates water-in-oil droplets, determines a rate for a series of droplets, or triggers a phase shift in the droplets. An external trigger generates the droplets based on the frequency of an XFEL utilized in droplet detection, thereby synchronizing a series of droplets with x-ray pulses for efficient crystal detection. The generated droplets can be coupled to an SFX with XFEL experiment compatible with common liquid injector such as a GDVN.
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公开(公告)号：US10557807B2
公开(公告)日：2020-02-11
申请号：US16328262
申请日：2018-05-22
Inventor： Alexandra Ros , Gerrit Brehm , Garrett Nelson , John Spence , Uwe Weierstall , Austin Echelmeier
IPC: G01N23/2005 , B01F13/00 , B33Y80/00 , G01N23/20025 , B01L3/00
Abstract: A 3D printed hybrid nozzle device combining a microfluidic mixer with a liquid jet injector that addresses the bottleneck of investigating substrate-initiated biological reaction paths employing serial crystallography with XFELs. The hybrid nozzle provides for injecting aqueous protein crystal jets after fast mixing (
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